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  1. AU="Obrenović-Kirćanski Biljana"
  2. AU="Ch'oe, Ok-hyang"
  3. AU="Chiaverina, Giulia"
  4. AU="Saunders, Gary I"
  5. AU="Ng, Liqi"
  6. AU="Kato, Takeshi"
  7. AU="Dalstra, Michel"
  8. AU="Ruben, Jurjen"
  9. AU="Peersman, Nele"
  10. AU=Yip Christina Y C AU=Yip Christina Y C
  11. AU=Mehan Vivek K.
  12. AU="Nara, Akina"
  13. AU=Saccente Michael
  14. AU="Wang, Xiulu" AU="Wang, Xiulu"
  15. AU="Milnes, Di"
  16. AU=Almudhi Abdulaziz
  17. AU="Kumowski, Nina"
  18. AU="Dedeke, Iyabode"
  19. AU="Srivastava, Mitul"
  20. AU=Que Jian-Yu
  21. AU="Midulla, Martina"
  22. AU="et al"
  23. AU="Pritchard, Jonathan"
  24. AU="Memeo, Lorenzo"
  25. AU="Taylan, Gokay"
  26. AU="Tijssen, Robert J. W."
  27. AU="Silva, Marcelina Jasmine"
  28. AU="Egbuna, Chukwuebuka"

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  1. Artikel ; Online: Thyroid replacement therapy effects on cardiac function in patients with hypothyroidism

    Đenić Aleksandar / Obrenović-Kirćanski Biljana

    Srpski Arhiv za Celokupno Lekarstvo, Vol 149, Iss 1-2, Pp 24-

    2021  Band 29

    Abstract: Introduction/Objective. Hypothyroidism is a hypometabolic syndrome with insufficient production or inadequate action of thyroid hormones. It is characterized by hypercholesterolemia, elevated LDL-C. The most common echocardiographic changes are in left ... ...

    Abstract Introduction/Objective. Hypothyroidism is a hypometabolic syndrome with insufficient production or inadequate action of thyroid hormones. It is characterized by hypercholesterolemia, elevated LDL-C. The most common echocardiographic changes are in left ventricular (LV) diastolic function. The aim of this study was to investigate the effects of achieving adequate thyroid hormone replacement therapy in hypothyroid patients on improving systolic and diastolic cardiac function and correcting serum lipid profile. Methods. Prospective study was conducted on 42 patients with newly diagnosed hypothyroidism, both sexes, aged 18–60 years, without comorbidity. The determined blood tests before, six, 12, and 24 weeks after starting the therapy with L-thyroxine were: FT4, TSH, total cholesterol, HDL-C, LDL-C and triglycerides. The effects of thyroid hormone replacement therapy on systolic and diastolic cardiac function were assessed by echocardiography. Results. It was concluded that 25 (59.5%) patients had subclinical and 17 (40.5%) overt hypothyroidism. The LV end-systolic diameter decreased statistically highly significant (p < 0.01) after 12 weeks and enddiastolic diameter of the right ventricle after six months of therapy. There was no significant decrease in LV end-diastolic diameter after six months of thyroid hormone replacement therapy. Mitral annular plane systolic excursion (MAPSE), left ventricular ejection fraction (LVEF), and tricuspid annular plane systolic excursion (TAPSE) values increased significantly (p < 0.01) after six weeks of therapy. Total cholesterol and LDL-C significantly decreased, HDL-C increased (p < 0.01) and there was no change in triglyceride concentrations after 24 weeks of therapy. Conclusions. Thyroid replacement therapy in hypothyroid subjects statistically significantly improves echocardiographic parameters of diastolic and systolic left and right ventricular function, reduces total serum cholesterol and LDL-C, and increases HDL-C.
    Schlagwörter hypothyroidism ; l-thyroxine ; diastolic cardiac function ; systolic cardiac function ; lipid profile ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Serbian Medical Society
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel: Morphogenetic dispositions for variability in acute kidney injury after cardiac surgery: Pilot study.

    Karan, Radmila / Kovačević-Kostić, Natasa / Kirćanski, Bratislav / Čumić, Jelena / Terzić, Duško / Milićević, Vladimir / Velinović, Vojislav / Velinović, Miloš / Obrenović-Kirćanski, Biljana

    Frontiers in medicine

    2022  Band 9, Seite(n) 943254

    Abstract: Background: The aim of our study was to evaluate the degree of genetic homozygosity in cardiac surgical patients with postoperative acute kidney injury (AKI), compared to the subgroup without postoperative AKI, as well as to evaluate antropomorpho- ... ...

    Abstract Background: The aim of our study was to evaluate the degree of genetic homozygosity in cardiac surgical patients with postoperative acute kidney injury (AKI), compared to the subgroup without postoperative AKI, as well as to evaluate antropomorpho-genetic variability in cardiac surgical patients with regard to the presence and severity degree of AKI.
    Materials and methods: The prospective cohort study included an analysis of 138 eligible coronary artery disease (CAD) surgical patients that were screened consecutively. The tested group was divided into three subgroups according to RIFLE criteria: Subgroup NoAKI (
    Results: Comparing subgroups NoAKI and risk, four ORHTs were significantly more frequent in the risk subgroup. Comparing subgroups NoAKI and injury, nine ORHTs were significantly more frequent in the injury subgroup; while comparing the injury subgroup and risk, five ORHTs were significantly more frequent in injury than in the risk subgroup. Results also showed a significant increase in the mean value of ORHTs for the injury subgroup compared to NoAKI subgroup (
    Conclusion: Our findings pointed to the higher degree of recessive homozygosity and decreased variability in AKI patients vs. NoAKI individuals, thus presumably facilitating the development and severity degree expression of AKI in patients after cardiac surgery.
    Sprache Englisch
    Erscheinungsdatum 2022-09-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.943254
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  3. Artikel ; Online: Aortic coarctation and associated cardiac lesions-optimal therapeutic approach

    Velinović Miloš / Karan Radmila / Kovačević-Kostić Nataša / Obrenović-Kirćanski Biljana / Stojimirov Milica / Milićević Vlado / Nikolić Dejan / Milić Dragan

    Vojnosanitetski Pregled, Vol 76, Iss 11, Pp 1197-

    Report of 2 cases

    2019  Band 1202

    Abstract: Abstract Introduction. Aortic coarcation is a congenital condition mostly detected and treated during childhood. Adult patients with coarctation and associated cardiac lesions represent a challenge and a subject of debates concerning adequate treatment. ... ...

    Abstract Abstract Introduction. Aortic coarcation is a congenital condition mostly detected and treated during childhood. Adult patients with coarctation and associated cardiac lesions represent a challenge and a subject of debates concerning adequate treatment. We report 2 patients with aortic coartation when a surgical treatment was necessary. Case report. First patient was a 61-year-old male with previous mechanical aortic valve implantation. He underwent one stage surgical reconstruction of aortic coarctation and surgical repair of aneurysm of ascending aorta. The second patient was a 49- year-old female with aortic aneurysm, bicuspid aortic valve, severe aortic insufficiency and coarctation of aorta below branching of subclavian artery. She underwent the Bentall procedure and surgical repair of coarctation by bypass where the proximal anastomosis was made between the terminal part of Dacron graft and the lateral part of graft used for Bentall, while the distal anastomosis was made between the terminal part of Dacron graft and the lateral part of descending aorta below coarctation. The postoperative course and the follow-up of the patients of 3 and 1 year, respectively, were without complications. Conclusion. Single operation is a better choice in the patients with concomitant pathology such as the aortic aneurysm, or aortic valve disease. Each patient should be analyzed on a single basis, and a decision about a surgical technique and surgical course brought accordingly.
    Schlagwörter aortic aneurysm ; aortic coarctation ; aortic valve insufficiency ; echocardiography ; cardiac surgical procedures ; treatment outcome ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2019-01-01T00:00:00Z
    Verlag Military Health Department, Ministry of Defance, Serbia
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: The arteriovenous hemangioma of the right ventricle

    Mikić Aleksandar / Matković Miloš / Vukićević Petar / Obrenović-Kirćanski Biljana / Karamarković Nemanja / Velinović Miloš / Šamanović Marko / Putnik Svetozar

    Vojnosanitetski Pregled, Vol 76, Iss 12, Pp 1301-

    Case report and literature review

    2019  Band 1303

    Abstract: Introduction. Cardiac hemangiomas of the right ventricle are very rare and mostly asymptomatic benign tumors. The surgical excision is the first line treatment. Case report. We report a case of 69-year-old woman with an asymptomatic arteriovenous ... ...

    Abstract Introduction. Cardiac hemangiomas of the right ventricle are very rare and mostly asymptomatic benign tumors. The surgical excision is the first line treatment. Case report. We report a case of 69-year-old woman with an asymptomatic arteriovenous hemangioma of the right ventricle. The complete surgical excision was performed with the use of cardiopulmonary bypass and the patient was discharged on the postoperative day 6 after the uneventral postoperative course. There was no relapse during the six-month followup. Literature review revealed totally 35 cases of this tumors including our case Conclusion. Described procedure can be performed safely with the excellent long-term results.
    Schlagwörter hemangioma ; heart ventricles ; cardiac surgical procedures ; diagnosis ; treatment outcome ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2019-01-01T00:00:00Z
    Verlag Military Health Department, Ministry of Defance, Serbia
    Dokumenttyp Artikel ; Online
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  5. Artikel: Endothelial dysfunction reversibility.

    Obrenović-Kirćanski, Biljana B

    Vojnosanitetski pregled

    2007  Band 64, Heft 5, Seite(n) 337–343

    Mesh-Begriff(e) Arteriosclerosis/physiopathology ; Arteriosclerosis/therapy ; Coronary Artery Disease/physiopathology ; Coronary Artery Disease/therapy ; Endothelium, Vascular/physiopathology ; Humans
    Sprache Englisch
    Erscheinungsdatum 2007-04-27
    Erscheinungsland Serbia
    Dokumenttyp Journal Article ; Review
    ZDB-ID 123795-0
    ISSN 0042-8450
    ISSN 0042-8450
    DOI 10.2298/vsp0705337o
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Endothelial dysfunction reversibility

    Obrenović-Kirćanski Biljana B.

    Vojnosanitetski Pregled, Vol 64, Iss 5, Pp 337-

    2007  Band 343

    Schlagwörter endothelium ; vascular ; atherosclerosis ; risk factors ; lifestyle ; drug therapy ; treatment outcome ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2007-01-01T00:00:00Z
    Verlag Military Health Department, Ministry of Defance, Serbia
    Dokumenttyp Artikel ; Online
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  7. Artikel: Genetic and Environmental Dispositions for Cardiovascular Variability: A Pilot Study.

    Karan, Radmila / Cvjeticanin, Suzana / Kovacevic-Kostic, Natasa / Nikolic, Dejan / Velinovic, Milos / Milicevic, Vladimir / Obrenovic-Kircanski, Biljana

    Journal of clinical medicine

    2018  Band 7, Heft 9

    Abstract: Background: The aim of our study was to evaluate the degree of genetic homozygosity in the group of patients with coronary artery disease (CAD), as well as to evaluate morphogenetic variability in CAD patients regarding the presence of investigated risk ...

    Abstract Background: The aim of our study was to evaluate the degree of genetic homozygosity in the group of patients with coronary artery disease (CAD), as well as to evaluate morphogenetic variability in CAD patients regarding the presence of investigated risk factors (RF) compared to a control sample of individuals. Additionally, we aimed to evaluate the distribution of ABO blood type frequencies between tested samples of individuals.
    Methods: This study analyzed individual phenotype and morphogenetic variability of 17 homozygously-recessive characteristics (HRC), by using HRC test in a sample of 148 individuals in CAD patients group and 156 individuals in the control group. The following RF were analyzed: hypertension, diabetes mellitus, hyperlipidemia, and smoking.
    Results: The mean value of HRC in CAD patients is significantly higher, while variability decreases compared to the control sample (CAD patients: 4.24 ± 1.59, control sample: 3.75 ± 1.69; V
    Conclusion: There is a higher degree of recessive homozygosity in CAD patients versus individuals in the control sample, and the presence of significant variations in the degree of recessive homozygosity as the number of tested RF increases.
    Sprache Englisch
    Erscheinungsdatum 2018-08-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm7090232
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  8. Artikel: The Gender Impact on Morphogenetic Variability in Coronary Artery Disease: A Preliminary Study.

    Karan, Radmila / Obrenovic-Kircanski, Biljana / Cvjeticanin, Suzana / Kovacevic-Kostic, Natasa / Velinovic, Milos / Milicevic, Vladimir / Vranes-Stoimirov, Milica / Nikolic, Dejan

    Journal of clinical medicine

    2018  Band 7, Heft 5

    Abstract: We analyzed morphogenetic variability and degree of genetic homozygosity in male and female individuals with coronary artery disease (CAD) versus unaffected controls. We have tested 235 CAD patients; 109 were diagnosed also with diabetes mellitus (DM) ... ...

    Abstract We analyzed morphogenetic variability and degree of genetic homozygosity in male and female individuals with coronary artery disease (CAD) versus unaffected controls. We have tested 235 CAD patients; 109 were diagnosed also with diabetes mellitus (DM) and 126 with hypertension (HTN). We additionally evaluated 152 healthy individuals without manifested CAD. For the evaluation of the degree of recessive homozygosity, we have performed the homozygously recessive characteristics (HRC) test and tested 19 HRCs. In controls, the frequency of HRC for males was 2.88 ± 1.89, while for females, it was 3.65 ± 1.60. In the CAD group, the frequency of HRC for males was 4.21 ± 1.47, while for females, it was 4.73 ± 1.60. There is significant difference in HRC frequencies between controls and CAD separately for males (
    Sprache Englisch
    Erscheinungsdatum 2018-05-03
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm7050103
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  9. Artikel ; Online: Do we need defibrillation threshold testing?

    Kovačević-Kostić Nataša / Karan Radmila / Obrenović-Kirćanski Biljana / Velinović M. / Vraneš M. / Mitrović P. / Milašinović G.

    Archives of Biological Sciences, Vol 65, Iss 2, Pp 465-

    A pilot study

    2013  Band 474

    Abstract: Defibrillation threshold testing (DFT) is a standard procedure during implantable cardioverter defibrillator (ICD) implantation, however, it is not without risks. We compared the one-year follow-up period in ICD-implanted patients, with and without DFT ... ...

    Abstract Defibrillation threshold testing (DFT) is a standard procedure during implantable cardioverter defibrillator (ICD) implantation, however, it is not without risks. We compared the one-year follow-up period in ICD-implanted patients, with and without DFT performed during implantation, for preventive indication in regard to appropriate and inappropriate ICD detection and therapy. One group consisted of 20 patients without DFT; another was comprised of 20 patients where DFT had been performed. There was no difference in the development of ventricular tachyarrhythmias between the groups. Appropriate therapy of ICD was 100%. DFT is not a predictor for successful ICD detection and therapy of ventricular tachyarrhythmias.
    Schlagwörter implantable cardioverter defibrillator ; defibrillation threshold testing ; sudden cardiac death ; primary prevention ; heart failure ; treatment ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag University of Belgrade, University of Novi Sad
    Dokumenttyp Artikel ; Online
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  10. Artikel ; Online: Atrial fibrillation after coronary artery bypass surgery

    Obrenović-Kirćanski Biljana / Orbović Bojana / Vraneš Mile / Parapid Biljana / Kovačević-Kostić Nataša / Velinović Miloš / Ristić Stana

    Srpski Arhiv za Celokupno Lekarstvo, Vol 140, Iss 7-8, Pp 521-

    Possibilities of prevention

    2012  Band 527

    Abstract: Atrial fibrillation occurs as a frequent complication after cardiac interventions. It can be found in 5% of all surgical patients, and it is far more common in cardiac (10% - 65% of patients) than in non-cardiac procedures. In a number of patients it ... ...

    Abstract Atrial fibrillation occurs as a frequent complication after cardiac interventions. It can be found in 5% of all surgical patients, and it is far more common in cardiac (10% - 65% of patients) than in non-cardiac procedures. In a number of patients it remains asymptomatic, but may be accompanied by very severe symptoms of hypotension, heart failure, syncope, systemic or pulmonary embolism, perioperative myocardial infarction, cerebrovascular insult and increased operative mortality. Patients whose postoperative course is complicated by atrial fibrillation require longer hospitalization. Possible predisposing factors of this arrhythmia are numerous and are associated with surgery, extensive coronary heart disease and revascularization, and preoperative diseases. According to the recommendations of the European Society of Cardiology orally applied beta-blocker, amiodarone and sotalol can be used for prophylaxis of atrial fibrillation. Following the recommendations, treatment of postoperative atrial fibrillation should include beta-blockers, amiodarone, and in patients with heart failure and left ventricular dysfunction, digoxin. Due to the increased risk of stroke, an anticoagulant protection is necessary. Many studies have been conducted with results supporting the prophylactic use of amiodarone and beta-blockers, while the treatment with new agents such as magnesium, statins, omega-3 fatty acids and inhibitors of the renin-angiotensin-aldosterone system is still being investigated.
    Schlagwörter postoperative atrial fibrillation ; myocardial revascularization ; amiodarone ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2012-01-01T00:00:00Z
    Verlag Serbian Medical Society
    Dokumenttyp Artikel ; Online
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