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  1. Article ; Online: De novo membrane protein structure prediction.

    Nugent, Timothy

    Methods in molecular biology (Clifton, N.J.)

    2015  Volume 1215, Page(s) 331–350

    Abstract: Recent advances in identifying residue-residue contacts from large multiple sequence alignments have enabled impressive gains to be made in the field of protein structure prediction. In this chapter, we discuss these advances and provide a step-by-step ... ...

    Abstract Recent advances in identifying residue-residue contacts from large multiple sequence alignments have enabled impressive gains to be made in the field of protein structure prediction. In this chapter, we discuss these advances and provide a step-by-step guide to applying the latest tools to the de novo modelling of alpha-helical transmembrane proteins. As a practical example, we demonstrate the process of building an accurate 3D model of a G protein-coupled receptor, correctly orientated in the membrane, using only its primary protein sequence.
    MeSH term(s) Amino Acid Sequence ; Animals ; Cattle ; Computational Biology/methods ; Membrane Proteins/chemistry ; Models, Molecular ; Molecular Sequence Data ; Protein Structure, Secondary ; Rhodopsin/chemistry ; Temperature
    Chemical Substances Membrane Proteins ; Rhodopsin (9009-81-8)
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-1465-4_15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Lateral pelvic lymphadenectomy for low rectal cancer: a META-analysis of recurrence rates.

    Fahy, M R / Kelly, M E / Nugent, T / Hannan, E / Winter, D C

    International journal of colorectal disease

    2020  Volume 36, Issue 3, Page(s) 551–558

    Abstract: Background: Locoregional recurrence (LR) remains a problem for patients with lower rectal cancer despite standardized surgery and improved neoadjuvant treatment regimens. Lateral pelvic lymph node dissection (LPLND) has been routine practice for some ... ...

    Abstract Background: Locoregional recurrence (LR) remains a problem for patients with lower rectal cancer despite standardized surgery and improved neoadjuvant treatment regimens. Lateral pelvic lymph node dissection (LPLND) has been routine practice for some time in the Orient/East, but other regions have concerns about morbidity. As perioperative care and surgical approaches are refined, this has been revisited for selected patients. The question as to whether LPLND improves oncological outcomes was explored here.
    Methods: A systematic review of patients who underwent TME with or without LPLND from 2000 to 2020 was performed. The primary endpoint was the rate of LR between the two groups.
    Results: Seven papers met the predefined search criteria in which 2000 patients underwent TME alone, while 1563 patients had TME and LPLND. The rate of LR was marginally higher with TME alone when compared with TME plus LPLND, but this result was not statistically significant (9.8 vs 9.4%, odds ratio 0.75, 95% CI 0.41-1.38, *p = 0.35). In addition, four studies reported on distant recurrence rates, with TME and LPLND showing a slight reduction in overall rates (27.3 vs 29.9%, respectively, OR 0.65, 95% CI 0.45-0.92, *p = 0.02).
    Conclusion: The addition of LPLND to TME is not associated with a significantly lower risk of LR in patients who undergo surgery for lower rectal cancer.
    MeSH term(s) Humans ; Lymph Node Excision ; Neoadjuvant Therapy ; Neoplasm Recurrence, Local ; Rectal Neoplasms/surgery
    Language English
    Publishing date 2020-11-26
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-020-03804-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2121: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Giant pneumosalpinx secondary to colonic diverticular disease.

    Nur, Talat / Fagan, Paul / Nugent, Trish / Kodeda, Karl

    ANZ journal of surgery

    2019  Volume 90, Issue 3, Page(s) E61–E62

    MeSH term(s) Diverticulum, Colon/complications ; Diverticulum, Colon/diagnostic imaging ; Diverticulum, Colon/surgery ; Fallopian Tube Diseases/diagnostic imaging ; Fallopian Tube Diseases/etiology ; Fallopian Tube Diseases/surgery ; Female ; Humans ; Middle Aged
    Language English
    Publishing date 2019-05-12
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.15246
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    Zs.A 180: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Endobronchial valve use in COVID-19 related pneumothorax and persistent air leak.

    Nugent, T S / Aladaileh, M / Donlon, N E / Murphy, N / Eaton, D

    Annals of the Royal College of Surgeons of England

    2021  Volume 104, Issue 5, Page(s) e137–e138

    Abstract: Pneumothoraces may occur rarely in coronavirus (COVID-19) patients, often resulting from a combination of fibrotic parenchymal changes and prolonged high-pressure ventilation. Very few studies have been published describing the management of pneumothorax ...

    Abstract Pneumothoraces may occur rarely in coronavirus (COVID-19) patients, often resulting from a combination of fibrotic parenchymal changes and prolonged high-pressure ventilation. Very few studies have been published describing the management of pneumothorax in the novel COVID-19 pneumonia patients. Although chest drain insertion represents the first line of treatment, a persistent pneumothorax and air leak requiring intervention could be managed by a thoracoscopic procedure or, as is the case here, by endobronchial valve insertion. Endobronchial valve insertion is a minimally invasive technique that provides a treatment option in patients with severe parenchymal COVID-19 related lung disease. As far as the authors are aware this is the first report of the use of endobronchial valves in a COVID-19 patient.
    MeSH term(s) Bronchoscopy/methods ; COVID-19/complications ; Chest Tubes ; Humans ; Pneumothorax/etiology ; Pneumothorax/surgery ; Prostheses and Implants
    Language English
    Publishing date 2021-11-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2021.0197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.234: Show issues Location:
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  5. Article ; Online: Management of chyle leaks following esophageal resection: a systematic review.

    Power, Robert / Smyth, Philip / Donlon, Noel E / Nugent, Timothy / Donohoe, Claire L / Reynolds, John V

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    2021  Volume 34, Issue 11

    Abstract: Background: Chyle leakage is an uncommon but potentially life-threatening complication following esophageal resections. The optimal management strategy is not clear, with a limited evidence base.: Methods: Searches were conducted up to 31 December ... ...

    Abstract Background: Chyle leakage is an uncommon but potentially life-threatening complication following esophageal resections. The optimal management strategy is not clear, with a limited evidence base.
    Methods: Searches were conducted up to 31 December 2020 on MEDLINE, Embase, and Web of Science for randomized trials or retrospective studies that evaluated the management of chyle leakage following esophageal resection. Two authors independently screened studies, extracted data, and assessed for bias. The protocol was prospectively registered on PROSPERO (CRD: 42021224895) and reported in accordance with preferred reporting items for systematic reviews and meta-analyses guidelines.
    Results: A total of 530 citations were reviewed. Twenty-five studies, totaling 1016 patients met the inclusion criteria, including two low-quality clinical trials and 23 retrospective case series. Heterogeneity of study design and outcomes prevented meta-analysis. The overall incidence of chyle leak/fistula was 3.2%. Eighteen studies describe management of chyle leaks conservatively, 17 by surgical ligation of the thoracic duct, 5 by pleurodesis, and 6 described percutaneous lymphangiography with thoracic duct embolization or disruption.
    Conclusions: The evidence base for optimal management of chyle leakage postesophagectomy is lacking, which may be related to its low incidence. There is a paucity of high-quality prospective studies directly comparing treatment modalities, but there is some low-certainty evidence that percutaneous approaches have reduced morbidity but lower efficacy compared with surgery. Further high-quality, prospective studies that compare interventions at different levels of severity are needed to determine the optimal approach to treatment.
    MeSH term(s) Chyle ; Chylothorax ; Humans ; Prospective Studies ; Retrospective Studies ; Thoracic Duct
    Language English
    Publishing date 2021-02-24
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 639470-x
    ISSN 1442-2050 ; 1120-8694
    ISSN (online) 1442-2050
    ISSN 1120-8694
    DOI 10.1093/dote/doab012
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    Zs.A 2378: Show issues Location:
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  6. Article: Around the clock: the effect of night shifts on your health & safety.

    Nugent, Terry

    JEMS : a journal of emergency medical services

    2007  Volume 32, Issue 3, Page(s) 92–100

    MeSH term(s) Emergency Medical Technicians ; Humans ; Occupational Health ; United States ; Work Schedule Tolerance/physiology
    Language English
    Publishing date 2007-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1292428-3
    ISSN 0197-2510
    ISSN 0197-2510
    DOI 10.1016/S0197-2510(07)70089-X
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    Zs.A 4390: Show issues Location:
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  7. Article ; Online: Readers' responses and author's reply to "emancipating the doctors".

    Nugent, Terry

    MedGenMed : Medscape general medicine

    2006  Volume 8, Issue 2, Page(s) 15; author reply 15

    MeSH term(s) Insurance, Health ; Reimbursement Mechanisms ; Single-Payer System ; United States
    Language English
    Publishing date 2006
    Publishing country United States
    Document type Comment ; Letter
    ISSN 1531-0132
    ISSN (online) 1531-0132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Readers respond to "preventing childhood obesity: an open letter to the US Congress".

    Nugent, Terry

    MedGenMed : Medscape general medicine

    2006  Volume 8, Issue 2, Page(s) 53; author reply 54

    MeSH term(s) Advertising as Topic ; Child ; Food Industry ; Government Agencies ; Humans ; Obesity/etiology ; Obesity/prevention & control ; United States
    Language English
    Publishing date 2006
    Publishing country United States
    Document type Comment ; Letter
    ISSN 1531-0132
    ISSN (online) 1531-0132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Ted, white, and blue

    Nugent, Ted

    the Nugent manifesto

    2010  

    Abstract: It's About Time. America has been craving leadership?and at last a gun-slinging, mega-rock star, deerslayer, and patriot has stepped forward to provide it. Make way for Ted Nugent. Cocked, locked, and ready to rock, the Motor City Madman, the thinking ... ...

    Institution ebrary, Inc
    Abstract It's About Time. America has been craving leadership?and at last a gun-slinging, mega-rock star, deerslayer, and patriot has stepped forward to provide it. Make way for Ted Nugent. Cocked, locked, and ready to rock, the Motor City Madman, the thinking man's Abraham Lincoln, has unleashed the ultimate high-octane political manifesto for the ages in Ted, White, and Blue?the most important patriotic statement since the Constitution. In Ted, White, and Blue you'll discover: Why war is the answer to so many of our current problems Why if Ted were a Mexican, he'd start a rev
    Keywords United States
    Language English
    Size Online-Ressource (xxix, 303 p), ill
    Publisher Regnery Pub., Inc
    Publishing place Washington, D.C
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 9781596986053 ; 9781596986343 ; 1596986050 ; 1596986344
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article ; Online: Readers' responses to "doctors and patients working together".

    Nugent, Terry

    MedGenMed : Medscape general medicine

    2005  Volume 7, Issue 4, Page(s) 6; author reply 7

    MeSH term(s) Health Care Costs ; Insurance, Health, Reimbursement/economics ; Medicare/economics ; Physician-Patient Relations ; United States
    Language English
    Publishing date 2005
    Publishing country United States
    Document type Comment ; Letter
    ISSN 1531-0132
    ISSN (online) 1531-0132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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