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  1. Article: Corrigendum: Murine models of acute myeloid leukemia.

    Kurtz, Kristen J / Conneely, Shannon E / O'Keefe, Madeleine / Wohlan, Katharina / Rau, Rachel E

    Frontiers in oncology

    2023  Volume 12, Page(s) 1089874

    Abstract: This corrects the article DOI: 10.3389/fonc.2022.854973.]. ...

    Abstract [This corrects the article DOI: 10.3389/fonc.2022.854973.].
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1089874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Murine Models of Acute Myeloid Leukemia.

    Kurtz, Kristen J / Conneely, Shannon E / O'Keefe, Madeleine / Wohlan, Katharina / Rau, Rachel E

    Frontiers in oncology

    2022  Volume 12, Page(s) 854973

    Abstract: Acute myeloid leukemia (AML) is a phenotypically and genetically heterogeneous hematologic malignancy. Extensive sequencing efforts have mapped the genomic landscape of adult and pediatric AML revealing a number of biologically and prognostically ... ...

    Abstract Acute myeloid leukemia (AML) is a phenotypically and genetically heterogeneous hematologic malignancy. Extensive sequencing efforts have mapped the genomic landscape of adult and pediatric AML revealing a number of biologically and prognostically relevant driver lesions. Beyond identifying recurrent genetic aberrations, it is of critical importance to fully delineate the complex mechanisms by which they contribute to the initiation and evolution of disease to ultimately facilitate the development of targeted therapies. Towards these aims, murine models of AML are indispensable research tools. The rapid evolution of genetic engineering techniques over the past 20 years has greatly advanced the use of murine models to mirror specific genetic subtypes of human AML, define cell-intrinsic and extrinsic disease mechanisms, study the interaction between co-occurring genetic lesions, and test novel therapeutic approaches. This review summarizes the mouse model systems that have been developed to recapitulate the most common genomic subtypes of AML. We will discuss the strengths and weaknesses of varying modeling strategies, highlight major discoveries emanating from these model systems, and outline future opportunities to leverage emerging technologies for mechanistic and preclinical investigations.
    Language English
    Publishing date 2022-06-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.854973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Attempted desensitization to calaspargase pegol: a familiar approach to a new problem.

    Kuhn, Alexis K / Martin, Catherine / Galardy, Paul / McCullough, Kristen / Greenmyer, Jacob / O'Keefe, Madeleine / Walter, Ashley / Thompson, Christineil / Ferdjallah, Asmaa / Kalmes, Jessica / Kohorst, Mira

    Leukemia & lymphoma

    2023  Volume 65, Issue 3, Page(s) 407–409

    MeSH term(s) Humans ; Asparaginase ; Polyethylene Glycols/adverse effects ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/etiology ; Drug Hypersensitivity/therapy
    Chemical Substances calaspargase pegol (EC 3.5.1.1) ; Asparaginase (EC 3.5.1.1) ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2023.2282950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2997: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: The U.K. national study of abuse and neglect among older people.

    Manthorpe, Jill / Biggs, Simon / McCreadie, Claudine / Tinker, Anthea / Hills, Amy / O'Keefe, Madeleine / Doyle, Melanie / Constantine, Rebecca / Scholes, Shaun / Erens, Bob

    Nursing older people

    2007  Volume 19, Issue 8, Page(s) 24–26

    Abstract: This article reports briefly on the first UK prevalence study (undertaken in 2006-7) of the abuse and neglect of older people living in the community. Older people living in the community who reported mistreatment and neglect (2.6 per cent) equate to ... ...

    Abstract This article reports briefly on the first UK prevalence study (undertaken in 2006-7) of the abuse and neglect of older people living in the community. Older people living in the community who reported mistreatment and neglect (2.6 per cent) equate to about 227,000 of the population aged 66 years and over. If figures are broadened to include neighbours and acquaintances, prevalence increases from 2.6 per cent to 4.0 per cent. This article identifies risk factors of loneliness, depression and poor quality of life. It suggests that nurses have a key role in day-to-day clinical practice in enabling older people to report abuse and neglect.
    MeSH term(s) Aged/psychology ; Aged/statistics & numerical data ; Attitude to Health ; Community Health Nursing ; Depression/complications ; Elder Abuse/prevention & control ; Elder Abuse/psychology ; Elder Abuse/statistics & numerical data ; Geriatric Assessment ; Health Services Needs and Demand ; Humans ; Loneliness ; Nurse's Role ; Patient Advocacy ; Population Surveillance ; Prevalence ; Quality of Life/psychology ; Residence Characteristics ; Risk Factors ; Surveys and Questionnaires ; United Kingdom/epidemiology
    Language English
    Publishing date 2007-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2028615-6
    ISSN 2047-8941 ; 1472-0795
    ISSN (online) 2047-8941
    ISSN 1472-0795
    DOI 10.7748/nop2007.10.19.8.24.c6268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2887: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 591: Show issues

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