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Article: Did the ERAS Protocol Improve Our Results in Locally Advanced Gastric Cancer Surgery?

Düzgün, Özgül / Özcan, Pırıltı / Özçelik, Mehmet Faik

2022 Volume 12, Issue 10

Abstract: ERAS is a protocol consisting of multidisciplinary approaches, including patient education, fluid resuscitation, keeping patients' innormothermic state, early feeding, and mobilization. We aimed to present and compare the postoperative results of ... ...

Abstract	ERAS is a protocol consisting of multidisciplinary approaches, including patient education, fluid resuscitation, keeping patients' innormothermic state, early feeding, and mobilization. We aimed to present and compare the postoperative results of patients operated on due to locally advanced gastric cancer who received neoadjuvant therapy in two high-volume tertiary centers, and aimed to present that ERAS protocols can be applied with success without increasing the complication rate. This retrospective study consisted of two groups: a non-ERAS group and an ERAS group. The ERAS group consisted of 106 patients and the non-ERAS group consisted of 104 patients. The time to first flatus was shorter in the ERAS group compared with the non-ERAS group: 2.8 (1-5) and 3.5 (1-5,
Language	English
Publishing date	2022-09-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12101549
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Article ; Online: Systemic Inflammatory Biomarkers as Surrogate Markers for Stage in Colon Cancer.

Uludag, Server Sezgin / Sanli, Ahmet Necati / Zengin, Abdullah Kagan / Ozcelik, Mehmet Faik

The American surgeon

2021 Volume 88, Issue 6, Page(s) 1256–1262

Abstract: Background: This study aimed to investigate whether the systemic inflammatory parameters currently in use in staging the disease can be used as biomarker tests operated colon cancer patients. Neutrophil, lymphocyte, monocyte, platelet, neutrophil/ ... ...

Abstract	Background: This study aimed to investigate whether the systemic inflammatory parameters currently in use in staging the disease can be used as biomarker tests operated colon cancer patients. Neutrophil, lymphocyte, monocyte, platelet, neutrophil/lymphocyte ratio (NLR), lymphocyte/monocyte ratio (LMR), platelet/lymphocyte ratio (PLR), neutrophil/monocyte ratio (NMR), CRP, albumin, lymphocyte/CRP ratio, CRP/albumin ratio, and neutrophil/albumin ratio as systemic inflammatory biomarkers and prognostic nutritional index (PNI) were evaluated. Methods: This retrospective study included 592 patients. Patients with colon cancer in the cohort were divided into 2 subgroups: Tumor, nodes, metastases (TNM) stage 0, TNM stage 1, and TNM stage 2; early stage (n: 332) and TNM stage 3 and TNM stage 4; late stage (n: 260) colon cancer patients. Results: LDH ( Conclusions: Our data suggest that high serum LDH, NLR, PLR, CRP/albumin, and neutrophil/albumin may be useful predictive markers for advanced stage in colon cancer. According to the receiver operating characteristic analysis results, CRP/albumin ratio can be used to discriminate early from late stage. Preoperative low monocyte count and PNI are associated with postoperative staging patients with colon cancer.
MeSH term(s)	Albumins ; Biomarkers ; Colonic Neoplasms/surgery ; Humans ; Leukocyte Count ; Lymphocytes ; Neutrophils ; Prognosis ; Retrospective Studies
Chemical Substances	Albumins ; Biomarkers
Language	English
Publishing date	2021-02-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/0003134821995059
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Article ; Online: Clinicopathological features and management of colonic lipomas: Case reports.

Erginoz, Ergin / Uludag, Server Sezgin / Cavus, Gokce Hande / Zengin, Kagan / Ozcelik, Mehmet Faik

Medicine

2022 Volume 101, Issue 10, Page(s) e29004

Abstract: Introduction: Colonic lipomas are benign tumors of adipose tissue that are often asymptomatic, but they may present with rectal bleeding or obstructive symptoms. These tumors are unique in that they are rarely encountered within the gastrointestinal ... ...

Abstract	Introduction: Colonic lipomas are benign tumors of adipose tissue that are often asymptomatic, but they may present with rectal bleeding or obstructive symptoms. These tumors are unique in that they are rarely encountered within the gastrointestinal system and can mimic malignant tumors in appearance. Surgical resection and endoscopic removal of tumors have been shown to be successful in their management. Patient concerns: In this report, we present 3 cases of colonic lipomas, 2 of which are located in the cecum and the other within the sigmoid colon. The presenting symptoms of the patients included abdominal pain, constipation, and dyspepsia. Diagnosis: Patients typically presented with anemia and an elevated C-reactive protein count. Colonoscopic and computerized tomography findings were used for diagnosis. Interventions: Hemicolectomy was performed, depending on the localization, and the pathologic specimens were consistent with lipoma. Outcomes: Surgical resection was curative in all patients. The postoperative period was uneventful in all patients and all patients are symptom-free and alive at 3 years follow-up. Conclusion: Colonic lipomas are benign mesenchymal tumors of the gastrointestinal system with a male predominance and are observed within the fourth to sixth decades of life. Various genetic abnormalities have been reported and they have been linked to the formation of intussusception. The squeeze sign on radiological imaging, cushion sign and tenting sign in colonoscopy, and naked fat sign during pathologic examination is helpful towards reaching a diagnosis. Surgical resection is the treatment of choice but minimally invasive endoscopic approaches have also been shown to be successful.
MeSH term(s)	Colectomy/methods ; Colonic Neoplasms/diagnosis ; Colonic Neoplasms/pathology ; Colonic Neoplasms/surgery ; Colonoscopy ; Female ; Humans ; Intussusception/surgery ; Lipoma/diagnosis ; Lipoma/pathology ; Lipoma/surgery ; Male
Language	English
Publishing date	2022-03-11
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000029004
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Article: Pancreaticogastrostomy for pancreatic body cystic neoplasms: An organ-sparing approach.

Orhan, Orhan / Carkman, Sinan / Erginoz, Ergin / Ozcelik, Mehmet Faik

International journal of surgery case reports

2020 Volume 76, Page(s) 153–155

Abstract: Introduction: Surgical management of pancreatic cysts differ according to the specific location of the cyst on the pancreas. Cysts located on the pancreatic head require a radical procedure such as pancreaticoduodenectomy (Whipple procedure). Cysts of ... ...

Abstract	Introduction: Surgical management of pancreatic cysts differ according to the specific location of the cyst on the pancreas. Cysts located on the pancreatic head require a radical procedure such as pancreaticoduodenectomy (Whipple procedure). Cysts of the pancreatic body or tail, however, require distal pancreatectomy as the standard surgical approach. An alternative surgical approach for cysts located in the mid-pancreas is central pancreatectomy with distal pancreaticogastrostomy. Presentation of case: In this report, we present a case of a 22-year-old woman with a cyst located on the mid-pancreas consistent with a solid pseudopapillary neoplasia. Central pancreatectomy with distal pancreaticogastrostomy was the surgical technique of choice performed in this case. Discussion: Central pancreatectomy has emerged as an alternative surgical approach to mid-pancreatic cysts which includes only the removal of a segment of the pancreas, thereby sparing the distal parenchyma. Compared with the traditional approach, this technique of partial resection of the pancreatic tissue is desirable due to its organ-sparing function. Conclusion: Central pancreatectomy with distal pancreaticogastrostomy can be an alternative to distal pancreatectomy for cysts located in the mid-pancreatic region. This rare procedure prevents any unnecessary healthy pancreatic tissue loss, reduces the risk of developing complications, and is an alternative treatment of choice to distal pancreatectomy.
Keywords	covid19
Language	English
Publishing date	2020-09-30
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2020.09.189
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Article: Effects of hypertonic saline replacement on colonic anastomosis in experimental hemorrhagic shock model in rats.

Karaduman, Zekeriya / Akıncı, Ozan / Tosun, Yasin / Abdulrahman, Sangar Mfaroq / Kepil, Nuray / Özçelik, Mehmet Faik

Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

2021 Volume 27, Issue 6, Page(s) 613–618

Abstract: Background: Inadequate intestinal perfusion resulting from hemorrhagic shock negatively affects wound healing. In this experimental study, we aimed to evaluate the effects of resuscitation with hypertonic saline on colonic anastomosis in rats with ... ...

Title translation	Sıçanlarda deneysel hemorajik şok modelinde hipertonik salin replasmanının kolon anastomozu üzerine etkileri.
Abstract	Background: Inadequate intestinal perfusion resulting from hemorrhagic shock negatively affects wound healing. In this experimental study, we aimed to evaluate the effects of resuscitation with hypertonic saline on colonic anastomosis in rats with controlled hemorrhagic shock. Methods: A total of 24 male Wistar albino rats weighing between 200 and 250 g were used in this study. The rats were divided into four groups as: Control, hypotonic, isotonic, and hypertonic. Median laparotomy, colon resection, and colocolonic anastomosis were performed to the rats in the control group. After creating controlled hemorrhagic shock to rats in other three groups, resuscitation was achieved with hypotonic, isotonic, and hypertonic saline. After resuscitation, median laparotomy, colon resection, and colocolonic anastomosis were performed on rats in these three groups. On the 5th post-operative day, a median laparotomy was applied to the rats in all groups and anastomosis lines were evaluated. Anastomotic bursting pressure, tissue hydroxyproline level, and tissue fibrosis degree were compared between the groups. Results: There was no statistically significant difference between the groups in terms of anastomotic bursting pressure, tissue hydroxyproline level, and tissue fibrosis degree (respectively; p=0.320, p=0.537, p>0.05). Conclusion: In rats with controlled hemorrhagic shock, resuscitation with hypertonic saline does not differ significantly from isotonic or hypotonic saline in terms of healing of colonic anastomosis.
MeSH term(s)	Anastomosis, Surgical ; Animals ; Colon/surgery ; Hydroxyproline ; Male ; Rats ; Rats, Wistar ; Saline Solution, Hypertonic ; Shock, Hemorrhagic/therapy
Chemical Substances	Saline Solution, Hypertonic ; Hydroxyproline (RMB44WO89X)
Language	English
Publishing date	2021-11-23
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2253739-9
ISSN	1306-696X
ISSN	1306-696X
DOI	10.14744/tjtes.2020.00268
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Article ; Online: An investigation into the predictive role of serum inflammatory parameters in the diagnosis of complicated acute cholecystitis.

Uludağ, Server Sezgin / Akıncı, Ozan / Güreş, Nazım / Tosun, Yasin / Şanlı, Ahmet Necati / Zengin, Abdullah Kağan / Özçelik, Mehmet Faik

Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

2022 Volume 28, Issue 6, Page(s) 818–823

Abstract: Background: Gallbladder gangrene and perforation are an important complication of acute calculous cholecystitis and are dif-ficult to detect preoperatively. Therefore, in this study, we aimed to evaluate whether serum inflammatory parameters are ... ...

Title translation	Komplike akut kolesistit tanısında serum enflamatuvar parametrelerin öngörücü rolüne yönelik bir araştırma.
Abstract	Background: Gallbladder gangrene and perforation are an important complication of acute calculous cholecystitis and are dif-ficult to detect preoperatively. Therefore, in this study, we aimed to evaluate whether serum inflammatory parameters are predictive factors for complicated cholecystitis (CC). Methods: In the present study, histopathological findings of 250 patients who were operated on with the diagnosis of acute chole-cystitis (AC) in the emergency department between 2014 and 2019 were evaluated and the cases were divided into two groups as AC and CC. Parameters, including age, gender, body mass index, white blood cell (WBC) count, C-reactive protein (CRP), neutrophil-to-lym-phocyte ratio (NLR), mean platelet volume (MPV), and platelet distribution width (PDW), were examined for their ability to predict CC. Results: The findings obtained in this study showed that WBC, CRP, and NLR were significantly higher in the CC group (p<0.05). WBC >9.000 cells/ml, CRP >29.0, and NLR >4.3 were the factors that could predict CC. There was no significant difference between the two groups concerning MPV and PDW (p>0.05). CC was observed more frequently in patients over 65 years of age, but there was not a statistically significant difference (p=0468). Conclusion: WBC, CRP, and NLR are valuable biochemical markers in predicting complicated AC. Advanced age may be a help-ful predictive factor for CC. These factors may be helpful in making an early cholecystectomy decision.
MeSH term(s)	Acute Disease ; C-Reactive Protein/analysis ; Cholecystitis, Acute/diagnosis ; Cholecystitis, Acute/surgery ; Humans ; Inflammation/diagnosis ; Leukocyte Count ; Mean Platelet Volume
Chemical Substances	C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2022-05-31
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2253739-9
ISSN	1307-7945 ; 1306-696X
ISSN (online)	1307-7945
ISSN	1306-696X
DOI	10.14744/tjtes.2021.35923
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Article ; Online: Effectiveness of pre-operative routine blood tests in predicting complicated acute appendicitis.

Uludağ, Server Sezgin / Akıncı, Ozan / Güreş, Nazim / Tunç, Emre / Erginöz, Ergin / Şanlı, Ahmet Necati / Zengin, Abdullah Kağan / Özçelik, Mehmet Faik

Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

2022 Volume 28, Issue 11, Page(s) 1590–1596

Abstract: Background: Early prediction and diagnosis of perforation in acute appendicitis allow surgeons to choose the most appropriate treatment. The purpose of this study is to evaluate whether pre-operative routine laboratory examinations have a role in ... ...

Title translation	Komplike akut apandisiti öngörmede ameliyat öncesi rutin kan testlerinin etkinliği.
Abstract	Background: Early prediction and diagnosis of perforation in acute appendicitis allow surgeons to choose the most appropriate treatment. The purpose of this study is to evaluate whether pre-operative routine laboratory examinations have a role in predicting complicated acute appendicitis. Methods: In the study, 783 patients operated with the diagnosis of acute appendicitis between the years 2014 and 2019 were analyzed retrospectively. Among the patients with non-perforated and perforated acute appendicitis, pre-operative laboratory tests include leukocyte (WBC), neutrophil, lymphocyte, platelet (PLT), mean platelet volume (MPV), platelet distribution width (PDW), C-reactive protein (CRP), and neutrophil-to-lymphocyte rate (NLR) parameters were compared. Results: Appendicitis was not detected histopathologically in 81 cases. In the study, 89.9% (n=631) of the 702 patients were non-perforated and 10.1% (n=71) were perforated acute appendicitis cases. Perforation rate was higher in elderly patients (p<0.01). It was seen that lymphocyte count was significantly lower in the perforated group, and CRP and NLR were significantly higher (p=0.048, p=0.001, p=0.028, respectively). In the diagnosis of perforated acute appendicitis, cutoff values were 44.0 mg/dL for CRP, 7.65 for NLR and 1.7/mm3 for lymphocytes. There was no statistical difference between the groups in terms of WBC, neutrophil, PLT, MPV, and PDW values. Conclusion: Low lymphocyte count, high CRP, and high NLR were found to be reliable and strong predictive parameters in the diagnosis of complicated acute appendicitis.
MeSH term(s)	Humans ; Aged ; Leukocyte Count ; C-Reactive Protein/analysis ; Retrospective Studies ; Appendicitis/diagnosis ; Appendicitis/surgery ; Mean Platelet Volume ; Acute Disease ; Biomarkers
Chemical Substances	C-Reactive Protein (9007-41-4) ; Biomarkers
Language	English
Publishing date	2022-10-25
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2253739-9
ISSN	1307-7945 ; 1306-696X
ISSN (online)	1307-7945
ISSN	1306-696X
DOI	10.14744/tjtes.2021.13472
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Article ; Online: Investigating the correlation between severe acute pancreatitis and pancreatic necrosis with some serum parameters.

Uludağ, Server Sezgin / Güreş, Nazim / Şirolu, Sabri / Aşkar, Ahmet / Şanlı, Ahmet Necati / Zengin, Abdullah Kağan / Özçelik, Mehmet Faik

Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

2022 Volume 28, Issue 11, Page(s) 1609–1615

Abstract: Background: Acute pancreatitis (AP) is a disease related to significant morbidity and even mortality. Various factors are involved in the etiology, especially gallstones and excessive alcohol consumption. Although, the course of the disease in most of ... ...

Title translation	Bazı serum parametreleri ile şiddetli akut pankreatit ve pankreas nekrozu arasındaki ilişkinin araştırılması.
Abstract	Background: Acute pancreatitis (AP) is a disease related to significant morbidity and even mortality. Various factors are involved in the etiology, especially gallstones and excessive alcohol consumption. Although, the course of the disease in most of the cases is generally mild, in some cases, the disease can be severe and lead to pancreatic or peripancreatic necrosis. Radiologically, 'Balthazar computed tomography severity index' (CTSI) is used to assess the severity and presence of necrosis in pancreatitis. In this study, we classified the severity of AP in patients with Balthazar CTSI and investigated whether there is a correlation between some serum parameters and AP severity and which serum parameters can be used as a safe marker to predict the AP severity and the development of pancreatic necrosis (PN). Methods: A total of 341 patients diagnosed with AP and hospitalized in our general surgery clinic between the years 2012 and 2018 were included in this study. Hematological and biochemical parameters of the patients were recorded. Abdominal CT's of the patients were evaluated according to the Balthazar CTSI. The correlation between these parameters and AP severity evaluated by Balthazar CTSI was investigated. Results: PN was detected in 19.4% of 341 patients who participated in the study. Patients whose PN detected in their abdominal CT's by Balthazar CTSI; neutrophil counts, neutrophil/lymphocyte ratio (NLR), thrombocyte/lymphocyte ratio, plateletlymphocyte ratio, and neutrophil/monocyte ratio (NMR) were significantly higher and the serum albumin was significantly lower than patients with PN. Conclusion: Neutrophil count, serum albumin levels, NLR, LR, and NMR can be used as predictive markers to determine AP severity.
MeSH term(s)	Humans ; Pancreatitis, Acute Necrotizing/diagnostic imaging ; Acute Disease ; Severity of Illness Index ; Biomarkers ; Serum Albumin ; Necrosis ; Prognosis ; Retrospective Studies
Chemical Substances	Biomarkers ; Serum Albumin
Language	English
Publishing date	2022-10-25
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2253739-9
ISSN	1307-7945 ; 1306-696X
ISSN (online)	1307-7945
ISSN	1306-696X
DOI	10.14744/tjtes.2021.96782
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Article: The effect of Amifostine (Ethyol) on intestinal anastomosis in rats with radiation enteritis.

Ozdemir, C S / Burgazli, K M / Beken-Ozdemir, E / Akdere, H / Mericliler, M / Ozcelik, M F

European review for medical and pharmacological sciences

2013 Volume 17, Issue 10, Page(s) 1351–1359

Abstract: Background: Preoperative radiotherapy in colorectal cancers is being used as an adjuvant therapy with increasing frequency. Postoperative complications in early and late periods in various ratios are reported. It has also been shown that radiation has a ...

Abstract	Background: Preoperative radiotherapy in colorectal cancers is being used as an adjuvant therapy with increasing frequency. Postoperative complications in early and late periods in various ratios are reported. It has also been shown that radiation has a delaying effect on wound healing and this effect is dose-dependent. Aim: This study investigated the effects of the Amifostine on healing of the irradiated colonic anastomosis. Materials and methods: 30 female Wistar rats were divided randomly into three groups equally (n=10). Colonic anastomosis were performed to all rats. Group I served as a control. 800 rad abdominopelvic irradiation on the 5th day of preoperation was given to group II and III. Rats in the group III, prior to radiation, were given Amifostine at a dose of 200 mg/kg. On the 5th postoperative day all the rats were sacrificed and the healing of anastomosis was measured with bursting pressure, hydroxyproline levels and histopathological evaluations. Statistical analyses were expressed by analysis of variance (ANOVA) test and p < 0.05 was regarded as significant. Results: In group II, all parameters were found lower compared with control group and Amifostine+Radiation group. As compared with hydroxyproline values and the anastomotic wound healing scores, except group II, no significantly difference were determined between the two other groups. In bursting pressure levels, Group I and III were higher than group II, but not statistically significant (p > 0.05). In group III (Amifostine+Radiation group), the hydroxyproline levels and anastomotic wound healing scores were found significantly higher than group II (p < 0.05), and no significant difference were found between the control group. Conclusions: It is determined that radiation given on the 5th preoperative day has a negative effect on anastomotic wound healing and administered Amifostine prevent this negative effect. In the light of these data, the Amifostine may have a positive effect on preoperative irradiated colonic anastomosis and may play an important role in future on the supporting of the colonic anastomosis.
MeSH term(s)	Amifostine/pharmacology ; Anastomosis, Surgical ; Animals ; Colon/surgery ; Enteritis/physiopathology ; Female ; Hydroxyproline/analysis ; Radiation Injuries/physiopathology ; Radiation-Protective Agents/pharmacology ; Radiotherapy/adverse effects ; Rats ; Rats, Wistar ; Wound Healing/radiation effects
Chemical Substances	Radiation-Protective Agents ; Amifostine (M487QF2F4V) ; Hydroxyproline (RMB44WO89X)
Language	English
Publishing date	2013-05
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
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Article: The effect of halofuginone, a specific inhibitor of collagen type 1 synthesis, in the prevention of esophageal strictures related to caustic injury.

Ozçelik, Mehmet Faik / Pekmezci, Salih / Saribeyoğlu, Kaya / Unal, Ethem / Gümüştaş, Koray / Doğusoy, Gülen

American journal of surgery

2004 Volume 187, Issue 2, Page(s) 257–260

Abstract: Background: To assess the effects of halofuginone, a specific inhibitor of synthesis of collagen type 1, which is the major constituent of fibrosis, on esophageal stricture formation due to caustic ingestion.: Methods: Sixty rats were divided into ... ...

Abstract	Background: To assess the effects of halofuginone, a specific inhibitor of synthesis of collagen type 1, which is the major constituent of fibrosis, on esophageal stricture formation due to caustic ingestion. Methods: Sixty rats were divided into four equal groups: control group; sham laparotomy group; caustic injury without treatment group; caustic injury with halofuginone treatment group. Caustic injuries were done by 50% sodium hydroxide. Halofuginone was administered by the first postoperative day. All animals were sacrificed on day 21; and the results were evaluated by hydroxyproline levels, stenosis index, lumen diameter, histopathological evaluation, wall thickness, and animal weights. Results: Mortality differences were significant comparing group 3 with group 1 and 2 (P = 0.006) and group 4 (P = 0.03). According to hydroxyproline levels, the differences are significantly higher (P <0.001) comparing group 3 with group 1, 2, and 4. The P value was considered significant in all other parameters (P <0.001) for all the groups but group 1 versus group 2 (P >0.05). Conclusions: Halofuginone, a specific inhibitor of collagen type 1 synthesis, significantly reduced esophageal stricture occurrence.
MeSH term(s)	Animals ; Burns, Chemical/complications ; Burns, Chemical/drug therapy ; Caustics ; Collagen Type I/antagonists & inhibitors ; Esophageal Stenosis/etiology ; Esophageal Stenosis/prevention & control ; Esophagus/drug effects ; Esophagus/pathology ; Fibrosis ; Injections, Intraperitoneal ; Male ; Models, Animal ; Piperidines ; Protein Synthesis Inhibitors/administration & dosage ; Protein Synthesis Inhibitors/pharmacology ; Quinazolines/administration & dosage ; Quinazolines/pharmacology ; Quinazolinones ; Rats ; Rats, Sprague-Dawley ; Sodium Hydroxide
Chemical Substances	Caustics ; Collagen Type I ; Piperidines ; Protein Synthesis Inhibitors ; Quinazolines ; Quinazolinones ; Sodium Hydroxide (55X04QC32I) ; halofuginone (L31MM1385E)
Language	English
Publishing date	2004-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2003.11.008
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