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  1. Article ; Online: A Novel Green Micellar HPLC-UV Method for the Estimation of Vandetanib in Pure Form, Human Urine, Human Plasma and Human Liver Microsomes Matrices with Application to Metabolic Stability Evaluation.

    Alanazi, Mohammed M / Obaidullah, Ahmad J / Attwa, Mohamed W

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 24

    Abstract: Vandetanib ( ... ...

    Abstract Vandetanib (Caprelsa
    Language English
    Publishing date 2022-12-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27249038
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  2. Article: Hepatoprotective and cardioprotective effect of

    Thakur, Shalini / Kumar, Rakesh / Asrani, R K / Thakur, Meenakshi / Patel, Shailesh Kumar / Patil, Rajendra Damu / Obaidullah, Ahmad J / Emran, Talha Bin

    Heliyon

    2024  Volume 10, Issue 4, Page(s) e25709

    Abstract: Artemisia ... ...

    Abstract Artemisia nilagirica
    Language English
    Publishing date 2024-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e25709
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  3. Article ; Online: Unraveling the impact of digital transformation on green innovation through microdata and machine learning.

    Han, Yuangang / Li, Zhentao / Feng, Tianchu / Qiu, Shilei / Hu, Jin / Yadav, Krishna Kumar / Obaidullah, Ahmad J

    Journal of environmental management

    2024  Volume 354, Page(s) 120271

    Abstract: How to use digitalization to support the green transformation of organizations has drawn much attention based on the rapid development of digitalization. However, digital transformation (DT) may be hindered by the "IT productivity paradox." Exploring the ...

    Abstract How to use digitalization to support the green transformation of organizations has drawn much attention based on the rapid development of digitalization. However, digital transformation (DT) may be hindered by the "IT productivity paradox." Exploring the influence of DT on green innovation, we analyze panel data encompassing A-share listed companies in Shanghai and Shenzhen spanning the period from 2010 to 2018. It tests the DT's non-linear impact, employing a random-forest and mediation effect models. The results reveal that (i) DT can promote green innovation; (ii) regarding heterogeneity, the promotion effect is mainly manifested in enterprises in non-state-owned and highly competitive industries; (iii) based on mechanism testing, DT relies on two routes to encourage green innovation: improving environmental information disclosure and reducing environmental uncertainty; and (iv) random-forest analysis shows that DT exhibits an inverted U-shaped non-linear effect on green innovation, including the "IT productivity paradox." This study enhances the existing discourse on DT and green innovation by furnishing empirical substantiation for the non-linear influence exerted by DT on green innovation. Furthermore, it imparts insights into the mechanisms and contextual limitations governing this association.
    MeSH term(s) China ; Machine Learning ; Disclosure ; Industry ; Uncertainty
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2024.120271
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    In stock of ZB MED Bonn / Germany

    Z 7556: Show issues

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  4. Article ; Online: In Vitro Evaluation and Bioinformatics Analysis of Schiff Bases Bearing Pyrazole Scaffold as Bioactive Agents: Antioxidant, Anti-Diabetic, Anti-Alzheimer, and Anti-Arthritic.

    Alkahtani, Hamad M / Almehizia, Abdulrahman A / Al-Omar, Mohamed A / Obaidullah, Ahmad J / Zen, Amer A / Hassan, Ashraf S / Aboulthana, Wael M

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 20

    Abstract: In continuation of our research programs for the discovery, production, and development of the pharmacological activities of molecules for various disease treatments, Schiff bases and pyrazole scaffold have a broad spectrum of activities in biological ... ...

    Abstract In continuation of our research programs for the discovery, production, and development of the pharmacological activities of molecules for various disease treatments, Schiff bases and pyrazole scaffold have a broad spectrum of activities in biological applications. In this context, this manuscript aims to evaluate and study Schiff base-pyrazole molecules as a new class of antioxidant (total antioxidant capacity, iron-reducing power, scavenging activity against DPPH, and ABTS radicals), anti-diabetic (α-amylase% inhibition), anti-Alzheimer's (acetylcholinesterase% inhibition), and anti-arthritic (protein denaturation% and proteinase enzyme% inhibitions) therapeutics. Therefore, the Schiff bases bearing pyrazole scaffold (
    MeSH term(s) Antioxidants/pharmacology ; Antioxidants/chemistry ; Schiff Bases/chemistry ; Acetylcholinesterase/metabolism ; Pyrazoles ; alpha-Amylases ; Molecular Structure ; Molecular Docking Simulation
    Chemical Substances Antioxidants ; Schiff Bases ; Acetylcholinesterase (EC 3.1.1.7) ; Pyrazoles ; alpha-Amylases (EC 3.2.1.1)
    Language English
    Publishing date 2023-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28207125
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  5. Article ; Online: Nematicidal Characterization of Newly Synthesized Thiazine Derivatives Using

    Khan, Naqeeb Ullah / Sajid, Muhammad / Obaidullah, Ahmad J / Rehman, Wajid / Faris Alotaibi, Hadil / Bibi, Saira / Alanazi, Mohammed M

    ACS omega

    2023  Volume 8, Issue 23, Page(s) 20767–20778

    Abstract: In humans, animals, and agriculture, parasitic nematode infection is a very serious issue. Many drugs are being used to control nematode infections. Owing to toxicity and nematodes' resistance to the available drugs, special attention is required to ... ...

    Abstract In humans, animals, and agriculture, parasitic nematode infection is a very serious issue. Many drugs are being used to control nematode infections. Owing to toxicity and nematodes' resistance to the available drugs, special attention is required to synthesize new drugs that are environmentally friendly with high-level efficacy. In the present study, various substituted thiazine derivatives (1 to 15) were synthesized, and the structures were confirmed by infrared, proton (
    Language English
    Publishing date 2023-06-03
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c01378
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  6. Article: Controlled Size Oils Based Green Fabrication of Silver Nanoparticles for Photocatalytic and Antimicrobial Application.

    Pervaiz, Seemab / Bibi, Iram / Rehman, Wajid / Alotaibi, Hadil Faris / Obaidullah, Ahmad J / Rasheed, Liaqat / M Alanazi, Mohammed

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 7

    Abstract: The particle size at the nanometric level allows the manifestation of remarkable properties, chiefly due to changes in surface-to-volume ratio. This study is attributed to the novel green synthesis of nano silver by using essential oils as a capping and ... ...

    Abstract The particle size at the nanometric level allows the manifestation of remarkable properties, chiefly due to changes in surface-to-volume ratio. This study is attributed to the novel green synthesis of nano silver by using essential oils as a capping and reducing agent. Clove oil, cinnamon oil, and cardamom oil were selected for the eco-friendly and low-cost fabrication of silver nanoparticles. The prepared nanoparticles were characterized by photoluminescence spectroscopy, FT-IR spectroscopy, X-Ray diffraction, energy dispersive X-ray spectroscopy, dynamic laser light scattering, thermogravimetric analysis, and transmission electron microscopy. It was found that samples prepared by using cinnamon oil (20 nm) and cardamom oil (12 nm) had smaller particle sizes as compared to those synthesized by using clove oil (45 nm). All the prepared samples exhibited very strong antimicrobial activities with a clear zone of inhibition (6-24 mm) against
    Language English
    Publishing date 2023-06-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12071090
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  7. Article: Ethnomedicinal values of

    Das, Sarita / Singh, Puneet K / Ameeruddin, Shaikh / Kumar Bindhani, Birendra / Obaidullah, Wajdi J / Obaidullah, Ahmad J / Mishra, Snehasish / Mohapatra, Ranjan K

    Frontiers in chemistry

    2023  Volume 11, Page(s) 1297300

    Abstract: Ethnopharmacological relevance: ...

    Abstract Ethnopharmacological relevance:
    Language English
    Publishing date 2023-11-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2023.1297300
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  8. Article: In Vitro Cytotoxicity and In Vivo Antitumor Activity of Lipid Nanocapsules Loaded with Novel Pyridine Derivatives.

    Abu Lila, Amr Selim / Amran, Mohammed / Tantawy, Mohamed A / Moglad, Ehssan H / Gad, Shadeed / Alotaibi, Hadil Faris / Obaidullah, Ahmad J / Khafagy, El-Sayed

    Pharmaceutics

    2023  Volume 15, Issue 6

    Abstract: This study demonstrates high drug-loading of novel pyridine derivatives (S1-S4) in lipid- and polymer-based core-shell nanocapsules (LPNCs) for boosting the anticancer efficiency and alleviating toxicity of these novel pyridine derivatives. The ... ...

    Abstract This study demonstrates high drug-loading of novel pyridine derivatives (S1-S4) in lipid- and polymer-based core-shell nanocapsules (LPNCs) for boosting the anticancer efficiency and alleviating toxicity of these novel pyridine derivatives. The nanocapsules were fabricated using a nanoprecipitation technique and characterized for particle size, surface morphology, and entrapment efficiency. The prepared nanocapsules exhibited a particle size ranging from 185.0 ± 17.4 to 223.0 ± 15.3 nm and a drug entrapment of >90%. The microscopic evaluation demonstrated spherical-shaped nanocapsules with distinct core-shell structures. The in vitro release study depicted a biphasic and sustained release pattern of test compounds from the nanocapsules. In addition, it was obvious from the cytotoxicity studies that the nanocapsules showed superior cytotoxicity against both MCF-7 and A549 cancer cell lines, as manifested by a significant decrease in the IC
    Language English
    Publishing date 2023-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15061755
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  9. Article ; Online: A systematic review on Nb

    Ahmad, Irshad / Al-Qattan, Ayman / Iqbal, Muhammad Zaheer / Anas, Alkhouri / Khasawneh, Mohammad Ahmad / Obaidullah, Ahmad J / Mahal, Ahmed / Duan, Meitao / Al Zoubi, Wail / Ghadi, Yazeed Yasin / Al-Zaqri, Nabil / Xia, Changlei

    Advances in colloid and interface science

    2024  Volume 324, Page(s) 103093

    Abstract: With the increasing popularity of photocatalytic technology and the highly growing issues of energy scarcity and environmental pollution, there is an increasing interest in extremely efficient photocatalytic systems. The widespread immense attention and ... ...

    Abstract With the increasing popularity of photocatalytic technology and the highly growing issues of energy scarcity and environmental pollution, there is an increasing interest in extremely efficient photocatalytic systems. The widespread immense attention and applicability of Nb
    Language English
    Publishing date 2024-01-26
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 210507-x
    ISSN 1873-3727 ; 0001-8686
    ISSN (online) 1873-3727
    ISSN 0001-8686
    DOI 10.1016/j.cis.2024.103093
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2716: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Histological assessment, anti-quorum sensing, and anti-biofilm activities of Dioon spinulosum extract: in vitro and in vivo approach.

    Elekhnawy, Engy / Negm, Walaa A / El-Aasr, Mona / Kamer, Amal Abo / Alqarni, Mohammed / Batiha, Gaber El-Saber / Obaidullah, Ahmad J / Fawzy, Heba M

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 180

    Abstract: Pseudomonas aeruginosa is an opportunistic bacterium causing several health problems and having many virulence factors like biofilm formation on different surfaces. There is a significant need to develop new antimicrobials due to the spreading resistance ...

    Abstract Pseudomonas aeruginosa is an opportunistic bacterium causing several health problems and having many virulence factors like biofilm formation on different surfaces. There is a significant need to develop new antimicrobials due to the spreading resistance to the commonly used antibiotics, partly attributed to biofilm formation. Consequently, this study aimed to investigate the anti-biofilm and anti-quorum sensing activities of Dioon spinulosum, Dyer Ex Eichler extract (DSE), against Pseudomonas aeruginosa clinical isolates. DSE exhibited a reduction in the biofilm formation by P. aeruginosa isolates both in vitro and in vivo rat models. It also resulted in a decrease in cell surface hydrophobicity and exopolysaccharide quantity of P. aeruginosa isolates. Both bright field and scanning electron microscopes provided evidence for the inhibiting ability of DSE on biofilm formation. Moreover, it reduced violacein production by Chromobacterium violaceum (ATCC 12,472). It decreased the relative expression of 4 quorum sensing genes (lasI, lasR, rhlI, rhlR) and the biofilm gene (ndvB) using qRT-PCR. Furthermore, DSE presented a cytotoxic activity with IC
    MeSH term(s) Animals ; Anti-Bacterial Agents/isolation & purification ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biofilms/drug effects ; Biofilms/growth & development ; Chromobacterium/drug effects ; Chromobacterium/growth & development ; Chromobacterium/metabolism ; Disease Models, Animal ; Female ; Gene Expression Regulation, Bacterial ; Indoles/metabolism ; Microbial Sensitivity Tests ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Pseudomonas Infections/microbiology ; Pseudomonas Infections/pathology ; Pseudomonas Infections/prevention & control ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/growth & development ; Pseudomonas aeruginosa/metabolism ; Quorum Sensing/drug effects ; Rats ; Skin Diseases, Bacterial/microbiology ; Skin Diseases, Bacterial/pathology ; Skin Diseases, Bacterial/prevention & control ; Zamiaceae/chemistry
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; Indoles ; Plant Extracts ; violacein (QJH0DSQ3SG)
    Language English
    Publishing date 2022-01-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-03953-x
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