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  1. Article ; Online: Novel Biomarkers of Kidney Injury

    Sidar Çopur / Nuri Barış Hasbal / Mehmet Kanbay

    Turkish Journal of Nephrology, Vol 32, Iss 3, Pp 181-

    Possibility Toward Preventive Strategies

    2023  Volume 187

    Keywords Internal medicine ; RC31-1245 ; Pediatrics ; RJ1-570
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher AVES
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: COVID-19

    Sena Ulu / Ozkan Gungor / Ebru Gok Oguz / Nuri Baris Hasbal / Didem Turgut / Mustafa Arici

    Renal Failure, Vol 42, Iss 1, Pp 710-

    a novel menace for the practice of nephrology and how to manage it with minor devastation?

    2020  Volume 725

    Abstract: Coronavirus disease 19 (COVID-19) became a nightmare for the world since December 2019. Although the disease affects people at any age; elderly patients and those with comorbidities were more affected. Everyday nephrologists see patients with ... ...

    Abstract Coronavirus disease 19 (COVID-19) became a nightmare for the world since December 2019. Although the disease affects people at any age; elderly patients and those with comorbidities were more affected. Everyday nephrologists see patients with hypertension, chronic kidney disease, maintenance dialysis treatment or kidney transplant who are also high-risk groups for the COVID-19. Beyond that, COVID-19 or severe acute respiratory syndrome (SARS) due to infection may directly affect kidney functions. This broad spectrum of COVID-19 influence on kidney patients and kidney functions obviously necessitate an up to date management policy for nephrological care. This review overviews and purifies recently published literature in a question to answer format for the practicing nephrologists that will often encounter COVID-19 and kidney related cases during the pandemic times.
    Keywords covid-19 ; hypertension ; acute kidney injury ; hemodialysis ; renal transplantation ; glomerulonephritis ; Diseases of the genitourinary system. Urology ; RC870-923 ; covid19
    Subject code 610 ; 616
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Plasma Exchange in the Treatment of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

    Ebru Gök Oğuz / Saime Paydaş / Nuri Barış Hasbal / Didem Turgut / Hatice Şahin / Bülent Kaya / Zerrin Bicik Bahçebaşı / Serap Yadigar / Serdal Gök / Mehmet Deniz Aylı

    Turkish Journal of Nephrology, Vol 31, Iss 4, Pp 307-

    A Retrospective Analysis

    2022  Volume 313

    Keywords Internal medicine ; RC31-1245 ; Pediatrics ; RJ1-570
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher AVES
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Leukocytoclastic Vasculitis Associated with a New Anticoagulant

    Nuri Barış Hasbal / Taner Baştürk / Yener Koç / Tuncay Sahutoğlu / Feyza Bayrakdar Çağlayan / Abdulkadir Ünsal

    Turkish Journal of Hematology, Vol 34, Iss 1, Pp 116-

    Rivaroxaban

    2017  Volume 117

    Keywords Internal medicine ; RC31-1245 ; Diseases of the blood and blood-forming organs ; RC633-647.5
    Language English
    Publishing date 2017-03-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Frequency of depressive symptoms in Syrian refugees and Turkish maintenance hemodialysis patients during COVID-19 pandemic.

    Mustafa Sevinc / Nuri Baris Hasbal / Tamer Sakaci / Taner Basturk / Elbis Ahbap / Mustafa Ortaboz / Emrah Erkan Mazi / Efruz Pirdogan / Jonathan Ling / Abdulkadir Unsal

    PLoS ONE, Vol 16, Iss 1, p e

    2021  Volume 0244347

    Abstract: Introduction Pneumonia of unknown cause was detected on 30 December 2019 in China. It was categorized as an outbreak and named as COVID-19 by the World Health Organization. The pandemic affects all people, but patient groups such as hemodialysis (HD) ... ...

    Abstract Introduction Pneumonia of unknown cause was detected on 30 December 2019 in China. It was categorized as an outbreak and named as COVID-19 by the World Health Organization. The pandemic affects all people, but patient groups such as hemodialysis (HD) patients have been particularly affected. We do not know if refugees suffered more during the outbreak. In this study, we compared depressive symptom frequency between Syrian refugee HD patients and Turkish ones. Methods The study had a single-center, cross-sectional design. Demographic and clinical data were collected retrospectively from patients' files containing details about past medical history, demographic variables and laboratory values. Validated Turkish and Arabic forms of Beck Depression Inventory (BDI) were used to assess depressive symptoms. BDI scores were compared according to nationality, demographic features and clinical data. A BDI score more than 14 was accepted as suspicion of depression. Results 119 patients were enrolled in the study. After the exclusion of 22 patients, 75 Turkish and 22 Syrian patients were included for further analysis. The median BDI (interquartile range) score for Turkish and Syrian patients were 12 (7-23) and 19.5 (12.7-25.2), respectively (p = 0.03). Suspicion of depression was present at 42.7% of Turkish, and 72.7% of Syrian HD patients (p = 0.013). Regarding all patients, phosphorus level, Kt/V, and nationality were significantly different between patients with and without suspicion of depression (p = 0.023, 0.039, 0.013, respectively). Conclusion Syrian patients had higher BDI scores and more depressive symptoms than Turkish patients. Additional national measures for better integration and more mental support to Syrian HD patients are needed.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Unexpectedly High Prevalence of Low Alpha-Galactosidase A Enzyme Activity in Patients with Focal Segmental Glomerulosclerosis

    Nuri Baris Hasbal / Feyza Bayrakdar Caglayan / Tamer Sakaci / Elbis Ahbap / Yener Koc / Mustafa Sevinc / Zuhal Atan Ucar / Abdulkadir Unsal / Taner Basturk

    Clinics, Vol

    2020  Volume 75

    Abstract: OBJECTIVES: Fabry disease (FD) is a rare disease associated with sphingolipid accumulation. Sphingolipids are components of plasma membranes that are important in podocyte function and accumulate in various glomerular diseases such as focal segmental ... ...

    Abstract OBJECTIVES: Fabry disease (FD) is a rare disease associated with sphingolipid accumulation. Sphingolipids are components of plasma membranes that are important in podocyte function and accumulate in various glomerular diseases such as focal segmental glomerulosclerosis (FSGS). Both FD and FSGS can cause podocyte damage and are classified as podocytopathies. In this respect, FD and FSGS share the same pathophysiologic pathways. Previous screening studies have shown that a significant proportion of end-stage renal disease (ESRD) patients receiving hemodialysis (HD) have unsuspected FD, and the prevalence of low alpha-galactosidase A (αGLA) enzyme activity in these patients is higher than that in the normal population. We aimed to compare αGLA enzyme activity in patients with biopsy-proven FSGS and ESRD receiving HD. METHODS: The records of 232 patients [62 FSGS (F/M: 33/29); 170 HD (M/F: 93/79)] were evaluated retrospectively. The screening was performed based on the αGLA enzyme activity on a dried blood spot, with the confirmation of plasma LysoGb3 levels, and the known GLA mutations were tested in patients with low enzyme activities. The two groups were compared using these parameters. RESULTS: The mean level of αGLA enzyme activity was found to be lower in FSGS patients than in the HD group (2.88±1.2 μmol/L/h versus 3.79±1.9 μmol/L/h, p<0.001). There was no significant relationship between the two groups with regard to the plasma LysoGb3 levels (2.2±1.22 ng/ml versus 1.7±0.66 ng/ml, p: 0.4). In the analysis of GLA mutations, a D313Y mutation [C(937G>T) in exon p] was found in one patient from the FSGS group. CONCLUSIONS: We found that αGAL activity in patients with FSGS is lower than that in patients undergoing HD. The low enzyme activity in patients with FSGS may be explained by considering the similar pathogenesis of FSGS and FD, which may also lead to sphingolipid deposition and podocyte injury.
    Keywords Alpha-Galactosidase A ; Focal Segmental Glomerulosclerosis ; LysoGb3 ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Elsevier España
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Frequency of Polyneuropathy in Patients on Long Term Peritoneal Dialysis Treatment

    Taner Basturk / Yener Koc / Arzu Ozdemir Kayalar / Figen Yilmaz / Nuri Baris Hasbal / Tamer Sakaci / Elbis Ahbap / Abdulkadir Unsal

    Journal of Clinical and Diagnostic Research, Vol 11, Iss 6, Pp OC37-OC

    2017  Volume 40

    Abstract: Introduction: Uremic polyneuropathy is very common among patients with Chronic Kidney Disease (CKD). The patients have electrophysiologic signs of impaired nerve function, although a lower percentage of patients are symptomatic. Electrophysiological ... ...

    Abstract Introduction: Uremic polyneuropathy is very common among patients with Chronic Kidney Disease (CKD). The patients have electrophysiologic signs of impaired nerve function, although a lower percentage of patients are symptomatic. Electrophysiological parameters are quantitative indices of Polyneuropathy (PNP) severity. Aim: To assess the frequency of PNP in patients on long term Peritoneal Dialysis (PD) treatment. Materials and Methods: Twenty three PD patients were analysed, who were receiving dialysis for at least five years and the study population divided into two groups according to duration of PD treatment. Group 1 consisted of the patients who were dialysed for at least 10 years and Group 2 consisted of patients who were dialysed for five to nine years. Patients who switched from Haemodialysis (HD) to PD and patients with coexisting diseases that could lead to disturbances in nerve conduction were excluded from the study. PNP was diagnosed when slowing of Nerve Conduction Velocity (NCV) and/or lengthening of distal latencies and/or decrease in amplitude of muscle action potential were present in two or more nerves and longer F wave response was present in one or two nerves. Carpal Tunnel Syndrome (CTS) was diagnosed if slowing of NCV and/or decrease in amplitude of muscle action potential and/or lengthening of distal latency of either sensory or motor median nerve present. Results: PNP was observed in 17 of the patients {73.9%; Group 1 (n=10) and Group 2 (n=7)}. Mixed type sensory motor neuropathy was diagnosed in nine patients from Group 1 and five patients from Group 2; one patient from Group 1 had demyelinating PNP affecting motor and sensory nerves; one patient from Group 2 had axonal PNP affecting motor and sensory nerves. From Group 1, two patients had CTS related to PNP and one patient had CTS without PNP. The results of motor conductivity testing showed lower conduction velocity for left popliteal nerve in Group 1 and Group 2 patients (13.85±2.17 ms, 4.80±1.11 ms, p=0.01). In both groups, mean ...
    Keywords end-stage renal disease ; electrophysiological parameters ; renal replacement therapy ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2017-06-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Pentraxin-2 is Associated with Renal Fibrosis in Patients Undergoing Renal Biopsy

    Taner Basturk / David Ojalvo / Emrah Erkan Mazi / Nuri Baris Hasbal / Ayse Aysim Ozagari / Elbis Ahbap / Tamer Sakaci / Yener Koc / Mustafa Sevinc / Abdulkadir Unsal

    Clinics

    Abstract: OBJECTIVES: Progressive renal disease is characterized by histological changes in the kidney and fibrosis is a common outcome. Renal biopsy is the only diagnostic tool to evaluate these histopathological changes. Pentraxin-2 (PTX-2) is an anti- ... ...

    Abstract OBJECTIVES: Progressive renal disease is characterized by histological changes in the kidney and fibrosis is a common outcome. Renal biopsy is the only diagnostic tool to evaluate these histopathological changes. Pentraxin-2 (PTX-2) is an anti-inflammatory constitutive plasma protein associated with the innate immune system. Recently, as a biomarker, the circulating level of PTX-2 is shown to be decreased in chronic fibrotic diseases. In this study, we aimed to investigate the relationship between renal fibrosis severity and serum PTX-2 levels in patients undergoing renal biopsy. METHODS: This cross-sectional study included 45 patients and 16 healthy individuals (HIs). The severity of renal fibrosis was evaluated according to the Banff and Sethi scoring systems by the same pathologist. PTX-2 was measured by an enzyme-linked immunosorbent assay and compared with the demographical, clinical, biochemical, and histopathological data of the patients and HIs. RESULTS: PTX-2 levels were lower in the biopsy group than in the HI group (p=0.12). Patients with moderate renal fibrosis had significantly lower serum PTX-2 levels than those in patients with minimal and mild fibrosis (p=0.017 and p=0.010, respectively). PTX-2 concentrations were correlated with serum albumin (r=0.30, p=0.016), and were negatively correlated with serum creatinine levels (rho=-0.42, p=0.01) and body mass index (r=-0.32, p=0.011). CONCLUSIONS: The results indicated that PTX-2 levels are significantly lower in patients with renal fibrosis than HIs, and declining further in patients with severe fibrosis.
    Keywords Pentraxin ; Renal Fibrosis ; Chronic Kidney Disease ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publisher Faculdade de Medicina / USP
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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