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  1. Conference proceedings: Injury-induced chondrocyte death can be alleviated by CCN2, a ‘novel’ regulator of cartilage homeostasis

    Holweg, Maximilian / Meder, Adrian / Südkamp, Norbert P. / Ochs, Gunnar / Kurz, Bodo / Rolauffs, Bernd

    2023  , Page(s) AB91–3431

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2023); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2023
    Keywords Medizin, Gesundheit ; joint trauma ; arthrosis ; post-traumatic osteoarthritis ; PTOA ; CCN2
    Publishing date 2023-10-23
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dkou546
    Database German Medical Science

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  2. Book ; Online ; Thesis: Mittel- sowie langfristige Ergebnisse von Hüftprothesenimplantationen nach osteosynthetisch versorgter proximaler Femurfraktur – klinische und radiologische Outcome-Analyse

    Schneider, Luisa [Verfasser] / Ochs, Gunnar Björn [Akademischer Betreuer]

    2020  

    Author's details Luisa Schneider ; Betreuer: Gunnar Björn Ochs
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Tübingen
    Publishing place Tübingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Book ; Online ; Thesis: Unabhängige Evaluation des Biomarkers Alpha Defensin zum Nachweis einer periprothetischen Infektion gemäß derzeitiger Klassifikationskriterien

    Fierdel, Frederic [Verfasser] / Ochs, Gunnar [Akademischer Betreuer]

    2019  

    Author's details Frederic Fierdel ; Betreuer: Gunnar Ochs
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Tübingen
    Publishing place Tübingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Article ; Online: Hip Revision Arthroplasty of Periprosthetic Fractures Vancouver B2 and B3 with a Modular Revision Stem: Short-Term Results and Review of Literature.

    Schreiner, Anna Janine / Steidle, Christoph / Schmidutz, Florian / Gonser, Christoph / Hemmann, Philipp / Stöckle, Ulrich / Ochs, Gunnar

    Zeitschrift fur Orthopadie und Unfallchirurgie

    2020  Volume 160, Issue 1, Page(s) 40–48

    Abstract: Background: Periprosthetic fractures Vancouver type B2/B3 after total hip arthroplasty (THA) is a challenging entity with increasing numbers. Limited data are available for this type of fracture treated with modular stems. Therefore, this study ... ...

    Title translation Hüftrevisionsendoprothetik bei periprothetischen Frakturen Typ Vancouver B2 und B3 mit einem modularen Revisionsschaft: Kurzfristige Resultate und ein Literaturüberblick.
    Abstract Background: Periprosthetic fractures Vancouver type B2/B3 after total hip arthroplasty (THA) is a challenging entity with increasing numbers. Limited data are available for this type of fracture treated with modular stems. Therefore, this study evaluated the outcome of Vancouver type B2/B3 fractures treated with a modular hip revision stem using a subproximal/distal anchorage and compared it to the current literature.
    Materials and methods: A consecutive series of periprosthetic Vancouver type B2/B3 fractures treated with a modular revision stem was retrospectively (2013 - 2016) evaluated. Assessment included the clinical (HHS, pain, ROM) as well as the radiological outcome (subsidence, loosening, facture healing). In adddition, the surgical technique is described in detail and results are compared with the current literature.
    Results: A total of 18 patients (female/male 12/6) with Vancouver B2/B3 (n = 12/6) fractures with a mean age of 75.5 (60 - 89) years were included. The revision stem was inserted via a modified transgluteal approach (n = 16) or classical transfemoral approach (n = 2). The mean follow-up was 18.5 months, with a mean Harris Hip Score of 72.5 ± 18.7 (35.0 - 99.0) points. The fracture healing rate was 94.4% (n = 17) with osseous integration according to Engh in all cases. Dislocations of the greater trochanter were recorded in seven patients (38.9%). According to Beals and Towers, all results were rated excellent or good. No implant-related failure or relevant subsidence during this time was observed. Major complications were observed in five patients with two periprosthetic joint infections and two cases of major revision surgery.
    Conclusion: This study assessing Vancouver B2/3 fractures shows reproducible, good, short-term results in terms of subsidence and clinical functional outcome by the use of a modular revision stem. The transfemoral approach together with the modular stem allows for a stable fixation and good fracture healing. However, our data and review of the literature also documents the difficulties and higher complication rate associated with Vancouver B2/3 fractures.
    MeSH term(s) Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Hip/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Periprosthetic Fractures/etiology ; Periprosthetic Fractures/surgery ; Reoperation ; Retrospective Studies
    Language English
    Publishing date 2020-08-03
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2280747-0
    ISSN 1864-6743 ; 1438-941X ; 1864-6697 ; 0044-3220
    ISSN (online) 1864-6743 ; 1438-941X
    ISSN 1864-6697 ; 0044-3220
    DOI 10.1055/a-1209-4002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online ; Thesis: Stellenwert der Navigation in der Becken- und Acetabulumchirurgie

    Schunck, Jessica [Verfasser] / Ochs, Gunnar [Akademischer Betreuer]

    Systematische Literaturanalyse und Umfrage unter den unfallchirurgischen Kliniken Deutschlands

    2017  

    Author's details Jessica Schunck ; Betreuer: Gunnar Ochs
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Tübingen
    Publishing place Tübingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article: [No title information]

    Schreiner, Anna Janine / Steidle, Christoph / Schmidutz, Florian / Gonser, Christoph / Hemmann, Philipp / Stöckle, Ulrich / Ochs, Gunnar

    Zeitschrift für Orthopädie und Unfallchirurgie

    2020  Volume 160, Issue 01, Page(s) 40–48

    Abstract: Background: Periprosthetic fractures Vancouver type B2/B3 after total hip ... arthroplasty (THA) is a challenging entity with increasing numbers. Limited data ... are available for this type of fracture treated with modular stems. Therefore, ...

    Abstract Background: Periprosthetic fractures Vancouver type B2/B3 after total hip

    arthroplasty (THA) is a challenging entity with increasing numbers. Limited data

    are available for this type of fracture treated with modular stems. Therefore,

    this study evaluated the outcome of Vancouver type B2/B3 fractures treated with

    a modular hip revision stem using a subproximal/distal anchorage and compared it

    to the current literature.
    Materials and Methods: A consecutive series of periprosthetic Vancouver

    type B2/B3 fractures treated with a modular revision stem was retrospectively

    (2013 – 2016) evaluated. Assessment included the clinical (HHS, pain, ROM) as

    well as the radiological outcome (subsidence, loosening, facture healing). In

    adddition, the surgical technique is described in detail and results are

    compared with the current literature.
    Results: A total of 18 patients (female/male 12/6) with Vancouver B2/B3

    (n = 12/6) fractures with a mean age of 75.5 (60 – 89) years were included. The

    revision stem was inserted via a modified transgluteal approach (n = 16) or

    classical transfemoral approach (n = 2). The mean follow-up was 18.5 months,

    with a mean Harris Hip Score of 72.5 ± 18.7 (35.0 – 99.0) points. The fracture

    healing rate was 94.4% (n = 17) with osseous integration according to Engh in

    all cases. Dislocations of the greater trochanter were recorded in seven

    patients (38.9%). According to Beals and Towers, all results were rated

    excellent or good. No implant-related failure or relevant subsidence during this

    time was observed. Major complications were observed in five patients with two

    periprosthetic joint infections and two cases of major revision surgery.
    Conclusion: This study assessing Vancouver B2/3 fractures shows

    reproducible, good, short-term results in terms of subsidence and clinical

    functional outcome by the use of a modular revision stem. The transfemoral

    approach together with the modular stem allows for a stable fixation and good

    fracture healing. However, our data and review of the literature also documents

    the difficulties and higher complication rate associated with Vancouver B2/3

    fractures.
    Keywords periprosthetic fractures ; Vancouver B2 B3 ; hip arthroplasty ; revision arthroplasty ; modular stem ; periprothetische Frakturen ; Vancouver B2 B3 ; Hüftendoprothetik ; Revisionsendoprothetik ; modularer Schaft
    Language English
    Publishing date 2020-08-03
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2280747-0
    ISSN 1864-6743 ; 1438-941X ; 1864-6697 ; 0044-3220
    ISSN (online) 1864-6743 ; 1438-941X
    ISSN 1864-6697 ; 0044-3220
    DOI 10.1055/a-1209-4002
    Database Thieme publisher's database

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  7. Article ; Online: Age-dependent risk factors for malnutrition in traumatology and orthopedic patients.

    Lambert, Christine / Nüssler, Andreas / Biesalski, Hans Konrad / Freude, Thomas / Bahrs, Christian / Ochs, Gunnar / Flesch, Ingo / Stöckle, Ulrich / Ihle, Christoph

    Nutrition (Burbank, Los Angeles County, Calif.)

    2017  Volume 37, Page(s) 60–67

    Abstract: Objective: The aim of this study was to investigate the prevalence of risk of malnutrition (RoM) in an orthopedic and traumatology patient cohort with a broad range of ages. In addition to the classical indicators for risk assessment (low body mass ... ...

    Abstract Objective: The aim of this study was to investigate the prevalence of risk of malnutrition (RoM) in an orthopedic and traumatology patient cohort with a broad range of ages. In addition to the classical indicators for risk assessment (low body mass index, weight loss, and comorbidity), this study aimed to analyze the effects of lifestyle factors (eating pattern, smoking, physical activity) on RoM.
    Methods: The prospective cohort study included 1053 patients in a level 1 trauma center in Germany. RoM was assessed by Nutritional Risk Screening (NRS) 2002 and for the elderly additionally by Mini Nutritional Assessment (MNA). Age-dependent risk factors identified in univariate statistical analysis were used for multivariate logistic regression models.
    Results: The prevalence of patients at RoM (NRS ≥3) was 22%. In the three age categories (<50 y, 50-69 y, and ≥70 y), loss of appetite, weight loss, number of comorbidities, drugs and gastrointestinal symptoms significantly increased RoM in univariate statistical analysis. In patients ages ≥70 y, several disease- and lifestyle-related factors (not living at home, less frequent consumption of vegetables and whole meal bread, low physical activity, and smoking) were associated with RoM. Multivariate logistic regression model for the total study population identified weight loss (odds ratio [OR], 6.09; 95% confidence interval [CI], 4.14-8.83), loss of appetite (OR, 3.81; 95% CI, 2.52-5.78), age-specific low BMI (OR, 1.87; 95% CI, 1.18-2.97), number of drugs taken (OR, 1.19; 95% CI, 1.12-1.26), age (OR, 1.03; 95% CI, 1.02-1.04), and days per week with vegetable consumption (OR, 0.938; 95% CI, 0.89-0.99) as risk factors.
    Conclusion: Malnutrition in trauma and orthopedic patients is not only a problem related to age. Lifestyle-related factors also contribute significantly to malnutrition in geriatric patients.
    MeSH term(s) Age Factors ; Aged ; Appetite ; Body Mass Index ; Comorbidity ; Diet ; Exercise ; Female ; Fractures, Bone/complications ; Fractures, Bone/therapy ; Geriatric Assessment ; Germany/epidemiology ; Humans ; Life Style ; Male ; Malnutrition/epidemiology ; Malnutrition/etiology ; Middle Aged ; Nutrition Assessment ; Orthopedics ; Prevalence ; Prospective Studies ; Risk Factors ; Surveys and Questionnaires ; Traumatology ; Weight Loss
    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2016.12.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Crucial Role of Vitamin D in the Musculoskeletal System.

    Wintermeyer, Elke / Ihle, Christoph / Ehnert, Sabrina / Stöckle, Ulrich / Ochs, Gunnar / de Zwart, Peter / Flesch, Ingo / Bahrs, Christian / Nussler, Andreas K

    Nutrients

    2016  Volume 8, Issue 6

    Abstract: Vitamin D is well known to exert multiple functions in bone biology, autoimmune diseases, cell growth, inflammation or neuromuscular and other immune functions. It is a fat-soluble vitamin present in many foods. It can be endogenously produced by ... ...

    Abstract Vitamin D is well known to exert multiple functions in bone biology, autoimmune diseases, cell growth, inflammation or neuromuscular and other immune functions. It is a fat-soluble vitamin present in many foods. It can be endogenously produced by ultraviolet rays from sunlight when the skin is exposed to initiate vitamin D synthesis. However, since vitamin D is biologically inert when obtained from sun exposure or diet, it must first be activated in human beings before functioning. The kidney and the liver play here a crucial role by hydroxylation of vitamin D to 25-hydroxyvitamin D in the liver and to 1,25-dihydroxyvitamin D in the kidney. In the past decades, it has been proven that vitamin D deficiency is involved in many diseases. Due to vitamin D's central role in the musculoskeletal system and consequently the strong negative impact on bone health in cases of vitamin D deficiency, our aim was to underline its importance in bone physiology by summarizing recent findings on the correlation of vitamin D status and rickets, osteomalacia, osteopenia, primary and secondary osteoporosis as well as sarcopenia and musculoskeletal pain. While these diseases all positively correlate with a vitamin D deficiency, there is a great controversy regarding the appropriate vitamin D supplementation as both positive and negative effects on bone mineral density, musculoskeletal pain and incidence of falls are reported.
    MeSH term(s) Bone Diseases/etiology ; Bone Diseases/metabolism ; Dietary Supplements ; Humans ; Musculoskeletal Pain/prevention & control ; Vitamin D/metabolism ; Vitamin D/pharmacology ; Vitamin D Deficiency
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2016-06-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu8060319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Malnutrition - An underestimated factor in the inpatient treatment of traumatology and orthopedic patients: A prospective evaluation of 1055 patients.

    Ihle, Christoph / Freude, Thomas / Bahrs, Christian / Zehendner, Eva / Braunsberger, Janick / Biesalski, Hans Konrad / Lambert, Christine / Stöckle, Ulrich / Wintermeyer, Elke / Grünwald, Julia / Grünwald, Leonard / Ochs, Gunnar / Flesch, Ingo / Nüssler, Andreas

    Injury

    2017  Volume 48, Issue 3, Page(s) 628–636

    Abstract: Introduction: Suboptimal nutritional status is often observed among hospitalized patients across all medical specialties. The objective of the present study was to (1) analyze the prevalence of malnutrition in hospitalized orthopedic and trauma patients ...

    Abstract Introduction: Suboptimal nutritional status is often observed among hospitalized patients across all medical specialties. The objective of the present study was to (1) analyze the prevalence of malnutrition in hospitalized orthopedic and trauma patients and (2) to evaluate the relationship between malnutrition and selected clinical outcomes.
    Materials and methods: The prospective field study was conducted between 06/2014 and 06/2015 in a German level I trauma center (Department of Traumatology, Septic Trauma Surgery and Arthroplasty) with a total number of 1055 patients. At hospital admission, patients were checked for malnutrition using the validated Nutritional Risk Screening (NRS). Patients at risk for malnutrition were defined as NRS≥3. Quality of life (SF-36) was assessed to evaluate the physical and mental health status prior to hospitalization. Clinical outcomes under consideration included 1) rate of adverse events, 2) length of hospitalization, and 3) mobilization after operative and conservative treatment. Patients were included independently of surgical intervention or age.
    Results: 22.3% (235) of our patients were at risk for malnutrition (NRS≥3) while a regular nutritional status (NRS<3) was diagnosed in 77.7% (819). The highest prevalence of malnutrition was found in Septic Surgery with 31.0% (106), followed by Traumatology with 19.2% (100) and Arthroplasty with 15.1% (29). Higher prevalence of malnutrition was observed among patients with typical fractures of the elderly, such as lumbar spine and pelvis (47.4%), proximal femur (36.4%) and proximal humeral (26.7%) fractures. Furthermore, patients at risk for malnutrition showed prolonged hospitalization (13.7±11.1 vs. 18.2±11.7days), delayed postoperative mobilization (2.2±2.9 vs. 4.0±4.9days) and delayed mobilization after conservative treatment (1.1±2.7 vs. 1.8±1.9days). A statistically significant correlation of NRS with each parameter (Spearman's rank correlation, p<0.05) was observed. The incidence of adverse events in patients at risk for malnutrition was statistically significantly higher compared to that of patients with a regular nutritional status (37.2% vs. 21.1%, p<0.001).
    Conclusions: Malnutrition is widespread regarding hospitalized patients in the field of orthopedic and trauma surgery and results in suboptimal clinical outcome. It should be considered as an important factor that significantly contributes to delayed recovery. Especially elderly trauma patients and patients suffering from postoperative infections should be monitored carefully during hospitalization.
    Language English
    Publishing date 2017-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 218778-4
    ISSN 1879-0267 ; 0020-1383
    ISSN (online) 1879-0267
    ISSN 0020-1383
    DOI 10.1016/j.injury.2017.01.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Conference proceedings: BMP9: Eine potentere Alternative zu BMP2 und BMP7 für die klinische Anwendung?

    Ehnert, Sabrina / Freude, Thomas / Lacorte, Patrysya / Schröter, Steffen / Ochs, Gunnar / Nussler, Andreas

    2014  , Page(s) GR12–1109

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2014); Berlin; ; Berufsverband der Fachärzte für Orthopädie; 2014
    Keywords Medizin, Gesundheit
    Publishing date 2014-10-13
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/14dkou477
    Database German Medical Science

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