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Article ; Online: Deciphering the total RNA content of extracellular vesicles.

Amorim, Maria G / Dias-Neto, Emmanuel / Nunes, Diana N

2020 Volume 645, Page(s) 141–154

Abstract: Extracellular vesicles (EVs) have been recognized as relevant players in cell-cell communication. To fully explore their potential as carriers of biological information in clinical settings, protocols capable of dealing with minute amounts of proteins, ... ...

Abstract	Extracellular vesicles (EVs) have been recognized as relevant players in cell-cell communication. To fully explore their potential as carriers of biological information in clinical settings, protocols capable of dealing with minute amounts of proteins, lipids, and nucleic acids present in their cargo are a requirement. Here we delve into a protocol to decipher the total transcriptome of EVs, from undetectable amounts of EVs-derived RNA from clinical samples.
MeSH term(s)	Cell Communication ; Extracellular Vesicles ; Proteins ; RNA/genetics ; Transcriptome
Chemical Substances	Proteins ; RNA (63231-63-0)
Language	English
Publishing date	2020-09-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1557-7988
ISSN (online)	1557-7988
DOI	10.1016/bs.mie.2020.08.001
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Article ; Online: EBV and further emerging directions towards increased precision in gastric cancer treatment.

Santos, Luana B C / Bartelli, Thais F / Nunes, Diana N / Dias-Neto, Emmanuel

Translational cancer research

2022 Volume 11, Issue 9, Page(s) 3012–3014

Language	English
Publishing date	2022-09-28
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	2901601-0
ISSN	2219-6803 ; 2218-676X
ISSN (online)	2219-6803
ISSN	2218-676X
DOI	10.21037/tcr-22-2024
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Article ; Online: Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts.

Lauer, Richard C / Barry, Marc / Smith, Tracey L / Thomas, Andrew Maltez / Wu, Jin / Du, Ruofei / Lee, Ji-Hyun / Rao, Arpit / Dobroff, Andrey S / Arap, Marco A / Nunes, Diana N / Silva, Israel T / Dias-Neto, Emmanuel / Chen, Isan / McCance, Dennis J / Cavenee, Webster K / Pasqualini, Renata / Arap, Wadih

eLife

2023 Volume 12

Abstract: Background: We have previously shown that the long non-coding (lnc)RNA : Methods: The reciprocal : Results: We consistently observed increased expression of : Conclusions: We concluded that upregulation of the lncRNA : Funding: We received ... ...

Abstract	Background: We have previously shown that the long non-coding (lnc)RNA Methods: The reciprocal Results: We consistently observed increased expression of Conclusions: We concluded that upregulation of the lncRNA Funding: We received support from the Human Tissue Repository and Tissue Analysis Shared Resource from the Department of Pathology of the University of New Mexico School of Medicine and a pilot award from the University of New Mexico Comprehensive Cancer Center. RP and WA were supported by awards from the Levy-Longenbaugh Donor-Advised Fund and the Prostate Cancer Foundation. EDN reports research fellowship support from the Brazilian National Council for Scientific and Technological Development (CNPq), Brazil, and the Associação Beneficente Alzira Denise Hertzog Silva (ABADHS), Brazil. This work has been funded in part by the NCI Cancer Center Support Grants (CCSG; P30) to the University of New Mexico Comprehensive Cancer Center (CA118100) and the Rutgers Cancer Institute of New Jersey (CA072720).
MeSH term(s)	Humans ; Male ; Antigens, Neoplasm/genetics ; Biomarkers, Tumor/genetics ; Neoplasm Recurrence, Local/genetics ; Prostate/metabolism ; Prostatic Neoplasms/metabolism ; Retrospective Studies ; RNA, Long Noncoding/genetics
Chemical Substances	Antigens, Neoplasm ; Biomarkers, Tumor ; RNA, Long Noncoding ; PRUNE2 protein, human
Language	English
Publishing date	2023-01-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.81929
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Article ; Online: Variability and bias in microbiome metagenomic sequencing: an interlaboratory study comparing experimental protocols.

Forry, Samuel P / Servetas, Stephanie L / Kralj, Jason G / Soh, Keng / Hadjithomas, Michalis / Cano, Raul / Carlin, Martha / Amorim, Maria G de / Auch, Benjamin / Bakker, Matthew G / Bartelli, Thais F / Bustamante, Juan P / Cassol, Ignacio / Chalita, Mauricio / Dias-Neto, Emmanuel / Duca, Aaron Del / Gohl, Daryl M / Kazantseva, Jekaterina / Haruna, Muyideen T /

Menzel, Peter / Moda, Bruno S / Neuberger-Castillo, Lorieza / Nunes, Diana N / Patel, Isha R / Peralta, Rodrigo D / Saliou, Adrien / Schwarzer, Rolf / Sevilla, Samantha / Takenaka, Isabella K T M / Wang, Jeremy R / Knight, Rob / Gevers, Dirk / Jackson, Scott A

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9785

Abstract: Several studies have documented the significant impact of methodological choices in microbiome analyses. The myriad of methodological options available complicate the replication of results and generally limit the comparability of findings between ... ...

Abstract	Several studies have documented the significant impact of methodological choices in microbiome analyses. The myriad of methodological options available complicate the replication of results and generally limit the comparability of findings between independent studies that use differing techniques and measurement pipelines. Here we describe the Mosaic Standards Challenge (MSC), an international interlaboratory study designed to assess the impact of methodological variables on the results. The MSC did not prescribe methods but rather asked participating labs to analyze 7 shared reference samples (5 × human stool samples and 2 × mock communities) using their standard laboratory methods. To capture the array of methodological variables, each participating lab completed a metadata reporting sheet that included 100 different questions regarding the details of their protocol. The goal of this study was to survey the methodological landscape for microbiome metagenomic sequencing (MGS) analyses and the impact of methodological decisions on metagenomic sequencing results. A total of 44 labs participated in the MSC by submitting results (16S or WGS) along with accompanying metadata; thirty 16S rRNA gene amplicon datasets and 14 WGS datasets were collected. The inclusion of two types of reference materials (human stool and mock communities) enabled analysis of both MGS measurement variability between different protocols using the biologically-relevant stool samples, and MGS bias with respect to ground truth values using the DNA mixtures. Owing to the compositional nature of MGS measurements, analyses were conducted on the ratio of Firmicutes: Bacteroidetes allowing us to directly apply common statistical methods. The resulting analysis demonstrated that protocol choices have significant effects, including both bias of the MGS measurement associated with a particular methodological choices, as well as effects on measurement robustness as observed through the spread of results between labs making similar methodological choices. In the analysis of the DNA mock communities, MGS measurement bias was observed even when there was general consensus among the participating laboratories. This study was the result of a collaborative effort that included academic, commercial, and government labs. In addition to highlighting the impact of different methodological decisions on MGS result comparability, this work also provides insights for consideration in future microbiome measurement study design.
MeSH term(s)	Humans ; Metagenomics/methods ; Metagenomics/standards ; RNA, Ribosomal, 16S/genetics ; Feces/microbiology ; Microbiota/genetics ; Bias ; Metagenome ; Gastrointestinal Microbiome/genetics ; Sequence Analysis, DNA/methods ; Bacteria/genetics ; Bacteria/classification ; Bacteria/isolation & purification ; High-Throughput Nucleotide Sequencing/methods
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2024-04-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comparative Study
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57981-4
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Article: Evaluation of Bacteria and Fungi DNA Abundance in Human Tissues

de Albuquerque, Gabriela E. / Moda, Bruno S. / Serpa, Marianna S. / Branco, Gabriela P. / Defelicibus, Alexandre / Takenaka, Isabella K. T. M. / de Amorim, Maria G. / Miola, Elizabeth C. / Martins, Valquiria C. A. / Torres, Katia L. / Bezerra, Stephania M. / Claro, Laura C. L. / Pelosof, Adriane G. / Sztokfisz, Claudia Z. / Abrantes, Lais L. S. / Coimbra, Felipe J. F. / Kowalski, Luiz P. / Alves, Fábio A. / Zequi, Stênio C. /

Udekwu, Klas I. / Silva, Israel T. / Nunes, Diana N. / Bartelli, Thais F. / Dias-Neto, Emmanuel

Genes. 2022 Jan. 27, v. 13, no. 2

2022

Abstract: Whereas targeted and shotgun sequencing approaches are both powerful in allowing the study of tissue-associated microbiota, the human: microorganism abundance ratios in tissues of interest will ultimately determine the most suitable sequencing approach. ... ...

Abstract	Whereas targeted and shotgun sequencing approaches are both powerful in allowing the study of tissue-associated microbiota, the human: microorganism abundance ratios in tissues of interest will ultimately determine the most suitable sequencing approach. In addition, it is possible that the knowledge of the relative abundance of bacteria and fungi during a treatment course or in pathological conditions can be relevant in many medical conditions. Here, we present a qPCR-targeted approach to determine the absolute and relative amounts of bacteria and fungi and demonstrate their relative DNA abundance in nine different human tissue types for a total of 87 samples. In these tissues, fungi genomes are more abundant in stool and skin samples but have much lower levels in other tissues. Bacteria genomes prevail in stool, skin, oral swabs, saliva, and gastric fluids. These findings were confirmed by shotgun sequencing for stool and gastric fluids. This approach may contribute to a more comprehensive view of the human microbiota in targeted studies for assessing the abundance levels of microorganisms during disease treatment/progression and to indicate the most informative methods for studying microbial composition (shotgun versus targeted sequencing) for various samples types.
Keywords	DNA ; humans ; saliva ; therapeutics
Language	English
Dates of publication	2022-0127
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes13020237
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Article ; Online: APOBEC-mediated DNA alterations: A possible new mechanism of carcinogenesis in EBV-positive gastric cancer.

Bobrovnitchaia, Irina / Valieris, Renan / Drummond, Rodrigo D / Lima, Joao P / Freitas, Helano C / Bartelli, Thais F / de Amorim, Maria G / Nunes, Diana N / Dias-Neto, Emmanuel / da Silva, Israel T

International journal of cancer

2019 Volume 146, Issue 1, Page(s) 181–191

Abstract: Mechanisms of viral oncogenesis are diverse and include the off-target activity of enzymes expressed by the infected cells, which evolved to target viral genomes for controlling their infection. Among these enzymes, the single-strand DNA editing ... ...

Abstract	Mechanisms of viral oncogenesis are diverse and include the off-target activity of enzymes expressed by the infected cells, which evolved to target viral genomes for controlling their infection. Among these enzymes, the single-strand DNA editing capability of APOBECs represent a well-conserved viral infection response that can also cause untoward mutations in the host DNA. Here we show, after evaluating somatic single-nucleotide variations and transcriptome data in 240 gastric cancer samples, a positive correlation between APOBEC3s mRNA-expression and the APOBEC-mutation signature, both increased in EBV+ tumors. The correlation was reinforced by the observation of APOBEC mutations preferentially occurring in the genomic loci of the most active transcripts. This EBV infection and APOBEC3 mutation-signature axis were confirmed in a validation cohort of 112 gastric cancer patients. Our findings suggest that APOBEC3 upregulation in EBV+ cancer may boost the mutation load, providing further clues to the mechanisms of EBV-induced gastric carcinogenesis. After further validation, this EBV-APOBEC axis may prove to be a secondary driving force in the mutational evolution of EBV+ gastric tumors, whose consequences in terms of prognosis and treatment implications should be vetted.
MeSH term(s)	APOBEC Deaminases ; Carcinogenesis ; Cytidine Deaminase/genetics ; DNA, Neoplasm/genetics ; Genes, Viral ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/pathogenicity ; Humans ; Mutation ; Stomach Neoplasms/pathology ; Stomach Neoplasms/virology
Chemical Substances	DNA, Neoplasm ; APOBEC Deaminases (EC 3.5.4.5) ; APOBEC3 proteins, human (EC 3.5.4.5) ; Cytidine Deaminase (EC 3.5.4.5)
Language	English
Publishing date	2019-06-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.32411
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Evaluation of Bacteria and Fungi DNA Abundance in Human Tissues.

de Albuquerque, Gabriela E / Moda, Bruno S / Serpa, Marianna S / Branco, Gabriela P / Defelicibus, Alexandre / Takenaka, Isabella K T M / de Amorim, Maria G / Miola, Elizabeth C / Martins, Valquiria C A / Torres, Katia L / Bezerra, Stephania M / Claro, Laura C L / Pelosof, Adriane G / Sztokfisz, Claudia Z / Abrantes, Lais L S / Coimbra, Felipe J F / Kowalski, Luiz P / Alves, Fábio A / Zequi, Stênio C /

Udekwu, Klas I / Silva, Israel T / Nunes, Diana N / Bartelli, Thais F / Dias-Neto, Emmanuel

Genes

2022 Volume 13, Issue 2

Abstract	Whereas targeted and shotgun sequencing approaches are both powerful in allowing the study of tissue-associated microbiota, the human: microorganism abundance ratios in tissues of interest will ultimately determine the most suitable sequencing approach. In addition, it is possible that the knowledge of the relative abundance of bacteria and fungi during a treatment course or in pathological conditions can be relevant in many medical conditions. Here, we present a qPCR-targeted approach to determine the absolute and relative amounts of bacteria and fungi and demonstrate their relative DNA abundance in nine different human tissue types for a total of 87 samples. In these tissues, fungi genomes are more abundant in stool and skin samples but have much lower levels in other tissues. Bacteria genomes prevail in stool, skin, oral swabs, saliva, and gastric fluids. These findings were confirmed by shotgun sequencing for stool and gastric fluids. This approach may contribute to a more comprehensive view of the human microbiota in targeted studies for assessing the abundance levels of microorganisms during disease treatment/progression and to indicate the most informative methods for studying microbial composition (shotgun versus targeted sequencing) for various samples types.
MeSH term(s)	Bacteria/genetics ; DNA, Fungal ; Fungi/genetics ; Humans ; Metagenomics/methods ; Sequence Analysis, DNA
Chemical Substances	DNA, Fungal
Language	English
Publishing date	2022-01-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes13020237
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Article ; Online: A transcriptome-based signature of pathological angiogenesis predicts breast cancer patient survival.

Guarischi-Sousa, Rodrigo / Monteiro, Jhonatas S / Alecrim, Lilian C / Michaloski, Jussara S / Cardeal, Laura B / Ferreira, Elisa N / Carraro, Dirce M / Nunes, Diana N / Dias-Neto, Emmanuel / Reimand, Jüri / Boutros, Paul C / Setubal, João C / Giordano, Ricardo J

PLoS genetics

2019 Volume 15, Issue 12, Page(s) e1008482

Abstract: The specific genes and molecules that drive physiological angiogenesis differ from those involved in pathological angiogenesis, suggesting distinct mechanisms for these seemingly related processes. Unveiling genes and pathways preferentially associated ... ...

Abstract	The specific genes and molecules that drive physiological angiogenesis differ from those involved in pathological angiogenesis, suggesting distinct mechanisms for these seemingly related processes. Unveiling genes and pathways preferentially associated with pathologic angiogenesis is key to understanding its mechanisms, thereby facilitating development of novel approaches to managing angiogenesis-dependent diseases. To better understand these different processes, we elucidated the transcriptome of the mouse retina in the well-accepted oxygen-induced retinopathy (OIR) model of pathological angiogenesis. We identified 153 genes changed between normal and OIR retinas, which represent a molecular signature relevant to other angiogenesis-dependent processes such as cancer. These genes robustly predict the survival of breast cancer patients, which was validated in an independent 1,000-patient test cohort (40% difference in 15-year survival; p = 2.56 x 10-21). These results suggest that the OIR model reveals key genes involved in pathological angiogenesis, and these may find important applications in stratifying tumors for treatment intensification or for angiogenesis-targeted therapies.
MeSH term(s)	Aged ; Animals ; Breast Neoplasms/genetics ; Breast Neoplasms/mortality ; Disease Models, Animal ; Female ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; High-Throughput Nucleotide Sequencing ; Humans ; Mice ; Middle Aged ; Neovascularization, Pathologic/chemically induced ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/mortality ; Oxygen/adverse effects ; Retina/chemistry ; Retina/drug effects ; Sequence Analysis, RNA
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2019-12-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1008482
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Article ; Online: A total transcriptome profiling method for plasma-derived extracellular vesicles: applications for liquid biopsies.

Amorim, Maria G / Valieris, Renan / Drummond, Rodrigo D / Pizzi, Melissa P / Freitas, Vanessa M / Sinigaglia-Coimbra, Rita / Calin, George A / Pasqualini, Renata / Arap, Wadih / Silva, Israel T / Dias-Neto, Emmanuel / Nunes, Diana N

Scientific reports

2017 Volume 7, Issue 1, Page(s) 14395

Abstract: Extracellular vesicles (EVs) are key mediators of intercellular communication. Part of their biological effects can be attributed to the transfer of cargos of diverse types of RNAs, which are promising diagnostic and prognostic biomarkers. EVs found in ... ...

Abstract	Extracellular vesicles (EVs) are key mediators of intercellular communication. Part of their biological effects can be attributed to the transfer of cargos of diverse types of RNAs, which are promising diagnostic and prognostic biomarkers. EVs found in human biofluids are a valuable source for the development of minimally invasive assays. However, the total transcriptional landscape of EVs is still largely unknown. Here we develop a new method for total transcriptome profiling of plasma-derived EVs by next generation sequencing (NGS) from limited quantities of patient-derived clinical samples, which enables the unbiased characterization of the complete RNA cargo, including both small- and long-RNAs, in a single library preparation step. This approach was applied to RNA extracted from EVs isolated by ultracentrifugation from the plasma of five healthy volunteers. Among the most abundant RNAs identified we found small RNAs such as tRNAs, miRNAs and miscellaneous RNAs, which have largely unknown functions. We also identified protein-coding and long noncoding transcripts, as well as circular RNA species that were also experimentally validated. This method enables, for the first time, the full spectrum of transcriptome data to be obtained from minute patient-derived samples, and will therefore potentially allow the identification of cell-to-cell communication mechanisms and biomarkers.
MeSH term(s)	Extracellular Vesicles/metabolism ; Female ; Gene Expression Profiling/methods ; Hematologic Tests/methods ; Humans ; Liquid Biopsy ; MicroRNAs/metabolism ; Plasma/metabolism ; Transcriptome
Chemical Substances	MicroRNAs
Language	English
Publishing date	2017-10-31
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Validation Studies
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-017-14264-5
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Article ; Online: Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer.

Staquicini, Fernanda I / Hajitou, Amin / Driessen, Wouter Hp / Proneth, Bettina / Cardó-Vila, Marina / Staquicini, Daniela I / Markosian, Christopher / Hoh, Maria / Cortez, Mauro / Hooda-Nehra, Anupama / Jaloudi, Mohammed / Silva, Israel T / Buttura, Jaqueline / Nunes, Diana N / Dias-Neto, Emmanuel / Eckhardt, Bedrich / Ruiz-Ramírez, Javier / Dogra, Prashant / Wang, Zhihui /

Cristini, Vittorio / Trepel, Martin / Anderson, Robin / Sidman, Richard L / Gelovani, Juri G / Cristofanilli, Massimo / Hortobagyi, Gabriel N / Bhujwalla, Zaver M / Burley, Stephen K / Arap, Wadih / Pasqualini, Renata

eLife

2021 Volume 10

Abstract: Triple-negative breast cancer (TNBC) is an aggressive tumor with limited treatment options and poor prognosis. We applied the in vivo phage display technology to isolate peptides homing to the immunosuppressive cellular microenvironment of TNBC as a ... ...

Abstract	Triple-negative breast cancer (TNBC) is an aggressive tumor with limited treatment options and poor prognosis. We applied the in vivo phage display technology to isolate peptides homing to the immunosuppressive cellular microenvironment of TNBC as a strategy for non-malignant target discovery. We identified a cyclic peptide (CSSTRESAC) that specifically binds to a vitamin D receptor, protein disulfide-isomerase A3 (PDIA3) expressed on the cell surface of tumor-associated macrophages (TAM), and targets breast cancer in syngeneic TNBC, non-TNBC xenograft, and transgenic mouse models. Systemic administration of CSSTRESAC to TNBC-bearing mice shifted the cytokine profile toward an antitumor immune response and delayed tumor growth. Moreover, CSSTRESAC enabled ligand-directed theranostic delivery to tumors and a mathematical model confirmed our experimental findings. Finally, in silico analysis showed PDIA3-expressing TAM in TNBC patients. This work uncovers a functional interplay between a cell surface vitamin D receptor in TAM and antitumor immune response that could be therapeutically exploited.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Enzyme Activation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Ligands ; Mice, Inbred BALB C ; Mice, Nude ; Models, Biological ; Oligopeptides/pharmacology ; Protein Disulfide-Isomerases/genetics ; Protein Disulfide-Isomerases/metabolism ; Signal Transduction ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/immunology ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology ; Tumor Burden/drug effects ; Tumor Microenvironment ; Tumor-Associated Macrophages/drug effects ; Tumor-Associated Macrophages/immunology ; Tumor-Associated Macrophages/metabolism ; Vitamin D-Binding Protein/genetics ; Vitamin D-Binding Protein/metabolism ; Xenograft Model Antitumor Assays ; Mice
Chemical Substances	Antineoplastic Agents ; Ligands ; Oligopeptides ; Vitamin D-Binding Protein ; Pdia3 protein, mouse (EC 5.3.4.1) ; Protein Disulfide-Isomerases (EC 5.3.4.1) ; PDIA3 protein, human (EC 5.3.4.1.)
Language	English
Publishing date	2021-06-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.65145
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