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  1. Article ; Online: Carbapenem-resistant

    Marais, Gert / Moodley, Clinton / Claassen-Weitz, Shantelle / Patel, Fadheela / Prentice, Elizabeth / Tootla, Hafsah / Nyakutira, Nyasha / Lennard, Katie / Reddy, Kessendri / Bamford, Colleen / Niehaus, Abraham / Whitelaw, Andrew / Brink, Adrian

    JAC-antimicrobial resistance

    2024  Volume 6, Issue 2, Page(s) dlae050

    Abstract: Background: The molecular epidemiology of carbapenem-resistant Enterobacterales in Cape Town remains largely unknown.: Objectives: This study aimed to describe the molecular epidemiology, resistome, virulome and mobilome of carbapenem-resistant : ... ...

    Abstract Background: The molecular epidemiology of carbapenem-resistant Enterobacterales in Cape Town remains largely unknown.
    Objectives: This study aimed to describe the molecular epidemiology, resistome, virulome and mobilome of carbapenem-resistant
    Methods: Eighty-five CRKP isolates from hospitalized patients underwent WGS as part of a prospective, multicentre, cross-sectional study, conducted between 1 November 2020 and 30 November 2022, across public-sector and private-sector hospitals in Cape Town, South Africa.
    Results: MLST revealed three novel types, ST6785, ST6786 and ST6787, while the most common were ST219, ST307, ST17, ST13 and ST2497. Different predominant clones were noted in each hospital. The most common carbapenemase gene was
    Conclusions: CRKP epidemiology in Cape Town reflects institutionally dominant, rather than regional, clones. The most prevalent carbapenemase gene was
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2632-1823
    ISSN (online) 2632-1823
    DOI 10.1093/jacamr/dlae050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Carbapenem-resistant Enterobacterales among hospitalized patients in Cape Town, South Africa: clinical and microbiological epidemiology.

    Tootla, Hafsah Deepa / Prentice, Elizabeth / Moodley, Clinton / Marais, Gert / Nyakutira, Nyasha / Reddy, Kessendri / Bamford, Colleen / Niehaus, Abraham / Whitelaw, Andrew / Brink, Adrian

    JAC-antimicrobial resistance

    2024  Volume 6, Issue 2, Page(s) dlae051

    Abstract: Background: Carbapenem-resistant Enterobacterales (CRE) are a substantial problem in Cape Town. CRE epidemiology is largely unknown and mortality remains high.: Objectives: To describe and characterize the clinical and microbiological epidemiology of ...

    Abstract Background: Carbapenem-resistant Enterobacterales (CRE) are a substantial problem in Cape Town. CRE epidemiology is largely unknown and mortality remains high.
    Objectives: To describe and characterize the clinical and microbiological epidemiology of CRE within Cape Town hospitals to better inform therapy with regard to current and novel antibiotics, as well as improve antimicrobial stewardship (AMS), and infection prevention and control (IPC).
    Methods: This prospective, multicentre study performed between 1 November 2020 and 30 November 2022, across three public and three private hospitals included hospitalized participants with CRE from clinical cultures. Participant demographics, clinical information and microbiology results were collected and analysed.
    Results: Ninety percent of participants were from public hospitals. The age distribution ranged from 7 days to 88 years. Notable risk factors for CRE infection included recent exposure to antibiotics, medical devices and surgery. The most prevalent species was
    Conclusions: This study identified common risk factors for CRE infection and generated a description of carbapenemase enzymes, species distribution and antibiograms, enabling a better understanding of CRE epidemiology. This provides insights into transmission patterns and resistance determinants of CREs, beneficial to informing data-driven regional patient management, AMS and IPC strategies.
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ISSN 2632-1823
    ISSN (online) 2632-1823
    DOI 10.1093/jacamr/dlae051
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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