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  1. AU="O'Callaghan, Carol"
  2. AU="Mathew, Susan Vincy"
  3. AU="Christopher H Chapman"
  4. AU="Odor, Peter M."
  5. AU="Griesdale, Donald E G"
  6. AU="Allicock, Orchid"
  7. AU=Alderton Alexandra
  8. AU=Zhao Guanlan
  9. AU="Seiradake, Elena"
  10. AU="Daqiu Yin"
  11. AU="Ribeiro, Miriam O"
  12. AU="Zhang, Yuanlin"
  13. AU="Conturso, Alaina C"
  14. AU="Wang, Zuyi"
  15. AU="Ambade, Preshit Nemdas"
  16. AU="Sarmah, Deepraj"
  17. AU="Little, James W."
  18. AU="Templin, Zoe"
  19. AU="Levick, Samantha"
  20. AU="Tatakis, Fotis"
  21. AU="de Vries, Florentine R"
  22. AU="Tsai, Y-T" AU="Tsai, Y-T"
  23. AU="Gonakoti, Sriram"
  24. AU="Wulf, J"
  25. AU="Mardsen, D"
  26. AU="James, David B A"
  27. AU="Montabone, Erika"
  28. AU="Susan J. Burke"
  29. AU="Chen, Yuguang"
  30. AU="Zhao, Zhenghuan"
  31. AU="De Chiara, Anna Rosaria"
  32. AU="Savage, Anne"
  33. AU="Salamanca, Albert"
  34. AU="Zhong, Xiao-Song"
  35. AU="Deguchi, Masashi"
  36. AU="Żmuda, J"
  37. AU="Liao, Yanyan"
  38. AU="Zhu, Jin-Wei"
  39. AU="Khan, Azkia"
  40. AU="Folkman, Judah"
  41. AU=Bhatia Rajesh
  42. AU="Thobois, Stéphane"
  43. AU="Lai, Chien-Chih"
  44. AU="Ahn, Bo Young"
  45. AU="Jeje, Olamide"
  46. AU="Fine, Samson W"
  47. AU="Riemann, Burkhard"
  48. AU="Nazir, Ahsan"
  49. AU="Kawakita, Emi"
  50. AU="Wang, Junnian"
  51. AU="Nie, Chong"

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  1. Artikel ; Online: Sirtuins at the crossroads of stemness, aging, and cancer.

    O'Callaghan, Carol / Vassilopoulos, Athanassios

    Aging cell

    2017  Band 16, Heft 6, Seite(n) 1208–1218

    Abstract: Sirtuins are stress-responsive proteins that direct various post-translational modifications (PTMs) and as a result, are considered to be master regulators of several cellular processes. They are known to both extend lifespan and regulate spontaneous ... ...

    Abstract Sirtuins are stress-responsive proteins that direct various post-translational modifications (PTMs) and as a result, are considered to be master regulators of several cellular processes. They are known to both extend lifespan and regulate spontaneous tumor development. As both aging and cancer are associated with altered stem cell function, the possibility that the involvement of sirtuins in these events is mediated by their roles in stem cells is worthy of investigation. Research to date suggests that the individual sirtuin family members can differentially regulate embryonic, hematopoietic as well as other adult stem cells in a tissue- and cell type-specific context. Sirtuin-driven regulation of both cell differentiation and signaling pathways previously involved in stem cell maintenance has been described where downstream effectors involved determine the biological outcome. Similarly, diverse roles have been reported in cancer stem cells (CSCs), depending on the tissue of origin. This review highlights the current knowledge which places sirtuins at the intersection of stem cells, aging, and cancer. By outlining the plethora of stem cell-related roles for individual sirtuins in various contexts, our purpose was to provide an indication of their significance in relation to cancer and aging, as well as to generate a clearer picture of their therapeutic potential. Finally, we propose future directions which will contribute to the better understanding of sirtuins, thereby further unraveling the full repertoire of sirtuin functions in both normal stem cells and CSCs.
    Mesh-Begriff(e) Aging ; Cell Differentiation ; Humans ; Neoplasms/genetics ; Sirtuins/genetics ; Sirtuins/metabolism ; Stem Cells/metabolism
    Chemische Substanzen Sirtuins (EC 3.5.1.-)
    Sprache Englisch
    Erscheinungsdatum 2017-10-10
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.12685
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet.

    Ahmed, Mohamed A / O'Callaghan, Carol / Chang, Elliot D / Jiang, Haiyan / Vassilopoulos, Athanassios

    Frontiers in oncology

    2020  Band 9, Seite(n) 1462

    Abstract: Calorie restriction (CR) is considered one of the most robust ways to extend life span and reduce the risk of age-related diseases, including cancer, as shown in many different organisms, whereas opposite effects have been associated with high fat diets ( ...

    Abstract Calorie restriction (CR) is considered one of the most robust ways to extend life span and reduce the risk of age-related diseases, including cancer, as shown in many different organisms, whereas opposite effects have been associated with high fat diets (HFDs). Despite the proven contribution of sirtuins in mediating the effects of CR in longevity, the involvement of these nutrient sensors, specifically, in the diet-induced effects on tumorigenesis has yet to be elucidated. Previous studies focusing on SIRT1, do not support a critical role for this sirtuin family member in CR-mediated cancer prevention. However, the contribution of other family members which exhibit strong deacetylase activity is unexplored. To fill this gap, we aimed at investigating the role of SIRT2 and SIRT3 in mediating the anti and pro-tumorigenic effect of CR and HFD, respectively. Our results provide strong evidence supporting distinct, context-dependent roles played by these two family members. SIRT2 is indispensable for the protective effect of CR against tumorigenesis. On the contrary, SIRT3 exhibited oncogenic properties in the context of HFD-induced tumorigenesis, suggesting that SIRT3 inhibition may mitigate the cancer-promoting effects of HFD. Given the different functions regulated by SIRT2 and SIRT3, unraveling downstream targets/pathways involved may provide opportunities to develop new strategies for cancer prevention.
    Sprache Englisch
    Erscheinungsdatum 2020-01-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2019.01462
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Hypermethylation of MAPK13 Promoter in Oesophageal Squamous Cell Carcinoma Is Associated with Loss of p38δ MAPK Expression.

    O' Callaghan, Carol / Fanning, Liam J / Barry, Orla P

    Cancers

    2015  Band 7, Heft 4, Seite(n) 2124–2133

    Abstract: The loss of tumour suppressor gene function is a hallmark of malignant transformation and can occur by a variety of genetic and/or epigenetic alterations. We have previously characterised p38δ mitogen-activated protein kinase (MAPK) as a tumour ... ...

    Abstract The loss of tumour suppressor gene function is a hallmark of malignant transformation and can occur by a variety of genetic and/or epigenetic alterations. We have previously characterised p38δ mitogen-activated protein kinase (MAPK) as a tumour suppressor in oesophageal squamous cell carcinoma (OESCC) and outlined how loss of p38δ MAPK expression promotes increased proliferation and migration, as well as reduced chemosensitivity. Our aim was to investigate the underlying molecular causes of loss of p38δ MAPK expression in OESCC. Sequence analysis of DNA from p38δ MAPK positive and p38δ MAPK negative OESCC cell lines was used to investigate potential loss of function causing mutations. Epigenetic control of p38δ expression in OESCC was examined using methylation-specific PCR and sequencing of bisulfite-converted DNA. We did not identify any mutations in the MAPK13 sequence in OESCC cell lines which lack p38δ MAPK expression. However, we identified a differential pattern of methylation between p38δ MAPK positive and p38δ MAPK negative cell lines. We outline here for the first time differential MAPK13 promoter methylation in OESCC. Our results suggest that epigenetic alterations are responsible, in part, for the suppression of p38δ MAPK expression and promotion of tumourigenesis in OESCC.
    Sprache Englisch
    Erscheinungsdatum 2015-10-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers7040881
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: p38δ MAPK: Emerging Roles of a Neglected Isoform.

    O'Callaghan, Carol / Fanning, Liam J / Barry, Orla P

    International journal of cell biology

    2014  Band 2014, Seite(n) 272689

    Abstract: p38δ mitogen activated protein kinase (MAPK) is a unique stress responsive protein kinase. While the p38 MAPK family as a whole has been implicated in a wide variety of biological processes, a specific role for p38δ MAPK in cellular signalling and its ... ...

    Abstract p38δ mitogen activated protein kinase (MAPK) is a unique stress responsive protein kinase. While the p38 MAPK family as a whole has been implicated in a wide variety of biological processes, a specific role for p38δ MAPK in cellular signalling and its contribution to both physiological and pathological conditions are presently lacking. Recent emerging evidence, however, provides some insights into specific p38δ MAPK signalling. Importantly, these studies have helped to highlight functional similarities as well as differences between p38δ MAPK and the other members of the p38 MAPK family of kinases. In this review we discuss the current understanding of the molecular mechanisms underlying p38δ MAPK activity. We outline a role for p38δ MAPK in important cellular processes such as differentiation and apoptosis as well as pathological conditions such as neurodegenerative disorders, diabetes, and inflammatory disease. Interestingly, disparate roles for p38δ MAPK in tumour development have also recently been reported. Thus, we consider evidence which characterises p38δ MAPK as both a tumour promoter and a tumour suppressor. In summary, while our knowledge of p38δ MAPK has progressed somewhat since its identification in 1997, our understanding of this particular isoform in many cellular processes still strikingly lags behind that of its counterparts.
    Sprache Englisch
    Erscheinungsdatum 2014-09-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2536742-0
    ISSN 1687-8884 ; 1687-8876
    ISSN (online) 1687-8884
    ISSN 1687-8876
    DOI 10.1155/2014/272689
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: p38δ MAPK phenotype: an indicator of chemotherapeutic response in oesophageal squamous cell carcinoma.

    O'Callaghan, Carol / Fanning, Liam J / Barry, Orla P

    Anti-cancer drugs

    2014  Band 26, Heft 1, Seite(n) 46–55

    Abstract: We recently documented p38δ differential expression and function in oesophageal squamous cell carcinoma (OESCC). This study expands upon these findings and investigates whether p38δ status in OESCC can influence response(s) to cytotoxic drugs. The ... ...

    Abstract We recently documented p38δ differential expression and function in oesophageal squamous cell carcinoma (OESCC). This study expands upon these findings and investigates whether p38δ status in OESCC can influence response(s) to cytotoxic drugs. The antiproliferative effect of conventional cisplatin and 5-fluorouracil (CF) treatment was compared with the recently reviewed triple regime of cisplatin, 5-fluorouracil and doxorubicin (ACF). p38δ-positive and p38δ-negative cell lines were employed using cell-growth and clonogenic assays. Key regulators of intrinsic and extrinsic apoptotic pathways were measured. Wound-healing assays and a Boyden chamber were used to investigate the effect of drug treatments on cell migration. Functional networks were analysed in terms of changes in MAPK expression. p38δ-negative OESCC is less sensitive to standard CF chemotherapy compared with p38δ-positive cells. However, following ACF treatment p38δ-negative cells showed markedly decreased proliferation and cell migration, and increased apoptosis. ACF induced apoptosis through the extrinsic pathway involving Fas activation, caspase-8 and caspase-3 cleavage and degradation of PARP. Loss of mitochondrial membrane potential (ΔΨm) was observed but downregulation of multidomain proapoptotic proteins, as well as BH3-only proteins, suggests involvement of pathways other than the mitochondrial pathway. Interestingly, induction of p38 and ERK1/2, but not JNK1/2, was observed following ACF treatment. p38δ-negative OESCC is more resistant to traditional CF treatment compared with p38δ-positive OESCC. In light of these results, p38δ phenotyping of tumour tissue may be of considerable value in deciding on an optimal therapeutic strategy for patients with p38δ-negative OESCC.
    Mesh-Begriff(e) Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Biomarkers, Tumor/metabolism ; Carcinoma, Squamous Cell/drug therapy ; Cell Line, Tumor/drug effects ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cisplatin/pharmacology ; Doxorubicin/pharmacology ; Drug Synergism ; Esophageal Neoplasms/drug therapy ; Esophageal Squamous Cell Carcinoma ; Fluorouracil/pharmacology ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Phenotype ; Signal Transduction ; p38 Mitogen-Activated Protein Kinases/metabolism
    Chemische Substanzen Antineoplastic Agents ; Biomarkers, Tumor ; Doxorubicin (80168379AG) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Cisplatin (Q20Q21Q62J) ; Fluorouracil (U3P01618RT)
    Sprache Englisch
    Erscheinungsdatum 2014-08-11
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1065301-6
    ISSN 1473-5741 ; 0959-4973
    ISSN (online) 1473-5741
    ISSN 0959-4973
    DOI 10.1097/CAD.0000000000000156
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: ACE2 abrogates tumor resistance to VEGFR inhibitors suggesting angiotensin-(1-7) as a therapy for clear cell renal cell carcinoma.

    Khanna, Prateek / Soh, Hong Jie / Chen, Chun-Hau / Saxena, Ruchi / Amin, Seema / Naughton, Maura / Joslin, Patrick Neset / Moore, Andrew / Bakouny, Ziad / O'Callaghan, Carol / Catalano, Paul / Signoretti, Sabina / McKay, Rana / Choueiri, Toni K / Bhasin, Manoj / Walther, Thomas / Bhatt, Rupal S

    Science translational medicine

    2021  Band 13, Heft 577

    Abstract: Angiotensin converting enzyme 2 (ACE2) is an enzyme that belongs to the renin-angiotensin system (RAS) and antagonizes the classical angiotensin (Ang) II/angiotensin II receptor type 1 (AT1) receptor pathway. Here, we report that higher ACE2 expression ... ...

    Abstract Angiotensin converting enzyme 2 (ACE2) is an enzyme that belongs to the renin-angiotensin system (RAS) and antagonizes the classical angiotensin (Ang) II/angiotensin II receptor type 1 (AT1) receptor pathway. Here, we report that higher ACE2 expression correlates with better overall survival in patients with clear cell renal cell carcinoma (ccRCC). Moreover, ACE2 has inhibitory effects on tumor proliferation in ccRCC in vitro and in preclinical animal models of ccRCC. We further show that Ang-(1-7), a heptapeptide generated by ACE2, is the likely mediator of this effect. Vascular endothelial growth factor receptor-tyrosine kinase inhibitor (VEGFR-TKI) treatment of ccRCC xenografts decreased ACE2 expression, and combination treatment with VEGFR-TKI and Ang-(1-7) generated additive suppression of tumor growth and improved survival outcomes. Last, the addition of Ang-(1-7) to programmed death-ligand 1 (PD-L1) pathway inhibitor and VEGFR-TKI showed further growth suppression in an immunocompetent RCC model. Together, these results suggest that targeting the ACE2/Ang-(1-7) axis is a promising therapeutic strategy against ccRCC.
    Mesh-Begriff(e) Angiotensin I ; Angiotensin II ; Angiotensin-Converting Enzyme 2 ; Animals ; Carcinoma, Renal Cell/drug therapy ; Humans ; Kidney Neoplasms/drug therapy ; Peptide Fragments ; Peptidyl-Dipeptidase A ; Protein Kinase Inhibitors ; Vascular Endothelial Growth Factor A
    Chemische Substanzen Peptide Fragments ; Protein Kinase Inhibitors ; Vascular Endothelial Growth Factor A ; Angiotensin II (11128-99-7) ; Angiotensin I (9041-90-1) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; angiotensin I (1-7) (IJ3FUK8MOF)
    Sprache Englisch
    Erscheinungsdatum 2021-01-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.abc0170
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6941: Hefte anzeigen Standort:
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  7. Artikel ; Online: Loss of p38δ mitogen-activated protein kinase expression promotes oesophageal squamous cell carcinoma proliferation, migration and anchorage-independent growth.

    O'Callaghan, Carol / Fanning, Liam J / Houston, Aileen / Barry, Orla P

    International journal of oncology

    2013  Band 43, Heft 2, Seite(n) 405–415

    Abstract: Oesophageal cancer is an aggressive tumour which responds poorly to both chemotherapy and radiation therapy and has a poor prognosis. Thus, a greater understanding of the biology of oesophageal cancer is needed in order to identify novel therapeutic ... ...

    Abstract Oesophageal cancer is an aggressive tumour which responds poorly to both chemotherapy and radiation therapy and has a poor prognosis. Thus, a greater understanding of the biology of oesophageal cancer is needed in order to identify novel therapeutic targets. Among these targets p38 MAPK isoforms are becoming increasingly important for a variety of cellular functions. The physiological functions of p38α and -β are now well documented in contrast to -γ and -δ which are comparatively under-studied and ill-defined. A major obstacle to deciphering the role(s) of the latter two p38 isoforms is the lack of specific chemical activators and inhibitors. In this study, we analysed p38 MAPK isoform expression in oesophageal cancer cell lines as well as human normal and tumour tissue. We observed specifically differential p38δ expression. The role(s) of p38δ and active (phosphorylated) p38δ (p-p38δ) in oesophageal squamous cell carcinoma (OESCC) was delineated using wild-type p38δ as well as active p-p38δ, generated by fusing p38δ to its upstream activator MKK6b(E) via a decapeptide (Gly-Glu)5 linker. OESCC cell lines which are p38δ-negative (KE-3 and -8) grew more quickly than cell lines (KE-6 and -10) which express endogenous p38δ. Re-introduction of p38δ resulted in a time-dependent decrease in OESCC cell proliferation which was exacerbated with p-p38δ. In addition, we observed that p38δ and p-p38δ negatively regulated OESCC cell migration in vitro. Finally both p38δ and p-p38δ altered OESCC anchorage-independent growth. Our results suggest that p38δ and p-p38δ have a role in the suppression of OESCC. Our research may provide a new potential target for the treatment of oesophageal cancer.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma ; Female ; Humans ; MAP Kinase Kinase 6/genetics ; Male ; Middle Aged ; Mitogen-Activated Protein Kinase 11/biosynthesis ; Mitogen-Activated Protein Kinase 11/metabolism ; Mitogen-Activated Protein Kinase 12/biosynthesis ; Mitogen-Activated Protein Kinase 12/metabolism ; Mitogen-Activated Protein Kinase 13/genetics ; Mitogen-Activated Protein Kinase 14/biosynthesis ; Mitogen-Activated Protein Kinase 14/metabolism ; Protein Isoforms/biosynthesis ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA Interference ; RNA, Small Interfering
    Chemische Substanzen Protein Isoforms ; RNA, Small Interfering ; Mitogen-Activated Protein Kinase 12 (EC 2.7.1.-) ; Mitogen-Activated Protein Kinase 13 (EC 2.7.1.-) ; Mitogen-Activated Protein Kinase 11 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 14 (EC 2.7.11.24) ; MAP Kinase Kinase 6 (EC 2.7.12.2)
    Sprache Englisch
    Erscheinungsdatum 2013-05-29
    Erscheinungsland Greece
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1154403-x
    ISSN 1791-2423 ; 1019-6439
    ISSN (online) 1791-2423
    ISSN 1019-6439
    DOI 10.3892/ijo.2013.1968
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status.

    Song, Ha Yong / Biancucci, Marco / Kang, Hong-Jun / O'Callaghan, Carol / Park, Seong-Hoon / Principe, Daniel R / Jiang, Haiyan / Yan, Yufan / Satchell, Karla Fullner / Raparia, Kirtee / Gius, David / Vassilopoulos, Athanassios

    Oncotarget

    2016  Band 7, Heft 49, Seite(n) 80336–80349

    Abstract: The observation that cellular transformation depends on breaching a crucial KRAS activity threshold, along with the finding that only a small percentage of cellsharboring KRAS mutations are transformed, support the idea that additional, not fully ... ...

    Abstract The observation that cellular transformation depends on breaching a crucial KRAS activity threshold, along with the finding that only a small percentage of cellsharboring KRAS mutations are transformed, support the idea that additional, not fully uncovered, regulatory mechanisms may contribute to KRAS activation. Here we report that KrasG12D mice lacking Sirt2 show an aggressive tumorigenic phenotype as compared to KrasG12D mice. This phenotype includes increased proliferation, KRAS acetylation, and activation of RAS downstream signaling markers. Mechanistically, KRAS K147 is identified as a novel SIRT2-specific deacetylation target by mass spectrometry, whereas its acetylation status directly regulates KRAS activity, ultimately exerting an impact on cellular behavior as revealed by cell proliferation, colony formation, and tumor growth. Given the significance of KRAS activity as a driver in tumorigenesis, identification of K147 acetylation as a novel post-translational modification directed by SIRT2 in vivo may provide a better understanding of the mechanistic link regarding the crosstalk between non-genetic and genetic factors in KRAS driven tumors.
    Mesh-Begriff(e) Acetylation ; Adenocarcinoma/enzymology ; Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Adenocarcinoma of Lung ; Animals ; Cell Proliferation ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Gene Deletion ; Gene Expression Regulation, Neoplastic ; Genetic Predisposition to Disease ; HCT116 Cells ; HEK293 Cells ; Humans ; Lung Neoplasms/enzymology ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Lysine ; Male ; Mice ; Mice, Knockout ; Mice, Nude ; Mutation ; NIH 3T3 Cells ; Pancreatic Neoplasms/enzymology ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Phenotype ; Protein Processing, Post-Translational ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Signal Transduction ; Sirtuin 2/deficiency ; Sirtuin 2/genetics ; Time Factors ; Tumor Burden
    Chemische Substanzen Sirt2 protein, mouse (EC 3.5.1.-) ; Sirtuin 2 (EC 3.5.1.-) ; Hras protein, mouse (EC 3.6.5.2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Lysine (K3Z4F929H6)
    Sprache Englisch
    Erscheinungsdatum 2016-09-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.12015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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