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  1. Article: Incidence of menstrual cycle abnormalities and polycystic ovary syndrome in female Japanese patients with type 1 diabetes mellitus. The role of androgens.

    Nakamichi, Tatsuya / Kawamura, Tomoyuki / Nishigaki, Satsuki / Odagiri, Shino / Yuyama, Yoshihiko / Nishikawa-Nakamura, Naoko / Hotta, Yuko / Hamazaki, Takashi

    Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology

    2024  Volume 33, Issue 2, Page(s) 59–65

    Abstract: Type 1 diabetes mellitus (T1DM) adversely affects gonadal function. This study aimed to define the characteristics and factors associated with menstrual cycle abnormalities and polycystic ovary syndrome (PCOS) in Japanese patients with T1DM. Our study ... ...

    Abstract Type 1 diabetes mellitus (T1DM) adversely affects gonadal function. This study aimed to define the characteristics and factors associated with menstrual cycle abnormalities and polycystic ovary syndrome (PCOS) in Japanese patients with T1DM. Our study enrolled 157 patients, including 55 with oligomenorrhea (prolonged menstrual cycle) and 102 without oligomenorrhea. LH/FSH ratio (p = 0.04) and total testosterone levels (p = 0.03) were significantly higher in the oligomenorrhea group than in the non-oligomenorrhea group. No significant differences were found between the two groups regarding age at menarche, age at T1DM diagnosis, treatment, glycated hemoglobin, or total daily insulin dose. Of the 55 patients in the oligomenorrhea group, 27 were diagnosed with PCOS based on the Rotterdam criteria. We concluded that female patients with T1DM, as well as abnormal menstrual cycles and hyperandrogenism, may suffer from undiagnosed PCOS and should be referred to a gynecologist for full assessment, diagnosis, and treatment.
    Language English
    Publishing date 2024-02-25
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2079760-6
    ISSN 0918-5739
    ISSN 0918-5739
    DOI 10.1297/cpe.2024-0011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical and Genetic Characteristics of Patients with Mild Hyperphenylalaninemia Identified by Newborn Screening Program in Japan.

    Odagiri, Shino / Kabata, Daijiro / Tomita, Shogo / Kudo, Satoshi / Sakaguchi, Tomoko / Nakano, Noriko / Yamamoto, Kouji / Shintaku, Haruo / Hamazaki, Takashi

    International journal of neonatal screening

    2021  Volume 7, Issue 1

    Abstract: Phenylketonuria (PKU) and hyperphenylalaninemia (HPA), both identified in newborn screening, are attributable to variants ... ...

    Abstract Phenylketonuria (PKU) and hyperphenylalaninemia (HPA), both identified in newborn screening, are attributable to variants in
    Language English
    Publishing date 2021-03-18
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2409-515X
    ISSN (online) 2409-515X
    DOI 10.3390/ijns7010017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Double pancreatic tumors in an adolescent: Imaging features.

    Odagiri, Shino / Tokuhara, Daisuke / Nishigaki, Satsuki / Cho, Yuki / Shintaku, Haruo

    Pediatrics international : official journal of the Japan Pediatric Society

    2016  Volume 58, Issue 11, Page(s) 1239–12342

    Abstract: Insulinoma is generally identified as a single tumor and seldom occurs in children or adolescents. A 14-year-old girl with difficulty in waking was found to have hyperinsulinemic hypoglycemia. On abdominal ultrasonography two hypoechoic masses (8 and 12 ... ...

    Abstract Insulinoma is generally identified as a single tumor and seldom occurs in children or adolescents. A 14-year-old girl with difficulty in waking was found to have hyperinsulinemic hypoglycemia. On abdominal ultrasonography two hypoechoic masses (8 and 12 mm in diameter) were seen in the pancreatic body: the larger mass was hypervascular, whereas the smaller one was hypovascular. Contrast-enhanced computed tomography showed enhancement of the larger mass, but did not delineate the smaller mass. On fat-suppressed T1-weighted magnetic resonance imaging, the larger mass was hypointense, but the smaller mass was hyperintense. Pathologically, the larger tumor was normal density, insulin positive, and rich in vascularity, whereas the smaller tumor was high density, insulin negative, and poor in vascularity. The present case suggests that difficulty waking should be considered as a potential etiology in insulinoma, and multiple suspected pancreatic insulinomas should be evaluated using a combination of imaging modalities to characterize each tumor.
    MeSH term(s) Adolescent ; Female ; Humans ; Insulinoma/diagnosis ; Magnetic Resonance Imaging/methods ; Neoplasm Staging ; Pancreas/diagnostic imaging ; Pancreatic Neoplasms/diagnosis ; Tomography, X-Ray Computed/methods ; Ultrasonography, Doppler, Color/methods
    Language English
    Publishing date 2016-11
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.13142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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