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  1. Article ; Online: Redefining COVID-19 Severity and Prognosis: The Role of Clinical and Immunobiotypes.

    Torres-Ruiz, Jiram / Pérez-Fragoso, Alfredo / Maravillas-Montero, José Luis / Llorente, Luis / Mejía-Domínguez, Nancy R / Páez-Franco, José Carlos / Romero-Ramírez, Sandra / Sosa-Hernández, Victor Andrés / Cervantes-Díaz, Rodrigo / Absalón-Aguilar, Abdiel / Nuñez-Aguirre, Miroslava / Juárez-Vega, Guillermo / Meza-Sánchez, David / Kleinberg-Bid, Ari / Hernández-Gilsoul, Thierry / Ponce-de-León, Alfredo / Gómez-Martín, Diana

    Frontiers in immunology

    2021  Volume 12, Page(s) 689966

    Abstract: Background: Most of the explanatory and prognostic models of COVID-19 lack of a comprehensive assessment of the wide COVID-19 spectrum of abnormalities. The aim of this study was to unveil novel biological features to explain COVID-19 severity and ... ...

    Abstract Background: Most of the explanatory and prognostic models of COVID-19 lack of a comprehensive assessment of the wide COVID-19 spectrum of abnormalities. The aim of this study was to unveil novel biological features to explain COVID-19 severity and prognosis (death and disease progression).
    Methods: A predictive model for COVID-19 severity in 121 patients was constructed by ordinal logistic regression calculating odds ratio (OR) with 95% confidence intervals (95% CI) for a set of clinical, immunological, metabolomic, and other biological traits. The accuracy and calibration of the model was tested with the area under the curve (AUC), Somer's D, and calibration plot. Hazard ratios with 95% CI for adverse outcomes were calculated with a Cox proportional-hazards model.
    Results: The explanatory variables for COVID-19 severity were the body mass index (BMI), hemoglobin, albumin, 3-Hydroxyisovaleric acid, CD8+ effector memory T cells, Th1 cells, low-density granulocytes, monocyte chemoattractant protein-1, plasma TRIM63, and circulating neutrophil extracellular traps. The model showed an outstanding performance with an optimism-adjusted AUC of 0.999, and Somer's D of 0.999. The predictive variables for adverse outcomes in COVID-19 were severe and critical disease diagnosis, BMI, lactate dehydrogenase, Troponin I, neutrophil/lymphocyte ratio, serum levels of IP-10, malic acid, 3, 4 di-hydroxybutanoic acid, citric acid, myoinositol, and cystine.
    Conclusions: Herein, we unveil novel immunological and metabolomic features associated with COVID-19 severity and prognosis. Our models encompass the interplay among innate and adaptive immunity, inflammation-induced muscle atrophy and hypoxia as the main drivers of COVID-19 severity.
    MeSH term(s) Adult ; Blood Coagulation ; Body Mass Index ; COVID-19/blood ; COVID-19/immunology ; COVID-19/metabolism ; Cytokines/blood ; Extracellular Traps/immunology ; Female ; Hemoglobins/analysis ; Humans ; Male ; Metabolome ; Middle Aged ; Muscular Atrophy ; Neutrophils/immunology ; Phenotype ; Prognosis ; SARS-CoV-2 ; Serum Albumin, Human/analysis ; Severity of Illness Index ; T-Lymphocytes/immunology ; Valerates/blood
    Chemical Substances Cytokines ; Hemoglobins ; Valerates ; beta-hydroxyisovaleric acid (3F752311CD) ; Serum Albumin, Human (ZIF514RVZR)
    Language English
    Publishing date 2021-09-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.689966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Neutrophil Extracellular Traps Contribute to COVID-19 Hyperinflammation and Humoral Autoimmunity.

    Torres-Ruiz, Jiram / Absalón-Aguilar, Abdiel / Nuñez-Aguirre, Miroslava / Pérez-Fragoso, Alfredo / Carrillo-Vázquez, Daniel Alberto / Maravillas-Montero, José Luis / Mejía-Domínguez, Nancy R / Llorente, Luis / Alcalá-Carmona, Beatriz / Lira-Luna, Jaquelin / Núñez-Álvarez, Carlos / Juárez-Vega, Guillermo / Meza-Sánchez, David / Hernández-Gilsoul, Thierry / Tapia-Rodríguez, Miguel / Gómez-Martín, Diana

    Cells

    2021  Volume 10, Issue 10

    Abstract: The coronavirus disease 2019 (COVID-19) is related to enhanced production of NETs, and autoimmune/autoinflammatory phenomena. We evaluated the proportion of low-density granulocytes (LDG) by flow cytometry, and their capacity to produce NETs was compared ...

    Abstract The coronavirus disease 2019 (COVID-19) is related to enhanced production of NETs, and autoimmune/autoinflammatory phenomena. We evaluated the proportion of low-density granulocytes (LDG) by flow cytometry, and their capacity to produce NETs was compared with that of conventional neutrophils. NETs and their protein cargo were quantified by confocal microscopy and ELISA. Antinuclear antibodies (ANA), anti-neutrophil cytoplasmic antibodies (ANCA) and the degradation capacity of NETs were addressed in serum. MILLIPLEX assay was used to assess the cytokine levels in macrophages' supernatant and serum. We found a higher proportion of LDG in severe and critical COVID-19 which correlated with severity and inflammatory markers. Severe/critical COVID-19 patients had higher plasmatic NE, LL-37 and HMGB1-DNA complexes, whilst ISG-15-DNA complexes were lower in severe patients. Sera from severe/critical COVID-19 patients had lower degradation capacity of NETs, which was reverted after adding hrDNase. Anti-NET antibodies were found in COVID-19, which correlated with ANA and ANCA positivity. NET stimuli enhanced the secretion of cytokines in macrophages. This study unveils the role of COVID-19 NETs as inducers of pro-inflammatory and autoimmune responses. The deficient degradation capacity of NETs may contribute to the accumulation of these structures and anti-NET antibodies are related to the presence of autoantibodies.
    MeSH term(s) Antibodies, Antinuclear ; Antimicrobial Cationic Peptides/blood ; Autoantibodies/metabolism ; Autoimmunity ; COVID-19/blood ; COVID-19/immunology ; Cross-Sectional Studies ; Cytokines/metabolism ; Cytokines/pharmacology ; Extracellular Traps/immunology ; Flow Cytometry ; Granulocytes/metabolism ; HMGB1 Protein/blood ; Healthy Volunteers ; Humans ; Immunity, Humoral ; Inflammation ; Microscopy, Confocal ; Monocytes/cytology ; Neutrophils/cytology ; Neutrophils/immunology ; SARS-CoV-2 ; Ubiquitins/pharmacology
    Chemical Substances Antibodies, Antinuclear ; Antimicrobial Cationic Peptides ; Autoantibodies ; Cytokines ; HMGB1 Protein ; HMGB1 protein, human ; Ubiquitins ; ropocamptide (3DD771JO2H) ; ISG15 protein, human (60267-61-0)
    Language English
    Publishing date 2021-09-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10102545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Novel clinical and immunological features associated with persistent post-acute sequelae of COVID-19 after six months of follow-up: a pilot study.

    Torres-Ruiz, Jiram / Lomelín-Gascón, Julieta / Lira Luna, Jaquelin / Vargas-Castro, Ana Sofia / Pérez-Fragoso, Alfredo / Nuñez-Aguirre, Miroslava / Alcalá-Carmona, Beatriz / Absalón-Aguilar, Abdiel / Balderas-Miranda, Jennifer T / Maravillas-Montero, José Luis / Mejía-Domínguez, Nancy R / Núñez-Álvarez, Carlos / Llorente, Luis / Romero-Ramírez, Sandra / Sosa-Hernández, Victor Andrés / Cervantes-Díaz, Rodrigo / Juárez-Vega, Guillermo / Meza-Sánchez, David / Rull-Gabayet, Marina /
    Martínez-Juárez, Luis Alberto / Morales, Linda / López-López, Lizeth Naomi / Negrete-Trujillo, José Adrián / Falcón-Lezama, Jorge Abelardo / Valdez-Vázquez, Rafael Ricardo / Gallardo-Rincón, Héctor / Tapia-Conyer, Roberto / Gómez-Martín, Diana

    Infectious diseases (London, England)

    2023  Volume 55, Issue 4, Page(s) 243–254

    Abstract: Background: Currently, there is scant information regarding the features associated to the persistence of post-COVID-19 syndrome, which is the main aim of the present study.: Methods: A cohort study of 102 COVID-19 patients was conducted. The post- ... ...

    Abstract Background: Currently, there is scant information regarding the features associated to the persistence of post-COVID-19 syndrome, which is the main aim of the present study.
    Methods: A cohort study of 102 COVID-19 patients was conducted. The post-COVID-19 symptoms were assessed by a standardised questionnaire. Lymphocyte immunophenotyping was performed by flow cytometry and chemokines/cytokines, neutrophil extracellular traps, the tripartite motif 63, anti-cellular, and anti-SARS-CoV-2 IgG antibodies were addressed in serum. The primary outcome was the persistence of post-COVID-19 syndrome after six months follow-up.
    Results: Thirteen patients (12.7%) developed the primary outcome and had a more frequent history of post-COVID-19 syndrome 3 months after infection onset (
    Conclusion: Our data suggest an important relationship between a pro-inflammatory state mediated through metabolic pathways related to obesity and increased cellular senescence as a key element in the persistence of post-COVID-19 syndrome at six months of follow-up.
    MeSH term(s) Humans ; COVID-19/complications ; Pilot Projects ; Post-Acute COVID-19 Syndrome ; CD8-Positive T-Lymphocytes ; Cohort Studies ; Chemokine CXCL10 ; Obesity
    Chemical Substances Chemokine CXCL10
    Language English
    Publishing date 2023-01-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2022.2158217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: FANSY POSTCOV: A composite clinical immunological predictive index for post-COVID-19 syndrome unveils distinctive features in a cohort study of mild to critical patients.

    Torres-Ruiz, Jiram / Lomelín-Gascón, Julieta / Lira-Luna, Jaquelin / Pérez-Fragoso, Alfredo / Tapia-Conyer, Roberto / Nuñez-Aguirre, Miroslava / Alcalá-Carmona, Beatriz / Absalón-Aguilar, Abdiel / Maravillas-Montero, José Luis / Mejía-Domínguez, Nancy Raquel / Núñez-Álvarez, Carlos / Llorente, Luis / Romero-Ramírez, Sandra / Sosa-Hernández, Victor Andrés / Cervantes-Díaz, Rodrigo / Juárez-Vega, Guillermo / Meza-Sánchez, David / Rull-Gabayet, Marina / Martínez-Juárez, Luis Alberto /
    Morales-Juárez, Linda / López-López, Lizeth Naomi / Negrete-Trujillo, José Adrián / Falcón-Lezama, Jorge Abelardo / Valdez-Vázquez, Rafael Ricardo / Gallardo-Rincón, Héctor / Gómez-Martín, Diana

    Clinical and translational medicine

    2021  Volume 11, Issue 11, Page(s) e623

    MeSH term(s) Area Under Curve ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Biomarkers/metabolism ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/immunology ; Cohort Studies ; Female ; Humans ; Male ; Odds Ratio ; Predictive Value of Tests ; ROC Curve ; Sex Factors ; Vascular Endothelial Growth Factor A/blood
    Chemical Substances Biomarkers ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2021-11-29
    Publishing country United States
    Document type Letter
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Clinical and immunological features associated to the development of a sustained immune humoral response in COVID-19 patients: Results from a cohort study.

    Torres-Ruiz, Jiram / Lomelín-Gascón, Julieta / Vargas-Castro, Ana Sofía / Lira-Luna, Jaquelin / Pérez-Fragoso, Alfredo / Tapia-Conyer, Roberto / Nuñez-Aguirre, Miroslava / Alcalá-Carmona, Beatriz / Absalón-Aguilar, Abdiel / Maravillas-Montero, José Luis / Mejía-Domínguez, Nancy Raquel / Núñez-Álvarez, Carlos / Rull-Gabayet, Marina / Llorente, Luis / Romero-Ramírez, Sandra / Sosa-Hernández, Victor Andrés / Cervantes-Díaz, Rodrigo / Juárez-Vega, Guillermo / Meza-Sánchez, David Eduardo /
    Martínez-Juárez, Luis Alberto / Morales-Juárez, Linda / López-López, Lizeth Naomi / Negrete-Trujillo, José Adrián / Falcón-Lezama, Jorge Abelardo / Valdez-Vázquez, Rafael Ricardo / Gallardo-Rincón, Héctor / Gómez-Martín, Diana

    Frontiers in immunology

    2022  Volume 13, Page(s) 943563

    Abstract: Background: Until now, most of the research addressing long-term humoral responses in coronavirus disease 2019 (COVID-19) had only evaluated the serum titers of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgGs, without the ... ...

    Abstract Background: Until now, most of the research addressing long-term humoral responses in coronavirus disease 2019 (COVID-19) had only evaluated the serum titers of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgGs, without the assessment of the baseline antiviral clinical and immune profile, which is the aim of this study and may be the key factor leading to a broad and sustained antibody response.
    Methods: We included 103 patients with COVID-19. When the patients sought medical attention (baseline), a blood sample was drawn to perform immunophenotype of lymphocytes by flow cytometry. The patients were assessed 15 days after baseline and then every month until the third month, followed by a last visit 6 months after recruitment. We evaluated the anti-SARS-COV-2 IgG at all time points, and the serum levels of cytokines, chemokines, anti-cellular (AC) antibodies and neutrophil extracellular traps were also assessed during the follow-up. The primary outcome of the study was the presence of a sustained immune humoral response, defined as an anti-SARS-CoV-2 IgG titer >4.99 arbitrary units/mL in at least two consecutive measures. We used generalized lineal models to assess the features associated with this outcome and to assess the effect of the changes in the cytokines and chemokines throughout time on the development of a sustained humoral immune response.
    Results: At baseline the features associated to a sustained immune humoral response were the diagnosis of critical disease, absolute number of lymphocytes, serum IP-10, IL-4, IL-2, regulatory T cells, CD8
    Conclusion: A sustained immune humoral response is strongly related to critical COVID-19, which is characterized by the presence of AC antibodies, quantitative abnormalities in the T cell compartment, and the serum cytokines and chemokines during acute infection and throughout time.
    MeSH term(s) Antibodies, Viral ; CD8-Positive T-Lymphocytes ; COVID-19 ; Chemokines ; Cohort Studies ; Critical Illness ; Cytokines ; Humans ; Immunoglobulin G ; SARS-CoV-2
    Chemical Substances Antibodies, Viral ; Chemokines ; Cytokines ; Immunoglobulin G
    Language English
    Publishing date 2022-08-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.943563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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