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  1. Article ; Online: The Kampala declaration on sepsis - The recognition and treatment of severe illness starts at the bedside by recording vital signs.

    Nsutebu, Emmanuel Fru / Kellett, John

    European journal of internal medicine

    2017  Volume 48, Page(s) e9–e10

    MeSH term(s) Critical Illness/therapy ; Guideline Adherence/organization & administration ; Health Personnel/education ; Humans ; Poverty Areas ; Practice Guidelines as Topic ; Quality Improvement/organization & administration ; Sepsis/diagnosis ; Sepsis/therapy ; Uganda ; Vital Signs
    Language English
    Publishing date 2017-12-15
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2017.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: How to close the maternal and neonatal sepsis gap in sub-Saharan Africa.

    Otu, Akaninyene / Nsutebu, Emmanuel Fru / Hirst, Jane E / Thompson, Kelly / Walker, Karen / Yaya, Sanni

    BMJ global health

    2020  Volume 5, Issue 4, Page(s) e002348

    MeSH term(s) Africa South of the Sahara/epidemiology ; Female ; Humans ; Infant, Newborn ; Maternal Health Services ; Neonatal Sepsis/diagnosis ; Neonatal Sepsis/epidemiology ; Pregnancy
    Language English
    Publishing date 2020-04-21
    Publishing country England
    Document type Editorial
    ISSN 2059-7908
    ISSN 2059-7908
    DOI 10.1136/bmjgh-2020-002348
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  3. Article ; Online: Use of specific antimicrobials for COVID-19: should we prescribe them now or wait for more evidence?

    AlAkhras, Abdullah / AlMessabi, Ahmed Husein / Abuzeid, Hala / Khoo, Saye / Nsutebu, Emmanuel Fru

    Postgraduate medical journal

    2020  Volume 96, Issue 1137, Page(s) 377–378

    MeSH term(s) Adult ; Anti-Infective Agents ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Humans ; Lopinavir ; Pandemics ; Pneumonia, Viral ; Ritonavir ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Anti-Infective Agents ; Lopinavir (2494G1JF75) ; Ritonavir (O3J8G9O825)
    Keywords covid19
    Language English
    Publishing date 2020-05-21
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postgradmedj-2020-137990
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  4. Article: Exploring Antimicrobial Stewardship Influential Interventions on Improving Antibiotic Utilization in Outpatient and Inpatient Settings: A Systematic Review and Meta-Analysis.

    Sadeq, Ahmed A / Hasan, Syed Shahzad / AbouKhater, Noha / Conway, Barbara R / Abdelsalam, Abeer E / Shamseddine, Jinan M / Babiker, Zahir Osman Eltahir / Nsutebu, Emmanuel Fru / Bond, Stuart E / Aldeyab, Mamoon A

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 10

    Abstract: Antimicrobial stewardship interventions are targeted efforts by healthcare organizations to optimize antimicrobial use in clinical practice. The study aimed to explore effective interventions in improving antimicrobial use in hospitals. Literature was ... ...

    Abstract Antimicrobial stewardship interventions are targeted efforts by healthcare organizations to optimize antimicrobial use in clinical practice. The study aimed to explore effective interventions in improving antimicrobial use in hospitals. Literature was systemically searched for interventional studies through PubMed, CINAHL, and Scopus databases that were published in the period between January 2010 to April 2022. A random-effects model was used to pool and evaluate data from eligible studies that reported antimicrobial stewardship (AMS) interventions in outpatient and inpatient settings. Pooled estimates presented as proportions and standardized mean differences. Forty-eight articles were included in this review: 32 in inpatient and 16 in outpatient settings. Seventeen interventions have been identified, and eight outcomes have been targeted. AMS interventions improved clinical, microbiological, and cost outcomes in most studies. When comparing non-intervention with intervention groups using meta-analysis, there was an insignificant reduction in length of stay (MD: -0.99; 95% CI: -2.38, 0.39) and a significant reduction in antibiotics' days of therapy (MD: -2.73; 95% CI: -3.92, -1.54). There were noticeable reductions in readmissions, mortality rates, and antibiotic prescriptions post antimicrobial stewardship multi-disciplinary team (AMS-MDT) interventions. Studies that involved a pharmacist as part of the AMS-MDT showed more significant improvement in measured outcomes than the studies that did not involve a pharmacist.
    Language English
    Publishing date 2022-09-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11101306
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  5. Article: Use of specific antimicrobials for COVID-19: should we prescribe them now or wait for more evidence?

    AlAkhras, Abdullah / AlMessabi, Ahmed Husein / Abuzeid, Hala / Khoo, Saye / Nsutebu, Emmanuel Fru

    Postgrad Med J

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32439730
    Database COVID19

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  6. Book ; Online: Use of specific antimicrobials for COVID-19

    AlAkhras, Abdullah / AlMessabi, Ahmed Husein / Abuzeid, Hala / Khoo, Saye / Nsutebu, Emmanuel Fru

    should we prescribe them now or wait for more evidence?

    2020  

    Keywords Editorials ; covid19
    Language English
    Publishing date 2020-07-01 00:00:00.0
    Publisher BMJ Publishing Group Ltd
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Use of specific antimicrobials for COVID-19

    AlAkhras, Abdullah / AlMessabi, Ahmed Husein / Abuzeid, Hala / Khoo, Saye / Nsutebu, Emmanuel Fru

    Postgraduate Medical Journal

    should we prescribe them now or wait for more evidence?

    2020  Volume 96, Issue 1137, Page(s) 377–378

    Keywords General Medicine ; covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postgradmedj-2020-137990
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Impact of Multidisciplinary Team Escalating Approach on Antibiotic Stewardship in the United Arab Emirates.

    Sadeq, Ahmed A / Shamseddine, Jinan M / Babiker, Zahir Osman Eltahir / Nsutebu, Emmanuel Fru / Moukarzel, Marleine B / Conway, Barbara R / Hasan, Syed Shahzad / Conlon-Bingham, Geraldine M / Aldeyab, Mamoon A

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 11

    Abstract: Antimicrobial stewardship programs (ASP) are an essential strategy to combat antimicrobial resistance. This study aimed to measure the impact of an ASP multidisciplinary team (MDT) escalating intervention on improvement of clinical, microbiological, and ... ...

    Abstract Antimicrobial stewardship programs (ASP) are an essential strategy to combat antimicrobial resistance. This study aimed to measure the impact of an ASP multidisciplinary team (MDT) escalating intervention on improvement of clinical, microbiological, and other measured outcomes in hospitalised adult patients from medical, intensive care, and burns units. The escalating intervention reviewed the patients' cases in the intervention group through the clinical pharmacists in the wards and escalated complex cases to ID clinical pharmacist and ID physicians when needed, while only special cases required direct infectious disease (ID) physicians review. Both non-intervention and intervention groups were each followed up for six months. The study involved a total of 3000 patients, with 1340 (45%) representing the intervention group who received a total of 5669 interventions. In the intervention group, a significant reduction in length of hospital stay (
    Language English
    Publishing date 2021-10-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10111289
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  9. Article ; Online: Advancing quality in sepsis management: a large-scale programme for improving sepsis recognition and management in the North West region of England.

    Nsutebu, Emmanuel Fru / Ibarz-Pavón, Ana Belén / Kanwar, Elizabeth / Prospero, Nancy / French, Neil / McGrath, Conor

    Postgraduate medical journal

    2018  Volume 94, Issue 1114, Page(s) 463–468

    Abstract: Objective: To evaluate the impact of a collaborative programme for the early recognition and management of patients admitted with sepsis in the northwest of England.: Setting: 14 hospitals in the northwest of England.: Intervention: A quality ... ...

    Abstract Objective: To evaluate the impact of a collaborative programme for the early recognition and management of patients admitted with sepsis in the northwest of England.
    Setting: 14 hospitals in the northwest of England.
    Intervention: A quality improvement programme (Advancing Quality (AQ) Sepsis) that promoted a sepsis care bundle including time-based recording of early warning scores, documenting systemic inflammatory response syndrome criteria and suspected source of infection, taking of blood cultures, measuring serum lactate levels, administration of intravenous antibiotics, administration of oxygen, fluid resuscitation, measurement of fluid balance and senior review.
    Main outcome measures: Inpatient mortality, 30-day readmission rates and duration of hospital ≥10 days.
    Results: Data for 7776 patients were included in this study between 1 July 2014 and 29 December 2015. Participation in the AQ Sepsis programme was associated with a reduction in readmissions within 30 days (OR 0.81 (0.69-0.95)) and hospital stays over 10 days (OR 0.69 (0.60-0.78)). However, there was no reduction in mortality. Administration of a second litre of intravenous fluid within 2 hours, oxygen therapy and review by a senior clinician were associated with increased mortality. Starting a fluid balance chart within 4 hours was the only clinical process measure that did not affect mortality. Taking a blood culture sample, administering antibiotic therapy and measuring serum lactate within 3 hours of hospital arrival were all associated with reduced mortality (OR 0.69 (0.59-0.81), OR 0.77 (0.67-0.89) and OR 0.64 (0.54-0.77), respectively) and shorter hospitalisations (OR 0.58 (0.49-0.69), OR0.81 (0.70-0.94) and OR 0.54 (0.45-0.66), respectively). However, none of these measures had an impact on the risk of readmission to hospital within 30 days.
    Conclusions: The AQ Sepsis collaborative in northwest of England improved readmission and length of stay for patients admitted with sepsis but did not affect mortality. Further cost-effectiveness evaluation of the programme is needed.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Early Diagnosis ; England/epidemiology ; Female ; Hospital Mortality ; Humans ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Patient Care Bundles ; Patient Readmission/statistics & numerical data ; Quality Improvement ; Retrospective Studies ; Sepsis/diagnosis ; Sepsis/mortality ; Sepsis/therapy
    Language English
    Publishing date 2018-08-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postgradmedj-2018-135833
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  10. Article ; Online: World Sepsis Day: a global agenda to target a leading cause of morbidity and mortality.

    Schlapbach, Luregn J / Kissoon, Niranjan / Alhawsawi, Abdulelah / Aljuaid, Maha H / Daniels, Ron / Gorordo-Delsol, Luis A / Machado, Flavia / Malik, Imrana / Nsutebu, Emmanuel Fru / Finfer, Simon / Reinhart, Konrad

    American journal of physiology. Lung cellular and molecular physiology

    2020  Volume 319, Issue 3, Page(s) L518–L522

    MeSH term(s) Humans ; Sepsis
    Keywords covid19
    Language English
    Publishing date 2020-08-19
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00369.2020
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