LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU="Odenigbo, Kenechukwu A"
  2. AU="Dana N. Mitzel"
  3. AU="Rothenberg, Steven"
  4. AU="Skilling, Tracey"
  5. AU=Barnett Stephen M
  6. AU="Motuzas, Juliuz"
  7. AU="Chata Quispe, Yulisa"
  8. AU="Hougaard, Anders"
  9. AU="Da Cruz ESilva, C Beir Ao"
  10. AU="Weinberg-Shukron, Ariella"
  11. AU="Frost, Patrice A"
  12. AU="Nielsen, David R"
  13. AU="Natsui, Hiroaki"
  14. AU="Ziv Ben-Ari"
  15. AU="Gönen, Murat"
  16. AU="Soliman, Essam S"
  17. AU="Poenisch, Falk"
  18. AU="Ng C."
  19. AU="Cabaton, Nicolas J"

Search results

Result 1 - 2 of total 2

Search options

  1. Article: Transcriptomic Analysis of the Ocular Posterior Segment Completes a Cell Atlas of the Human Eye.

    Monavarfeshani, Aboozar / Yan, Wenjun / Pappas, Christian / Odenigbo, Kenechukwu A / He, Zhigang / Segrè, Ayellet V / van Zyl, Tavé / Hageman, Gregory S / Sanes, Joshua R

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Although the visual system extends through the brain, most vision loss originates from defects in the eye. Its central element is the neural retina, which senses light, processes visual signals, and transmits them to the rest of the brain through the ... ...

    Abstract Although the visual system extends through the brain, most vision loss originates from defects in the eye. Its central element is the neural retina, which senses light, processes visual signals, and transmits them to the rest of the brain through the optic nerve (ON). Surrounding the retina are numerous other structures, conventionally divided into anterior and posterior segments. Here we used high-throughput single nucleus RNA sequencing (snRNA-seq) to classify and characterize cells in the extraretinal components of the posterior segment: ON, optic nerve head (ONH), peripheral sclera, peripapillary sclera (PPS), choroid, and retinal pigment epithelium (RPE). Defects in each of these tissues are associated with blinding diseases - for example, glaucoma (ONH and PPS), optic neuritis (ON), retinitis pigmentosa (RPE), and age-related macular degeneration (RPE and choroid). From ∼151,000 single nuclei, we identified 37 transcriptomically distinct cell types, including multiple types of astrocytes, oligodendrocytes, fibroblasts, and vascular endothelial cells. Our analyses revealed a differential distribution of many cell types among distinct structures. Together with our previous analyses of the anterior segment and retina, the new data complete a "Version 1" cell atlas of the human eye. We used this atlas to map the expression of >180 genes associated with the risk of developing glaucoma, which is known to involve ocular tissues in both anterior and posterior segments as well as neural retina. Similar methods can be used to investigate numerous additional ocular diseases, many of which are currently untreatable.
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.26.538447
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Transcriptomic analysis of the ocular posterior segment completes a cell atlas of the human eye.

    Monavarfeshani, Aboozar / Yan, Wenjun / Pappas, Christian / Odenigbo, Kenechukwu A / He, Zhigang / Segrè, Ayellet V / van Zyl, Tavé / Hageman, Gregory S / Sanes, Joshua R

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 34, Page(s) e2306153120

    Abstract: Although the visual system extends through the brain, most vision loss originates from defects in the eye. Its central element is the neural retina, which senses light, processes visual signals, and transmits them to the rest of the brain through the ... ...

    Abstract Although the visual system extends through the brain, most vision loss originates from defects in the eye. Its central element is the neural retina, which senses light, processes visual signals, and transmits them to the rest of the brain through the optic nerve (ON). Surrounding the retina are numerous other structures, conventionally divided into anterior and posterior segments. Here, we used high-throughput single-nucleus RNA sequencing (snRNA-seq) to classify and characterize cells in six extraretinal components of the posterior segment: ON, optic nerve head (ONH), peripheral sclera, peripapillary sclera (PPS), choroid, and retinal pigment epithelium (RPE). Defects in each of these tissues are associated with blinding diseases-for example, glaucoma (ONH and PPS), optic neuritis (ON), retinitis pigmentosa (RPE), and age-related macular degeneration (RPE and choroid). From ~151,000 single nuclei, we identified 37 transcriptomically distinct cell types, including multiple types of astrocytes, oligodendrocytes, fibroblasts, and vascular endothelial cells. Our analyses revealed a differential distribution of many cell types among distinct structures. Together with our previous analyses of the anterior segment and retina, the data presented here complete a "Version 1" cell atlas of the human eye. We used this atlas to map the expression of >180 genes associated with the risk of developing glaucoma, which is known to involve ocular tissues in both anterior and posterior segments as well as the neural retina. Similar methods can be used to investigate numerous additional ocular diseases, many of which are currently untreatable.
    MeSH term(s) Humans ; Transcriptome ; Endothelial Cells ; Optic Disk ; Glaucoma/genetics ; Optic Nerve ; Sclera
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2306153120
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top