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Article ; Online: Stromal-vascular fraction of adipose tissue as an alternative source of cellular material for regenerative medicine

A. S. Sultanova / O. Ya. Bespalova / O. Yu. Galkin

The Ukrainian Biochemical Journal, Vol 93, Iss 1, Pp 40-

2021  Volume 50

Abstract: Adipose tissue is the most convenient source of cellular material for regenerative medicine as it can be obtained in significant quantities via cosmetic liposuction, lipoaspiration of subcutaneous fat or by excision of fat deposits. Adipose tissue ... ...

Abstract Adipose tissue is the most convenient source of cellular material for regenerative medicine as it can be obtained in significant quantities via cosmetic liposuction, lipoaspiration of subcutaneous fat or by excision of fat deposits. Adipose tissue consists of adipocytes and cells, which are the part of the stromal-vascular fraction (SVF). Different cell populations can be isolated from SVF, among which the population of adipose tissue stem cells (adipose-derived stem cells, ADSC) is especially important for regenerative medicine. SVF can be obtained relatively easily from adipose tissue (adipose tissue is an alternative to bone marrow in terms of being a source of stem cells) and used to treat various pathologies. Recent studies show that SVF not only has a therapeutic effect similar to that of ADSC, but in some cases is even more effective. The article provides the analysis of the main methods of SVF obtainment, characteristics of SVF cellular composition, its potential for use in clinical medicine and its main advantages over other sources of cellular material, including­ ADSC cultured in vitro, for regenerative medicine.
Keywords stromal-vascular fraction ; adipose-derived stem cells ; adipocytes ; regenerative medicine ; Biochemistry ; QD415-436 ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code 610
Language English
Publishing date 2021-02-01T00:00:00Z
Publisher National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
Document type Article ; Online
Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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