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  1. Article ; Online: Predictive Value of Tumor-Infiltrating Lymphocytes and Ki-67 for Pathological Response to Total Neoadjuvant Therapy in Rectal Cancer.

    Mohammed, Amrallah / Bakry, Adel / Gharieb, Shimaa / Hanna, Amira / Obaya, Ahmed / Abdelhady, Waleed / Metwalli, Abdelrahman

    Journal of gastrointestinal cancer

    2024  

    Abstract: Purpose: Patients with locally advanced rectal cancer (LARC) who underwent total neoadjuvant therapy (TNT) showed an increase in the percentage of complete pathological response (pCR). The purpose of this study was to determine the correlation between ... ...

    Abstract Purpose: Patients with locally advanced rectal cancer (LARC) who underwent total neoadjuvant therapy (TNT) showed an increase in the percentage of complete pathological response (pCR). The purpose of this study was to determine the correlation between Ki-67, tumor-infiltrating lymphocytes (TIL), and TNT in LARC patients.
    Method: In total, one hundred fifty-nine patients with LARC were included in this prospective study. The international working group was used to categorize the TIL into three groups based on the percentage and density of staining: group 0 (0-10%), group 1 (11-59%), and group 2 (≥ 60%). Ki-67 expression was classified as low (≤ 50%) or high (> 50%).
    Result: Most patients had tumor grade III (74.2%) and T2-T3 (78.6%). Lymph node involvement (48.7%) and tumor size ≥ 3 cm were detected in approximately half of the patients. Forty-four percent of patients had a high Ki-67 index; 15.7% of patients belonged to group 1, and 21.4% belonged to group 2. pCR was detected in 18.2% of the patients. TIL and Ki-67 levels were significantly correlated with pCR (p = 0.001 and 0.003 for multivariate analysis and 0.001 and 0.03 for univariate analysis, respectively).
    Conclusion: There was a statistically significant correlation between Ki-67, TIL, and pCR following TNT protocol, which may help maximize the therapeutic outcome.
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452514-5
    ISSN 1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
    ISSN (online) 1941-6636 ; 1559-0739
    ISSN 1941-6628 ; 1537-3649
    DOI 10.1007/s12029-024-01026-6
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    Zs.A 2184: Show issues Location:
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  2. Article ; Online: Expression of epithelial-mesenchymal transition biomarkers: Discoidin domain receptor 2, Snail-1, and Ovol-2 as predictors of clinical outcome in patients with epithelial ovarian carcinoma.

    Harb, Ola A / Elfeky, Mariem A / El-Beshbishi, Wafaa / Obaya, Ahmed A / Abdallah, Wael M / Ibrahim, Amr / Awd, Amr A / Embaby, Ahmed

    Journal of cancer research and therapeutics

    2022  Volume 18, Issue 4, Page(s) 1073–1082

    Abstract: Context: Discoidin domain receptor 2 (DDR-2), which belongs to the receptor tyrosine kinase family, Snail-1, which is a member of zinc-finger transcription factor family, and Ovol-2, which is a member of Ovol family, are incriminated in epithelial- ... ...

    Abstract Context: Discoidin domain receptor 2 (DDR-2), which belongs to the receptor tyrosine kinase family, Snail-1, which is a member of zinc-finger transcription factor family, and Ovol-2, which is a member of Ovol family, are incriminated in epithelial-mesenchymal transition (EMT) during cancer progression.
    Aim: In the current study, we aim to clarify the extent to which EMT biomarkers, DDR-2, Snail-1, and Ovol-2 expression, are involved in the progression of EOC aiming at identification of novel markers for predicting the prognosis of EOC patients.
    Settings and design: This was a prospective cohort that was performed in the Faculty of Medicine, Zagazig University.
    Materials and methods: We evaluated DDR-2, Snail-1, and Ovol-2 expression in 60 patients of EOC using immunohistochemistry. We followed our patients for about 36 months and analyzed the relationship between markers expression and the prognosis of patients.
    Statistical analysis used: SPSS program (Statistical Package for the Social Sciences).
    Results: High expression of both DDR-2 and Snail-1 was related to higher grade (P = 0.006) and advanced FIGO stage of the tumor (P < 0.001). Ovol-2 high expression was associated with lower grade of the tumor (P = 0.002) and early stage of the tumor (P < 0.001). High Ovol-2 and low DDR2 and Snail-1 expression were strongly correlated with better response to therapy (P = 0.003 and 0.005, respectively) and increased 3-year survival rates (P < 0.001).
    Conclusion: DDR-2 and Snail-1 are markers of poor prognosis in EOC while Ovol-2 is a marker of good prognosis.
    MeSH term(s) Biomarkers ; Biomarkers, Tumor ; Carcinoma, Ovarian Epithelial ; Discoidin Domain Receptor 2 ; Epithelial-Mesenchymal Transition/genetics ; Female ; Humans ; Ovarian Neoplasms/pathology ; Prognosis ; Prospective Studies ; Snail Family Transcription Factors/genetics ; Snail Family Transcription Factors/metabolism ; Transcription Factors/metabolism ; Zinc
    Chemical Substances Biomarkers ; Biomarkers, Tumor ; Snail Family Transcription Factors ; Transcription Factors ; Discoidin Domain Receptor 2 (EC 2.7.10.1) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2022-09-16
    Publishing country India
    Document type Journal Article
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/jcrt.JCRT_605_19
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  3. Article ; Online: Evaluation of miRNA 223/125a and COBLL1 Expressions and ROR-1 Levels as Reliable Markers in B- chronic Lymphocytic Leukemia.

    Hussein, Samia / Abdelazem, Abdallah S / Abdelmoneem, Shimaa / Abdelnabi, Al-Shabrawy M / Khamis, Tarek / Obaya, Ahmed Ali / Ebian, Huda F

    Asian Pacific journal of cancer prevention : APJCP

    2022  Volume 23, Issue 8, Page(s) 2735–2742

    Abstract: Background: miRNA 223 /125a and Cordon-bleu Protein Like 1 (COBLL1) are novel biomarkers that can predict prognosis and guide treatment decisions in patients with chronic lymphocytic leukemia (CLL). Also, there is a growing interest in CLL monitoring ... ...

    Abstract Background: miRNA 223 /125a and Cordon-bleu Protein Like 1 (COBLL1) are novel biomarkers that can predict prognosis and guide treatment decisions in patients with chronic lymphocytic leukemia (CLL). Also, there is a growing interest in CLL monitoring based on flow cytometry of receptor tyrosine kinase-like orphan receptor-1 (ROR-1).  Objective: This study aimed to evaluate the relationship between miRNA 223 /125a and COBLL1 expressions and ROR-1 expression in patients with CLL. Also, the study evaluated the relationship between the expression of these biomarkers with tumor staging and cancer progression.
    Methods: Our study included 40 patients newly diagnosed with B-CLL. In peripheral blood (PB), miRNA 223/125a and COBLL1 expressions were detected by real-time polymerase chain reaction (real-time PCR) and ROR-1 percentage was detected by flow cytometry before and after treatment.  Results: High level of COBLL1 expression was statistically significantly associated with high ROR-1 percentage expression (P= 0.03). However, a high level of miRNA 223/125a expression was statistically significantly associated with low ROR-1 percentage expression (P=0.002). The sensitivity and specificity of ROR-1 as a predictor of high WBCs count after treatment were 96.6 and 81.1%, respectively. There was a statistically significant reduction of ROR-1 percentage after treatment compared to before treatment (P <0.001).
    Conclusion: ROR-1 percentage expression can be considered a possible prognostic predictor in CLL along with miRNA 223/125a and COBLL1 expressions. This can be explained by the significant correlation between ROR-1 and the studied molecular biomarkers; miRNA 223/125a and COBLL1. In addition, there was a significantly higher ROR-1 percentage in patients with higher WBC counts. Moreover, there was a significant reduction in ROR-1 percentage after treatment.
    MeSH term(s) Biomarkers ; Gene Expression ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; MicroRNAs/genetics ; Prognosis
    Chemical Substances Biomarkers ; MIRN223 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2022-08-01
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2022.23.8.2735
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  4. Article ; Online: Evaluating the value of Amphiregulin, Phosphatase and Tensin Homologue (PTEN) and P21 Expression for Anti-EGFR Treatment in Metastatic Colorectal Carcinoma.

    Obaya, Ahmed Ali / Mohammed, Amrallah A / Rashied, Hanaa / Morsy, Adel Mahmoud / Osman, Gamal / Allam, Ahmed S / Elsayed, Ahmed M / Harb, Ola A / Elsayed, Walid S H

    Asian Pacific journal of cancer prevention : APJCP

    2021  Volume 22, Issue 4, Page(s) 1025–1034

    Abstract: Background: Despite the significant progress in target therapy for the treatment of metastatic colorectal carcinoma (mCRC), the overall survival isn't satisfactory.: Methods: We assessed the expression of Amphiregulin, PTEN, and P21 in sections from ... ...

    Abstract Background: Despite the significant progress in target therapy for the treatment of metastatic colorectal carcinoma (mCRC), the overall survival isn't satisfactory.
    Methods: We assessed the expression of Amphiregulin, PTEN, and P21 in sections from 23 paraffin blocks prepared from 23 patients with left-sided mCRC using immunohistochemistry (IHC). The relationship between their level of expressions, clinicopathological parameters, response to anti-EGFR, and prognosis were analyzed.
    Results: High Amphiregulin, PTEN and low P21 expression levels were associated with low tumor grade (p= 0.038 and 0.025 respectively), better response to anti-EGFR treatment (p <0.001), and favorable outcome {progression-free survival (PFS) and overall survival (OS)} (p <0.05). There was a direct relation between Amphiregulin and PTEN expressions (phi coefficient=+0.840), while there was an inverse relation between P21expression and both Amphiregulin (phi coefficient= -0.840) and PTEN expressions (phi coefficient = -1.000), which was statistically significant (P <0.001).
    Conclusion: High Amphiregulin and PTEN expression levels and low P21 expression levels were associated with better response to anti-EGFR therapy and improved survival outcome. They might be considered predictive markers of response to anti-EGFR therapy in mCRC.

    .
    MeSH term(s) Aged ; Amphiregulin/metabolism ; Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/metabolism ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; ErbB Receptors/antagonists & inhibitors ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Metastasis ; Phosphoric Monoester Hydrolases/metabolism ; Predictive Value of Tests ; Prognosis ; Proto-Oncogene Proteins p21(ras)/metabolism ; Tensins/metabolism
    Chemical Substances Amphiregulin ; Antineoplastic Agents ; Biomarkers, Tumor ; Tensins ; ErbB Receptors (EC 2.7.10.1) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2021-04-01
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2021.22.4.1025
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  5. Article ; Online: 68

    Hamed, Maged Abdel Galil / Basha, Mohammad Abd Alkhalik / Ahmed, Hussien / Obaya, Ahmed Ali / Afifi, Amira Hamed Mohamed / Abdelbary, Eman H

    Academic radiology

    2018  Volume 26, Issue 4, Page(s) 450–460

    Abstract: Rationale and objectives: 68: Materials and methods: The present prospective study included 188 patients who exhibited rising of PSA level on a routine follow-up examination after definitive treatment of PC. All patients underwent a : Results: 68!# ...

    Abstract Rationale and objectives: 68
    Materials and methods: The present prospective study included 188 patients who exhibited rising of PSA level on a routine follow-up examination after definitive treatment of PC. All patients underwent a
    Results: 68
    Conclusion: 68
    MeSH term(s) Aged ; Gallium Radioisotopes/pharmacology ; Humans ; Male ; Membrane Glycoproteins/pharmacology ; Middle Aged ; Neoplasm Grading ; Neoplasm Metastasis/diagnostic imaging ; Neoplasm Recurrence, Local/diagnostic imaging ; Organometallic Compounds/pharmacology ; Positron Emission Tomography Computed Tomography/methods ; Prospective Studies ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy ; Radiopharmaceuticals/pharmacology ; Reproducibility of Results
    Chemical Substances Gallium Radioisotopes ; Membrane Glycoproteins ; Organometallic Compounds ; Radiopharmaceuticals ; gallium 68 PSMA-11 ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2018-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2018.05.020
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    Zs.A 4594: Show issues Location:
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  6. Article ; Online: C-MYC and BCL2: Correlation between Protein Over-Expression and Gene Translocation and Impact on Outcome in Diffuse Large B Cell Lymphoma

    Mohammed, Amrallah A / Rashed, Hayam E / Abdelrahman, Aziza E / Obaya, Ahmed A / Toam, Mostafa / Abdel Nour, Hanim M / Abdelhamid, Mohamed I / Elsayed, Fifi Mostafa

    Asian Pacific journal of cancer prevention : APJCP

    2019  Volume 20, Issue 5, Page(s) 1463–1470

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Immunohistochemistry/methods ; Immunophenotyping/methods ; Lymphoma, Large B-Cell, Diffuse/genetics ; Male ; Middle Aged ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-myc/genetics ; RNA, Messenger/genetics ; Retrospective Studies ; Translocation, Genetic/genetics
    Chemical Substances BCL2 protein, human ; MYC protein, human ; Proto-Oncogene Proteins c-bcl-2 ; Proto-Oncogene Proteins c-myc ; RNA, Messenger
    Language English
    Publishing date 2019-05-25
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2019.20.5.1463
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  7. Article ; Online: Does a combined CT and MRI protocol enhance the diagnostic efficacy of LI-RADS in the categorization of hepatic observations? A prospective comparative study.

    Basha, Mohammad Abd Alkhalik / AlAzzazy, Mohamad Zakarya / Ahmed, Ayman F / Yousef, Hala Y / Shehata, Samar Mohamad / El Sammak, Dena Abd El Aziz / Fathy, Talaat / Obaya, Ahmed Ali / Abdelbary, Eman H

    European radiology

    2018  Volume 28, Issue 6, Page(s) 2592–2603

    Abstract: Objective: To compare diagnostic performance and agreement between CT, MRI and combined CT/MRI in reference to LI-RADS classification system to categorize hepatic observations detected in hepatic patients during screening ultrasound.: Methods: 240 ... ...

    Abstract Objective: To compare diagnostic performance and agreement between CT, MRI and combined CT/MRI in reference to LI-RADS classification system to categorize hepatic observations detected in hepatic patients during screening ultrasound.
    Methods: 240 patients with 296 liver observations detected during ultrasound surveillance underwent hepatic CT and MRI examinations, histopathology, and clinical and radiological follow-up. Using LI-RADS v2014, six radiologists evaluated the observations independently and assigned a LI-RADS category to each observation using CT, MRI and combined CT/MRI.
    Results: Combined CT and MRI in LI-RADS yielded better accuracy (91.29 %), sensitivity (90.71 %) and specificity (92.31 %) for hepatocellular carcinoma (HCC) diagnosis than using MRI or CT alone; accuracy, sensitivity and specificity decreased to 85.37 %, 86.34 %, and 83.65 %, respectively, for MRI and 67.6 %, 54.10 % and 91.35 %, respectively, for CT. The intraclass agreement of the LI-RADS scores between CT, MRI and combined CT/MRI was excellent (κ=0.9624 (95 % CI: 0.9318-0.9806)).
    Conclusion: CT and MRI are complementary to each other. Combined CT/MRI enabled a more precise determination of LI-RADS category of hepatic observations; however, due to the expense and minor increase in accuracy, the combined methodology should only be utilized in cases of suspected HCC.
    Key points: • Hepatic observation may be categorized differently depending on the imaging modality used. • We compared LI-RADS categorization between CT, MRI and combined CT/MRI. • MRI produces higher accuracy and sensitivity, while CT produces higher specificity. • Combining CT and MRI improves LIRADS categorization reports. • Considering additional cost, combined methodology could be restricted to challenging cases.
    MeSH term(s) Adult ; Aged ; Carcinoma, Hepatocellular/diagnosis ; Female ; Humans ; Liver Cirrhosis/diagnosis ; Liver Neoplasms/diagnosis ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Multimodal Imaging/methods ; Prospective Studies ; Sensitivity and Specificity ; Tomography, X-Ray Computed/methods ; Ultrasonography
    Language English
    Publishing date 2018-01-24
    Publishing country Germany
    Document type Comparative Study ; Evaluation Study ; Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-017-5232-y
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    Zs.A 3300: Show issues Location:
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  8. Article ; Online: Diagnostic performance of

    Basha, Mohammad Abd Alkhalik / Hamed, Maged Abdel Gelil / Refaat, Rania / AlAzzazy, Mohamad Zakarya / Bessar, Manar A / Mohamed, Elshaimaa Mohamed / Ahmed, Ayman F / Tantawy, Heba Fathy / Altaher, Khaled Mohamed / Obaya, Ahmed Ali / Afifi, Amira Hamed Mohamed

    Japanese journal of radiology

    2018  Volume 36, Issue 6, Page(s) 382–393

    Abstract: Objective: To determine the diagnostic accuracy of WB-MRI and : Materials and methods: Fifty-six patients with confirmed MM were included in the present study for pre-treatment evaluation. Among these individuals, 22 patients were available for the ... ...

    Abstract Objective: To determine the diagnostic accuracy of WB-MRI and
    Materials and methods: Fifty-six patients with confirmed MM were included in the present study for pre-treatment evaluation. Among these individuals, 22 patients were available for the post-treatment evaluation of response to therapy. All patients were imaged with both WB-MRI and
    Results: For detection of active myelomatous tissue at diagnosis, WB-MRI achieved higher sensitivity (94%) than
    Conclusion: WB-MRI is more sensitive than
    MeSH term(s) Adult ; Aged ; Biopsy ; Female ; Fluorodeoxyglucose F18 ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Multiple Myeloma/diagnostic imaging ; Multiple Myeloma/therapy ; Positron Emission Tomography Computed Tomography/methods ; Prospective Studies ; Radiopharmaceuticals ; Reproducibility of Results ; Sensitivity and Specificity ; Treatment Outcome ; Whole Body Imaging/methods
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2018-04-18
    Publishing country Japan
    Document type Comparative Study ; Journal Article
    ZDB-ID 2488907-6
    ISSN 1867-108X ; 1867-1071
    ISSN (online) 1867-108X
    ISSN 1867-1071
    DOI 10.1007/s11604-018-0738-z
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    Zs.A 2249: Show issues Location:
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  9. Article ; Online: Bosniak classification version 2019: a prospective comparison of CT and MRI.

    Almalki, Yassir Edrees / Basha, Mohammad Abd Alkhalik / Refaat, Rania / Alduraibi, Sharifa Khalid / Abdalla, Ahmed A El-Hamid M / Yousef, Hala Y / Zaitoun, Mohamed M A / Elsayed, Saeed Bakry / Mahmoud, Nader E M / Alayouty, Nader Ali / Ali, Susan Adil / Alnaggar, Ahmad Abdullah / Saber, Sameh / El-Maghraby, Ahmed Mohamed / Elsheikh, Amgad M / Radwan, Mohamed Hesham Saleh Saleh / Abdelmegid, Ahmed Gamil Ibrahim / Aly, Sameh Abdelaziz / Shanab, Waleed S Abo /
    Obaya, Ahmed Ali / Abdelhai, Shaimaa Farouk / Elshorbagy, Shereen / Haggag, Yasser M / Mokhtar, Hwaida M / Sabry, Nesreen M / Altohamy, Jehan Ibrahim / Abouelkheir, Rasha Taha / Omran, Tawfik / Shalan, Ahmed / Algazzar, Youssef H / Metwally, Maha Ibrahim

    European radiology

    2022  Volume 33, Issue 2, Page(s) 1286–1296

    Abstract: Objective: To assess the diagnostic accuracy and agreement of CT and MRI in terms of the Bosniak classification version 2019 (BCv2019).: Materials and methods: A prospective multi-institutional study enrolled 63 patients with 67 complicated cystic ... ...

    Abstract Objective: To assess the diagnostic accuracy and agreement of CT and MRI in terms of the Bosniak classification version 2019 (BCv2019).
    Materials and methods: A prospective multi-institutional study enrolled 63 patients with 67 complicated cystic renal masses (CRMs) discovered during ultrasound examination. All patients underwent CT and MRI scans and histopathology. Three radiologists independently assessed CRMs using BCv2019 and assigned Bosniak class to each CRM using CT and MRI. The final analysis included 60 histopathologically confirmed CRMs (41 were malignant and 19 were benign).
    Results: Discordance between CT and MRI findings was noticed in 50% (30/60) CRMs when data were analyzed in terms of the Bosniak classes. Of these, 16 (53.3%) were malignant. Based on consensus reviewing, there was no difference in the sensitivity, specificity, and accuracy of the BCv2019 with MRI and BCv2019 with CT (87.8%; 95% CI = 73.8-95.9% versus 75.6%; 95% CI = 59.7-87.6%; p = 0.09, 84.2%; 95% CI = 60.4-96.6% versus 78.9%; 95% CI = 54.4-93.9%; p = 0.5, and 86.7%; 95% CI = 64.0-86.6% versus 76.7%; 95% CI = 75.4-94.1%; p = 0.1, respectively). The number and thickness of septa and the presence of enhanced nodules accounted for the majority of variations in Bosniak classes between CT and MRI. The inter-reader agreement (IRA) was substantial for determining the Bosniak class in CT and MRI (k = 0.66; 95% CI = 0.54-0.76, k = 0.62; 95% CI = 0.50-0.73, respectively). The inter-modality agreement of the BCv219 between CT and MRI was moderate (κ = 0.58).
    Conclusion: In terms of BCv2019, CT and MRI are comparable in the classification of CRMs with no significant difference in diagnostic accuracy and reliability.
    Key points: • There is no significant difference in the sensitivity, specificity, and accuracy of the BCv2019 with MRI and BCv2019 with CT. • The number of septa and their thickness and the presence of enhanced nodules accounted for the majority of variations in Bosniak classes between CT and MRI. • The inter-reader agreement was substantial for determining the Bosniak class in CT and MRI and the inter-modality agreement of the BCv219 between CT and MRI was moderate.
    MeSH term(s) Humans ; Kidney Diseases, Cystic/diagnosis ; Reproducibility of Results ; Tomography, X-Ray Computed ; Magnetic Resonance Imaging ; Kidney/pathology ; Kidney Neoplasms ; Retrospective Studies
    Language English
    Publishing date 2022-08-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-022-09044-3
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  10. Article ; Online: Gynecology Imaging Reporting and Data System (GI-RADS): diagnostic performance and inter-reviewer agreement.

    Basha, Mohammad Abd Alkhalik / Refaat, Rania / Ibrahim, Safaa A / Madkour, Nadia M / Awad, Awad Mahmoud / Mohamed, Elshaimaa Mohamed / El Sammak, Ahmed A / Zaitoun, Mohamed M A / Dawoud, Hitham A / Khamis, Mai E M / Mohamed, Heba A E / El-Maghraby, Ahmed Mohamed / Abdalla, Ahmed A El-Hamid M / Assy, Mostafa Mohamad / Nada, Mohamad Gamal / Obaya, Ahmed Ali / Abdelbary, Eman H

    European radiology

    2019  Volume 29, Issue 11, Page(s) 5981–5990

    Abstract: Objective: To evaluate diagnostic performance and inter-reviewer agreement (IRA) of the Gynecologic Imaging Reporting and Data System (GI-RADS) for diagnosis of adnexal masses (AMs) by pelvic ultrasound (US).: Patients and methods: A prospective ... ...

    Abstract Objective: To evaluate diagnostic performance and inter-reviewer agreement (IRA) of the Gynecologic Imaging Reporting and Data System (GI-RADS) for diagnosis of adnexal masses (AMs) by pelvic ultrasound (US).
    Patients and methods: A prospective multicenter study included 308 women (mean age, 41 ± 12.5 years; range, 15-73 years) with 325 AMs detected by US. All US examinations were analyzed, and AMs were categorized into five categories according to the GI-RADS classification. We used histopathology and US follow-up as the reference standards for calculating diagnostic performance of GI-RADS for detecting malignant AMs. The Fleiss kappa (κ) tests were applied to evaluate the IRA of GI-RADS scoring results for predicting malignant AMs.
    Results: A total of 325 AMs were evaluated: 127 (39.1%) were malignant and 198 (60.9%) were benign. Of 95 AMs categorized as GI-RADS 2 (GR2), none was malignant; of 94 AMs categorized as GR3, three were malignant; of 13 AMs categorized as GR4, six were malignant; and of 123 AMs categorized as GR5, 118 were malignant. On a lesion-based analysis, the GI-RADS had a sensitivity, a specificity, and an accuracy of 92.9%, 97.5%, and 95.7%, respectively, when regarding only those AMs classified as GR5 for predicting malignancy. Considering combined GR4 and GR5 as a predictor for malignancy, the sensitivity, specificity, and accuracy of GI-RADS were 97.6%, 93.9%, and 95.4%, respectively. The IRA of the GI-RADS category was very good (κ = 0.896). The best cutoff value for predicting malignant AMs was >GR3.
    Conclusions: The GI-RADS is very valuable for improving US structural reports.
    Key points: • There is still a lack of a standard in the assessment of AMs. • GI-RADS is very valuable for improving US structural reports of AMs. • GI-RADS criteria are easy and work at least as well as IOTA.
    MeSH term(s) Adnexal Diseases/diagnostic imaging ; Adolescent ; Adult ; Aged ; Data Systems ; Female ; Gynecology ; Humans ; Middle Aged ; Observer Variation ; Ovarian Diseases/diagnostic imaging ; Prospective Studies ; Radiology Information Systems/standards ; Reference Standards ; Research Design ; Sensitivity and Specificity ; Ultrasonography ; Young Adult
    Language English
    Publishing date 2019-04-16
    Publishing country Germany
    Document type Evaluation Study ; Journal Article ; Multicenter Study
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-019-06181-0
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