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  1. Article: Pigment gallstone pathogenesis: slime production by biliary bacteria is more important than beta-glucuronidase production.

    Stewart, L / Ponce, R / Oesterle, A L / Griffiss, J M / Way, L W

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2000  Volume 4, Issue 5, Page(s) 547–553

    Abstract: Pigment stones are thought to form as a result of deconjugation of bilirubin by bacterial beta-glucuronidase, which results in precipitation of calcium bilirubinate. Calcium bilirubinate is then aggregated into stones by an anionic glycoprotein. Slime ( ... ...

    Abstract Pigment stones are thought to form as a result of deconjugation of bilirubin by bacterial beta-glucuronidase, which results in precipitation of calcium bilirubinate. Calcium bilirubinate is then aggregated into stones by an anionic glycoprotein. Slime (glycocalyx), an anionic glycoprotein produced by bacteria causing foreign body infections, has been implicated in the formation of the precipitate that blocks biliary stents. We previously showed that bacteria are present within the pigment portions of gallstones and postulated a bacterial role in pigment stone formation through beta-glucuronidase or slime production. Ninety-one biliary bacterial isolates from 61 patients and 12 control stool organisms were tested for their production of beta-glucuronidase and slime. The average slime production was 42 for biliary bacteria and 2.5 for stool bacteria (P <0.001). Overall, 73% of biliary bacteria and 8% of stool bacteria produced slime (optical density >3). In contrast, only 38% of biliary bacteria produced beta-glucuronidase. Eighty-two percent of all patients, 90% of patients with common bile duct (CBD) stones, 100% of patients with primary CBD stones, and 93% of patients with biliary tubes had one or more bacterial species in their stones that produced slime. By comparison, only 47% of all patients, 60% of patients with CBD stones, 62% of patients with primary CBD stones, and 50% of patients with biliary tubes had one or more bacteria that produced beta-glucuronidase. Most biliary bacteria produced slime, and slime production correlated better than beta-glucuronidase production did with stone formation and the presence of biliary tubes or stents. Patients with primary CBD stones and biliary tubes had the highest incidence of slime production. These findings suggest that bacterial slime is important in gallstone formation and the blockage of biliary tubes.
    MeSH term(s) Bacteria/enzymology ; Biliary Tract/microbiology ; Cholelithiasis/enzymology ; Cholelithiasis/etiology ; Cholelithiasis/microbiology ; Cholelithiasis/physiopathology ; Feces/microbiology ; Female ; Gallstones/enzymology ; Gallstones/microbiology ; Glucuronidase/biosynthesis ; Humans ; Male ; Middle Aged
    Chemical Substances Glucuronidase (EC 3.2.1.31)
    Language English
    Publishing date 2000-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2012365-6
    ISSN 1934-3213 ; 1873-4626 ; 1091-255X
    ISSN (online) 1934-3213 ; 1873-4626
    ISSN 1091-255X
    DOI 10.1016/s1091-255x(00)80100-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 354: Show issues

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  2. Article: Intestinal immunisation with Escherichia coli protects rats against Escherichia coli induced cholangitis.

    Aagaard, B D / Heyworth, M F / Oesterle, A L / Jones, A L / Way, L W

    Gut

    1996  Volume 39, Issue 1, Page(s) 136–140

    Abstract: Background: Cholangitis, an infection of the biliary tract, is most commonly caused by Gram negative bacteria, particularly Escherichia coli. Factors governing the severity of cholangitis, including the role of biliary IgA, are poorly understood.: ... ...

    Abstract Background: Cholangitis, an infection of the biliary tract, is most commonly caused by Gram negative bacteria, particularly Escherichia coli. Factors governing the severity of cholangitis, including the role of biliary IgA, are poorly understood.
    Aims: The aim of this work was to find out if biliary IgA directed against E coli protects rats against hepatobiliary infection with E coli.
    Subjects: Male Sprague-Dawley rats weighing 270-350 grams were used in all of the experiments.
    Methods: At laparotomy, rats were immunised by injecting killed E coli or normal saline (controls) into Peyer's patches. With or without subsequent antigenic boosting (by oral administration of killed E coli), bile was collected at a second laparotomy, and rats were infected by introducing viable E coli into the bile duct. Production of IgA anti-E coli antibody was measured by enzyme linked immunosorbent assay of bile, and the presence of hepatobiliary infection was determined by quantitative culture of liver homogenates.
    Results: Systemic infection was present in six of 12 control rats and in one of 24 immunised rats (p = 0.005) after death. There was an inverse correlation between immunisation and E coli colony counts in cultured liver homogenates (p = 0.024).
    Conclusion: The findings suggest that biliary IgA directed against E coli protected rats against hepatobiliary E coli infection and systemic sepsis.
    MeSH term(s) Animals ; Antibodies, Bacterial/analysis ; Bile/immunology ; Blotting, Western ; Cholangitis/etiology ; Cholangitis/prevention & control ; Enzyme-Linked Immunosorbent Assay ; Escherichia coli/isolation & purification ; Escherichia coli Infections/complications ; Escherichia coli Infections/immunology ; Escherichia coli Infections/prevention & control ; Immunization ; Immunoglobulin A/immunology ; Male ; Rats ; Rats, Sprague-Dawley ; Vaccines, Inactivated/administration & dosage
    Chemical Substances Antibodies, Bacterial ; Immunoglobulin A ; Vaccines, Inactivated
    Language English
    Publishing date 1996-07
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gut.39.1.136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 160: Show issues Location:
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  3. Article ; Online: Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

    Abu-Shawareb, H / Acree, R / Adams, P / Adams, J / Addis, B / Aden, R / Adrian, P / Afeyan, B B / Aggleton, M / Aghaian, L / Aguirre, A / Aikens, D / Akre, J / Albert, F / Albrecht, M / Albright, B J / Albritton, J / Alcala, J / Alday, C /
    Alessi, D A / Alexander, N / Alfonso, J / Alfonso, N / Alger, E / Ali, S J / Ali, Z A / Allen, A / Alley, W E / Amala, P / Amendt, P A / Amick, P / Ammula, S / Amorin, C / Ampleford, D J / Anderson, R W / Anklam, T / Antipa, N / Appelbe, B / Aracne-Ruddle, C / Araya, E / Archuleta, T N / Arend, M / Arnold, P / Arnold, T / Arsenlis, A / Asay, J / Atherton, L J / Atkinson, D / Atkinson, R / Auerbach, J M / Austin, B / Auyang, L / Awwal, A A S / Aybar, N / Ayers, J / Ayers, S / Ayers, T / Azevedo, S / Bachmann, B / Back, C A / Bae, J / Bailey, D S / Bailey, J / Baisden, T / Baker, K L / Baldis, H / Barber, D / Barberis, M / Barker, D / Barnes, A / Barnes, C W / Barrios, M A / Barty, C / Bass, I / Batha, S H / Baxamusa, S H / Bazan, G / Beagle, J K / Beale, R / Beck, B R / Beck, J B / Bedzyk, M / Beeler, R G / Behrendt, W / Belk, L / Bell, P / Belyaev, M / Benage, J F / Bennett, G / Benedetti, L R / Benedict, L X / Berger, R L / Bernat, T / Bernstein, L A / Berry, B / Bertolini, L / Besenbruch, G / Betcher, J / Bettenhausen, R / Betti, R / Bezzerides, B / Bhandarkar, S D / Bickel, R / Biener, J / Biesiada, T / Bigelow, K / Bigelow-Granillo, J / Bigman, V / Bionta, R M / Birge, N W / Bitter, M / Black, A C / Bleile, R / Bleuel, D L / Bliss, E / Blue, B / Boehly, T / Boehm, K / Boley, C D / Bonanno, R / Bond, E J / Bond, T / Bonino, M J / Borden, M / Bourgade, J-L / Bousquet, J / Bowers, J / Bowers, M / Boyd, R / Boyle, D / Bozek, A / Bradley, D K / Bradley, K S / Bradley, P A / Bradley, L / Brannon, L / Brantley, P S / Braun, D / Braun, T / Brienza-Larsen, K / Briggs, R / Briggs, T M / Britten, J / Brooks, E D / Browning, D / Bruhn, M W / Brunner, T A / Bruns, H / Brunton, G / Bryant, B / Buczek, T / Bude, J / Buitano, L / Burkhart, S / Burmark, J / Burnham, A / Burr, R / Busby, L E / Butlin, B / Cabeltis, R / Cable, M / Cabot, W H / Cagadas, B / Caggiano, J / Cahayag, R / Caldwell, S E / Calkins, S / Callahan, D A / Calleja-Aguirre, J / Camara, L / Camp, D / Campbell, E M / Campbell, J H / Carey, B / Carey, R / Carlisle, K / Carlson, L / Carman, L / Carmichael, J / Carpenter, A / Carr, C / Carrera, J A / Casavant, D / Casey, A / Casey, D T / Castillo, A / Castillo, E / Castor, J I / Castro, C / Caughey, W / Cavitt, R / Celeste, J / Celliers, P M / Cerjan, C / Chandler, G / Chang, B / Chang, C / Chang, J / Chang, L / Chapman, R / Chapman, T D / Chase, L / Chen, H / Chen, K / Chen, L-Y / Cheng, B / Chittenden, J / Choate, C / Chou, J / Chrien, R E / Chrisp, M / Christensen, K / Christensen, M / Christiansen, N S / Christopherson, A R / Chung, M / Church, J A / Clark, A / Clark, D S / Clark, K / Clark, R / Claus, L / Cline, B / Cline, J A / Cobble, J A / Cochrane, K / Cohen, B / Cohen, S / Collette, M R / Collins, G W / Collins, L A / Collins, T J B / Conder, A / Conrad, B / Conyers, M / Cook, A W / Cook, D / Cook, R / Cooley, J C / Cooper, G / Cope, T / Copeland, S R / Coppari, F / Cortez, J / Cox, J / Crandall, D H / Crane, J / Craxton, R S / Cray, M / Crilly, A / Crippen, J W / Cross, D / Cuneo, M / Cuotts, G / Czajka, C E / Czechowicz, D / Daly, T / Danforth, P / Danly, C / Darbee, R / Darlington, B / Datte, P / Dauffy, L / Davalos, G / Davidovits, S / Davis, P / Davis, J / Dawson, S / Day, R D / Day, T H / Dayton, M / Deck, C / Decker, C / Deeney, C / DeFriend, K A / Deis, G / Delamater, N D / Delettrez, J A / Demaret, R / Demos, S / Dempsey, S M / Desjardin, R / Desjardins, T / Desjarlais, M P / Dewald, E L / DeYoreo, J / Diaz, S / Dimonte, G / Dittrich, T R / Divol, L / Dixit, S N / Dixon, J / Do, A / Dodd, E S / Dolan, D / Donovan, A / Donovan, M / Döppner, T / Dorrer, C / Dorsano, N / Douglas, M R / Dow, D / Downie, J / Downing, E / Dozieres, M / Draggoo, V / Drake, D / Drake, R P / Drake, T / Dreifuerst, G / Drury, O / DuBois, D F / DuBois, P F / Dunham, G / Durocher, M / Dylla-Spears, R / Dymoke-Bradshaw, A K L / Dzenitis, B / Ebbers, C / Eckart, M / Eddinger, S / Eder, D / Edgell, D / Edwards, M J / Efthimion, P / Eggert, J H / Ehrlich, B / Ehrmann, P / Elhadj, S / Ellerbee, C / Elliott, N S / Ellison, C L / Elsner, F / Emerich, M / Engelhorn, K / England, T / English, E / Epperson, P / Epstein, R / Erbert, G / Erickson, M A / Erskine, D J / Erlandson, A / Espinosa, R J / Estes, C / Estabrook, K G / Evans, S / Fabyan, A / Fair, J / Fallejo, R / Farmer, N / Farmer, W A / Farrell, M / Fatherley, V E / Fedorov, M / Feigenbaum, E / Fehrenbach, T / Feit, M / Felker, B / Ferguson, W / Fernandez, J C / Fernandez-Panella, A / Fess, S / Field, J E / Filip, C V / Fincke, J R / Finn, T / Finnegan, S M / Finucane, R G / Fischer, M / Fisher, A / Fisher, J / Fishler, B / Fittinghoff, D / Fitzsimmons, P / Flegel, M / Flippo, K A / Florio, J / Folta, J / Folta, P / Foreman, L R / Forrest, C / Forsman, A / Fooks, J / Foord, M / Fortner, R / Fournier, K / Fratanduono, D E / Frazier, N / Frazier, T / Frederick, C / Freeman, M S / Frenje, J / Frey, D / Frieders, G / Friedrich, S / Froula, D H / Fry, J / Fuller, T / Gaffney, J / Gales, S / Le Galloudec, B / Le Galloudec, K K / Gambhir, A / Gao, L / Garbett, W J / Garcia, A / Gates, C / Gaut, E / Gauthier, P / Gavin, Z / Gaylord, J / Geddes, C G R / Geissel, M / Génin, F / Georgeson, J / Geppert-Kleinrath, H / Geppert-Kleinrath, V / Gharibyan, N / Gibson, J / Gibson, C / Giraldez, E / Glebov, V / Glendinning, S G / Glenn, S / Glenzer, S H / Goade, S / Gobby, P L / Goldman, S R / Golick, B / Gomez, M / Goncharov, V / Goodin, D / Grabowski, P / Grafil, E / Graham, P / Grandy, J / Grasz, E / Graziani, F R / Greenman, G / Greenough, J A / Greenwood, A / Gregori, G / Green, T / Griego, J R / Grim, G P / Grondalski, J / Gross, S / Guckian, J / Guler, N / Gunney, B / Guss, G / Haan, S / Hackbarth, J / Hackel, L / Hackel, R / Haefner, C / Hagmann, C / Hahn, K D / Hahn, S / Haid, B J / Haines, B M / Hall, B M / Hall, C / Hall, G N / Hamamoto, M / Hamel, S / Hamilton, C E / Hammel, B A / Hammer, J H / Hampton, G / Hamza, A / Handler, A / Hansen, S / Hanson, D / Haque, R / Harding, D / Harding, E / Hares, J D / Harris, D B / Harte, J A / Hartouni, E P / Hatarik, R / Hatchett, S / Hauer, A A / Havre, M / Hawley, R / Hayes, J / Hayes, S / Hayes-Sterbenz, A / Haynam, C A / Haynes, D A / Headley, D / Heal, A / Heebner, J E / Heerey, S / Heestand, G M / Heeter, R / Hein, N / Heinbockel, C / Hendricks, C / Henesian, M / Heninger, J / Henrikson, J / Henry, E A / Herbold, E B / Hermann, M R / Hermes, G / Hernandez, J E / Hernandez, V J / Herrmann, M C / Herrmann, H W / Herrera, O D / Hewett, D / Hibbard, R / Hicks, D G / Higginson, D P / Hill, D / Hill, K / Hilsabeck, T / Hinkel, D E / Ho, D D / Ho, V K / Hoffer, J K / Hoffman, N M / Hohenberger, M / Hohensee, M / Hoke, W / Holdener, D / Holdener, F / Holder, J P / Holko, B / Holunga, D / Holzrichter, J F / Honig, J / Hoover, D / Hopkins, D / Berzak Hopkins, L F / Hoppe, M / Hoppe, M L / Horner, J / Hornung, R / Horsfield, C J / Horvath, J / Hotaling, D / House, R / Howell, L / Hsing, W W / Hu, S X / Huang, H / Huckins, J / Hui, H / Humbird, K D / Hund, J / Hunt, J / Hurricane, O A / Hutton, M / Huynh, K H-K / Inandan, L / Iglesias, C / Igumenshchev, I V / Ivanovich, I / Izumi, N / Jackson, M / Jackson, J / Jacobs, S D / James, G / Jancaitis, K / Jarboe, J / Jarrott, L C / Jasion, D / Jaquez, J / Jeet, J / Jenei, A E / Jensen, J / Jimenez, J / Jimenez, R / Jobe, D / Johal, Z / Johns, H M / Johnson, D / Johnson, M A / Gatu Johnson, M / Johnson, R J / Johnson, S / Johnson, S A / Johnson, T / Jones, K / Jones, O / Jones, M / Jorge, R / Jorgenson, H J / Julian, M / Jun, B I / Jungquist, R / Kaae, J / Kabadi, N / Kaczala, D / Kalantar, D / Kangas, K / Karasiev, V V / Karasik, M / Karpenko, V / Kasarky, A / Kasper, K / Kauffman, R / Kaufman, M I / Keane, C / Keaty, L / Kegelmeyer, L / Keiter, P A / Kellett, P A / Kellogg, J / Kelly, J H / Kemic, S / Kemp, A J / Kemp, G E / Kerbel, G D / Kershaw, D / Kerr, S M / Kessler, T J / Key, M H / Khan, S F / Khater, H / Kiikka, C / Kilkenny, J / Kim, Y / Kim, Y-J / Kimko, J / Kimmel, M / Kindel, J M / King, J / Kirkwood, R K / Klaus, L / Klem, D / Kline, J L / Klingmann, J / Kluth, G / Knapp, P / Knauer, J / Knipping, J / Knudson, M / Kobs, D / Koch, J / Kohut, T / Kong, C / Koning, J M / Koning, P / Konior, S / Kornblum, H / Kot, L B / Kozioziemski, B / Kozlowski, M / Kozlowski, P M / Krammen, J / Krasheninnikova, N S / Krauland, C M / Kraus, B / Krauser, W / Kress, J D / Kritcher, A L / Krieger, E / Kroll, J J / Kruer, W L / Kruse, M K G / Kucheyev, S / Kumbera, M / Kumpan, S / Kunimune, J / Kur, E / Kustowski, B / Kwan, T J T / Kyrala, G A / Laffite, S / Lafon, M / LaFortune, K / Lagin, L / Lahmann, B / Lairson, B / Landen, O L / Land, T / Lane, M / Laney, D / Langdon, A B / Langenbrunner, J / Langer, S H / Langro, A / Lanier, N E / Lanier, T E / Larson, D / Lasinski, B F / Lassle, D / LaTray, D / Lau, G / Lau, N / Laumann, C / Laurence, A / Laurence, T A / Lawson, J / Le, H P / Leach, R R / Leal, L / Leatherland, A / LeChien, K / Lechleiter, B / Lee, A / Lee, M / Lee, T / Leeper, R J / Lefebvre, E / Leidinger, J-P / LeMire, B / Lemke, R W / Lemos, N C / Le Pape, S / Lerche, R / Lerner, S / Letts, S / Levedahl, K / Lewis, T / Li, C K / Li, H / Li, J / Liao, W / Liao, Z M / Liedahl, D / Liebman, J / Lindford, G / Lindman, E L / Lindl, J D / Loey, H / London, R A / Long, F / Loomis, E N / Lopez, F E / Lopez, H / Losbanos, E / Loucks, S / Lowe-Webb, R / Lundgren, E / Ludwigsen, A P / Luo, R / Lusk, J / Lyons, R / Ma, T / Macallop, Y / MacDonald, M J / MacGowan, B J / Mack, J M / Mackinnon, A J / MacLaren, S A / MacPhee, A G / Magelssen, G R / Magoon, J / Malone, R M / Malsbury, T / Managan, R / Mancini, R / Manes, K / Maney, D / Manha, D / Mannion, O M / Manuel, A M / Manuel, M J-E / Mapoles, E / Mara, G / Marcotte, T / Marin, E / Marinak, M M / Mariscal, D A / Mariscal, E F / Marley, E V / Marozas, J A / Marquez, R / Marshall, C D / Marshall, F J / Marshall, M / Marshall, S / 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/ Moreno, K / Morgan, B E / Morrow, T / Morton, J W / Moses, E / Moy, K / Muir, R / Murillo, M S / Murray, J E / Murray, J R / Munro, D H / Murphy, T J / Munteanu, F M / Nafziger, J / Nagayama, T / Nagel, S R / Nast, R / Negres, R A / Nelson, A / Nelson, D / Nelson, J / Nelson, S / Nemethy, S / Neumayer, P / Newman, K / Newton, M / Nguyen, H / Di Nicola, J-M G / Di Nicola, P / Niemann, C / Nikroo, A / Nilson, P M / Nobile, A / Noorai, V / Nora, R C / Norton, M / Nostrand, M / Note, V / Novell, S / Nowak, P F / Nunez, A / Nyholm, R A / O'Brien, M / Oceguera, A / Oertel, J A / Oesterle, A L / Okui, J / Olejniczak, B / Oliveira, J / Olsen, P / Olson, B / Olson, K / Olson, R E / Opachich, Y P / Orsi, N / Orth, C D / Owen, M / Padalino, S / Padilla, E / Paguio, R / Paguio, S / Paisner, J / Pajoom, S / Pak, A / Palaniyappan, S / Palma, K / Pannell, T / Papp, F / Paras, D / Parham, T / Park, H-S / Pasternak, A / Patankar, S / Patel, M V / Patel, P K / Patterson, R / Patterson, S / Paul, B / Paul, M / Pauli, E / Pearce, O T / Pearcy, J / Pedretti, A / Pedrotti, B / Peer, A / Pelz, L J / Penetrante, B / Penner, J / Perez, A / Perkins, L J / Pernice, E / Perry, T S / Person, S / Petersen, D / Petersen, T / Peterson, D L / Peterson, E B / Peterson, J E / Peterson, J L / Peterson, K / Peterson, R R / Petrasso, R D / Philippe, F / Phillion, D / Phipps, T J / Piceno, E / Pickworth, L / Ping, Y / Pino, J / Piston, K / Plummer, R / Pollack, G D / Pollaine, S M / Pollock, B B / Ponce, D / Ponce, J / Pontelandolfo, J / Porter, J L / Post, J / Poujade, O / Powell, C / Powell, H / Power, G / Pozulp, M / Prantil, M / Prasad, M / Pratuch, S / Price, S / Primdahl, K / Prisbrey, S / Procassini, R / Pruyne, A / Pudliner, B / Qiu, S R / Quan, K / Quinn, M / Quintenz, J / Radha, P B / Rainer, F / Ralph, J E / Raman, K S / Raman, R / Rambo, P W / Rana, S / Randewich, A / Rardin, D / Ratledge, M / Ravelo, N / Ravizza, F / Rayce, M / Raymond, A / Raymond, B / Reed, B / Reed, C / Regan, S / Reichelt, B / Reis, V / Reisdorf, S / Rekow, V / Remington, B A / Rendon, A / Requieron, W / Rever, M / Reynolds, H / Reynolds, J / Rhodes, J / Rhodes, M / Richardson, M C / Rice, B / Rice, N G / Rieben, R / Rigatti, A / Riggs, S / Rinderknecht, H G / Ring, K / Riordan, B / Riquier, R / Rivers, C / Roberts, D / Roberts, V / Robertson, G / Robey, H F / Robles, J / Rocha, P / Rochau, G / Rodriguez, J / Rodriguez, S / Rosen, M D / Rosenberg, M / Ross, G / Ross, J S / Ross, P / Rouse, J / Rovang, D / Rubenchik, A M / Rubery, M S / Ruiz, C L / Rushford, M / Russ, B / Rygg, J R / Ryujin, B S / Sacks, R A / Sacks, R F / Saito, K / Salmon, T / Salmonson, J D / Sanchez, J / Samuelson, S / Sanchez, M / Sangster, C / Saroyan, A / Sater, J / Satsangi, A / Sauers, S / Saunders, R / Sauppe, J P / Sawicki, R / Sayre, D / Scanlan, M / Schaffers, K / Schappert, G T / Schiaffino, S / Schlossberg, D J / Schmidt, D W / Schmit, P F / Smidt, J M / Schneider, D H G / Schneider, M B / Schneider, R / Schoff, M 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    Physical review letters

    2024  Volume 132, Issue 6, Page(s) 65102

    Abstract: On December 5, 2022, an indirect drive fusion implosion on the National Ignition Facility (NIF) achieved a target gain G_{target} of 1.5. This is the first laboratory demonstration of exceeding "scientific breakeven" (or G_{target}>1) where 2.05 MJ of ... ...

    Abstract On December 5, 2022, an indirect drive fusion implosion on the National Ignition Facility (NIF) achieved a target gain G_{target} of 1.5. This is the first laboratory demonstration of exceeding "scientific breakeven" (or G_{target}>1) where 2.05 MJ of 351 nm laser light produced 3.1 MJ of total fusion yield, a result which significantly exceeds the Lawson criterion for fusion ignition as reported in a previous NIF implosion [H. Abu-Shawareb et al. (Indirect Drive ICF Collaboration), Phys. Rev. Lett. 129, 075001 (2022)PRLTAO0031-900710.1103/PhysRevLett.129.075001]. This achievement is the culmination of more than five decades of research and gives proof that laboratory fusion, based on fundamental physics principles, is possible. This Letter reports on the target, laser, design, and experimental advancements that led to this result.
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.132.065102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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