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Article ; Online: Atezolizumab in patients with advanced non-small-cell lung cancer who are platinum-doublet ineligible.

O'Sullivan, Hazel / Popat, Sanjay

2023 Volume 402, Issue 10400, Page(s) 426–427

MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/drug therapy ; Platinum/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols
Chemical Substances	atezolizumab (52CMI0WC3Y) ; Platinum (49DFR088MY) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-07-06
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(23)00807-3
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Ua VI Zs.5: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 94: Show issues

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Article ; Online: Updates in Management of Malignant Pleural Mesothelioma.

John, Alexius / O'Sullivan, Hazel / Popat, Sanjay

Current treatment options in oncology

2023 Volume 24, Issue 12, Page(s) 1758–1789

Abstract: Opinion statement: Malignant pleural mesothelioma (MPM) is an aggressive asbestos-associated thoracic malignancy that is usually incurable. As demonstrated in the landmark MARS2 trial, surgical resection does not improve survival outcomes and its role ... ...

Abstract	Opinion statement: Malignant pleural mesothelioma (MPM) is an aggressive asbestos-associated thoracic malignancy that is usually incurable. As demonstrated in the landmark MARS2 trial, surgical resection does not improve survival outcomes and its role in managing MPM is limited. Whilst platinum-pemetrexed chemotherapy in combination with bevacizumab was the standard first-line approach for unresectable disease, landmark phase 3 trials have now established the role of immune checkpoint inhibitors (CPIs) in the upfront management of unresectable disease: either nivolumab-ipilimumab or carboplatin-pemetrexed-pembrolizumab. Patient selection for optimal strategy remains an ongoing question. For relapsed disease novel genomic-based therapies targeting a range of aberrations including losses of the tumour suppressor genes BAP1, CDKN2A and NF2, are being evaluated. Nonetheless, the future of MPM therapeutics holds promise. Here we overview current treatment strategies in the management of MPM.
MeSH term(s)	Humans ; Mesothelioma, Malignant ; Mesothelioma/diagnosis ; Mesothelioma/etiology ; Mesothelioma/therapy ; Pemetrexed/therapeutic use ; Lung Neoplasms/pathology ; Pleural Neoplasms/diagnosis ; Pleural Neoplasms/etiology ; Pleural Neoplasms/therapy ; Antineoplastic Combined Chemotherapy Protocols/adverse effects
Chemical Substances	Pemetrexed (04Q9AIZ7NO)
Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057351-0
ISSN	1534-6277 ; 1527-2729
ISSN (online)	1534-6277
ISSN	1527-2729
DOI	10.1007/s11864-023-01148-2
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Zs.A 5523: Show issues

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Article ; Online: "The third wing of the plane": Fathers' perceptions of their role in the treatment process for daughters with eating disorders.

O'Sullivan, Hazel / Goodwin, John / O'Malley, Maria / Happell, Brenda / O'Donovan, Aine

International journal of mental health nursing

2024

Abstract: Eating disorders are complex mental health conditions exacerbated by high mortality rates. International and national guidelines recommend family involvement in the treatment process, recognising the family as an important source of support to young ... ...

Abstract	Eating disorders are complex mental health conditions exacerbated by high mortality rates. International and national guidelines recommend family involvement in the treatment process, recognising the family as an important source of support to young people. Research suggests fathers engage less in the process compared to mothers. In studies exploring parental perspectives, most samples consisted of mothers, with fathers minimally represented. Few studies explore family involvement from the perspective of fathers. This study aimed to explore the experiences of fathers regarding their involvement in the treatment process. Qualitative descriptive methods were used, involving focus group interviews of seven fathers. Interviews were assisted by a semi-structured interview guide. A qualitative content analysis approach was used to analyse the data regarding paternal experiences of engagement in the treatment process. Fathers understood the importance of the whole family working together but viewed mothers as taking a more central role in the treatment process, with fathers more at the periphery. Gender emerged as an influencing factor in paternal involvement, with mothers primarily taking on responsibility for the child with the eating disorder and fathers providing secondary support. Healthcare providers need to be aware of the contribution of gendered roles within the family system and consider this when working with families within the treatment process. Consequently, mental health nurses have an important role in encouraging fathers to become actively involved in the treatment process.
Language	English
Publishing date	2024-01-31
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2076760-2
ISSN	1447-0349 ; 1445-8330
ISSN (online)	1447-0349
ISSN	1445-8330
DOI	10.1111/inm.13278
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Zs.A 5240: Show issues

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Article ; Online: Emergency caesareans are associated with an increased risk of recurrent early preterm birth: a commentary.

Glazewska-Hallin, Agnieszka / Rosen O'Sullivan, Hannah / Shennan, Andrew

BJOG : an international journal of obstetrics and gynaecology

2022 Volume 131, Issue 1, Page(s) 1–4

MeSH term(s)	Infant, Newborn ; Pregnancy ; Female ; Humans ; Premature Birth/epidemiology ; Premature Birth/etiology ; Cesarean Section/adverse effects
Language	English
Publishing date	2022-09-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2000931-8
ISSN	1471-0528 ; 0306-5456 ; 1470-0328
ISSN (online)	1471-0528
ISSN	0306-5456 ; 1470-0328
DOI	10.1111/1471-0528.17271
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Article ; Online: The role of transabdominal cerclage in preventing recurrent preterm delivery in women with a history of term full dilatation cesarean section followed by a spontaneous preterm birth or late miscarriage and a subsequent pregnancy with cerclage: a retrospective cohort study.

Rosen O'Sullivan, Hannah / Glazewska-Hallin, Agnieszka / Suff, Natalie / Seed, Paul / Shennan, Andrew

American journal of obstetrics & gynecology MFM

2023 Volume 5, Issue 11, Page(s) 101144

MeSH term(s)	Pregnancy ; Female ; Infant, Newborn ; Humans ; Premature Birth/epidemiology ; Premature Birth/etiology ; Premature Birth/prevention & control ; Abortion, Spontaneous ; Cesarean Section/adverse effects ; Retrospective Studies ; Dilatation
Language	English
Publishing date	2023-08-27
Publishing country	United States
Document type	Letter
ISSN	2589-9333
ISSN (online)	2589-9333
DOI	10.1016/j.ajogmf.2023.101144
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Article ; Online: Comparing the outcomes of parasacral transcutaneous electrical nerve stimulation for the treatment of lower urinary tract dysfunction in children: A systematic review and meta-analysis of randomized controlled trials.

O'Sullivan, Hugh / Kelly, Gabrielle / Toale, James / Cascio, Salvatore

Neurourology and urodynamics

2021 Volume 40, Issue 2, Page(s) 570–581

Abstract: Aims: Despite published evidence in recent decades suggesting improvement in lower urinary tract symptoms (LUTS) with the use of parasacral transcutaneous electrical nerve stimulation (PTENS), no consensus guidelines for therapy exist. This study ... ...

Abstract	Aims: Despite published evidence in recent decades suggesting improvement in lower urinary tract symptoms (LUTS) with the use of parasacral transcutaneous electrical nerve stimulation (PTENS), no consensus guidelines for therapy exist. This study systematically reviews the literature to assess the effect of PTENS in children with LUTS. Methods: A database search conducted up to December 2019 included Medline, EMBASE, and the Cochrane Library. From the literature review, 6 randomized controlled studies (234 participants) comparing PTENS and standard treatment (urotherapy/anticholinergics) were considered. From each study, the success rates were available for PTENS and the control group. The ratio of success rates was computed-that is, the risk ratio (RR) and the risk difference (RD). Results: The overall success rate with PTENS was 1.92 times that of children undergoing standard urotherapy alone (RR: 1.92, 95% confidence interval [CI: 1.02, 3.61]) and 1.56 for those undergoing either urotherapy alone or with pharmacotherapy (anticholinergics; RR: 1.56, 95% CI [1.04, 2.40]). No difference in the success rate was found when PTENS was used in patients failing previous treatment (urotherapy and pharmacological therapy; RR: 0.175, 95% CI [0.02, 1.45]). Conclusions: Current evidence suggests that PTENS is beneficial in children with LUTS. The chance of success is 1.92 times that of children undergoing standard urotherapy. However, in children who have failed urotherapy and pharmacological therapy, PTENS monotherapy has a limited role and should be an adjunct. Literature shortcomings included small numbers of patients, differing inclusion criteria, and PTENS protocols. A need exists for quality multicenter randomized controlled trials to prove the efficacy of PTENS in children with LUTS.
MeSH term(s)	Child ; Female ; Humans ; Lower Urinary Tract Symptoms/drug therapy ; Male ; Randomized Controlled Trials as Topic ; Transcutaneous Electric Nerve Stimulation/methods ; Treatment Outcome
Language	English
Publishing date	2021-01-07
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	604904-7
ISSN	1520-6777 ; 0733-2467
ISSN (online)	1520-6777
ISSN	0733-2467
DOI	10.1002/nau.24601
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Zs.A 1828: Show issues

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Article ; Online: Response to letter entitled: Re: 'Inadequacy of PCR genotyping in advanced non-small cell lung cancer: EGFR L747_A755delinsSS exon 19 deletion is not detected by the real-time PCR Idylla<sup>TM</sup> EGFR mutation test but is detected by ctDNA NGS and responds to osimertinib': Not looking back.

O'Sullivan, Hazel / d'Arienzo, Paolo D / Yousaf, Nadia / Cui, Wanyuan / Popat, Sanjay

European journal of cancer (Oxford, England : 1990)

2022 Volume 174, Page(s) 318–320

MeSH term(s)	Acrylamides ; Aniline Compounds ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Circulating Tumor DNA/genetics ; ErbB Receptors/genetics ; Exons ; Genotype ; Humans ; Indoles ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Mutation ; Pyrimidines ; Real-Time Polymerase Chain Reaction
Chemical Substances	Acrylamides ; Aniline Compounds ; Circulating Tumor DNA ; Indoles ; Pyrimidines ; osimertinib (3C06JJ0Z2O) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2022-08-07
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2022.06.040
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Fertility Preserving Surgery Outcomes for Ovarian Malignancy: Data from a Tertiary Cancer Centre in Central London.

Gaughran, Jonathan / Rosen O'Sullivan, Hannah / Lyne, Tom / Abdelbar, Ahmed / Abdalla, Mostafa / Sayasneh, Ahmad

Journal of clinical medicine

2022 Volume 11, Issue 11

Abstract: Fertility Sparing Surgery (FSS) appears to be a safe means of treating early-stage ovarian cancer based on relatively limited evidence. However, there is currently insufficient evidence to aid women in counselling about their potential fertility outcomes. ...

Abstract	Fertility Sparing Surgery (FSS) appears to be a safe means of treating early-stage ovarian cancer based on relatively limited evidence. However, there is currently insufficient evidence to aid women in counselling about their potential fertility outcomes. The aim of this study was to assess the reproductive outcomes and prognosis of women who have undergone FSS for ovarian malignancy. Between 1 June 2008 and 1 June 2018, a retrospective review of a clinical database was conducted to identify all consecutive patients who underwent FSS in a central London gynaecological oncology centre. All patients with a histological diagnosis of ovarian malignancy (excluding borderline ovarian tumours) were eligible. All identified patients were then prospectively called into a follow up and asked to complete a questionnaire about their fertility outcomes. A total of 47 women underwent FSS; 36 were included in this study. The mean age was 30.3 years (95% Confidence Interval [CI]: 27.6 to 33.0 years). During the study period, 17/36 (47.2%) of the women had attempted to conceive following surgery, with a successful live birth rate of 52.9% (9/17). The mean time of recurrence was 125.3 months (95% CI: 106.5−144.1 months). The mean time to death was 139.5 months (95% CI: 124.3−154.8). The cancer grade, tumour stage and use of Assisted Reproductive Technology (ART) were the main factors significantly associated with the risk of recurrence and death. In conclusion, this study suggests that a large proportion of women will not attempt to conceive following FSS. For those who do attempt to conceive, the likelihood of achieving a live birth is high. However, careful counselling about the higher risk of recurrence and worse survival for women with high grade cancer, disease Stage > IA and potentially those who undergo ART is essential before contemplating FFS.
Language	English
Publishing date	2022-06-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11113195
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Article ; Online: Inadequacy of PCR genotyping in advanced non-small cell lung cancer: EGFR L747_A755delinsSS exon 19 deletion is not detected by the real-time PCR Idylla™ EGFR mutation test but is detected by ctDNA next generation sequencing and responds to osimertinib.

O'Sullivan, Hazel / d'Arienzo, Paolo D / Yousaf, Nadia / Cui, Wanyuan / Popat, Sanjay

European journal of cancer (Oxford, England : 1990)

2022 Volume 166, Page(s) 38–40

MeSH term(s)	Acrylamides ; Aniline Compounds/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Circulating Tumor DNA/genetics ; ErbB Receptors/genetics ; Exons ; Genotype ; High-Throughput Nucleotide Sequencing ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Mutation ; Protein Kinase Inhibitors/therapeutic use ; Real-Time Polymerase Chain Reaction
Chemical Substances	Acrylamides ; Aniline Compounds ; Circulating Tumor DNA ; Protein Kinase Inhibitors ; osimertinib (3C06JJ0Z2O) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2022-03-08
Publishing country	England
Document type	Letter
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2022.02.007
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 583: Show issues

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Article ; Online: Characterization of sebaceous and non-sebaceous cutaneous manifestations in patients with lynch syndrome: a systematic review.

Aziz, Shahram / O'Sullivan, Hazel / Heelan, Kara / Alam, Afrina / McVeigh, Terri P

Familial cancer

2022 Volume 22, Issue 2, Page(s) 167–175

Abstract: A subset of patients with Lynch Syndrome demonstrates cutaneous manifestations of the disorder. Characterization of these Lynch-related skin lesions could help in early recognition of patients with Lynch Syndrome. A broad search of the literature on OVID ...

Abstract	A subset of patients with Lynch Syndrome demonstrates cutaneous manifestations of the disorder. Characterization of these Lynch-related skin lesions could help in early recognition of patients with Lynch Syndrome. A broad search of the literature on OVID Medline and Embase was carried out to capture papers reporting cutaneous manifestations in Lynch Syndrome patients. The results were uploaded into Mendeley reference management software. The PRISMA workflow was used in the literature selection process. In this systematic review, data were collected from 961 cases from 413 studies, including 380 molecularly confirmed Lynch Syndrome cases. The main skin lesions were: Sebaceous adenomas (43%), sebaceous carcinomas (27%), keratoacanthomas (16%), sebaceomas (13%), squamous cell carcinomas (23%), and basal cell carcinomas (10%). MSH2 variants were the most common underlying genotype (72%). Assessment of mismatch repair by immunohistochemistry, microsatellite instability analysis, or both were performed on 328 skin lesions from 220 (58%) molecularly confirmed cases. In those skin lesions, 95% of Immunohistochemistry and 90% of the microsatellite instability test results were concordant with the underlying genotype. Sebaceous skin lesions are well-recognised phenotypic features of Lynch Syndrome. Our results show that squamous and basal cell carcinomas are relatively common in patients with Lynch syndrome; however, available evidence cannot confirm that Lynch syndrome is causal. Immunohistochemistry and/or microsatellite instability testing of skin tumours in patients with a family history of Lynch Syndrome-associated cancers may be a useful approach in identifying patients requiring referral to Clinical Genetics and/or consideration of germline genetic testing for Lynch Syndrome.
MeSH term(s)	Humans ; Muir-Torre Syndrome/genetics ; Microsatellite Instability ; Sebaceous Gland Neoplasms/genetics ; Genotype ; Carcinoma, Basal Cell ; MutS Homolog 2 Protein/genetics
Chemical Substances	MutS Homolog 2 Protein (EC 3.6.1.3)
Language	English
Publishing date	2022-11-23
Publishing country	Netherlands
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1502496-9
ISSN	1573-7292 ; 1389-9600
ISSN (online)	1573-7292
ISSN	1389-9600
DOI	10.1007/s10689-022-00319-8
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