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  1. Article ; Online: In patients with COVID-19 receiving IMV or ECMO, adding baricitinib to usual care reduced all-cause mortality.

    Shah, Aditya / O'Horo, John C

    Annals of internal medicine

    2022  Volume 175, Issue 6, Page(s) JC64

    Abstract: Source citation: Ely EW, Ramanan AV, Kartman CE, et al. ...

    Abstract Source citation: Ely EW, Ramanan AV, Kartman CE, et al.
    MeSH term(s) Adult ; Azetidines ; COVID-19/drug therapy ; Extracorporeal Membrane Oxygenation ; Humans ; Purines ; Pyrazoles ; SARS-CoV-2 ; Sulfonamides
    Chemical Substances Azetidines ; Purines ; Pyrazoles ; Sulfonamides ; baricitinib (ISP4442I3Y)
    Language English
    Publishing date 2022-06-07
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/J22-0033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Sequential Time to Positivity as a Prognostic Indicator in

    Comba, Isin Y / Go, John Raymond / Vaillant, James / O'Horo, John C / Stevens, Ryan W / Palraj, Raj / Abu Saleh, Omar

    Open forum infectious diseases

    2024  Volume 11, Issue 4, Page(s) ofae173

    Abstract: Background: We aimed to determine the factors associated with sequential blood culture time to positivity (STTP) and validate the previously defined time to positivity (TTP) ratio threshold of 1.5 in predicting adverse disease outcomes and mortality of ! ...

    Abstract Background: We aimed to determine the factors associated with sequential blood culture time to positivity (STTP) and validate the previously defined time to positivity (TTP) ratio threshold of 1.5 in predicting adverse disease outcomes and mortality of
    Methods: We conducted an observational study of adult patients with SAB. The TTP ratio was calculated by dividing the TTP of the second blood culture by that of the first.
    Results: Of 186 patients, 69 (37%) were female, with a mean age of 63.6 years. Median TTP was 12 hours (interquartile range [IQR], 10-15 hours) from the initial and 21 hours (17-29) from sequential blood cultures. Methicillin-resistant
    Conclusions: The STTP varies based on methicillin susceptibility of
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofae173
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  3. Article ; Online: In reply-Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research.

    O'Horo, John C / Badley, Andrew D

    Mayo Clinic proceedings

    2021  Volume 96, Issue 4, Page(s) 1092–1093

    MeSH term(s) Ambulatory Care Facilities ; COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-02-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2021.02.005
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  4. Article: Septic shock definitions and associated outcomes in blood culture positive critically ill patients.

    Lal, Amos / Rayes, Hamza / O'Horo, John C / Singh, Tarun D / Gajic, Ognjen / Kashyap, Rahul

    Annals of translational medicine

    2023  Volume 11, Issue 5, Page(s) 192

    Abstract: Background: The proposed definition of septic shock in the Sepsis-3 consensus statement has been previously validated in critically ill patients. However, the subset of critically ill patients with sepsis and positive blood cultures needs further ... ...

    Abstract Background: The proposed definition of septic shock in the Sepsis-3 consensus statement has been previously validated in critically ill patients. However, the subset of critically ill patients with sepsis and positive blood cultures needs further evaluation. To compare the combined (old and new septic shock) versus old definition of septic shock in sepsis patients that have positive blood cultures and are critically ill.
    Methods: A retrospective cohort study of adult patients (age ≥18 years), who had evidence of positive blood cultures, requiring intensive care unit (ICU) admission at a large tertiary care academic center from January 2009 through October 2015. Eligible subjects who opted out of research participation, those requiring intensive care admission after elective surgery, and those who were deemed to have a low probability of infection were excluded. Basic demographics data, clinical and laboratory parameters, and outcomes of interest were pulled from the validated institutional database/repository and contrasted between the patients who qualified the new and old definitions criteria (combined) of septic shock versus the group meeting the old septic shock criteria only.
    Results: We included a total of 477 patients in the final analysis who qualified for old and new septic shock definitions. For the entire cohort, median age was 65.6 (IQR, 55-75) years, with male predominance (N=258, 54%). When compared to patients in the group who only met the old definition (N=206), the patients who met the combined (new or both new and old, N=271) definition had a higher APACHE III scores, 92 (IQR, 76-112)
    Conclusions: In patients with sepsis with positive blood cultures, the group of patients meeting the combined definition (new or both new and old) have higher severity of illness, higher mortality, and a worse standardized mortality ratio as compared to patients meeting the old definition of septic shock.
    Language English
    Publishing date 2023-02-24
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-22-5147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Body temperature and infection in critically ill patients on continuous kidney replacement therapy.

    Challener, Douglas W / Gao, Xiaolan / Tehranian, Shahrzad / Kashani, Kianoush B / O'Horo, John C

    BMC nephrology

    2023  Volume 24, Issue 1, Page(s) 161

    Abstract: Purpose: Continuous kidney replacement therapy (CKRT) is an increasingly common intervention for critically ill patients with kidney failure. Because CKRT affects body temperature, detecting infections in patients on CKRT is challenging. Understanding ... ...

    Abstract Purpose: Continuous kidney replacement therapy (CKRT) is an increasingly common intervention for critically ill patients with kidney failure. Because CKRT affects body temperature, detecting infections in patients on CKRT is challenging. Understanding the relation between CKRT and body temperature may facilitate earlier detection of infection.
    Methods: We retrospectively reviewed adult patients (≥ 18 years) admitted to the intensive care unit at Mayo Clinic in Rochester, Minnesota, from December 1, 2006, through November 31, 2015, who required CKRT. We summarized central body temperatures for these patients according to the presence or absence of infection.
    Results: We identified 587 patients who underwent CKRT during the study period, of whom 365 had infections, and 222 did not have infections. We observed no statistically significant differences in minimum (P = .70), maximum (P = .22), or mean (P = .55) central body temperature for patients on CKRT with infection vs. those without infection. While not on CKRT (before CKRT initiation and after cessation), all three body temperature measurements were significantly higher in patients with infection than in those without infection (all P < .02).
    Conclusion: Body temperature is insufficient to indicate an infection in critically ill patients on CKRT. Clinicians should remain watchful for other signs, symptoms, and indications of infection in patients on CKRT because of expected high infection rates.
    MeSH term(s) Adult ; Humans ; Body Temperature ; Critical Illness/therapy ; Retrospective Studies ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/therapy ; Acute Kidney Injury/etiology ; Continuous Renal Replacement Therapy/adverse effects ; Renal Replacement Therapy/adverse effects
    Language English
    Publishing date 2023-06-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-023-03225-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: In reply - Candida Bronchitis and Mucus Plugging.

    Shah, Aditya / O'Horo, John C

    Mayo Clinic proceedings

    2020  Volume 95, Issue 4, Page(s) 825

    MeSH term(s) Bronchitis ; Bronchoscopy ; Candida ; Humans ; Intensive Care Units ; Mucus
    Language English
    Publishing date 2020-04-01
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2019.12.027
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    Ua VI Zs.183: Show issues Location:
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  7. Article ; Online: A Blueprint to Control the SARS-CoV-2 Pandemic.

    O'Horo, John C / Williams, Amy W / Badley, Andrew D

    Mayo Clinic proceedings

    2021  Volume 96, Issue 5, Page(s) 1128–1131

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/therapy ; COVID-19 Vaccines/therapeutic use ; Communicable Disease Control/methods ; Communicable Disease Control/organization & administration ; Disease Transmission, Infectious/prevention & control ; Early Diagnosis ; Humans ; Immunity, Herd ; Public Health/methods ; SARS-CoV-2/immunology
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-03-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2021.03.013
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  8. Article ; Online: Brevibacterium Species: An Emerging Opportunistic Cause of Bloodstream Infections.

    Shweta, Fnu / Gurram, Pooja R / O'Horo, John C / Khalil, Sarwat

    Mayo Clinic proceedings

    2021  Volume 96, Issue 4, Page(s) 1093–1094

    MeSH term(s) Aged ; Brevibacterium/isolation & purification ; Female ; Humans ; Male ; Middle Aged ; Sepsis/diagnosis ; Sepsis/microbiology ; Sepsis/therapy
    Language English
    Publishing date 2021-04-05
    Publishing country England
    Document type Letter
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2021.01.022
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  9. Article: The Diagnostic Accuracy of Metagenomic Next-Generation Sequencing in Diagnosing

    Tekin, Aysun / Truong, Hong Hieu / Rovati, Lucrezia / Lal, Amos / Gerberi, Danielle J / Gajic, Ognjen / O'Horo, John C

    Open forum infectious diseases

    2023  Volume 10, Issue 9, Page(s) ofad442

    Abstract: Background: Pneumocystis: Methods: Five databases were searched through December 19, 2022, to identify original studies comparing MNGS with clinically diagnosed PCP. To assess the accuracy, symmetric hierarchical summary receiver operating ... ...

    Abstract Background: Pneumocystis
    Methods: Five databases were searched through December 19, 2022, to identify original studies comparing MNGS with clinically diagnosed PCP. To assess the accuracy, symmetric hierarchical summary receiver operating characteristic models were used.
    Results: Eleven observational studies reporting 1442 patients (424 with PCP) were included. Six studies focused exclusively on recipients of biologic immunosuppression (none with HIV-associated immunosuppression). Six were exclusively on bronchoalveolar lavage, while 1 was on blood samples. The sensitivity of MGNS was 0.96 (95% CI, 0.90-0.99), and specificity was 0.96 (95% CI, 0.92-0.98), with negative and positive likelihood ratios of 0.02 (95% CI, 0.01-0.05) and 19.31 (95% CI, 10.26-36.36), respectively. A subgroup analysis of studies exclusively including bronchoalveolar lavage (BAL) and blood samples demonstrated a sensitivity of 0.94 (95% CI, 0.78-0.99) and 0.93 (95% CI, 0.80-0.98) and a specificity of 0.96 (95% CI, 0.88-0.99) and 0.98 (95% CI, 0.76-1.00), respectively. The sensitivity analysis on recipients of biologic immunosuppression showed a sensitivity and specificity of 0.96 (95% CI, 0.90-0.98) and 0.94 (95% CI, 0.84-0.98), respectively. The overall confidence in the estimates was low.
    Conclusions: Despite the low certainty of evidence, MNGS detects PCP with high sensitivity and specificity. This also applies to recipients of biologic immunosuppression and tests performed exclusively on blood samples without the need for BAL. Further studies are required in individuals with HIV-associated immunosuppression.
    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad442
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  10. Article ; Online: Multiomics single timepoint measurements to predict severe COVID-19 - Authors' reply.

    Garapati, Kishore / Byeon, Seul Kee / Walsh, Jesse R / Jenkinson, Garrett / Cattaneo, Roberto / O'Horo, John C / Badley, Andrew D / Pandey, Akhilesh

    The Lancet. Digital health

    2023  Volume 5, Issue 2, Page(s) e57

    MeSH term(s) Humans ; COVID-19 ; Multiomics ; SARS-CoV-2
    Language English
    Publishing date 2023-01-25
    Publishing country England
    Document type Letter ; Comment
    ISSN 2589-7500
    ISSN (online) 2589-7500
    DOI 10.1016/S2589-7500(22)00250-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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