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  1. Article ; Online: Pain coping skills training un-locks patient-centered pain care during the COVID- 19 lockdown.

    O'Brien, Marie

    Pain management nursing : official journal of the American Society of Pain Management Nurses

    2021  Volume 23, Issue 4, Page(s) 504–516

    Abstract: Background: In 2020, the COVID-19 virus sparked a crisis constituting a nationwide public health emergency that rapidly altered the provision of healthcare services for all Americans. Infectious disease mitigation led to widespread lockdowns of ... ...

    Abstract Background: In 2020, the COVID-19 virus sparked a crisis constituting a nationwide public health emergency that rapidly altered the provision of healthcare services for all Americans. Infectious disease mitigation led to widespread lockdowns of perceived nonessential services, programs, and non-emergent healthcare interventions. This lockdown exacerbated the public health dyad of uncontrolled pain and the opioid epidemic, which was already in a crisis state. Current literature supports the management of uncontrolled pain with a biopsychosocial approach, empowering patients to explore self-care to enhance activities of daily living. Pain Coping Skills Training (PCST) delivers real-life strategies that improve quality of life and strengthen self-efficacy. Self-efficacy has been identified as a patient outcome measure that demonstrates improved patient-perceived function and quality of life despite pain intensity. Studies have shown that nurse practitioners (APRN) are well-positioned to provide PCST to chronic pain sufferers.
    Methods: A pretest-posttest design was utilized for this project to enhance pain self- efficacy through an APRN-led community-based intervention.
    Intervention: Community-dwelling adults treated in a specialty pain management practice were self-selected to participate in a 6-week telehealth delivered PCST Program. This APRN delivered program presented basic pain education and a broad range of evidence-based nonpharmacologic pain management self-care tools. The primary outcome was improved Pain Self-efficacy measured with the pain self-efficacy questionnaire (PSEQ), with secondary outcomes of improved perceived pain intensity and function measured with the pain, enjoyment, and general activity (PEG) scale tracked weekly.
    Results: Baseline PSEQ and weekly PEG scores were obtained and compared to scores after the program. Collateral data points included confidence in using complementary and alternative nonpharmacologic interventions, satisfaction with the program, and a qualitative patient statement regarding pre-and post-intervention participation.
    Conclusions: This project concluded that a Nurse Practitioner delivered PCST program via telehealth technology could provide community-dwelling adults with an intervention that improves pain self-efficacy, enhances self-reported PEG measures, and meets the social distancing requirements that continue to impact patients during the COVID-19 pandemic.
    MeSH term(s) Activities of Daily Living ; Adaptation, Psychological ; COVID-19 ; Chronic Pain/therapy ; Communicable Disease Control ; Humans ; Pandemics ; Patient-Centered Care ; Quality of Life
    Language English
    Publishing date 2021-11-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2213260-0
    ISSN 1532-8635 ; 1524-9042
    ISSN (online) 1532-8635
    ISSN 1524-9042
    DOI 10.1016/j.pmn.2021.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Neutrally charged self-assembling peptide hydrogel recapitulates in vitro mechanisms of breast cancer progression.

    Clough, Helen C / O'Brien, Marie / Zhu, Xinyi / Miller, Aline F / Saiani, Alberto / Tsigkou, Olga

    Materials science & engineering. C, Materials for biological applications

    2021  Volume 127, Page(s) 112200

    Abstract: Self-assembling peptide hydrogels (SAPH) are a popular biomaterial due to their biocompatibility with a wide range of cell types, synthetic design, structural properties that provide a more accurate 3D microenvironment, and potential for cell- and/or ... ...

    Abstract Self-assembling peptide hydrogels (SAPH) are a popular biomaterial due to their biocompatibility with a wide range of cell types, synthetic design, structural properties that provide a more accurate 3D microenvironment, and potential for cell- and/or drug-delivery system. Mimicking solid tumors in vitro using hydrogels is one method of testing anti-cancer drug efficacy and observing cancerous cell-ECM interactions within a 3D system. In this study, a SAPH, PeptiGel®Alpha1, was used to model in vitro the 3D breast tumor microenvironment. PeptiGel®Alpha1 is composed of entangled nanofibers with consistent diameter and mechanical properties similar to breast cancer that more accurately mimic the stiffness of breast tumor tissue than Matrigel® or collagen type I. PeptiGel®Alpha1 supported the viability and growth of the breast cancer cell lines MCF-7 and MDA-MB-231 and recapitulated key features of solid tumors such as hypoxia and invasion. MCF-7 cells in the hydrogels formed large spheroids resembling acini, while MDA-MB-231 remained dispersed. When treated with tamoxifen, PeptiGel®Alpha1 acted as a barrier, providing drug penetration geometry similar to that in vivo, providing better prediction of the drug effect. Finally, it was observed that MCF-7 cells engulfed the peptide matrix after 14 days, highlighting a potential use in drug delivery. PeptiGel®Alpha1 is a suitable platform for in vitro modeling of breast cancer.
    MeSH term(s) Breast Neoplasms/pathology ; Cell Line, Tumor ; Collagen Type I ; Disease Progression ; Female ; Humans ; Hydrogels ; MCF-7 Cells ; Peptides ; Tumor Microenvironment
    Chemical Substances Collagen Type I ; Hydrogels ; Peptides
    Language English
    Publishing date 2021-05-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2012160-X
    ISSN 1873-0191 ; 0928-4931
    ISSN (online) 1873-0191
    ISSN 0928-4931
    DOI 10.1016/j.msec.2021.112200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Engineering a cell-hydrogel-fibre composite to mimic the structure and function of the tendon synovial sheath.

    Imere, Angela / Ligorio, Cosimo / O'Brien, Marie / Wong, Jason K F / Domingos, Marco / Cartmell, Sarah H

    Acta biomaterialia

    2020  Volume 119, Page(s) 140–154

    Abstract: The repair of tendon injuries is often compromised by post-operative peritendinous adhesions. Placing a physical barrier at the interface between the tendon and the surrounding tissue could potentially solve this problem by reducing adhesion formation. ... ...

    Abstract The repair of tendon injuries is often compromised by post-operative peritendinous adhesions. Placing a physical barrier at the interface between the tendon and the surrounding tissue could potentially solve this problem by reducing adhesion formation. At present, no such system is available for routine use in clinical practice. Here, we propose the development of a bilayer membrane combining a nanofibrous poly(ε-caprolactone) (PCL) electrospun mesh with a layer of self-assembling peptide hydrogel (SAPH) laden with type-B synoviocytes. This bilayer membrane would act as an anti-adhesion system capable of restoring tendon lubrication, while assisting with synovial sheath regeneration. The PCL mesh showed adequate mechanical properties (Young's modulus=19±4 MPa, ultimate tensile stress=9.6±1.7 MPa, failure load=0.5±0.1 N), indicating that the membrane is easy to handle and capable to withstand the frictional forces generated on the tendon's surface during movement (~0.3 N). Morphological analysis confirmed the generation of a mesh with nanosized PCL fibres and small pores (< 3 μm), which prevented fibroblast infiltration to impede extrinsic healing but still allowing diffusion of nutrients and waste. Rheological tests showed that incorporation of SAPH layer allows good lubrication properties when the membrane is articulated against porcine tendon or hypodermis, suggesting that restoration of tendon gliding is possible upon implantation. Moreover, viability and metabolic activity tests indicated that the SAPH was conducive to rabbit synoviocyte growth and proliferation over 28 days of 3D culture, sustaining cell production of specific matrix components, particularly hyaluronic acid. Synoviocyte-laden peptide hydrogel promoted a sustained endogenous production of hyaluronic acid, providing an anti-friction layer that potentially restores the tendon gliding environment.
    MeSH term(s) Animals ; Hyaluronic Acid ; Hydrogels ; Polyesters ; Rabbits ; Swine ; Tendon Injuries/pathology ; Tendons/pathology ; Tissue Adhesions/pathology ; Tissue Engineering
    Chemical Substances Hydrogels ; Polyesters ; Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2020-11-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2020.11.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Expanding access to nurse-managed medication for opioid use disorder.

    Cos, Travis A / Starbird, Laura E / Lee, Heeyoung / Chun, Bianca / Gonnella, Kristine / Bird, Jillian / Livsey, Kae / Bastos, Shelley / O'Brien, Marie / Clark, Ivy / Jenkins, Darlene / Tavolaro-Ryley, Laureen

    Nursing outlook

    2021  Volume 69, Issue 5, Page(s) 848–855

    Abstract: Background: Advanced practice registered nurses (APRNs) are increasingly caring for individuals with opioid use disorder. Advances have been made to increase APRN education, outreach, and prescribing privileges, but as demand for medication for opioid ... ...

    Abstract Background: Advanced practice registered nurses (APRNs) are increasingly caring for individuals with opioid use disorder. Advances have been made to increase APRN education, outreach, and prescribing privileges, but as demand for medication for opioid use disorder (MOUD) grows, evidence suggests that policy and care barriers inhibit the ability of APRNs to support MOUD.
    Purpose: This paper highlights the significant challenges of expanding access to buprenorphine prescribing by APRNs.
    Findings: Barriers and recommendations were derived from the culmination of literature review, expert consensus discussions among a diverse stakeholder panel including patient representatives, and feedback from community webinars with care providers.
    Discussion: We provide an overview of existing care barriers, promising practices, and proposed recommendations to enhance the care of individuals and communities with opioid use disorder.
    MeSH term(s) Advanced Practice Nursing ; Buprenorphine/therapeutic use ; Drug Prescriptions/nursing ; Health Services Accessibility/organization & administration ; Humans ; Narcotic Antagonists/therapeutic use ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/epidemiology ; Opioid-Related Disorders/nursing
    Chemical Substances Narcotic Antagonists ; Buprenorphine (40D3SCR4GZ)
    Language English
    Publishing date 2021-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 300568-9
    ISSN 1528-3968 ; 0029-6554
    ISSN (online) 1528-3968
    ISSN 0029-6554
    DOI 10.1016/j.outlook.2021.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: TGF-β3-loaded graphene oxide - self-assembling peptide hybrid hydrogels as functional 3D scaffolds for the regeneration of the nucleus pulposus.

    Ligorio, Cosimo / O'Brien, Marie / Hodson, Nigel W / Mironov, Aleksandr / Iliut, Maria / Miller, Aline F / Vijayaraghavan, Aravind / Hoyland, Judith A / Saiani, Alberto

    Acta biomaterialia

    2021  Volume 127, Page(s) 116–130

    Abstract: Intervertebral disc (IVD) degeneration is a process that starts in the central nucleus pulposus (NP) and leads to inflammation, extracellular matrix (ECM) degradation, and progressive loss of disc height. Early treatment of IVD degeneration is critical ... ...

    Abstract Intervertebral disc (IVD) degeneration is a process that starts in the central nucleus pulposus (NP) and leads to inflammation, extracellular matrix (ECM) degradation, and progressive loss of disc height. Early treatment of IVD degeneration is critical to the reduction of low back pain and related disability. As such, minimally invasive therapeutic approaches that can halt and reverse NP degeneration at the early stages of the disease are needed. Recently, we developed an injectable graphene oxide (GO) - self-assembling peptide FEFKFEFK (F: phenylalanine; K: lysine; E: glutamic acid) hybrid hydrogels as potential delivery platform for cells and/or drugs in the NP. In this current study, we explored the possibility of using the GO present in these hybrid hydrogels as a vehicle for the sequestration and controlled delivery of transforming growth factor beta-3 (TGF-β3), an anabolic growth factor (GF) known to direct NP cell fate and function. For this purpose, we first investigated the potential of GO to bind and sequestrate TGF-β3. We then cultured bovine NP cells in the new functional scaffolds and investigated their response to the presence of GO and TGF-β3. Our results clearly showed that GO flakes can sequestrate TGF-β3 through strong binding interactions resulting in a slow and prolonged release, with the GF remaining active even when bound to the GO flakes. The adsorption of the GF on the GO flakes to create TGF-β3-loaded GO flakes and their subsequent incorporation in the hydrogels through mixing, [(GO/TGF-β3
    MeSH term(s) Animals ; Cattle ; Extracellular Matrix ; Graphite ; Hydrogels/pharmacology ; Intervertebral Disc ; Intervertebral Disc Degeneration/therapy ; Nucleus Pulposus ; Peptides/pharmacology ; Regeneration ; Transforming Growth Factor beta3
    Chemical Substances Hydrogels ; Peptides ; Transforming Growth Factor beta3 ; graphene oxide ; Graphite (7782-42-5)
    Language English
    Publishing date 2021-04-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2021.03.077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Four-Dimensional Imaging of Soft Tissue and Implanted Biomaterial Mechanics: A Barbed Suture Case Study for Tendon Repair.

    Rawson, Shelley D / Shearer, Tom / Lowe, Tristan / O'Brien, Marie / Wong, Jason K F / Margetts, Lee / Cartmell, Sarah H

    ACS applied materials & interfaces

    2018  Volume 10, Issue 45, Page(s) 38681–38691

    Abstract: Timely, recent developments in X-ray microcomputed tomography (XμCT) imaging such as increased resolution and improved sample preparation enable nondestructive time-lapse imaging of polymeric biomaterials when implanted in soft tissue, which we ... ...

    Abstract Timely, recent developments in X-ray microcomputed tomography (XμCT) imaging such as increased resolution and improved sample preparation enable nondestructive time-lapse imaging of polymeric biomaterials when implanted in soft tissue, which we demonstrate herein. Imaging the full three-dimensional (3D) structure of an implanted biomaterial provides new opportunities to assess the micromechanics of the interface between the implant and tissues and how this changes over time as force is applied in load-bearing musculoskeletal applications. In this paper, we present a case study demonstrating in situ XμCT and finite element analysis, using a dynamically loaded barbed suture repair for its novel use in tendon tissue. The aim of this study was to identify the distribution of stress in the suture and tendon as load is applied. The data gained demonstrate a clear 3D visualization of microscale features in both the tissue and implant in wet conditions. XμCT imaging has revealed, for the first time, pores around the suture, preventing full engagement of all the barbs with the tendon tissue. Subsequent finite element analysis reveals the localized stress and strain, which are not evenly distributed along the suture, or throughout the tissue. This case study demonstrates for the first time a powerful in situ mechanical imaging tool, which could be readily adapted by other laboratories to interrogate and optimize the interface between the implanted biomaterials and the soft tissue.
    MeSH term(s) Animals ; Biocompatible Materials/chemistry ; Hand Injuries/surgery ; Humans ; Sutures ; Swine ; Tendon Injuries/diagnostic imaging ; Tendon Injuries/surgery ; Tendons/diagnostic imaging ; Tendons/surgery ; Tensile Strength ; X-Ray Microtomography/methods
    Chemical Substances Biocompatible Materials
    Language English
    Publishing date 2018-11-05
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.8b09700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A comparison of the content of memory rehabilitation groups for patients with neurological disabilities.

    O'Brien, Marie Claire / das Nair, Roshan / Lincoln, Nadina B

    Neuropsychological rehabilitation

    2013  Volume 23, Issue 3, Page(s) 321–332

    Abstract: The aim of the study was to compare the fidelity of manualised group memory rehabilitation programmes for participants with neurological disabilities. A sample of 11 neurological patients with memory problems, enrolled in a randomised controlled trial ... ...

    Abstract The aim of the study was to compare the fidelity of manualised group memory rehabilitation programmes for participants with neurological disabilities. A sample of 11 neurological patients with memory problems, enrolled in a randomised controlled trial comparing compensation, restitution and self-help treatments, were observed during group sessions. Time-sampling was used to record the activity of the participants and the content of the discussion at one minute intervals. There was a significant difference between groups in the amount of time the group leader and participants spent talking (p < .001). Participants in the compensation and restitution groups spent significantly more time in memory rehabilitation discussion than participants in the self-help group (p < .001). There was also a significant difference between the amount of time spent discussing internal and external memory aids in the compensation and restitution groups (p < .001). These results support the fidelity of the interventions provided. This study also highlights the usefulness of time-sampling as a method to record the content and activity in rehabilitation groups.
    MeSH term(s) Adult ; Brain Injuries/complications ; Brain Injuries/rehabilitation ; Female ; Humans ; Male ; Memory Disorders/etiology ; Memory Disorders/rehabilitation ; Middle Aged ; Self-Help Groups ; Stroke/complications ; Stroke Rehabilitation ; Treatment Outcome
    Language English
    Publishing date 2013
    Publishing country England
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 1080508-4
    ISSN 1464-0694 ; 0960-2011
    ISSN (online) 1464-0694
    ISSN 0960-2011
    DOI 10.1080/09602011.2012.753920
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  8. Article ; Online: Anisotropic crack propagation and deformation in dentin observed by four-dimensional X-ray nano-computed tomography.

    Lu, Xuekun / Fernández, Marta Peña / Bradley, Robert S / Rawson, Shelley D / O'Brien, Marie / Hornberger, Benjamin / Leibowitz, Marty / Tozzi, Gianluca / Withers, Philip J

    Acta biomaterialia

    2019  Volume 96, Page(s) 400–411

    Abstract: Understanding the cracking behaviour of biological composite materials is of practical importance. This paper presents the first study to track the interplay between crack initiation, microfracture and plastic deformation in three dimensions (3D) as a ... ...

    Abstract Understanding the cracking behaviour of biological composite materials is of practical importance. This paper presents the first study to track the interplay between crack initiation, microfracture and plastic deformation in three dimensions (3D) as a function of tubule and collagen fibril arrangement in elephant dentin using in situ X-ray nano-computed tomography (nano-CT). A nano-indenter with a conical tip has been used to incrementally indent three test-pieces oriented at 0°, 45° and 70° to the long axis of the tubules (i.e. radial to the tusk). For the 0° sample two significant cracks formed, one of which linked up with microcracks in the axial-radial plane of the tusk originating from the tubules and the other one occurred as a consequence of shear deformation at the tubules. The 70° test-piece was able to bear the greatest loads despite many small cracks forming around the indenter. These were diverted by the microstructure and did not propagate significantly. The 45° test-piece showed intermediate behaviour. In all cases strains obtained by digital volume correlation were well in excess of the yield strain (0.9%), indeed some plastic deformation could even be seen through bending of the tubules. The hoop strains around the conical indenter were anisotropic with the smallest strains correlating with the primary collagen orientation (axial to the tusk) and the largest strains aligned with the hoop direction of the tusk. STATEMENT OF SIGNIFICANCE: This paper presents the first comprehensive study of the anisotropic nature of microfracture, crack propagation and deformation in elephant dentin using time-lapse X-ray nano-computed tomography. To unravel the interplay of collagen fibrils and local deformation, digital volume correlation (DVC) has been applied to map the local strain field while the crack initiation and propagation is tracked in real time. Our results highlight the intrinsic and extrinsic shielding mechanisms and correlate the crack growth behavior in nature to the service requirement of dentin to resist catastrophic fracture. This is of wide interest not just in terms of understanding dentin fracture but also can extend beyond dentin to other anisotropic structural composite biomaterials such as bone, antler and chitin.
    MeSH term(s) Animals ; Anisotropy ; Compressive Strength ; Dentin/diagnostic imaging ; Elephants ; Four-Dimensional Computed Tomography ; Imaging, Three-Dimensional ; Nanotechnology ; Stress, Mechanical ; Time-Lapse Imaging ; X-Rays
    Language English
    Publishing date 2019-06-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2019.06.042
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  9. Article ; Online: In vitro evaluation of poly (lactic-co-glycolic acid)/polyisoprene fibers for soft tissue engineering.

    Marques, Douglas R / Dos Santos, Luís A L / O'Brien, Marie A / Cartmell, Sarah H / Gough, Julie E

    Journal of biomedical materials research. Part B, Applied biomaterials

    2016  Volume 105, Issue 8, Page(s) 2581–2591

    Abstract: The polymeric blend of poly (lactic-co-glycolic acid) (PLGA) and polyisoprene (PI) has recently been explored for application as stents for tracheal stenosis and spring for the treatment of craniosynostosis. From the positive results presented in other ... ...

    Abstract The polymeric blend of poly (lactic-co-glycolic acid) (PLGA) and polyisoprene (PI) has recently been explored for application as stents for tracheal stenosis and spring for the treatment of craniosynostosis. From the positive results presented in other biomedical applications comes the possibility of investigating the application of this material as scaffold for tissue engineering (TE), acquiring a deeper knowledge about the polymeric blend by exploring a new processing technique while attending to the most fundamental demands of TE scaffolds. PLGA/PI was processed into randomly oriented microfibers through the dripping technique and submitted to physical-chemical and in vitro characterization. The production process of fibers did not show an effect over the polymer's chemical composition, despite the fact that PLGA and PI were observed to be immiscible. Mechanical assays reinforce the suitability of these scaffolds for soft tissue applications. Skeletal muscle cells demonstrated increases in metabolic activity and proliferation to the same levels of the control group. Human dermal fibroblasts didn't show the same behaviour, but presented cell growth with the same development profile as presented in the control group. It is plausible to believe that PLGA/PI fibrous three-dimensional scaffolds are suitable for applications in soft tissue engineering. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2581-2591, 2017.
    MeSH term(s) Animals ; Butadienes/chemistry ; Cell Line ; Dermis/cytology ; Dermis/metabolism ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Hemiterpenes/chemistry ; Humans ; Lactic Acid/chemistry ; Materials Testing ; Mice ; Myoblasts, Skeletal/cytology ; Myoblasts, Skeletal/metabolism ; Pentanes/chemistry ; Polyglycolic Acid/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer ; Tissue Engineering ; Tissue Scaffolds/chemistry
    Chemical Substances Butadienes ; Hemiterpenes ; Pentanes ; isoprene (0A62964IBU) ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Polyglycolic Acid (26009-03-0) ; Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2016-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2099992-6
    ISSN 1552-4981 ; 1552-4973 ; 0021-9304
    ISSN (online) 1552-4981
    ISSN 1552-4973 ; 0021-9304
    DOI 10.1002/jbm.b.33796
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  10. Article ; Online: Machine Learning EEG to Predict Cognitive Functioning and Processing Speed Over a 2-Year Period in Multiple Sclerosis Patients and Controls.

    Kiiski, Hanni / Jollans, Lee / Donnchadha, Seán Ó / Nolan, Hugh / Lonergan, Róisín / Kelly, Siobhán / O'Brien, Marie Claire / Kinsella, Katie / Bramham, Jessica / Burke, Teresa / Hutchinson, Michael / Tubridy, Niall / Reilly, Richard B / Whelan, Robert

    Brain topography

    2018  Volume 31, Issue 3, Page(s) 346–363

    Abstract: Event-related potentials (ERPs) show promise to be objective indicators of cognitive functioning. The aim of the study was to examine if ERPs recorded during an oddball task would predict cognitive functioning and information processing speed in Multiple ...

    Abstract Event-related potentials (ERPs) show promise to be objective indicators of cognitive functioning. The aim of the study was to examine if ERPs recorded during an oddball task would predict cognitive functioning and information processing speed in Multiple Sclerosis (MS) patients and controls at the individual level. Seventy-eight participants (35 MS patients, 43 healthy age-matched controls) completed visual and auditory 2- and 3-stimulus oddball tasks with 128-channel EEG, and a neuropsychological battery, at baseline (month 0) and at Months 13 and 26. ERPs from 0 to 700 ms and across the whole scalp were transformed into 1728 individual spatio-temporal datapoints per participant. A machine learning method that included penalized linear regression used the entire spatio-temporal ERP to predict composite scores of both cognitive functioning and processing speed at baseline (month 0), and months 13 and 26. The results showed ERPs during the visual oddball tasks could predict cognitive functioning and information processing speed at baseline and a year later in a sample of MS patients and healthy controls. In contrast, ERPs during auditory tasks were not predictive of cognitive performance. These objective neurophysiological indicators of cognitive functioning and processing speed, and machine learning methods that can interrogate high-dimensional data, show promise in outcome prediction.
    MeSH term(s) Adult ; Brain/physiopathology ; Cognition/physiology ; Electroencephalography ; Female ; Humans ; Machine Learning ; Male ; Middle Aged ; Multiple Sclerosis/physiopathology ; Multiple Sclerosis/psychology ; Neuropsychological Tests ; Scalp
    Language English
    Publishing date 2018-01-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1078442-1
    ISSN 1573-6792 ; 0896-0267
    ISSN (online) 1573-6792
    ISSN 0896-0267
    DOI 10.1007/s10548-018-0620-4
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