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  1. Book ; Online: Bits and Pieces

    O'Brien, Sarah

    Screening Animal Life and Death

    2023  

    Keywords Theatre studies ; Film, TV & radio ; Television ; Animals & nature in art (still life, landscapes & seascapes, etc) ; slaughter, taxidermy, cinema, film, television, media, animals, race, species, process, assembly, disassembly, food, meat, domestic, home, houses, decor, interior design, diorama, specimen, Atlanta
    Language English
    Size 1 electronic resource (211 pages)
    Publisher University of Michigan Press
    Document type Book ; Online
    Note English
    HBZ-ID HT030376306
    ISBN 9780472056255 ; 0472056255
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Embedding the service user voice to co-produce UK mental health nurse education-A lived experience narrative.

    O'Brien, Sam / Davenport, Caroline

    Journal of psychiatric and mental health nursing

    2024  

    Abstract: WHAT IS KNOWN ON THE SUBJECT?: Co-production aims to value service user voices and is increasingly used in healthcare. Less is known about how co-production in nursing education is experienced by service users. WHAT THE PAPER ADDS TO EXISTING KNOWLEDGE?: ...

    Abstract WHAT IS KNOWN ON THE SUBJECT?: Co-production aims to value service user voices and is increasingly used in healthcare. Less is known about how co-production in nursing education is experienced by service users. WHAT THE PAPER ADDS TO EXISTING KNOWLEDGE?: This paper shares the experience of one service user who teaches student nurses in a UK university. For the first author, the paper highlights that co-producing nurse education has been valuable and rewarding for both a service user and students. WHAT ARE THE IMPLICATIONS FOR PRACTICE?: Co-production has the potential to benefit student nurses, including challenging their perceptions of 'difficult' patients. To achieve this, teaching sessions must be equally produced and delivered. By employing and including service users, universities have the potential to improve experiences for students and service users alike. ABSTRACT: Introduction Co-production is increasingly used in health care but there is less attention to a co-produced mental health nurse education. Aim This article sought to explore the co-production experiences of a service user who teaches mental health nurses, alongside the benefits of this to nurse education. Methods The article is a lived experience narrative co-written with a nursing lecturer. Thesis Co-produced mental health nurse education challenges students' perceptions towards self-harm and encourages empathy and understanding of service user distress. Implications for Practice Co-production has many benefits to nurse education including a positive student experience, and validation of the service user experience to support meaningful recovery.
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328479-4
    ISSN 1365-2850 ; 1351-0126
    ISSN (online) 1365-2850
    ISSN 1351-0126
    DOI 10.1111/jpm.13031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4466: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Acquiring a new diagnostic approach for aVWS.

    O'Brien, Sarah

    Blood

    2023  Volume 141, Issue 1, Page(s) 7–9

    MeSH term(s) Humans ; Infant ; von Willebrand Diseases ; von Willebrand Factor ; Heart Defects, Congenital
    Chemical Substances von Willebrand Factor
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022018184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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    Zs.MO 364: Show issues

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  4. Article: Highlights from the 2023 American Society of Clinical Oncology Annual Meeting: leukemia and lymphoma.

    O'Brien, Susan

    Clinical advances in hematology & oncology : H&O

    2023  Volume 21, Issue 7, Page(s) 359–361

    MeSH term(s) Humans ; Leukemia/diagnosis ; Leukemia/therapy ; Lymphoma/diagnosis ; Lymphoma/drug therapy ; Medical Oncology
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Congress
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6505: Show issues Location:
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  5. Article ; Online: Ecological dependencies and the illusion of cooperation in microbial communities.

    Hesse, Elze / O'Brien, Siobhán

    Microbiology (Reading, England)

    2024  Volume 170, Issue 2

    Abstract: Ecological dependencies - where organisms rely on other organisms for survival - are a ubiquitous feature of life on earth. Multicellular hosts rely on symbionts to provide essential vitamins and amino acids. Legume plants similarly rely on nitrogen- ... ...

    Abstract Ecological dependencies - where organisms rely on other organisms for survival - are a ubiquitous feature of life on earth. Multicellular hosts rely on symbionts to provide essential vitamins and amino acids. Legume plants similarly rely on nitrogen-fixing rhizobia to convert atmospheric nitrogen to ammonia. In some cases, dependencies can arise via loss-of-function mutations that allow one partner to benefit from the actions of another. It is common in microbiology to label ecological dependencies between species as cooperation - making it necessary to invoke cooperation-specific frameworks to explain the phenomenon. However, in many cases, such traits are not (at least initially) cooperative, because they are not selected for because of the benefits they confer on a partner species. In contrast, dependencies in microbial communities may originate from fitness benefits gained from genomic-streamlining (i.e. Black Queen Dynamics). Here, we outline how the Black Queen Hypothesis predicts the formation of metabolic dependencies via loss-of-function mutations in microbial communities, without needing to invoke any cooperation-specific explanations. Furthermore we outline how the Black Queen Hypothesis can act as a blueprint for true cooperation as well as discuss key outstanding questions in the field. The nature of interactions in microbial communities can predict the ability of natural communities to withstand and recover from disturbances. Hence, it is vital to gain a deeper understanding of the factors driving these dynamic interactions over evolutionary time.
    MeSH term(s) Humans ; Illusions ; Microbiota ; Amino Acids ; Biological Evolution ; Nitrogen
    Chemical Substances Amino Acids ; Nitrogen (N762921K75)
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180712-x
    ISSN 1465-2080 ; 1350-0872
    ISSN (online) 1465-2080
    ISSN 1350-0872
    DOI 10.1099/mic.0.001442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.140: Show issues Location:
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  6. Article: An update on acalabrutinib to treat chronic lymphocytic leukemia.

    Blackmon, A / O'Brien, S

    Drugs of today (Barcelona, Spain : 1998)

    2021  Volume 57, Issue 7, Page(s) 417–431

    Abstract: Acalabrutinib was approved by the U.S. Food and Drug Administration (FDA) for treatment-naive (TN) and relapsed/refractory (R/R) use for patients with chronic lymphocytic leukemia (CLL) in November 2019 following the phase III ASCEND and ELEVATE-TN ... ...

    Abstract Acalabrutinib was approved by the U.S. Food and Drug Administration (FDA) for treatment-naive (TN) and relapsed/refractory (R/R) use for patients with chronic lymphocytic leukemia (CLL) in November 2019 following the phase III ASCEND and ELEVATE-TN registration trials. Acalabrutinib is a second-generation Bruton tyrosine kinase inhibitor (BTKi) that was developed after ibrutinib, the first-in-class BTKi. Ibrutinib is usually well tolerated and provides durable remissions; however, some patients experience toxicities from the off-target effects that lead to treatment discontinuation. A recent press release of the phase III ELEVATE-RR trial comparing acalabrutinib to ibrutinib in relapsed high-risk CLL reported noninferior progression-free survival and statistically significantly lower rates of atrial fibrillation; however, publication of this data is pending. There is currently 53 months of follow-up for patients receiving acalabrutinib compared with 8 years for those on ibrutinib. Acalabrutinib is approved as monotherapy in the R/R or TN setting, and in the TN setting can be combined with the anti-CD20 monoclonal antibody obinutuzumab. The data for acalabrutinib development and clinical use are discussed in this review.
    MeSH term(s) Benzamides ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Protein Kinase Inhibitors/adverse effects ; Pyrazines/adverse effects ; Pyrimidines/adverse effects
    Chemical Substances Benzamides ; Protein Kinase Inhibitors ; Pyrazines ; Pyrimidines ; acalabrutinib (I42748ELQW)
    Language English
    Publishing date 2021-07-12
    Publishing country Spain
    Document type Journal Article ; Review
    ISSN 1699-3993
    ISSN 1699-3993
    DOI 10.1358/dot.2021.57.7.3285932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Low-grade appendiceal mucinous neoplasm.

    Ibrahim, A / Shabo, W / O'Brien, S / Hanson, J / Anwar, M

    Irish medical journal

    2024  Volume 117, Issue 1, Page(s) 903

    MeSH term(s) Humans ; Neoplasms ; Neoplasms, Cystic, Mucinous, and Serous
    Language English
    Publishing date 2024-01-18
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 193134-9
    ISSN 0332-3102 ; 0021-129X
    ISSN 0332-3102 ; 0021-129X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 148: Show issues Location:
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  8. Article: 3D Visualisation of the Spine.

    O'Brien, Scarlett / Darwish, Nagy

    Advances in experimental medicine and biology

    2023  Volume 1406, Page(s) 139–168

    Abstract: The 3D visualisation of the spine is thought of from multiple viewpoints. Firstly, radiological imaging is considered, with plain radiography, CT and MRI imaging discussed in detail with relevant applications to spinal surgery.3D printing can be used in ... ...

    Abstract The 3D visualisation of the spine is thought of from multiple viewpoints. Firstly, radiological imaging is considered, with plain radiography, CT and MRI imaging discussed in detail with relevant applications to spinal surgery.3D printing can be used in spinal surgery with multiple applications including education, pre-operative planning for complex cases and making patient-specific guides and implants. The rapidly growing field of intraoperative navigation and robotics have been discussed, in addition to their benefits and limitations within spinal surgery, as well as some technical tips.An understanding of relevant anatomy and biomechanics is necessary for any surgeon, and so this chapter describes the key concepts to be familiar with, particularly the spinal motion segment and the different methods for classifying spinal injuries and how that relates to stability. The concepts discussed have been brought together by applying this knowledge to some interesting clinical cases. They highlight the importance of 3D visualisation of the spine, which must be considered throughout the decision-making process when managing patients. Spinal surgeons use multiple imaging modalities, knowledge of anatomy and biomechanics, as well as considering the need for navigation in more complex cases, all on a daily basis. With the advancement of technology available for 3D visualisation of the spine, we will be able to improve patient outcomes even further in the future.
    MeSH term(s) Humans ; Spine/diagnostic imaging ; Spine/surgery ; Prostheses and Implants ; Forecasting ; Robotics ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-031-26462-7_7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: In Our Own Words: The Complex Sensory Experiences of Autistic Adults.

    MacLennan, K / O'Brien, S / Tavassoli, T

    Journal of autism and developmental disorders

    2021  Volume 52, Issue 7, Page(s) 3061–3075

    Abstract: Autistic adults commonly experience sensory reactivity differences. Sensory hyperreactivity is frequently researched, whilst hyporeactivity and seeking, and experiences across domains, e.g., vision, are often neglected. Therefore, we aimed to understand ... ...

    Abstract Autistic adults commonly experience sensory reactivity differences. Sensory hyperreactivity is frequently researched, whilst hyporeactivity and seeking, and experiences across domains, e.g., vision, are often neglected. Therefore, we aimed to understand more about the sensory experiences of autistic adults. We conducted a mixed-methods study, co-produced with stakeholders; recruiting 49 autistic adults who completed an online survey. Firstly, quantitative results and content analysis enhanced our understanding of sensory input/contexts associated with sensory hyperreactivity, hyporeactivity, and seeking across modalities. Secondly, thematic analysis developed themes relating to 'Outcomes', 'Control', 'Tolerance and management', and 'The role of other people', informing a theoretical model of sensory reactivity differences in autistic adults. These findings have implications for support services and improving quality of life for autistic adults.
    MeSH term(s) Adult ; Autism Spectrum Disorder/complications ; Autistic Disorder/complications ; Humans ; Quality of Life ; Surveys and Questionnaires
    Language English
    Publishing date 2021-07-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391999-7
    ISSN 1573-3432 ; 0162-3257
    ISSN (online) 1573-3432
    ISSN 0162-3257
    DOI 10.1007/s10803-021-05186-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 765: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: Assisted human reproduction legislation: Listening to the voice of patients.

    O'Brien, S / Schaler, L / Giblin, A / Glover, L E / Wingfield, M

    European journal of obstetrics, gynecology, and reproductive biology

    2023  Volume 284, Page(s) 169–174

    Abstract: Objective: Legislation and policies regarding assisted human reproduction (AHR) vary widely across nations and societies. As one of only 5 European countries which currently lacks legislation, Ireland now has a unique opportunity to learn from other ... ...

    Abstract Objective: Legislation and policies regarding assisted human reproduction (AHR) vary widely across nations and societies. As one of only 5 European countries which currently lacks legislation, Ireland now has a unique opportunity to learn from other jurisdictions and introduce AHR law that is reflective of the ongoing myriad developments in this complex field. Draft legislation, initially published in 2017, was revised in 2022 with strong political commitment to enacting in the same year. This study sought to ascertain the views of fertility patients (service users) to the proposed AHR legislation in its current format, prior to its implementation.
    Study design: A survey questionnaire, previously designed to investigate the attitudes and perceptions of healthcare professionals (HCPs) towards a broad range of issues contained within the draft AHR Bill, was adapted for a patient/service user population. The survey link was distributed via secure email to all patients that had a doctor consult at our fertility clinic in 2020-2021.
    Results: The survey link was sent to 4420 patients/service users, of whom 1044 (23.6%) responded. A majority had experienced AHR treatment. Service users indicated strong support for AHR regulation and for access to all AHR techniques for all patients, irrespective of relationship or gender status. A majority of respondents disagreed with aspects of the draft bill regarding mandatory counselling, the timing of assignment of parentage in surrogacy, the exclusion of international surrogacy and the exclusion of men from posthumous AHR. Interestingly, the fertility patient cohort were more liberal in their views and opinions regarding AHR than the Irish HCPs previously surveyed.
    Conclusion: This study demonstrates the views of a large group of AHR patients/service users towards proposed AHR legislation. Many of their views concur with but others differ from those of the drafters of the legislation and from those of healthcare professionals. Consideration of the views of all these groups and a collaborative approach would help ensure that Ireland has AHR legislation that is inclusive and fit for purpose in the 21st century.
    MeSH term(s) Male ; Humans ; Reproductive Techniques, Assisted ; Attitude ; Europe ; Ireland ; Reproduction
    Language English
    Publishing date 2023-03-21
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2023.03.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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