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  1. Article: Abdominal Wall Defect Reconstruction with Use of Biological Mesh and Negative Pressure Wound Therapy: a Case Report.

    Symeonidis, Savvas / Anestiadou, Elissavet / Bitsianis, Stefanos / Gemousakakis, Georgios / Ntampakis, Georgios / Loutzidou, Lydia / Ouzounidis, Nikolaos / Kotidis, Efstathios / Mantzoros, Ioannis / Angelopoulos, Stamatios

    Maedica

    2022  Volume 17, Issue 2, Page(s) 518–523

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2022-07-11
    Publishing country Romania
    Document type Editorial
    ZDB-ID 2399972-X
    ISSN 2069-6116 ; 1841-9038
    ISSN (online) 2069-6116
    ISSN 1841-9038
    DOI 10.26574/maedica.2022.17.2.518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effect of Intraperitoneal Chemotherapy with Regorafenib on IL-6 and TNF-α Levels and Peritoneal Cytology: Experimental Study in Rats with Colorectal Peritoneal Carcinomatosis.

    Bitsianis, Stefanos / Mantzoros, Ioannis / Anestiadou, Elissavet / Christidis, Panagiotis / Chatzakis, Christos / Zapsalis, Konstantinos / Symeonidis, Savvas / Ntampakis, Georgios / Domvri, Kalliopi / Tsakona, Anastasia / Bekiari, Chryssa / Ioannidis, Orestis / Aggelopoulos, Stamatios

    Journal of clinical medicine

    2023  Volume 12, Issue 23

    Abstract: Cytoreductive surgery (CRS), combined with hyperthermic intraperitoneal chemotherapy, has significantly improved survival outcomes in patients with peritoneal carcinomatosis from colorectal cancer (CRC). Regorafenib is an oral agent administered in ... ...

    Abstract Cytoreductive surgery (CRS), combined with hyperthermic intraperitoneal chemotherapy, has significantly improved survival outcomes in patients with peritoneal carcinomatosis from colorectal cancer (CRC). Regorafenib is an oral agent administered in patients with refractory metastatic CRC. Our aim was to investigate the outcomes of intraperitoneal administration of regorafenib for intraperitoneal chemotherapy (IPEC) or/and CRS in a rat model of colorectal peritoneal metastases regarding immunology and peritoneal cytology. A total of 24 rats were included. Twenty-eight days after carcinogenesis induction, rats were randomized into following groups: group A: control group; group B: CRS only; group C: IPEC only; and group D: CRS + IPEC. On day 56 after carcinogenesis, euthanasia and laparotomy were performed. Serum levels of interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) as well as peritoneal cytology were investigated. Groups B and D had statistically significant lower mean levels of IL-6 and TNF-α compared to groups A and C, but there was no significant difference between them. Both B and D groups presented a statistically significant difference regarding the rate of negative peritoneal cytology, when compared to the control group, but not to group C. In conclusion, regorafenib-based IPEC, combined with CRS, may constitute a promising tool against peritoneal carcinomatosis by altering the tumor microenvironment.
    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12237267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Role of Adipose Tissue Mesenchymal Stem Cells in Colonic Anastomosis Healing in Inflammatory Bowel Disease: Experimental Study in Rats.

    Ntampakis, Georgios / Pramateftakis, Manousos-Georgios / Ioannidis, Orestis / Bitsianis, Stefanos / Christidis, Panagiotis / Symeonidis, Savvas / Koliakos, Georgios / Karakota, Maria / Bekiari, Chrysanthi / Tsakona, Anastasia / Cheva, Angeliki / Aggelopoulos, Stamatios

    Journal of clinical medicine

    2023  Volume 12, Issue 19

    Abstract: 1) Background: A surgical operation on an inflamed bowel is, diachronically, a challenge for the surgeon, especially for patients with inflammatory bowel disease. Adipose tissue-derived mesenchymal stromal cells are already in use in clinical settings ... ...

    Abstract (1) Background: A surgical operation on an inflamed bowel is, diachronically, a challenge for the surgeon, especially for patients with inflammatory bowel disease. Adipose tissue-derived mesenchymal stromal cells are already in use in clinical settings for their anti-inflammatory properties. The rationale of the current study was to use AdMSCs in high-risk anastomoses to monitor if they attenuate inflammation and prevent anastomotic leak. (2) Methods: a total of 4 groups of rats were subjected to a surgical transection of the large intestine and primary anastomosis. In two groups, DSS 5% was administered for 7 days prior to the procedure, to induce acute intestinal inflammation. After the anastomosis, 5 × 10
    Language English
    Publishing date 2023-10-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12196336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Giant Adrenocortical Carcinoma: A Case Report and Review of the Relevant Literature.

    Mantzoros, Ioannis / Bitsianis, Stefanos / Loutzidou, Lydia / Ntampakis, Georgios / Chatzakis, Christos / Christidis, Panagiotis / Gkiouliava, Anna / Koraki, Eleni / Aggelopoulos, Stamatios

    The American journal of case reports

    2021  Volume 22, Page(s) e928875

    Abstract: BACKGROUND Adrenocortical carcinomas are rare and aggressive tumors often diagnosed as incidentalomas. The malignancy can present with abnormal hormone secretion or the tumor may be non-functioning and present as a palpable mass causing discomfort. Here, ...

    Abstract BACKGROUND Adrenocortical carcinomas are rare and aggressive tumors often diagnosed as incidentalomas. The malignancy can present with abnormal hormone secretion or the tumor may be non-functioning and present as a palpable mass causing discomfort. Here, we present a case of an adrenal cortical carcinoma originally identified as an incidentaloma. CASE REPORT A 63-year-old woman presented with abdominal pain and discomfort. A large abdominal mass, occupying the left upper and lower quadrant, was palpated. Imaging revealed a mass occupying the left abdomen between the stomach and the spleen, applying pressure on the pylorus, duodenum, splenic vessels, and pancreas. The mass size was 21.2×13×14.6 cm. Hormonal investigations were normal. Surgical exploration was performed, and the tumor was excised. Pathological analysis revealed an adrenocortical carcinoma and the patient underwent adjuvant chemotherapy. Twelve months later, the carcinoma recurred. The patient underwent a second operation in which the recurrent mass was excised along with the tail of the pancreas and a small part of the left lobe of the liver. The postoperative period was uneventful, and the patient was discharged home on the 7th postoperative day. No further adjuvant therapy was applied. The patient remains disease-free 18 months after the reoperation. CONCLUSIONS Giant adrenocortical carcinomas, although rare, pose a challenge to the surgical team both diagnostically and therapeutically. Surgical excision with the appropriate oncologic support can guarantee excellent outcomes.
    MeSH term(s) Adrenal Cortex Neoplasms/diagnostic imaging ; Adrenal Cortex Neoplasms/surgery ; Adrenocortical Carcinoma/diagnostic imaging ; Adrenocortical Carcinoma/surgery ; Combined Modality Therapy ; Female ; Humans ; Liver ; Middle Aged ; Neoplasm Recurrence, Local
    Language English
    Publishing date 2021-04-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.928875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The feasibility and effect of intraperitoneal administration of regorafenib on peritoneal carcinomatosis from colorectal cancer in the rat.

    Bitsianis, Stefanos / Mantzoros, Ioannis / Gkiouliava, Anna / Chatzakis, Christos / Bekiari, Chryssa / Loutzidou, Lydia / Ntampakis, Georgios / Christidis, Panagiotis / Domvri, Kalliopi / Porpodis, Konstantinos / Ioannidis, Orestis / Aggelopoulos, Stamatios

    Annali italiani di chirurgia

    2022  Volume 93, Page(s) 592–598

    Abstract: Aim: Our goal was to investigate the potential use and efficacy of regorafenib for IPEC in an animal model of colorectal derived peritoneal metastases. Twenty four male rats were included. Carcinogenesis was induced in all rats through intraperitoneal ... ...

    Abstract Aim: Our goal was to investigate the potential use and efficacy of regorafenib for IPEC in an animal model of colorectal derived peritoneal metastases. Twenty four male rats were included. Carcinogenesis was induced in all rats through intraperitoneal injection of cancer.
    Material and methods: Cells at T0. At T1(Day 28) they were randomly allocated 1:1:1:1 into 4 groups and underwent median laparotomy and the corresponding intervention. Specifically, Group A: no other intervention; Group B: cytoreductive surgery; Group C: intraperitoneal chemotherapy with regorafenib; and Group D: cytoreductive surgery and intraperitoneal chemotherapy with regorafenib. At T2 (Day 56) rats were euthanized and laparotomy was performed for further investigation. The primary outcome was the experimental Peritoneal Cancer Index (ePCI) at T2. Secondary outcomes include relative change of body weight between T1 and T2, weight of the ascites, anastomotic leak/peritonitis and death.
    Results: The ePCI was significantly lower in Group D as opposed to all other groups. Comparing Group C versus Group A we found a trend towards lesser tumor progression, but no significant difference. Growth of rats in Group D was significantly least affected compared to all other groups. Animals undergoing CRS in Group B developed less ascites than Group A and C. Less ascites was found in Group D compared to Group A and C.
    Conclusions: Intraperitoneal chemotherapy with regorafenib combined with cytoreductive surgery may impair metastases' progression.
    Key words: Regorafenib, Chemotherapy, Cytoreductive surgery, Colorectal cancer, Intraperitoneal injection.
    MeSH term(s) Animals ; Antineoplastic Combined Chemotherapy Protocols ; Ascites ; Colorectal Neoplasms/pathology ; Combined Modality Therapy ; Cytoreduction Surgical Procedures ; Feasibility Studies ; Hyperthermia, Induced ; Injections, Intraperitoneal ; Male ; Peritoneal Neoplasms/pathology ; Phenylurea Compounds ; Pyridines ; Rats ; Survival Rate
    Chemical Substances Phenylurea Compounds ; Pyridines ; regorafenib (24T2A1DOYB)
    Language English
    Publishing date 2022-10-18
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 418927-9
    ISSN 2239-253X ; 0003-469X
    ISSN (online) 2239-253X
    ISSN 0003-469X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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