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  1. Book: Checkliste Neonatologie

    Genzel-Boroviczény, Orsolya / Nußbaum, Claudia

    2022  

    Author's details herausgegeben von Orsolya Genzel-Boroviczény, Claudia Nußbaum ; unter Mitarbeit von Susanne Bechtold-Dalla Pozza [und weiteren]
    Keywords Perinatale Medizin ; Humanmedizin ; Pharmaka/Neonatologie ; Frühgeborene ; Frühgeburt ; Neugeborenen-Intensivmedizin ; perinataler Schwerpunkt ; Perinatalzentrum ; pädiatrische Intensivpflege ; Arzt in Weiterbildung ; Neonatologie ; Neugeborenenstation
    Language German
    Size 544 Seiten, Illustrationen, Diagramme, 18 cm x 11 cm
    Edition 7., überarbeitete Auflage
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Publishing country Germany
    Document type Book
    Note Zugang zu Online-Inhalten über Code
    Old title Vorangegangen ist
    HBZ-ID HT020991568
    ISBN 978-3-13-244225-2 ; 3-13-244225-9 ; 9783132442269 ; 9783132442276 ; 3132442267 ; 3132442275
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 A 113 available for loan (reading room) Lesesaal EG
    Zugang zu Online-Inhalten über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Article ; Online: Circulating glycocalyx biomarkers in the acute phase and long-term follow-up in patients with Kawasaki disease.

    Jakob, André / Nussbaum, Claudia / Pastor-Villaescusa, Belén

    Microvascular research

    2023  Volume 147, Page(s) 104507

    MeSH term(s) Humans ; Mucocutaneous Lymph Node Syndrome ; Follow-Up Studies ; Glycocalyx ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-02-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80307-8
    ISSN 1095-9319 ; 0026-2862
    ISSN (online) 1095-9319
    ISSN 0026-2862
    DOI 10.1016/j.mvr.2023.104507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 746: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: The Endothelial Glycocalyx: Physiology and Pathology in Neonates, Infants and Children.

    Puchwein-Schwepcke, Alexandra / Genzel-Boroviczény, Orsolya / Nussbaum, Claudia

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 733557

    Abstract: The endothelial glycocalyx (EG) as part of the endothelial surface layer (ESL) is an important regulator of vascular function and homeostasis, including permeability, vascular tone, leukocyte recruitment and coagulation. Located at the interface between ... ...

    Abstract The endothelial glycocalyx (EG) as part of the endothelial surface layer (ESL) is an important regulator of vascular function and homeostasis, including permeability, vascular tone, leukocyte recruitment and coagulation. Located at the interface between the endothelium and the blood stream, this highly fragile structure is prone to many disruptive factors such as inflammation and oxidative stress. Shedding of the EG has been described in various acute and chronic diseases characterized by endothelial dysfunction and angiopathy, such as sepsis, trauma, diabetes and cardiovascular disease. Circulating EG components including syndecan-1, hyaluronan and heparan sulfate are being evaluated in animal and clinical studies as diagnostic and prognostic markers in several pathologies, and advances in microscopic techniques have enabled
    Language English
    Publishing date 2021-09-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.733557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Case Report: Stüve-Wiedemann syndrome-a rare cause of persistent pulmonary hypertension of the newborn.

    Jin, Jessica / Rothämel, Paula / Büchel, Johanna / Kammer, Birgit / Brunet, Theresa / Pattathu, Joseph / Flemmer, Andreas W / Nussbaum, Claudia / Schroepf, Sebastian

    Frontiers in pediatrics

    2024  Volume 11, Page(s) 1329404

    Abstract: Introduction: Persistent pulmonary hypertension of the newborn (PPHN) is a life-threatening condition characterized by hypoxemia due to elevated pulmonary vascular resistance. PPHN commonly arises secondary to various underlying conditions, including ... ...

    Abstract Introduction: Persistent pulmonary hypertension of the newborn (PPHN) is a life-threatening condition characterized by hypoxemia due to elevated pulmonary vascular resistance. PPHN commonly arises secondary to various underlying conditions, including infection, meconium aspiration, and respiratory distress syndrome. Management includes pulmonary vasodilators, mechanical ventilation, oxygen supplementation, vasopressors, and volume replacement. Stüve-Wiedemann syndrome (SWS), a rare genetic disorder characterized by bone dysplasia, respiratory distress, hyperthermia, and swallowing difficulties, may present with pulmonary hypertension, indicating a poor prognosis.
    Case description: A term female neonate presented with secondary respiratory failure and severe PPHN of unknown etiology on the second day of life, necessitating intubation. Clinical findings included facial dysmorphia, camptodactyly, skeletal anomalies, and generalized muscular hypotonia. High-frequency oscillation ventilation and surfactant administration yielded marginal improvement. On the third day of life, a severe pulmonary hypertensive crisis necessitated inhaled and systemic pulmonary vasodilators along with volume and catecholamine therapy. Whole exome sequencing revealed a homozygous mutation in the leukemia inhibitory factor receptor (
    Discussion/conclusion: The case underscores the importance of considering and prompting evaluation of rare genetic causes in the differential diagnosis of PPHN, especially when other abnormalities are present and conventional therapies prove inadequate. Therapeutic strategies must account for the different pathophysiology of primary PPHN including vascular remodeling, as seen in SWS, which may not respond to pulmonary vasodilators typically employed in secondary PPHN due to vasoconstriction. In this case, the patient responded well to treatment for primary PPHN, but the use of high-frequency oscillation ventilation and surfactant was not helpful.
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1329404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Long-Term Microvascular Changes in Multisystem Inflammatory Syndrome in Children.

    Boever, Julie / Nussbaum, Claudia / Arnold, Leonie / Haas, Nikolaus A / Dold, Simone K / Oberhoffer, Felix S / Jakob, André

    JAMA pediatrics

    2024  Volume 178, Issue 3, Page(s) 304–306

    MeSH term(s) Child ; Humans ; COVID-19/complications ; Systemic Inflammatory Response Syndrome ; Microcirculation
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2023.6022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.74: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Switching a baby from IV levomethadone to IV fentanyl.

    Bender, Hans Ulrich / Muench, Hans-Georg / Nussbaum, Claudia Franziska

    Journal of opioid management

    2021  Volume 17, Issue 2, Page(s) 181–183

    Abstract: Methadone, or in Germany levomethadone, may be used for the treatment of iatrogenic opioid withdrawal syndrome in pediatric intensive care units. The limited literature on opioid rotation in children does not provide data for the switch from methadone to ...

    Abstract Methadone, or in Germany levomethadone, may be used for the treatment of iatrogenic opioid withdrawal syndrome in pediatric intensive care units. The limited literature on opioid rotation in children does not provide data for the switch from methadone to another opioid. We report switching a very ill preterm baby in an unstable condition from IV levomethadone to IV fentanyl identifying a possible conversion ratio of 6.0-4.5:1 emphasizing critical steps as equipotency appropriate for neonates and dose reduction for incomplete cross-tolerance. If clinical deterioration occurs in infants on opioid tapering with levomethadone, we hope that our observations may be helpful.
    MeSH term(s) Analgesics, Opioid/adverse effects ; Child ; Fentanyl/adverse effects ; Germany ; Humans ; Infant ; Infant, Newborn ; Methadone ; Narcotics
    Chemical Substances Analgesics, Opioid ; Narcotics ; Methadone (UC6VBE7V1Z) ; Fentanyl (UF599785JZ)
    Language English
    Publishing date 2021-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397614-7
    ISSN 1551-7489
    ISSN 1551-7489
    DOI 10.5055/jom.2021.0627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Association between inflammation, glycocalyx biomarkers, and endothelial function in children with hypercholesterolemia.

    Pastor-Villaescusa, Belén / Meier, Julia / Ruske, Fabienne / Prell, Christine / Gruezner, Juliane / Koenig, Miriam / Jakob, André / Koletzko, Berthold / Nussbaum, Claudia

    Annals of nutrition & metabolism

    2024  

    Abstract: Introduction: Hypercholesterolemia is a risk factor for premature arteriosclerosis. Inflammation and oxidative stress are thought to contribute to endothelial dysfunction preceding vasculopathy. We investigated the association between inflammation, ... ...

    Abstract Introduction: Hypercholesterolemia is a risk factor for premature arteriosclerosis. Inflammation and oxidative stress are thought to contribute to endothelial dysfunction preceding vasculopathy. We investigated the association between inflammation, glycocalyx biomarkers, endothelial function and vascular parameters in children with hypercholesterolemia.
    Methods: In 22 patients (LDL-cholesterol > 130 mg/dl; median age [IQR]: 13 [2.3] years) and 22 controls (13 [2.5] years) tumor necrosis factor-alpha (TNF-α), oxidized cholesterol (oxLDL), and glycocalyx biomarkers (Syndecan-1, Hyaluronan) were measured using immunoassays. Endothelial function was assessed by peripheral arterial tonometry, sublingual glycocalyx and microcirculation by videomicroscopy and carotid intima media thickness by ultrasound.
    Results: OxLDL was significantly higher in patients (78.9 [38.2] vs. 50.3 [16.6] U/l, p=0.002), whereas all other experimental parameters were comparable between groups. Multivariate analysis revealed a significant association of Syndecan-1 with TNF-α (β=0.75, p<0.001) and with hypercholesterolemia (β=0.31, p=0.030). The interaction term combining TNF-α and hypercholesterolemia showed a significant effect (p=0.034). Sex was an independent predictor of endothelial function.
    Conclusion: The combined effect of hypercholesterolemia and inflammation on glycocalyx perturbation and the impact of sex in the premature development of arteriosclerosis deserve further evaluation. Therapeutic approaches tackling low grade systemic inflammation-may offer potential to prevent or delay progression of CVD and cardiovascular complications.  .
    Language English
    Publishing date 2024-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 392341-1
    ISSN 1421-9697 ; 0250-6807 ; 1018-9688
    ISSN (online) 1421-9697
    ISSN 0250-6807 ; 1018-9688
    DOI 10.1159/000536042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Online ; Thesis: Neue Aspekte der Mikrozirkulation im Rahmen von Entzündung, Entwicklung und Erkrankung

    Nußbaum, Claudia [Verfasser]

    2017  

    Author's details Claudia Nußbaum
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Book ; Online ; Thesis: Veränderungen der sublingualen Mikrozirkulation und der mikrovaskulären endothelialen Glykokalyx bei Kindern im peri- und postoperativen Setting

    Wagner, Marie Christin [Verfasser] / Nußbaum, Claudia [Akademischer Betreuer]

    2022  

    Author's details Marie Christin Wagner ; Betreuer: Claudia Nußbaum
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Book ; Online ; Thesis: Nicht-invasive Beatmung bei Frühgeborenen

    Lengauer, Maximilian [Verfasser] / Nussbaum, Claudia [Akademischer Betreuer]

    Evaluation einer Score-basierten Weaningstrategie

    2022  

    Author's details Maximilian Lengauer ; Betreuer: Claudia Nussbaum
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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