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  1. Article ; Online: Establishment of the LNCaP Cell Line - The Dawn of an Era for Prostate Cancer Research.

    Abate-Shen, Cory / Nunes de Almeida, Francisca

    Cancer research

    2022  Volume 82, Issue 9, Page(s) 1689–1691

    Abstract: Among the relatively few established human prostate cancer cell lines, LNCaP cells are unique in their ability to model key stages of prostate cancer progression. Analyses of LNCaP cells and their derivatives have been invaluable for elucidating ... ...

    Abstract Among the relatively few established human prostate cancer cell lines, LNCaP cells are unique in their ability to model key stages of prostate cancer progression. Analyses of LNCaP cells and their derivatives have been invaluable for elucidating important translational aspects of prostate tumorigenesis, metastasis, and drug response, particularly in the context of androgen receptor signaling. Here, we present major highlights from a wealth of literature that has exploited LNCaP cells and their derivatives to inform on prostate cancer progression and androgen response for improving the treatment of patients with prostate cancer. See related article by Horoszewicz and colleagues, Cancer Res 1983;43:1809-18.
    MeSH term(s) Androgens ; Cell Line ; Cell Transformation, Neoplastic ; Humans ; Male ; Prostate/pathology ; Prostatic Neoplasms/pathology
    Chemical Substances Androgens
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-22-1065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.135/5: Show issues Location:
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  2. Article ; Online: Correction: In vivo genome-wide CRISPR screening identifies CITED2 as a driver of prostate cancer bone metastasis.

    Arriaga, Juan M / Ronaldson-Bouchard, Kacey / Picech, Florencia / Nunes de Almeida, Francisca / Afari, Stephanie / Chhouri, Houssein / Vunjak-Novakovic, Gordana / Abate-Shen, Cory

    Oncogene

    2024  

    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Published Erratum
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-024-03031-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2218: Show issues Location:
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  3. Article ; Online: In vivo genome-wide CRISPR screening identifies CITED2 as a driver of prostate cancer bone metastasis.

    Arriaga, Juan M / Ronaldson-Bouchard, Kacey / Picech, Florencia / Nunes de Almeida, Francisca / Afari, Stephanie / Chhouri, Houssein / Vunjak-Novakovic, Gordana / Abate-Shen, Cory

    Oncogene

    2024  Volume 43, Issue 17, Page(s) 1303–1315

    Abstract: Most cancer deaths are due to metastatic dissemination to distant organs. Bone is the most frequently affected organ in metastatic prostate cancer and a major cause of prostate cancer deaths. Yet, our partial understanding of the molecular factors that ... ...

    Abstract Most cancer deaths are due to metastatic dissemination to distant organs. Bone is the most frequently affected organ in metastatic prostate cancer and a major cause of prostate cancer deaths. Yet, our partial understanding of the molecular factors that drive bone metastasis has been a limiting factor for developing preventative and therapeutic strategies to improve patient survival and well-being. Although recent studies have uncovered molecular alterations that occur in prostate cancer metastasis, their functional relevance for bone metastasis is not well understood. Using genome-wide CRISPR activation and inhibition screens we have identified multiple drivers and suppressors of prostate cancer metastasis. Through functional validation, including an innovative organ-on-a-chip invasion platform for studying bone tropism, our study identifies the transcriptional modulator CITED2 as a novel driver of prostate cancer bone metastasis and uncovers multiple new potential molecular targets for bone metastatic disease.
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-024-02995-5
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  4. Article ; Online: Regulation of Cdc42 and its effectors in epithelial morphogenesis.

    Pichaud, Franck / Walther, Rhian F / Nunes de Almeida, Francisca

    Journal of cell science

    2019  Volume 132, Issue 10

    Abstract: Cdc42 - a member of the small Rho GTPase family - regulates cell polarity across organisms from yeast to humans. It is an essential regulator of polarized morphogenesis in epithelial cells, through coordination of apical membrane morphogenesis, lumen ... ...

    Abstract Cdc42 - a member of the small Rho GTPase family - regulates cell polarity across organisms from yeast to humans. It is an essential regulator of polarized morphogenesis in epithelial cells, through coordination of apical membrane morphogenesis, lumen formation and junction maturation. In parallel, work in yeast and
    MeSH term(s) Animals ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Humans ; Morphogenesis ; cdc42 GTP-Binding Protein/metabolism
    Chemical Substances cdc42 GTP-Binding Protein (EC 3.6.5.2)
    Language English
    Publishing date 2019-05-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.217869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Cdc42 defines apical identity and regulates epithelial morphogenesis by promoting apical recruitment of Par6-aPKC and Crumbs.

    Nunes de Almeida, Francisca / Walther, Rhian F / Pressé, Mary T / Vlassaks, Evi / Pichaud, Franck

    Development (Cambridge, England)

    2019  Volume 146, Issue 15

    Abstract: Cdc42 regulates epithelial morphogenesis together with the Par complex (Baz/Par3-Par6-aPKC), Crumbs (Crb/CRB3) and Stardust (Sdt/PALS1). However, how these proteins work together and interact during epithelial morphogenesis is not well understood. To ... ...

    Abstract Cdc42 regulates epithelial morphogenesis together with the Par complex (Baz/Par3-Par6-aPKC), Crumbs (Crb/CRB3) and Stardust (Sdt/PALS1). However, how these proteins work together and interact during epithelial morphogenesis is not well understood. To address this issue, we used the genetically amenable
    MeSH term(s) Animals ; Cell Polarity/physiology ; Drosophila Proteins/metabolism ; Drosophila melanogaster/growth & development ; Drosophila melanogaster/metabolism ; Epithelium/growth & development ; GTP-Binding Proteins/metabolism ; Membrane Proteins/metabolism ; Morphogenesis/physiology ; Photoreceptor Cells/cytology ; Protein Binding/physiology ; Protein Kinase C/metabolism
    Chemical Substances Cdc42 protein, Drosophila ; Drosophila Proteins ; Membrane Proteins ; crb protein, Drosophila ; Par-6 protein, Drosophila (EC 2.7.11.13) ; Protein Kinase C (EC 2.7.11.13) ; aPKC protein, Drosophila (EC 2.7.11.13) ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2019-08-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.175497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ub I Zs.183: Show issues Location:
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  6. Article ; Online: Pak4 Is Required during Epithelial Polarity Remodeling through Regulating AJ Stability and Bazooka Retention at the ZA.

    Walther, Rhian F / Nunes de Almeida, Francisca / Vlassaks, Evi / Burden, Jemima J / Pichaud, Franck

    Cell reports

    2016  Volume 15, Issue 1, Page(s) 45–53

    Abstract: The ability of epithelial cells to assemble into sheets relies on their zonula adherens (ZA), a circumferential belt of adherens junction (AJ) material, which can be remodeled during development to shape organs. Here, we show that during ZA remodeling in ...

    Abstract The ability of epithelial cells to assemble into sheets relies on their zonula adherens (ZA), a circumferential belt of adherens junction (AJ) material, which can be remodeled during development to shape organs. Here, we show that during ZA remodeling in a model neuroepithelial cell, the Cdc42 effector P21-activated kinase 4 (Pak4/Mbt) regulates AJ morphogenesis and stability through β-catenin (β-cat/Arm) phosphorylation. We find that β-catenin phosphorylation by Mbt, and associated AJ morphogenesis, is needed for the retention of the apical determinant Par3/Bazooka at the remodeling ZA. Importantly, this retention mechanism functions together with Par1-dependent lateral exclusion of Par3/Bazooka to regulate apical membrane differentiation. Our results reveal an important functional link between Pak4, AJ material morphogenesis, and polarity remodeling during organogenesis downstream of Par3.
    MeSH term(s) Adherens Junctions/metabolism ; Adherens Junctions/ultrastructure ; Animals ; Cell Differentiation ; Cell Polarity ; Compound Eye, Arthropod/cytology ; Compound Eye, Arthropod/embryology ; Compound Eye, Arthropod/metabolism ; Drosophila/cytology ; Drosophila/embryology ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Intracellular Signaling Peptides and Proteins ; Membrane Proteins/metabolism ; Protein Kinases/genetics ; Protein Kinases/metabolism ; beta Catenin/metabolism
    Chemical Substances Drosophila Proteins ; Intracellular Signaling Peptides and Proteins ; Membrane Proteins ; baz protein, Drosophila ; beta Catenin ; Protein Kinases (EC 2.7.-) ; mbt protein, Drosophila (EC 2.7.11.1)
    Language English
    Publishing date 2016-03-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2016.03.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Open data set of live cyanobacterial cells imaged using an X-ray laser.

    van der Schot, Gijs / Svenda, Martin / Maia, Filipe R N C / Hantke, Max F / DePonte, Daniel P / Seibert, M Marvin / Aquila, Andrew / Schulz, Joachim / Kirian, Richard A / Liang, Mengning / Stellato, Francesco / Bari, Sadia / Iwan, Bianca / Andreasson, Jakob / Timneanu, Nicusor / Bielecki, Johan / Westphal, Daniel / Nunes de Almeida, Francisca / Odić, Duško /
    Hasse, Dirk / Carlsson, Gunilla H / Larsson, Daniel S D / Barty, Anton / Martin, Andrew V / Schorb, Sebastian / Bostedt, Christoph / Bozek, John D / Carron, Sebastian / Ferguson, Ken / Rolles, Daniel / Rudenko, Artem / Epp, Sascha W / Foucar, Lutz / Rudek, Benedikt / Erk, Benjamin / Hartmann, Robert / Kimmel, Nils / Holl, Peter / Englert, Lars / Loh, N Duane / Chapman, Henry N / Andersson, Inger / Hajdu, Janos / Ekeberg, Tomas

    Scientific data

    2016  Volume 3, Page(s) 160058

    Abstract: Structural studies on living cells by conventional methods are limited to low resolution because radiation damage kills cells long before the necessary dose for high resolution can be delivered. X-ray free-electron lasers circumvent this problem by ... ...

    Abstract Structural studies on living cells by conventional methods are limited to low resolution because radiation damage kills cells long before the necessary dose for high resolution can be delivered. X-ray free-electron lasers circumvent this problem by outrunning key damage processes with an ultra-short and extremely bright coherent X-ray pulse. Diffraction-before-destruction experiments provide high-resolution data from cells that are alive when the femtosecond X-ray pulse traverses the sample. This paper presents two data sets from micron-sized cyanobacteria obtained at the Linac Coherent Light Source, containing a total of 199,000 diffraction patterns. Utilizing this type of diffraction data will require the development of new analysis methods and algorithms for studying structure and structural variability in large populations of cells and to create abstract models. Such studies will allow us to understand living cells and populations of cells in new ways. New X-ray lasers, like the European XFEL, will produce billions of pulses per day, and could open new areas in structural sciences.
    MeSH term(s) Cells ; Crystallography, X-Ray ; Cyanobacteria ; Electrons ; Lasers ; Models, Molecular ; Models, Theoretical ; Nanoparticles ; Proteins ; Pulse ; Time Factors ; X-Ray Diffraction ; X-Rays
    Chemical Substances Proteins
    Language English
    Publishing date 2016-08-01
    Publishing country England
    Document type Comment ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/sdata.2016.58
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