Article: Pharmacokinetics of flunixin and its effect on prostaglandin F2 alpha metabolite concentrations after oral and intravenous administration in heifers.
Journal of veterinary pharmacology and therapeutics
1995 Volume 18, Issue 4, Page(s) 254–259
Abstract: Flunixin meglumine (FM) was administered either orally as granules or intravenously to six heifers in a two period crossover study. Single doses of 2.2 mg/kg body weight were used. Pharmacokinetic variables were calculated using statistical moment ... ...
Abstract | Flunixin meglumine (FM) was administered either orally as granules or intravenously to six heifers in a two period crossover study. Single doses of 2.2 mg/kg body weight were used. Pharmacokinetic variables were calculated using statistical moment methods. The effect exerted by flunixin was measured as changes in the basal plasma concentration of the main metabolite of prostaglandin (PG) F2 alpha. After oral FM the arithmetic means of pharmacokinetic variables were: MRT = 12.7 h; MAT = 6.3 h; Cmax = 0.9 microgram/mL; tmax = 3.5 h. The bioavailability was 60% and the mean half-life (harmonic mean) was 6.2 h. Oral administration of FM inhibited as effectively as intravenous administration the prostaglandin biosynthesis. The concentration of the PG metabolite decreased almost as rapidly as after intravenous administration. The duration of the effect was prolonged and the PG metabolite concentration was significantly lower between 10 and 30 h after oral than after intravenous administration. The results indicate that oral dosing of flunixin, in the form of granules, can be an alternative to intravenous administration for therapeutic use in cattle. |
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MeSH term(s) | Administration, Oral ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Biological Availability ; Cattle/metabolism ; Chromatography, High Pressure Liquid ; Clonixin/administration & dosage ; Clonixin/analogs & derivatives ; Clonixin/pharmacokinetics ; Clonixin/therapeutic use ; Cross-Over Studies ; Dinoprost/analogs & derivatives ; Dinoprost/blood ; Estrus/blood ; Female ; Half-Life ; Injections, Intravenous/veterinary |
Chemical Substances | Anti-Inflammatory Agents, Non-Steroidal ; 15-keto-13,14-dihydroprostaglandin F2alpha (27376-76-7) ; flunixin meglumine (8Y3JK0JW3U) ; Dinoprost (B7IN85G1HY) ; Clonixin (V7DXN0M42R) |
Language | English |
Publishing date | 1995-08 |
Publishing country | England |
Document type | Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 435216-6 |
ISSN | 1365-2885 ; 0140-7783 |
ISSN (online) | 1365-2885 |
ISSN | 0140-7783 |
DOI | 10.1111/j.1365-2885.1995.tb00589.x |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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