Article ; Online: Differentiation of human cartilage degeneration by functional MRI mapping-an ex vivo study.
2019 Volume 29, Issue 12, Page(s) 6671–6681
Abstract: Objective: To evaluate whether the response to loading of cartilage samples as assessed ex vivo by quantitative MRI (qMRI) mapping techniques can differentiate intact and early degenerative cartilage.: Methods: Upon IRB approval and written informed ... ...
| Abstract | Objective: To evaluate whether the response to loading of cartilage samples as assessed ex vivo by quantitative MRI (qMRI) mapping techniques can differentiate intact and early degenerative cartilage. Methods: Upon IRB approval and written informed consent, 59 macroscopically intact osteochondral samples were obtained from the central lateral femoral condyles of patients undergoing total knee replacement. Spatially resolved T1, T2, T2*, and T1ρ maps were generated prior to and during displacement-controlled quasi-static indentation loading to 405 μm (Δ Results: For T1ρ, consistent loading-induced increases were found for δ Conclusion: Aberrant load-bearing of early degenerative cartilage may be detected using T1ρ mapping as a function of loading. Hence, the diagnostic differentiation of intact versus early degenerative cartilage may allow the reliable identification of early and potentially reversible cartilage degeneration, thereby opening new opportunities for diagnosis and treatment of cartilage pathologies. Key points: • T1ρ mapping of the cartilage response to loading allows the reliable identification of early degenerative changes ex vivo. • Distinct response-to-loading patterns of cartilage tissue as assessed by functional MRI techniques are associated with biomechanical and histological tissue properties. • Non-invasive functional MR imaging techniques may facilitate the more sensitive monitoring of therapeutic outcomes and treatment strategies. |
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| MeSH term(s) | Adult ; Aged ; Aged, 80 and over ; Cartilage Diseases/diagnosis ; Cartilage, Articular/pathology ; Female ; Humans ; Knee Joint/pathology ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged |
| Language | English |
| Publishing date | 2019-06-11 |
| Publishing country | Germany |
| Document type | Comparative Study ; Journal Article |
| ZDB-ID | 1085366-2 |
| ISSN | 1432-1084 ; 0938-7994 ; 1613-3749 |
| ISSN (online) | 1432-1084 |
| ISSN | 0938-7994 ; 1613-3749 |
| DOI | 10.1007/s00330-019-06283-9 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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