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  1. Article ; Online: Association between the early repolarization pattern and nocturnal suicide attempts.

    Kameyama, Hiroshi / Sugimoto, Kenichi / Kodaka, Fumitoshi / Okuno, Kenji / Masaki, Takahiro / Nukariya, Kazutaka / Shigeta, Masahiro

    Neuropsychopharmacology reports

    2024  

    Abstract: Aim: Numerous recent reports have highlighted the association between mental disorders and electrocardiographic findings. The early repolarization pattern (ERP) on electrocardiogram has been linked with a history of suicide attempts and attention ... ...

    Abstract Aim: Numerous recent reports have highlighted the association between mental disorders and electrocardiographic findings. The early repolarization pattern (ERP) on electrocardiogram has been linked with a history of suicide attempts and attention deficit hyperactivity disorder, and associations with impulsivity have also been reported. It is known that suicidal intent is more common at night. Patients who have a mental disorder and ERP may have a higher likelihood of impulsivity, potentially increasing the risk of suicide at night.
    Methods: The subjects were 43 patients with a history of suicide attempts who had undergone electrocardiographic examination at Jikei University School of Medicine Kashiwa Hospital and received intervention from our department. Due to the diurnal variation in electrocardiographic findings, only patients who underwent the examination during the daytime were included. Patients' clinical backgrounds were compared according to the presence or absence of ERP, and the association between nocturnal suicide attempts and ERP was examined using multivariate analysis.
    Results: The frequency of nocturnal suicidal behavior was 76.2% in patients with ERP and 31.8% in those without ERP, but the difference was not significant after Bonferroni correction. In the multivariate analysis, there was a significant association of ERP with nocturnal suicide attempts (p = 0.018).
    Conclusion: The finding of an association between ERP and nocturnal suicide attempts indicates that ERP is a biological indicator that can predict nocturnal suicide attempts.
    Language English
    Publishing date 2024-03-17
    Publishing country United States
    Document type Journal Article
    ISSN 2574-173X
    ISSN (online) 2574-173X
    DOI 10.1002/npr2.12433
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  2. Article ; Online: Relationship between the early repolarization pattern and a history of suicide attempts among drug-free psychiatric patients.

    Kameyama, Hiroshi / Sugimoto, Kenichi / Kodaka, Fumitoshi / Ito, Kyoko / Nukariya, Kazutaka / Kato, Tomohiro / Shigeta, Masahiro

    Neuropsychopharmacology reports

    2022  Volume 42, Issue 3, Page(s) 256–262

    Abstract: Aim: Suicide attempts are an important severe psychiatric symptom and a clear outcome for mental disorders. Although the relationship between the early repolarization pattern in electrocardiogram and psychiatric disorders has recently been reported, ... ...

    Abstract Aim: Suicide attempts are an important severe psychiatric symptom and a clear outcome for mental disorders. Although the relationship between the early repolarization pattern in electrocardiogram and psychiatric disorders has recently been reported, these reports have not been able to exclude the influence of psychiatric drugs. This study aimed to investigate the relationship between the early repolarization pattern and a history of suicide attempts among patients not receiving psychiatric medication.
    Methods: A total of 71 patients with a history of suicide attempts were investigated, 38 of whom were analyzed for this study. We compared the frequency of the early repolarization pattern between a suicide attempt group and a control group. Then, we investigated the association between the early repolarization pattern and the suicide attempt group by logistic regression analysis, including electrocardiographic findings associated with psychiatric disorders.
    Results: The findings indicated that the frequency of the early repolarization pattern was significantly higher in the suicide attempt group (n = 20; 52.6%) than in the control group (n = 4; 10.5%) (P < 0.001), and the results of the logistic regression analysis indicated that the early repolarization pattern was associated with suicide attempts.
    Conclusions: These findings suggest that the early repolarization pattern is associated with a history of suicide attempts.
    MeSH term(s) Humans ; Mental Disorders/drug therapy ; Mental Disorders/epidemiology ; Risk Factors ; Suicide, Attempted/psychology
    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Journal Article
    ISSN 2574-173X
    ISSN (online) 2574-173X
    DOI 10.1002/npr2.12254
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  3. Article ; Online: Education level is associated with neuropsychiatric symptoms in patients with amnestic-mild cognitive impairment.

    Inamura, Keisuke / Shinagawa, Shunichiro / Nagata, Tomoyuki / Tagai, Kenji / Nukariya, Kazutaka / Shigeta, Masahiro

    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

    2022  Volume 22, Issue 3, Page(s) 343–352

    Abstract: Background: We examined differences in the severity of neuropsychiatric symptom (NPS) subsyndromes according to education level among patients with amnestic-mild cognitive impairment (a-MCI) with the aim of identifying patient demographics related to ... ...

    Abstract Background: We examined differences in the severity of neuropsychiatric symptom (NPS) subsyndromes according to education level among patients with amnestic-mild cognitive impairment (a-MCI) with the aim of identifying patient demographics related to NPS subsyndromes.
    Methods: Overall, 140 patients with a-MCI were included. We divided the patients into three groups according to their educational level (primary education, middle education, and high education) and compared their demographics. To explore the severity of NPS subsyndromes according to educational level, we used the Neuropsychiatric Inventory (NPI) after adjustments for the Mini-Mental State Examination (MMSE) score. Finally, NPS subsyndromes that were identified as being related to educational level were further explored using a general linear model (GLM).
    Results: Significant differences in several demographics were observed among the three groups. Among the NPS subsyndromes, the scores for aggressiveness were significantly higher in the primary and high education groups than in the middle education group, while the apathy/eating problem scores were significantly higher in the primary education group than in the other groups. The GLM analyses showed that aggressiveness was related to marital status and the Zarit Caregiver Burden Interview (ZBI-J) score, while apathy/eating problems were related to the instrumental activities of daily living (IADL) percentage, the ZBI-J score, and the education level in years.
    Conclusions: Among NPS subsyndromes, aggressiveness and apathy/eating problems differed according to education level in patients with a-MCI. A GLM analysis suggested that not only education level, but also various other factors should be considered when determining the need for NPS interventions.
    MeSH term(s) Activities of Daily Living ; Alzheimer Disease/psychology ; Apathy ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/psychology ; Humans ; Neuropsychological Tests
    Language English
    Publishing date 2022-02-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2213105-X
    ISSN 1479-8301 ; 1346-3500
    ISSN (online) 1479-8301
    ISSN 1346-3500
    DOI 10.1111/psyg.12818
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  4. Article ; Online: Clinicodemographic and Psychosocial Factors Related to Presentation or Severity of Delusions of Theft among Females with Amnestic Mild Cognitive Impairment and Alzheimer's Disease.

    Inamura, Keisuke / Shinagawa, Shunichiro / Tsuneizumi, Yuri / Nagata, Tomoyuki / Tagai, Kenji / Nukariya, Kazutaka / Shigeta, Masahiro

    Clinical gerontologist

    2020  Volume 45, Issue 3, Page(s) 673–680

    Abstract: ... ...

    Abstract Objectives
    MeSH term(s) Activities of Daily Living ; Alzheimer Disease/complications ; Alzheimer Disease/diagnosis ; Alzheimer Disease/psychology ; Cognitive Dysfunction/psychology ; Delusions/psychology ; Female ; Humans ; Theft/psychology
    Language English
    Publishing date 2020-01-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 226146-7
    ISSN 1545-2301 ; 0731-7115
    ISSN (online) 1545-2301
    ISSN 0731-7115
    DOI 10.1080/07317115.2020.1720884
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  5. Article ; Online: Effects of neuropsychiatric symptoms of dementia on reductions in activities of daily living in patients with Alzheimer's disease.

    Okabe, Kiwamu / Nagata, Tomoyuki / Shinagawa, Shunichiro / Inamura, Keisuke / Tagai, Kenji / Nukariya, Kazutaka / Shigeta, Masahiro

    Geriatrics & gerontology international

    2020  Volume 20, Issue 6, Page(s) 584–588

    Abstract: Aim: In patients with Alzheimer's disease (AD), cognitive impairments cause a progressive reduction in Activities of Daily Living (ADL). Neuropsychiatric symptoms (NPS) also appear in most patients; however, the association between NPS and reductions in ...

    Abstract Aim: In patients with Alzheimer's disease (AD), cognitive impairments cause a progressive reduction in Activities of Daily Living (ADL). Neuropsychiatric symptoms (NPS) also appear in most patients; however, the association between NPS and reductions in ADL remains unclear. The present study evaluated whether NPS influence such reductions using two different ADL measures in patients with AD.
    Methods: Among 546 consecutive outpatients who visited the memory clinic at the Jikei University Kashiwa Hospital, we recruited 208 patients with AD and investigated the correlations between either the Physical Self-Maintenance Scale (PSMS) score or the Instrumental ADL (IADL) level, and each of the Behavioral Pathology in AD (Behave-AD) subscales. To clarify the causal relationships of these correlations, we then verified the associations between statistically significant demographic variables and the Behave-AD subscales as well as the two ADL scales (PSMS score and IADL percentage) using a general linear model.
    Results: Neither the PSMS nor the IADL results were significantly influenced by the aberrant motor behaviors score. However, the IADL was significantly influenced by the Mini-Mental State Exam (MMSE) score. Furthermore, diurnal rhythm disturbances and the interaction between diurnal rhythm disturbances score and the MMSE score significantly influenced the PSMS results.
    Conclusion: Basic ADL reductions may be influenced by diurnal rhythm disturbances, in addition to cognitive impairments in patients with AD. Furthermore, the interaction between the diurnal rhythm disturbances score and cognitive function may also influence basic ADL. Geriatr Gerontol Int 2020; ••: ••-••.
    MeSH term(s) Activities of Daily Living/psychology ; Aged ; Aged, 80 and over ; Alzheimer Disease/psychology ; Cross-Sectional Studies ; Executive Function ; Female ; Humans ; Male ; Mental Status and Dementia Tests
    Language English
    Publishing date 2020-03-31
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.13918
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    Zs.A 5801: Show issues Location:
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  6. Article ; Online: Guidelines for diagnosis and treatment of depression in older adults: A report from the Japanese Society of mood disorders.

    Baba, Hajime / Kito, Shinsuke / Nukariya, Kazutaka / Takeshima, Minoru / Fujise, Noboru / Iga, Junichi / Oshibuchi, Hidehiro / Kawano, Masahiko / Kimura, Mahiko / Mizukami, Katsuyoshi / Mimura, Masaru

    Psychiatry and clinical neurosciences

    2022  Volume 76, Issue 6, Page(s) 222–234

    Abstract: The Committee for Treatment Guidelines of Mood Disorders, Japanese Society of Mood Disorders, published a Japanese guideline for the treatment of late-life depression in 2020. Based on that guideline, the present guideline was developed and revised to ... ...

    Abstract The Committee for Treatment Guidelines of Mood Disorders, Japanese Society of Mood Disorders, published a Japanese guideline for the treatment of late-life depression in 2020. Based on that guideline, the present guideline was developed and revised to incorporate the suggestions of global experts and the latest published evidence. In the diagnosis of late-life depression, it is important to carefully differentiate it from bipolar disorders, depressive states caused by physical and organic brain disease, drug effects, and dementia, and to determine the comorbidity between late-life depression and dementia. It is necessary to fully understand the clinical characteristics and psychosocial background of late-life depression, evaluate the patient's condition, and provide basic interventions based on these factors. Problem-solving therapy, reminiscence therapy/life review therapy, and behavioral activation therapy, and other forms of psychotherapy can reduce depressive symptoms. In terms of pharmacotherapy, newer antidepressants or non-tricyclic antidepressants are recommended for late-life depression, and it is recommended that the efficacy of least the minimal effective dosage should first be determined. Switching antidepressants and aripiprazole augmentation can be used to treatment-resistant therapy. Electroconvulsive therapy and repetitive transcranial magnetic stimulation have demonstrated usefulness for late-life depression. Exercise therapy, high-intensity light therapy, and diet therapy also show some effectiveness and are useful for late-life depression. Continuation therapy should be maintained for at least 1 year after remission.
    MeSH term(s) Aged ; Antidepressive Agents/therapeutic use ; Dementia ; Depression/therapy ; Humans ; Japan ; Mood Disorders/drug therapy ; Mood Disorders/therapy
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2022-04-06
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1292906-2
    ISSN 1440-1819 ; 1323-1316
    ISSN (online) 1440-1819
    ISSN 1323-1316
    DOI 10.1111/pcn.13349
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  7. Article ; Online: Sex differences in the severity of neuropsychiatric symptoms and their relationship with clinico-demographic and psychosocial factors in patients with amnestic mild cognitive impairment and mild Alzheimer's disease.

    Inamura, Keisuke / Shinagawa, Shunichiro / Tsuneizumi, Yuri / Nagata, Tomoyuki / Tagai, Kenji / Nukariya, Kazutaka / Shigeta, Masahiro

    Aging & mental health

    2018  Volume 24, Issue 3, Page(s) 431–438

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) Alzheimer Disease/diagnosis ; Amnesia ; Cognitive Dysfunction/diagnosis ; Female ; Humans ; Male ; Neuropsychological Tests ; Sex Factors
    Language English
    Publishing date 2018-12-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1474804-6
    ISSN 1364-6915 ; 1360-7863
    ISSN (online) 1364-6915
    ISSN 1360-7863
    DOI 10.1080/13607863.2018.1539834
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    Zs.A 5081: Show issues Location:
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  8. Article ; Online: The relationship between the severity of depressive symptoms and diabetes-related emotional distress in patients with type 2 diabetes.

    Hosoya, Takumi / Matsushima, Masato / Nukariya, Kazutaka / Utsunomiya, Kazunori

    Internal medicine (Tokyo, Japan)

    2012  Volume 51, Issue 3, Page(s) 263–269

    Abstract: Objective: To examine the relationship between the severity of depressive symptoms and the burden through diabetes care, or diagnosed diabetes in patients with type 2 diabetes, irrespective of the diabetic complications and glycemic control.: Patients ...

    Abstract Objective: To examine the relationship between the severity of depressive symptoms and the burden through diabetes care, or diagnosed diabetes in patients with type 2 diabetes, irrespective of the diabetic complications and glycemic control.
    Patients and methods: Subjects were 126 outpatients with type 2 diabetes who completed the Beck Depression Inventory-II (BDI-II), Problem Areas in Diabetes (PAID) scale, and Short Form-36 (SF-36).
    Results: The factor with a significant impact on the BDI-II score in the multiple regression model was the PAID score (standardized coefficient =0.17, 95% confidence interval [CI], 0.12-0.21). The factors having a significant impact on the physical component summary of SF-36 (PCS) in the multiple regression model were BDI-II score (-0.95; 95% CI, -1.32 - -0.58), age (-0.43; 95% CI, -0.61 - -0.25), and the number of complicated macroangiopathies (-8.90; 95% CI, -12.71 - -5.08). The factors with a significant impact on the mental component summary of SF-36 (MCS) in the multiple regression model were BDI-II score (-0.90; 95% CI, -1.16 - -0.65) and age (0.13; 95% CI, 0.00-0.25).
    Conclusion: These findings show that diabetes-related emotional distress is significantly related to the severity of depressive symptoms in patients with type 2 diabetes, independent of the severity of complications and glycemic control. Moreover, the severity of depressive symptoms is negatively correlated with comprehensive health-related QOL in patients with type 2 diabetes. Clinicians need to consider factors other than indices of metabolic control and diabetic complications, in determining the adverse effects of depressive symptoms on the physical QOL of patients with type 2 diabetes.
    MeSH term(s) Aged ; Cross-Sectional Studies ; Depression/epidemiology ; Depression/psychology ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/psychology ; Emotions ; Female ; Humans ; Male ; Middle Aged ; Severity of Illness Index
    Language English
    Publishing date 2012-02-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.51.5768
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    Zs.A 240: Show issues Location:
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  9. Article ; Online: Executive Dysfunction Correlated With 2-Year Treatment Response in Patients With Late-Life Undifferentiated Somatoform Disorders.

    Inamura, Keisuke / Shinagawa, Shunichiro / Nagata, Tomoyuki / Tagai, Kenji / Nukariya, Kazutaka / Nakayama, Kazuhiko

    Psychosomatics

    2016  Volume 57, Issue 4, Page(s) 378–389

    Abstract: Background: Late-life somatoform disorders (SDs) are characterized by various aging-associated factors. Recently, cognitive decline, including executive dysfunction, has been reported as an etiological factor of late-life SDs. The response to treatment ... ...

    Abstract Background: Late-life somatoform disorders (SDs) are characterized by various aging-associated factors. Recently, cognitive decline, including executive dysfunction, has been reported as an etiological factor of late-life SDs. The response to treatment for late-life SDs varies from one patient to another. Treatment strategies for late-life SDs require these etiological factors to be considered. We hypothesized that the treatment response in patients with late-life SDs was associated with executive dysfunction.
    Objective: The aim of the present study was to confirm the changes in disease severity over a 2-year follow-up period and to determine which etiological factors are related to the treatment response in patients with late-life SDs.
    Methods: We examined 55 patients with late-life SDs who were treated with pharmacotherapy and supportive psychotherapy at baseline. The changes in the disease severity and cognitive profiles over a 2-year follow-up period were evaluated. Additionally, we investigated which etiological factors at baseline were related to treatment resistance.
    Results: Of the 55 patients who were enrolled in the present study, 31 completed the 2-year follow-up period. Overall, the disease severity improved significantly in patients with late-life SDs. On the contrary, executive function decreased throughout the research period. Moreover, we found that executive dysfunction and the presence of hyperlipidemia at baseline were related to treatment resistance.
    Conclusions: These results suggest that aging-associated etiological factors be considered for the treatment of late-life SDs.
    MeSH term(s) Aged ; Antidepressive Agents/therapeutic use ; Anxiety/psychology ; Benzodiazepines/therapeutic use ; Cognitive Dysfunction/psychology ; Executive Function ; Female ; Follow-Up Studies ; Humans ; Late Onset Disorders ; Male ; Middle Aged ; Neuropsychological Tests ; Prognosis ; Psychotherapy ; Somatoform Disorders/psychology ; Somatoform Disorders/therapy
    Chemical Substances Antidepressive Agents ; Benzodiazepines (12794-10-4)
    Language English
    Publishing date 2016-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 209487-3
    ISSN 1545-7206 ; 0033-3182
    ISSN (online) 1545-7206
    ISSN 0033-3182
    DOI 10.1016/j.psym.2016.02.006
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  10. Article ; Online: White matter hyperintensities are associated with the severity of late-life somatoform disorders and executive functions.

    Inamura, Keisuke / Shinagawa, Shunichiro / Nagata, Tomoyuki / Tagai, Kenji / Nukariya, Kazutaka / Nakayama, Kazuhiko

    Nordic journal of psychiatry

    2015  , Page(s) 1–8

    Abstract: Background: Medically unexplained symptoms are often seen in the elderly. Recently, correlations between medically unexplained symptoms and somatoform disorders (SDs) have been reported. The existence of many interactive psychiatric aetiologies is known ...

    Abstract Background: Medically unexplained symptoms are often seen in the elderly. Recently, correlations between medically unexplained symptoms and somatoform disorders (SDs) have been reported. The existence of many interactive psychiatric aetiologies is known among SDs. Late-life SDs might be influenced by some aetiological factors caused by ageing processes, such as structural changes in the brain and cognitive dysfunctions.
    Aims: Under such circumstances, we investigated the presence of subcortical white matter hyperintensities (WMHs), which increase with ageing, and hypothesized that subcortical WMHs are related to the disease severity of late-life SDs. Furthermore, we confirmed whether cognitive dysfunction influences this process.
    Methods: To evaluate these hypotheses, we examined patients with medically unexplained symptoms who met the criteria for undifferentiated somatoform disorder and divided the patients into three groups according to the degree of subcortical WMHs: grade 0, grade 1, and grade 2. The subcortical WMHs were rated using Fazekas grading. Differences in symptom severity and cognitive functions were compared among the three groups.
    Results: The grade 2 group had the severest symptoms. Furthermore, the grade 2 group had lower cognitive function scores than the other groups.
    Conclusions: The present study showed that the presence of subcortical WMHs in patients with late-life SDs was a predictor of disease severity. Moreover, cognitive dysfunction appeared to play a role in the advancement of disease severity.
    Language English
    Publishing date 2015-06-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1104974-1
    ISSN 1502-4725 ; 0803-9488 ; 0029-1455
    ISSN (online) 1502-4725
    ISSN 0803-9488 ; 0029-1455
    DOI 10.3109/08039488.2015.1053096
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