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  1. AU="Ntelkis, Nikolaos"
  2. AU=Pitrou Isabelle
  3. AU="Ouwehand, Willem"
  4. AU=Glover Natasha M.
  5. AU=Guo Zhinian
  6. AU="Alison M. Lee"
  7. AU="Walcher, Felix"
  8. AU=Marupudi Neena I.
  9. AU="Earp, Karly M"
  10. AU="Zeng, Hui Hui"
  11. AU="Marco Pallecchi"
  12. AU=Marcus Adam I
  13. AU="Martin, Phillip"
  14. AU=Ouyang Yi-Bing
  15. AU="Tam, Patrick Chung Kay"
  16. AU="Patrick R. H. Steinmetz"
  17. AU="Odierna, Francesco"
  18. AU="Monteiro, Valter" AU="Monteiro, Valter"
  19. AU=Konkel Alex
  20. AU="Alnakib, Yasir"
  21. AU=Tallerico Rossana
  22. AU=Scherer Kai
  23. AU="Cao, Guiyun"
  24. AU="Zarrouki, Youssef"
  25. AU="Abayomi, Akin"
  26. AU=Kpatcha Tchazou
  27. AU=Glaeser Robert M
  28. AU="Mioara Cristea"
  29. AU="Turiegano, Enrique"
  30. AU="Russcher, H"
  31. AU="Lim, Kean-Jin"
  32. AU="Spurek, Monika"
  33. AU="Giulia A. Zamboni"

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  1. Artikel ; Online: Engineering the plant metabolic system by exploiting metabolic regulation.

    Selma, Sara / Ntelkis, Nikolaos / Nguyen, Trang Hieu / Goossens, Alain

    The Plant journal : for cell and molecular biology

    2023  Band 114, Heft 5, Seite(n) 1149–1163

    Abstract: Plants are the most sophisticated biofactories and sources of food and biofuels present in nature. By engineering plant metabolism, the production of desired compounds can be increased and the nutritional or commercial value of the plant species can be ... ...

    Abstract Plants are the most sophisticated biofactories and sources of food and biofuels present in nature. By engineering plant metabolism, the production of desired compounds can be increased and the nutritional or commercial value of the plant species can be improved. However, this can be challenging because of the complexity of the regulation of multiple genes and the involvement of different protein interactions. To improve metabolic engineering (ME) capabilities, different tools and strategies for rerouting the metabolic pathways have been developed, including genome editing and transcriptional regulation approaches. In addition, cutting-edge technologies have provided new methods for understanding uncharacterized biosynthetic pathways, protein degradation mechanisms, protein-protein interactions, or allosteric feedback, enabling the design of novel ME approaches.
    Mesh-Begriff(e) CRISPR-Cas Systems ; Plants/genetics ; Plants/metabolism ; Gene Editing/methods ; Metabolic Engineering/methods ; Metabolic Networks and Pathways ; Genome, Plant
    Sprache Englisch
    Erscheinungsdatum 2023-03-03
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1088037-9
    ISSN 1365-313X ; 0960-7412
    ISSN (online) 1365-313X
    ISSN 0960-7412
    DOI 10.1111/tpj.16157
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Engineering the plant metabolic system by exploiting metabolic regulation

    Selma, Sara / Ntelkis, Nikolaos / Nguyen, Trang Hieu / Goossens, Alain

    The Plant Journal. 2023 June, v. 114, no. 5 p.1149-1163

    2023  

    Abstract: Plants are the most sophisticated biofactories and sources of food and biofuels present in nature. By engineering plant metabolism, the production of desired compounds can be increased and the nutritional or commercial value of the plant species can be ... ...

    Abstract Plants are the most sophisticated biofactories and sources of food and biofuels present in nature. By engineering plant metabolism, the production of desired compounds can be increased and the nutritional or commercial value of the plant species can be improved. However, this can be challenging because of the complexity of the regulation of multiple genes and the involvement of different protein interactions. To improve metabolic engineering (ME) capabilities, different tools and strategies for rerouting the metabolic pathways have been developed, including genome editing and transcriptional regulation approaches. In addition, cutting‐edge technologies have provided new methods for understanding uncharacterized biosynthetic pathways, protein degradation mechanisms, protein–protein interactions, or allosteric feedback, enabling the design of novel ME approaches.
    Schlagwörter biofuels ; biosynthesis ; genome ; protein degradation ; transcription (genetics)
    Sprache Englisch
    Erscheinungsverlauf 2023-06
    Umfang p. 1149-1163.
    Erscheinungsort John Wiley & Sons, Ltd
    Dokumenttyp Artikel ; Online
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 1088037-9
    ISSN 1365-313X ; 0960-7412
    ISSN (online) 1365-313X
    ISSN 0960-7412
    DOI 10.1111/tpj.16157
    Datenquelle NAL Katalog (AGRICOLA)

    Volltext online

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  3. Artikel ; Online: Functional Synthetic Biology.

    Aldulijan, Ibrahim / Beal, Jacob / Billerbeck, Sonja / Bouffard, Jeff / Chambonnier, Gaël / Ntelkis, Nikolaos / Guerreiro, Isaac / Holub, Martin / Ross, Paul / Selvarajah, Vinoo / Sprent, Noah / Vidal, Gonzalo / Vignoni, Alejandro

    Synthetic biology (Oxford, England)

    2023  Band 8, Heft 1, Seite(n) ysad006

    Abstract: Synthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of functions in various contexts and organisms. However, current ... ...

    Abstract Synthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of functions in various contexts and organisms. However, current paradigms in the field entangle sequence and functionality in a manner that makes abstraction difficult, reduces engineering flexibility and impairs predictability and design reuse. Functional Synthetic Biology aims to overcome these impediments by focusing the design of biological systems on function, rather than on sequence. This reorientation will decouple the engineering of biological devices from the specifics of how those devices are put to use, requiring both conceptual and organizational change, as well as supporting software tooling. Realizing this vision of Functional Synthetic Biology will allow more flexibility in how devices are used, more opportunity for reuse of devices and data, improvements in predictability and reductions in technical risk and cost.
    Sprache Englisch
    Erscheinungsdatum 2023-04-08
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ISSN 2397-7000
    ISSN (online) 2397-7000
    DOI 10.1093/synbio/ysad006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: A tomato B-box protein regulates plant development and fruit quality through the interaction with PIF4, HY5 and RIN transcription factors.

    Shiose, Lumi / Dos Reis Moreira, Juliene / Lira, Bruno Silvestre / Ponciano, Gabriel / Gomez Ocampo, Gabriel / Wu, Raquel Tsu Ay / Dos Santos Júnior, José Laurindo / Ntelkis, Nikolaos / Clicque, Elke / Oliveira, Maria José / Lubini, Greice / Floh, Eny Iochevet Segal / Botto, Javier Francisco / Ferreira, Marcelo José Pena / Goossens, Alain / Freschi, Luciano / Rossi, Magdalena

    Journal of experimental botany

    2024  

    Abstract: During the last decade, the knowledge about BBX proteins has abruptly increased. Genome-wide studies identified BBX gene family in several ornamental, industry and food crops; however, the reports regarding the role of these genes as regulators of ... ...

    Abstract During the last decade, the knowledge about BBX proteins has abruptly increased. Genome-wide studies identified BBX gene family in several ornamental, industry and food crops; however, the reports regarding the role of these genes as regulators of agronomically important traits are scarce. Here, by phenotyping a knockout mutant, we performed a comprehensive functional characterization of the tomato locus Solyc12g089240, hereafter called SlBBX20. The data revealed the encoded protein as a positive regulator of light signaling affecting several physiological processes during plant lifespan. By the inhibition of PHYTOCHROME INTERACTING FACTOR 4 (SlPIF4)-auxin crosstalk, SlBBX20 regulates photomorphogenesis. Later, it controls the balance between cell division and expansion to guarantee the correct vegetative and reproductive development. In fruits, SlBBX20 is transcriptionally induced by the master transcription factor RIPENING INHIBITOR (SlRIN) and, together with ELONGATED HYPOCOTYL 5 (SlHY5), upregulates flavonoids biosynthetic genes. Finally, SlBBX20 promotes the accumulation of steroidal glycoalkaloids and attenuates Botrytis cinerea infection. This work clearly demonstrates that BBX proteins are multilayer regulators of plant physiology, not only because they affect multiple processes along plant development but also regulate other genes at the transcriptional and post-translational levels.
    Sprache Englisch
    Erscheinungsdatum 2024-03-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2976-2
    ISSN 1460-2431 ; 0022-0957
    ISSN (online) 1460-2431
    ISSN 0022-0957
    DOI 10.1093/jxb/erae119
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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