Article ; Online: Subcallosal cingulate deep brain stimulation evokes two distinct cortical responses via differential white matter activation.
Proceedings of the National Academy of Sciences of the United States of America
2024 Volume 121, Issue 14, Page(s) e2314918121
Abstract: Subcallosal cingulate (SCC) deep brain stimulation (DBS) is an emerging therapy for refractory depression. Good clinical outcomes are associated with the activation of white matter adjacent to the SCC. This activation produces a signature cortical evoked ...
| Abstract | Subcallosal cingulate (SCC) deep brain stimulation (DBS) is an emerging therapy for refractory depression. Good clinical outcomes are associated with the activation of white matter adjacent to the SCC. This activation produces a signature cortical evoked potential (EP), but it is unclear which of the many pathways in the vicinity of SCC is responsible for driving this response. Individualized biophysical models were built to achieve selective engagement of two target bundles: either the forceps minor (FM) or cingulum bundle (CB). Unilateral 2 Hz stimulation was performed in seven patients with treatment-resistant depression who responded to SCC DBS, and EPs were recorded using 256-sensor scalp electroencephalography. Two distinct EPs were observed: a 120 ms symmetric response spanning both hemispheres and a 60 ms asymmetrical EP. Activation of FM correlated with the symmetrical EPs, while activation of CB was correlated with the asymmetrical EPs. These results support prior model predictions that these two pathways are predominantly activated by clinical SCC DBS and provide first evidence of a link between cortical EPs and selective fiber bundle activation. |
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| MeSH term(s) | Humans ; Deep Brain Stimulation/methods ; White Matter ; Gyrus Cinguli/physiology ; Corpus Callosum ; Evoked Potentials |
| Language | English |
| Publishing date | 2024-03-25 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 209104-5 |
| ISSN | 1091-6490 ; 0027-8424 |
| ISSN (online) | 1091-6490 |
| ISSN | 0027-8424 |
| DOI | 10.1073/pnas.2314918121 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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