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  1. Article ; Online: COVID‑19 in pregnant women in South Africa: A retrospective review.

    Bhoora, S / Zamparini, J / Odell, N / Murray, L / Balie, G / Sanyika, N / Mall, K / Ramdin, T / Mahomed, A / Chauke, L

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

    2022  Volume 112, Issue 12, Page(s) 911–918

    Abstract: Background: The majority of maternal deaths in South Africa (SA) occur as a result of non-pregnancy-related infections (NPRI). Pregnancy is a known risk factor in severe COVID‑19, increasing the burden of NPRI in SA. In this study, we describe the ... ...

    Abstract Background: The majority of maternal deaths in South Africa (SA) occur as a result of non-pregnancy-related infections (NPRI). Pregnancy is a known risk factor in severe COVID‑19, increasing the burden of NPRI in SA. In this study, we describe the prevalence, profile and clinical outcomes of pregnant women with COVID‑19 admitted to a tertiary facility.
    Objectives: To describe the prevalence, profile and clinical outcomes of pregnant women with COVID‑19 admitted to a tertiary facility in Gauteng, SA.
    Methods: We performed a retrospective review of all pregnant women with COVID‑19 admitted to Charlotte Maxeke Johannesburg Academic Hospital between 6 March and 30 August 2020. Data collected included demographics, medical history, obstetric history, clinical findings and laboratory variables. Outcomes assessed were mortality, admission to intensive care unit (ICU), symptomatic v. asymptomatic disease, maternal and fetal outcome and mode of delivery.
    Results: A total of 204 pregnant women were included in the study. Of these, 33 (16.2%) women were critically ill, with 21 (10.3%) admitted to the ICU and 3 (1.5%) deaths related to COVID‑19. The median gestational age was 37 weeks and median birthweight 2 940 g. Sixty-seven women (33%) were HIV-positive, in keeping with national statistics regarding HIV in pregnancy. Caesarean section was the most common mode of delivery (n=105, 60%). However, no women underwent caesarean section for indications related to COVID‑19.
    Conclusion: COVID‑19-related mortality in our cohort was higher than that seen internationally, likely due to differences in background maternal mortality rates and difficulty in accessing care.
    Language English
    Publishing date 2022-12-01
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 390968-2
    ISSN 2078-5135 ; 0038-2469 ; 0256-9574
    ISSN (online) 2078-5135
    ISSN 0038-2469 ; 0256-9574
    DOI 10.7196/SAMJ.2022.v112i12.16552
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  2. Article ; Online: Small-molecule inhibitors of ferrochelatase are antiangiogenic agents.

    Sishtla, Kamakshi / Lambert-Cheatham, Nathan / Lee, Bit / Han, Duk Hee / Park, Jaehui / Sardar Pasha, Sheik Pran Babu / Lee, Sanha / Kwon, Sangil / Muniyandi, Anbukkarasi / Park, Bomina / Odell, Noa / Waller, Sydney / Park, Il Yeong / Lee, Soo Jae / Seo, Seung-Yong / Corson, Timothy W

    Cell chemical biology

    2022  Volume 29, Issue 6, Page(s) 1010–1023.e14

    Abstract: Activity of the heme synthesis enzyme ferrochelatase (FECH) is implicated in multiple diseases. In particular, it is a mediator of neovascularization in the eye and thus an appealing therapeutic target for preventing blindness. However, no drug-like ... ...

    Abstract Activity of the heme synthesis enzyme ferrochelatase (FECH) is implicated in multiple diseases. In particular, it is a mediator of neovascularization in the eye and thus an appealing therapeutic target for preventing blindness. However, no drug-like direct FECH inhibitors are known. Here, we set out to identify small-molecule inhibitors of FECH as potential therapeutic leads using a high-throughput screening approach to identify potent inhibitors of FECH activity. A structure-activity relationship study of a class of triazolopyrimidinone hits yielded drug-like FECH inhibitors. These compounds inhibit FECH in cells, bind the active site in cocrystal structures, and are antiangiogenic in multiple in vitro assays. One of these promising compounds was antiangiogenic in vivo in a mouse model of choroidal neovascularization. This foundational work may be the basis for new therapeutic agents to combat not only ocular neovascularization but also other diseases characterized by FECH activity.
    MeSH term(s) Angiogenesis Inhibitors/pharmacology ; Animals ; Ferrochelatase/chemistry ; Ferrochelatase/metabolism ; Mice ; Neovascularization, Pathologic
    Chemical Substances Angiogenesis Inhibitors ; Ferrochelatase (EC 4.99.1.1)
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2022.01.001
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  3. Article ; Online: Drosophila importin-7 functions upstream of the Elmo signaling module to mediate the formation and stability of muscle attachments.

    Liu, Ze Cindy / Odell, Nadia / Geisbrecht, Erika R

    Journal of cell science

    2013  Volume 126, Issue Pt 22, Page(s) 5210–5223

    Abstract: Establishment and maintenance of stable muscle attachments is essential for coordinated body movement. Studies in Drosophila have pioneered a molecular understanding of the morphological events in the conserved process of muscle attachment formation, ... ...

    Abstract Establishment and maintenance of stable muscle attachments is essential for coordinated body movement. Studies in Drosophila have pioneered a molecular understanding of the morphological events in the conserved process of muscle attachment formation, including myofiber migration, muscle-tendon signaling, and stable junctional adhesion between muscle cells and their corresponding target insertion sites. In both Drosophila and vertebrate models, integrin complexes play a key role in the biogenesis and stability of muscle attachments through the interactions of integrins with extracellular matrix (ECM) ligands. We show that Drosophila importin-7 (Dim7) is an upstream regulator of the conserved Elmo-Mbc→Rac signaling pathway in the formation of embryonic muscle attachment sites (MASs). Dim7 is encoded by the moleskin (msk) locus and was identified as an Elmo-interacting protein. Both Dim7 and Elmo localize to the ends of myofibers coincident with the timing of muscle-tendon attachment in late myogenesis. Phenotypic analysis of elmo mutants reveal muscle attachment defects similar to those previously described for integrin mutants. Furthermore, Elmo and Dim7 interact both biochemically and genetically in the developing musculature. The muscle detachment phenotype resulting from mutations in the msk locus can be rescued by components in the Elmo signaling pathway, including the Elmo-Mbc complex, an activated Elmo variant, or a constitutively active form of Rac. In larval muscles, the localization of Dim7 and activated Elmo to the sites of muscle attachment is attenuated upon RNAi knockdown of integrin heterodimer complex components. Our results show that integrins function as upstream signals to mediate Dim7-Elmo enrichment to the MASs.
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/growth & development ; Extracellular Matrix/genetics ; Gene Expression Regulation, Developmental ; Karyopherins/genetics ; Karyopherins/metabolism ; Movement/physiology ; Muscle Development/genetics ; Myoblasts/cytology ; Myoblasts/metabolism ; RNA Interference ; Signal Transduction/genetics
    Chemical Substances Adaptor Proteins, Signal Transducing ; Ced-12 protein, Drosophila ; Drosophila Proteins ; Karyopherins ; Msk protein, Drosophila
    Language English
    Publishing date 2013-09-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.132241
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  4. Article ; Online: RESPONSE OF INFLAMMATORY CYSTOID MACULAR EDEMA TO TREATMENT USING ORAL ACETAZOLAMIDE.

    Pepple, Kathryn L / Nguyen, Macklin H / Pakzad-Vaezi, Kaivon / Williamson, Kathleen / Odell, Naomi / Lee, Cecilia / Leveque, Thellea K / Van Gelder, Russell N

    Retina (Philadelphia, Pa.)

    2018  Volume 39, Issue 5, Page(s) 948–955

    Abstract: Purpose: To determine the treatment effect of oral acetazolamide on refractory inflammatory macular edema.: Methods: A retrospective review of identified patients with uveitic or pseudophakic macular edema treated using acetazolamide between 2007 and ...

    Abstract Purpose: To determine the treatment effect of oral acetazolamide on refractory inflammatory macular edema.
    Methods: A retrospective review of identified patients with uveitic or pseudophakic macular edema treated using acetazolamide between 2007 and 2014. Visual acuity and central macular subfield thickness was determined at baseline and at first follow-up. Baseline optical coherence tomography features were analyzed as predictors of acetazolamide response.
    Results: Sixteen patients (19 eyes) of 61 screened met all criteria. Mean age was 57.9 years (19.7-81.1). The most common diagnosis was idiopathic uveitis (n = 6, 31.6%). Mean uveitis duration was 4.4 years (0.2-27.5). Average central macular subfield thickness decreased significantly (from 471.8 ± 110.6 μm to 358.3 ± 50.4 μm) (P < 0.0001). Average visual acuity (logarithm of the minimum angle of resolution) improved significantly from 20/54 (0.43 ± 0.25) to 20/37 (0.27 ± 0.16) (P = 0.003). Pretreatment optical coherence tomographies demonstrated intraretinal fluid (n = 19, 100%), subretinal fluid (n = 8, 42.1%), epiretinal membrane (n = 13, 68.3%), and vitreomacular traction (n = 1, 5.2%). No optical coherence tomography characteristic was predictive of a response to therapy.
    Conclusion: There is a significant benefit to vision and central macular subfield thickness after acetazolamide treatment in patients with inflammatory macular edema. In patients with refractory inflammatory macular edema, treatment using acetazolamide can provide anatomical and visual benefit without corticosteroid-related adverse effects.
    MeSH term(s) Acetazolamide/administration & dosage ; Administration, Oral ; Adult ; Aged ; Aged, 80 and over ; Carbonic Anhydrase Inhibitors/administration & dosage ; Dose-Response Relationship, Drug ; Female ; Fluorescein Angiography ; Fundus Oculi ; Humans ; Macula Lutea/pathology ; Macular Edema/diagnosis ; Macular Edema/drug therapy ; Male ; Middle Aged ; Retrospective Studies ; Tomography, Optical Coherence ; Treatment Outcome ; Visual Acuity ; Young Adult
    Chemical Substances Carbonic Anhydrase Inhibitors ; Acetazolamide (O3FX965V0I)
    Language English
    Publishing date 2018-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000002044
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  5. Article ; Online: A Common Suite of Coagulation Proteins Function in Drosophila Muscle Attachment.

    Green, Nicole / Odell, Nadia / Zych, Molly / Clark, Cheryl / Wang, Zong-Heng / Biersmith, Bridget / Bajzek, Clara / Cook, Kevin R / Dushay, Mitchell S / Geisbrecht, Erika R

    Genetics

    2016  Volume 204, Issue 3, Page(s) 1075–1087

    Abstract: The organization and stability of higher order structures that form in the extracellular matrix (ECM) to mediate the attachment of muscles are poorly understood. We have made the surprising discovery that a subset of clotting factor proteins are also ... ...

    Abstract The organization and stability of higher order structures that form in the extracellular matrix (ECM) to mediate the attachment of muscles are poorly understood. We have made the surprising discovery that a subset of clotting factor proteins are also essential for muscle attachment in the model organism Drosophila melanogaster One such coagulation protein, Fondue (Fon), was identified as a novel muscle mutant in a pupal lethal genetic screen. Fon accumulates at muscle attachment sites and removal of this protein results in decreased locomotor behavior and detached larval muscles. A sensitized genetic background assay reveals that fon functions with the known muscle attachment genes Thrombospondin (Tsp) and Tiggrin (Tig). Interestingly, Tig is also a component of the hemolymph clot. We further demonstrate that an additional clotting protein, Larval serum protein 1γ (Lsp1γ), is also required for muscle attachment stability and accumulates where muscles attach to tendons. While the local biomechanical and organizational properties of the ECM vary greatly depending on the tissue microenvironment, we propose that shared extracellular protein-protein interactions influence the strength and elasticity of ECM proteins in both coagulation and muscle attachment.
    MeSH term(s) Animals ; Blood Coagulation Factors/genetics ; Blood Coagulation Factors/metabolism ; Blood Proteins/genetics ; Blood Proteins/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; Hemolymph/metabolism ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/physiology ; Protein Binding ; Tendons/metabolism ; Tendons/physiology ; Thrombospondins/genetics ; Thrombospondins/metabolism
    Chemical Substances Blood Coagulation Factors ; Blood Proteins ; Drosophila Proteins ; Extracellular Matrix Proteins ; Thrombospondins ; Tig protein, Drosophila ; fon protein, Drosophila ; larval serum protein, Drosophila
    Language English
    Publishing date 2016-08-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1534/genetics.116.189787
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  6. Article ; Online: Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS-CoV-2 infection in South Africa: An International Network of Obstetric Survey Systems-based cohort study.

    Budhram, Samantha / Vannevel, Valerie / Botha, Tanita / Chauke, Lawrence / Bhoora, Shastra / Balie, Gaynor M / Odell, Natalie / Lombaard, Hennie / Wise, Amy / Georgiou, Chrysanthi / Ngxola, Nondumiso / Wynne, Emma / Mbewu, Unati / Mabenge, Mfundo / Phinzi, Sibusiso / Gubu-Ntaba, Nontsikelelo / Goldman, Gareth / Tunkyi, Kay / Prithipal, Sudhir /
    Naidoo, Keshree / Venkatachalam, Santhi / Moodley, Terence / Mould, Sean / Hlabisa, Mzuvele / Govender, Logie / Maistry, Charlene / Habineza, John P / Israel, Priya / Foolchand, Serantha / Tsibiyane, Nomandla V / Panday, Mala / Soma-Pillay, Priya / Adam, Sumaiya / Molokoane, Felicia / Mojela, Matthew S / van Rensburg, Elizabeth J / Mashamba, Tshililo / Matjila, Mushi / Fawcus, Sue / Osman, Ayesha / Venter, Mareli / Petro, Gregory / Fakier, Ahminah / Langenegger, Eduard / Cluver, Catherine A / Bekker, Adrie / de Waard, Liesl / Stewart, Chantal / Ngene, Nnabuike C / Lunda, Ongombe / N Cebekhulu, Sylvia / Moodley, Siva / Koranteng-Peprah, Mama-Asu / Ati, Emmanuel M C / Maswime, Salome / Yates, Laura M

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2021  Volume 155, Issue 3, Page(s) 455–465

    Abstract: Objective: To describe risk factors and outcomes of pregnant women infected with SARS-CoV-2 admitted to South African healthcare facilities.: Methods: A population-based cohort study was conducted utilizing an amended International Obstetric ... ...

    Abstract Objective: To describe risk factors and outcomes of pregnant women infected with SARS-CoV-2 admitted to South African healthcare facilities.
    Methods: A population-based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS-CoV-2 infection, hospitalized between April 14, 2020, and November 24, 2020, were analyzed.
    Results: A total of 36 hospitals submitted data on 673 infected hospitalized pregnant women; 217 (32.2%) were admitted for COVID-19 illness and 456 for other indications. There were 39 deaths with a case fatality rate of 6.3%: 32 (14.7%) deaths occurred in women admitted for COVID-19 illness compared to 7 (1.8%) in women admitted for other indications. Of the women, 106 (15.9%) required critical care. Maternal tuberculosis, but not HIV co-infection or other co-morbidities, was associated with admission for COVID-19 illness. Rates of cesarean delivery did not differ significantly between women admitted for COVID-19 and those admitted for other indications. There were 179 (35.4%) preterm births, 25 (4.7%) stillbirths, 12 (2.3%) neonatal deaths, and 162 (30.8%) neonatal admissions. Neonatal outcomes did not differ significantly from those of infected women admitted for other indications.
    Conclusion: The maternal mortality rate was high among women admitted with SARS-CoV-2 infection and higher in women admitted primarily for COVID-19 illness with tuberculosis being the only co-morbidity associated with admission.
    MeSH term(s) COVID-19 ; Cohort Studies ; Female ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Outcome/epidemiology ; Pregnant Women ; Premature Birth ; SARS-CoV-2 ; South Africa/epidemiology
    Language English
    Publishing date 2021-09-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.13917
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    Zs.MO 183: Show issues

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  7. Article: Molecular genetics of radiographically defined de novo glioblastoma multiforme.

    Tortosa, A / Ino, Y / Odell, N / Swilley, S / Sasaki, H / Louis, D N / Henson, J W

    Neuropathology and applied neurobiology

    2000  Volume 26, Issue 6, Page(s) 544–552

    Abstract: Glioblastoma multiforme (GBM) represents the final endpoint of anaplastic progression in astrocytomas. GBM which arise without clinical evidence of a prior low-grade astrocytoma (LGA) have been designated de novo GBM, and are thought to develop rapidly ... ...

    Abstract Glioblastoma multiforme (GBM) represents the final endpoint of anaplastic progression in astrocytomas. GBM which arise without clinical evidence of a prior low-grade astrocytoma (LGA) have been designated de novo GBM, and are thought to develop rapidly from initial tumour formation. However, a purely clinical definition of de novo GBM does not exclude a long-standing, asymptomatic low-grade tumour. This study therefore sought to determine the genetic features of a unique group of cases in which GBMs were documented to have arisen radiographically in defined period of time (radiographically defined de novo GBM). Clinical and genetic features were examined in a group of 11 patients with a histological diagnosis of high-grade astrocytoma at first biopsy and radiographically defined de novo GBM. The mean age of the patients at tumour diagnosis was 62 years (range 32-87). Six of 11 tumours arose in the temporal lobes. Eight of 11 tumours had epidermal growth factor receptor (EGFR) overexpression, and EGFR gene amplification was found in five of the six analysed cases. Overexpression of p53 was observed in only one tumour, and a TP53 mutation was present in this case. p16 immunostaining was undetectable in 10 cases, and homozygous deletion of CDKN2A was observed in four of the six studied tumours. pRb expression was lost in four tumours. Mutations in the PTEN gene were detected in two of six cases. The results in this unique group of cases confirms the prior hypothesis that the profile of genetic alterations in de novo GBM is distinct from that of GBM arising from a known LGA, and that these specific genetic pathways promote the rapid development of GBM.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Brain Neoplasms/diagnosis ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Frameshift Mutation ; Gene Deletion ; Glioblastoma/diagnosis ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Homozygote ; Humans ; Immunohistochemistry ; Magnetic Resonance Imaging ; Middle Aged ; Mutation, Missense ; PTEN Phosphohydrolase ; Phosphoric Monoester Hydrolases/genetics ; Tomography, X-Ray Computed ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Tumor Suppressor Proteins
    Chemical Substances Cyclin-Dependent Kinase Inhibitor p16 ; Tumor Suppressor Protein p53 ; Tumor Suppressor Proteins ; ErbB Receptors (EC 2.7.10.1) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; PTEN Phosphohydrolase (EC 3.1.3.67) ; PTEN protein, human (EC 3.1.3.67)
    Language English
    Publishing date 2000-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80371-6
    ISSN 1365-2990 ; 0305-1846
    ISSN (online) 1365-2990
    ISSN 0305-1846
    DOI 10.1046/j.0305-1846.2000.00290.x
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  8. Book ; Online: Performance of the CMS High Granularity Calorimeter prototype to charged pion beams of 20$-$300 GeV/c

    Acar, B. / Adamov, G. / Adloff, C. / Afanasiev, S. / Akchurin, N. / Akgün, B. / Alhusseini, M. / Alison, J. / de Almeida, J. P. Figueiredo de sa Sousa / de Almeida, P. G. Dias / Alpana, A. / Alyari, M. / Andreev, I. / Aras, U. / Aspell, P. / Atakisi, I. O. / Bach, O. / Baden, A. / Bakas, G. /
    Bakshi, A. / Banerjee, S. / DeBarbaro, P. / Bargassa, P. / Barney, D. / Beaudette, F. / Beaujean, F. / Becheva, E. / Becker, A. / Behera, P. / Belloni, A. / Bergauer, T. / Berni, M. El / Besancon, M. / Bhattacharya, S. / Bhowmik, D. / Bilki, B. / Bilokin, S. / Blazey, G. C. / Blekman, F. / Bloch, P. / Bodek, A. / Bonanomi, M. / Bonis, J. / Bonnemaison, A. / Bonomally, S. / Borg, J. / Bouyjou, F. / Bower, N. / Braga, D. / Brennan, L. / Brianne, E. / Brondolin, E. / Bryant, P. / Buhmann, E. / Buhmann, P. / Butler-Nalin, A. / Bychkova, O. / Callier, S. / Calvet, D. / Canderan, K. / Cankocak, K. / Cao, X. / Cappati, A. / Caraway, B. / Caregari, S. / Carty, C. / Cauchois, A. / Ceard, L. / Cerci, D. S. / Cerci, S. / Cerminara, G. / Chadeeva, M. / Charitonidis, N. / Chatterjee, R. / Chen, J. A. / Chen, Y. M. / Cheng, H. J. / Cheng, K. Y. / Cheung, H. / Chokheli, D. / Cipriani, M. / Čoko, D. / Couderc, F. / Cuba, E. / Danilov, M. / Dannheim, D. / Daoud, W. / Das, I. / Dauncey, P. / Davies, G. / Davignon, O. / Day, E. / Debbins, P. / Defranchis, M. M. / Delagnes, E. / Demiragli, Z. / Demirbas, U. / Derylo, G. / Diaz, D. / Diehl, L. / Dinaucourt, P. / Dincer, G. G. / Dittmann, J. / Dragicevic, M. / Dugad, S. / Dulucq, F. / Dumanoglu, I. / Dünser, M. / Dutta, S. / Dutta, V. / Edberg, T. K. / Elias, F. / Emberger, L. / Eno, S. C. / Ershov, Yu. / Extier, S. / Fahim, F. / Fallon, C. / Fard, K. Sarbandi / Fedi, G. / Ferragina, L. / Forthomme, L. / Frahm, E. / Franzoni, G. / Freeman, J. / French, T. / Gadow, K. / Gandhi, P. / Ganjour, S. / Gao, X. / Garcia, M. T. Ramos / Garcia-Bellido, A. / Garutti, E. / Gastaldi, F. / Gastler, D. / Gecse, Z. / Germer, A. / Gerwig, H. / Gevin, O. / Ghosh, S. / Gilbert, A. / Gilbert, W. / Gill, K. / Gingu, C. / Gninenko, S. / Golunov, A. / Golutvin, I. / Gonultas, B. / Gorbounov, N. / Göttlicher, P. / Gouskos, L. / Graf, C. / Gray, A. B. / Grieco, C. / Gr\"önroos, S. / Gu, Y. / Guilloux, F. / Guler, E. Gurpinar / Guler, Y. / Gülmez, E. / Guo, J. / Gutti, H. / Hakimi, A. / Hammer, M. / Hartbrich, O. / Hassanshahi, H. M. / Hatakeyama, K. / Hazen, E. / Heering, A. / Hegde, V. / Heintz, U. / Heuchel, D. / Hinton, N. / Hirschauer, J. / Hoff, J. / Hou, W. S. / Hou, X. / Hua, H. / Huck, S. / Hussain, A. / Incandela, J. / Irles, A. / Irshad, A. / Isik, C. / Jain, S. / Jaroslavceva, J. / Jheng, H. R. / Joshi, U. / Kaadze, K. / Kachanov, V. / Kalipoliti, L. / Kaminskiy, A. / Kanuganti, A. R. / Kao, Y. W. / Kapoor, A. / Kara, O. / Karneyeu, A. / Kałuzińska, O. / Kaya, M. / Kaya, O. / Kazhykharim, Y. / Khan, F. A. / Khukhunaishvili, A. / Kieseler, J. / Kilpatrick, M. / Kim, S. / Koetz, K. / Kolberg, T. / Komm, M. / Köseyan, O. K. / Kraus, V. / Krawczyk, M. / Kristiansen, K. / Kristić, A. / Krohn, M. / Kronheim, B. / Krüger, K. / Kulis, S. / Kumar, M. / Kunori, S. / Kuo, C. M. / Kuryatkov, V. / Kvasnicka, J. / Kyre, S. / Lai, Y. / Lamichhane, K. / Landsberg, G. / Lange, C. / Langford, J. / Laurien, S. / Lee, M. Y. / Lee, S. W. / Leiton, A. G. Stahl / Levin, A. / Li, A. / Li, J. H. / Li, Y. Y. / Liang, Z. / Liao, H. / Lin, Z. / Lincoln, D. / Linssen, L. / Lipton, R. / Liu, G. / Liu, Y. / Lobanov, A. / Lohezic, V. / Lomidze, D. / Lu, R. S. / Lu, S. / Lupi, M. / Lysova, I. / Magnan, A. -M. / Magniette, F. / Mahjoub, A. / Martens, S. / Matysek, M. / Meier, B. / Malakhov, A. / Mallios, S. / Mandjavize, I. / Mannelli, M. / Mans, J. / Marchioro, A. / Martelli, A. / Martinez, G. / Masterson, P. / Matthewman, M. / Mayekar, S. N. / David, A. / Coco, S. / Meng, B. / Menkel, A . / Mestvirishvili, A. / Milella, G. / Mirza, I. / Moccia, S. / Mohanty, G. B. / Monti, F. / Moortgat, F. W. / Morrissey, I. / Motta, J. / Murthy, S. / Musić, J. / Musienko, Y. / Nabili, S. / Nguyen, M. / Nikitenko, A. / Noonan, D. / Noy, M. / Nurdan, K. / Nursanto, M. Wulansatiti / Ochando, C. / Odell, N. / Okawa, H. / Onel, Y. / Ortez, W. / Ozegović, J. / Ozkorucuklu, S. / Paganis, E. / Palmer, C. A. / Pandey, S. / Pantaleo, F. / Papageorgakis, C. / Papakrivopoulos, I. / Paranjpe, M. / Parshook, J. / Pastika, N. / Paulini, M. / Peitzmann, T. / Peltola, T. / Peng, N. / Perraguin, A. Buchot / Petiot, P. / Pierre-Emile, T. / Pinto, M. Vicente Barreto / Popova, E. / Pöschl, R. / Prosper, H. / Prvan, M. / Puljak, I. / Qasim, S. R. / Qu, H. / Quast, T. / Quinn, R. / Quinnan, M. / Rane, A. / Rao, K. K. / Rapacz, K. / Raux, L. / Redjeb, W. / Reinecke, M. / Revering, M. / Richard, F. / Roberts, A. / Sanchez, A. M. / Rohlf, J. / Rolph, J. / Romanteau, T. / Rosado, M. / Rose, A. / Rovere, M. / Roy, A. / Rubinov, P. / Rusack, R. / Rusinov, V. / Ryjov, V. / Sahin, O. M. / Salerno, R. / Saradhy, R. / Sarkar, T. / Sarkisla, M. A. / Sauvan, J. B. / Schmidt, I. / Schmitt, M. / Schuwalow, S. / Scott, E. / Seez, C. / Sefkow, F. / Selivanova, D. / Sharma, S. / Shelake, M. / Shenai, A. / Shukla, R. / Sicking, E. / De, M. / Silva, P. / Simkina, P. / Simon, F. / Simsek, A. E. / Sirois, Y. / Smirnov, V. / Sobering, T. J. / Spencer, E. / Srimanobhas, N. / Steen, A. / Strait, J. / Strobbe, N. / Su, X. F. / Sudo, Y. / Suarez, C. Mantilla / Sukhov, E. / Sulak, L. / Sun, L. / Suryadevara, P. / Syal, C. / de La Taille, C. / Tali, B. / Tan, C. L. / Tao, J. / Tarabini, A. / Tatli, T. / Thaus, R. / Taylor, R. D. / Tekten, S. / Thiebault, A. / Thienpont, D. / Tiley, C. / Tiras, E. / Titov, M. / Tlisov, D. / Tok, U. G. / Kayis, A. / Troska, J. / Tsai, L. S. / Tsamalaidze, Z. / Tsipolitis, G. / Tsirou, A. / Undleeb, S. / Urbanski, D. / Uslan, E. / Ustinov, V. / Uzunian, A. / Varela, J. / Velasco, M. / Vernazza, E. / Viazlo, O. / Vichoudis, P. / Virdee, T. / Voirin, E. / Vojinovi\c, M. / Vojinovic, M. / Wade, A. / Wang, C. / Wang, C. C. / Wang, D. / Wang, F. / Wang, X. / Wang, Z. / Wayne, M. / Webb, S. N. / Whitbeck, A. / Wickwire, R. / Wilson, J. S. / Wu, H. Y. / Wu, L. / Xiao, M. / Yang, J. / Yeh, C. H / Yohay, R. / Yu, D. / Yu, S. S. / Yuan, C. / Miao, Y. / Yumiceva, F. / Yusuff, I. / Zabi, A. / Zacharopoulou, A. / Zamiatin, N. / Zarubin, A. / Zehetner, P. / Zerwas, D. / Zhang, H. / Zhang, J. / Zhang, Y. / Zhang, Z. / Zhao, X.

    2022  

    Abstract: The upgrade of the CMS experiment for the high luminosity operation of the LHC comprises the replacement of the current endcap calorimeter by a high granularity sampling calorimeter (HGCAL). The electromagnetic section of the HGCAL is based on silicon ... ...

    Abstract The upgrade of the CMS experiment for the high luminosity operation of the LHC comprises the replacement of the current endcap calorimeter by a high granularity sampling calorimeter (HGCAL). The electromagnetic section of the HGCAL is based on silicon sensors interspersed between lead and copper (or copper tungsten) absorbers. The hadronic section uses layers of stainless steel as an absorbing medium and silicon sensors as an active medium in the regions of high radiation exposure, and scintillator tiles directly readout by silicon photomultipliers in the remaining regions. As part of the development of the detector and its readout electronic components, a section of a silicon-based HGCAL prototype detector along with a section of the CALICE AHCAL prototype was exposed to muons, electrons and charged pions in beam test experiments at the H2 beamline at the CERN SPS in October 2018. The AHCAL uses the same technology as foreseen for the HGCAL but with much finer longitudinal segmentation. The performance of the calorimeters in terms of energy response and resolution, longitudinal and transverse shower profiles is studied using negatively charged pions, and is compared to GEANT4 predictions. This is the first report summarizing results of hadronic showers measured by the HGCAL prototype using beam test data.

    Comment: Accepted for publication by JINST
    Keywords Physics - Instrumentation and Detectors
    Subject code 621
    Publishing date 2022-11-09
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book ; Online: The DAQ system of the 12,000 Channel CMS High Granularity Calorimeter Prototype

    Acar, B. / Adamov, G. / Adloff, C. / Afanasiev, S. / Akchurin, N. / Akgün, B. / Alhusseini, M. / Alison, J. / Altopp, G. / Alyari, M. / An, S. / Anagul, S. / Andreev, I. / Andrews, M. / Aspell, P. / Atakisi, I. A. / Bach, O. / Baden, A. / Bakas, G. /
    Bakshi, A. / Bargassa, P. / Barney, D. / Becheva, E. / Behera, P. / Belloni, A. / Bergauer, T. / Besancon, M. / Bhattacharya, S. / Bhowmik, D. / Bloch, P. / Bodek, A. / Bonanomi, M. / Bonnemaison, A. / Bonomally, S. / Borg, J. / Bouyjou, F. / Braga, D. / Brashear, J. / Brondolin, E. / Bryant, P. / Bueghly, J. / Bilki, B. / Burkle, B. / Butler-Nalin, A. / Callier, S. / Calvet, D. / Cao, X. / Caraway, B. / Caregari, S. / Ceard, L. / Cekmecelioglu, Y. C. / Cerminara, G. / Charitonidis, N. / Chatterjee, R. / Chen, Y. M. / Chen, Z. / Cheng, K. y. / Chernichenko, S. / Cheung, H. / Chien, C. H. / Choudhury, S. / Čoko, D. / Collura, G. / Couderc, F. / Dumanoglu, I. / Dannheim, D. / Dauncey, P. / David, A. / Davies, G. / Day, E. / DeBarbaro, P. / De Guio, F. / de La Taille, C. / De Silva, M. / Debbins, P. / Delagnes, E. / Deltoro, J. M. / Derylo, G. / de Almeida, P. G. Dias / Diaz, D. / Dinaucourt, P. / Dittmann, J. / Dragicevic, M. / Dugad, S. / Dutta, V. / Dutta, S. / Eckdahl, J. / Edberg, T. K. / Berni, M. El / Eno, S. C. / Ershov, Yu. / Everaerts, P. / Extier, S. / Fahim, F. / Fallon, C. / Alves, B. A. Fontana Santos / Frahm, E. / Franzoni, G. / Freeman, J. / French, T. / Guler, E. Gurpinar / Guler, Y. / Gagnan, M. / Gandhi, P. / Ganjour, S. / Garcia-Bellido, A. / Gecse, Z. / Geerebaert, Y. / Gerwig, H. / Gevin, O. / Gilbert, W. / Gilbert, A. / Gill, K. / Gingu, C. / Gninenko, S. / Golunov, A. / Golutvin, I. / Gonzalez, T. / Gorbounov, N. / Gouskos, L. / Gu, Y. / Guilloux, F. / Gülmez, E. / Hammer, M. / Harilal, A. / Hatakeyama, K. / Heering, A. / Hegde, V. / Heintz, U. / Hinger, V. / Hinton, N. / Hirschauer, J. / Hoff, J. / Hou, W. S. / Isik, C. / Incandela, J. / Jain, S. / Jheng, H. R. / Joshi, U. / Kara, O. / Kachanov, V. / Kalinin, A. / Kameshwar, R. / Kaminskiy, A. / Karneyeu, A. / Kaya, O. / Kaya, M. / Khukhunaishvili, A. / Kim, S. / Koetz, K. / Kolberg, T. / Kristić, A. / Krohn, M. / Krüger, K. / Kulagin, N. / Kulis, S. / Kunori, S. / Kuo, C. M. / Kuryatkov, V. / Kyre, S. / Köseyan, O. K. / Lai, Y. / Lamichhane, K. / Landsberg, G. / Langford, J. / Lee, M. Y. / Levin, A. / Li, A. / Li, B. / Li, J. -H. / Liao, H. / Lincoln, D. / Linssen, L. / Lipton, R. / Liu, Y. / Lobanov, A. / Lu, R. S. / Lysova, I. / Magnan, A. M. / Magniette, F. / Maier, A. A. / Malakhov, A. / Mandjavize, I. / Mannelli, M. / Mans, J. / Marchioro, A. / Martelli, A. / Masterson, P. / Meng, B. / Mengke, T. / Mestvirishvili, A. / Mirza, I. / Moccia, S. / Morrissey, I. / Mudholkar, T. / Musić, J. / Musienko, I. / Nabili, S. / Nagar, A. / Nikitenko, A. / Noonan, D. / Noy, M. / Nurdan, K. / Ochando, C. / Odegard, B. / Odell, N. / Onel, Y. / Ortez, W. / Ozegović, J. / Rodriguez, L. Pacheco / Paganis, E. / Pagenkopf, D. / Palladino, V. / Pandey, S. / Pantaleo, F. / Papageorgakis, C. / Papakrivopoulos, I. / Parshook, J. / Pastika, N. / Paulini, M. / Paulitsch, P. / Peltola, T. / Gomes, R. Pereira / Perkins, H. / Petiot, P. / Pitters, F. / Prosper, H. / Prvan, M. / Puljak, I. / Quast, T. / Quinn, R. / Quinnan, M. / Rapacz, K. / Raux, L. / Reichenbach, G. / Reinecke, M. / Revering, M. / Rodriguez, A. / Romanteau, T. / Rose, A. / Rovere, M. / Roy, A. / Rubinov, P. / Rusack, R. / Simsek, A. E. / Sozbilir, U. / Sahin, O. M. / Sanchez, A. / Saradhy, R. / Sarkar, T. / Sarkisla, M. A. / Sauvan, J. B. / Schmidt, I. / Schmitt, M. / Scott, E. / Seez, C. / Sefkow, F. / Sharma, S. / Shein, I. / Shenai, A. / Shukla, R. / Sicking, E. / Sieberer, P. / Sirois, Y. / Smirnov, V. / Spencer, E. / Steen, A. / Strait, J. / Strebler, T. / Strobbe, N. / Su, J. W. / Sukhov, E. / Sun, L. / Sun, M. / Syal, C. / Tali, B. / Tok, U. G. / Topaksu, A. Kayis / Tan, C. L. / Tastan, I. / Tatli, T. / Thaus, R. / Tekten, S. / Thienpont, D. / Pierre-Emile, T. / Tiras, E. / Titov, M. / Tlisov, D. / Troska, J. / Tsamalaidze, Z. / Tsipolitis, G. / Tsirou, A. / Tyurin, N. / Undleeb, S. / Urbanski, D. / Ustinov, V. / Uzunian, A. / van de Klundert, M. / Varela, J. / Velasco, M. / Pinto, M. Vicente Barreto / da Silva, P. M. / Virdee, T. / de Oliveira, R. Vizinho / Voelker, J. / Voirin, E. / Wang, Z. / Wang, X. / Wang, F. / Wayne, M. / Webb, S. N. / Weinberg, M. / Whitbeck, A. / White, D. / Wickwire, R. / Wilson, J. S. / Wu, H. Y. / Wu, L. / Yeh, C. H / Yohay, R. / Yu, G. B. / Yu, S. S. / Yu, D. / Yumiceva, F. / Zacharopoulou, A. / Zamiatin, N. / Zarubin, A. / Zenz, S. / Zhang, H. / Zhang, J.

    2020  

    Abstract: The CMS experiment at the CERN LHC will be upgraded to accommodate the 5-fold increase in the instantaneous luminosity expected at the High-Luminosity LHC (HL-LHC). Concomitant with this increase will be an increase in the number of interactions in each ... ...

    Abstract The CMS experiment at the CERN LHC will be upgraded to accommodate the 5-fold increase in the instantaneous luminosity expected at the High-Luminosity LHC (HL-LHC). Concomitant with this increase will be an increase in the number of interactions in each bunch crossing and a significant increase in the total ionising dose and fluence. One part of this upgrade is the replacement of the current endcap calorimeters with a high granularity sampling calorimeter equipped with silicon sensors, designed to manage the high collision rates. As part of the development of this calorimeter, a series of beam tests have been conducted with different sampling configurations using prototype segmented silicon detectors. In the most recent of these tests, conducted in late 2018 at the CERN SPS, the performance of a prototype calorimeter equipped with ${\approx}12,000\rm{~channels}$ of silicon sensors was studied with beams of high-energy electrons, pions and muons. This paper describes the custom-built scalable data acquisition system that was built with readily available FPGA mezzanines and low-cost Raspberry PI computers.
    Keywords Physics - Instrumentation and Detectors ; High Energy Physics - Experiment
    Subject code 621
    Publishing date 2020-12-07
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book ; Online: Construction and commissioning of CMS CE prototype silicon modules

    Acar, B. / Adamov, G. / Adloff, C. / Afanasiev, S. / Akchurin, N. / Akgün, B. / Alhusseini, M. / Alison, J. / Altopp, G. / Alyari, M. / An, S. / Anagul, S. / Andreev, I. / Andrews, M. / Aspell, P. / Atakisi, I. A. / Bach, O. / Baden, A. / Bakas, G. /
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    2020  

    Abstract: As part of its HL-LHC upgrade program, the CMS Collaboration is developing a High Granularity Calorimeter (CE) to replace the existing endcap calorimeters. The CE is a sampling calorimeter with unprecedented transverse and longitudinal readout for both ... ...

    Abstract As part of its HL-LHC upgrade program, the CMS Collaboration is developing a High Granularity Calorimeter (CE) to replace the existing endcap calorimeters. The CE is a sampling calorimeter with unprecedented transverse and longitudinal readout for both electromagnetic (CE-E) and hadronic (CE-H) compartments. The calorimeter will be built with $\sim$30,000 hexagonal silicon modules. Prototype modules have been constructed with 6-inch hexagonal silicon sensors with cell areas of 1.1~$cm^2$, and the SKIROC2-CMS readout ASIC. Beam tests of different sampling configurations were conducted with the prototype modules at DESY and CERN in 2017 and 2018. This paper describes the construction and commissioning of the CE calorimeter prototype, the silicon modules used in the construction, their basic performance, and the methods used for their calibration.

    Comment: 35 pages, submitted to JINST
    Keywords Physics - Instrumentation and Detectors ; High Energy Physics - Experiment
    Subject code 621
    Publishing date 2020-12-10
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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