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  1. AU="Offin, M."
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  1. Article ; Online: ARCS-M: forging progress from this negative trial in malignant pleural mesothelioma.

    Zauderer, Marjorie G / Offin, Michael

    The Lancet. Oncology

    2022  Volume 23, Issue 4, Page(s) 445–446

    MeSH term(s) Humans ; Mesothelioma/pathology ; Mesothelioma/therapy ; Mesothelioma, Malignant ; Pleural Neoplasms/pathology ; Pleural Neoplasms/therapy
    Language English
    Publishing date 2022-03-31
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(22)00099-7
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    Zs.A 5696: Show issues Location:
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    Zs.MO 460: Show issues

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  2. Article ; Online: Safety and efficacy of percutaneous cryoablation for primary and metastatic pleural based tumors.

    Alexander, Erica S / Petre, Elena N / Offin, Michael / Zauderer, Marjorie / Zhao, Ken / Sotirchos, Vlasios / Solomon, Stephen B / Ziv, Etay

    European journal of radiology

    2024  Volume 175, Page(s) 111465

    Abstract: Purpose: Assess safety and local tumor progression-free survival (LTPFS) of percutaneous cryoablation for pleural-based thoracic malignancies.: Materials and methods: Retrospective study of 46 patients (17 treated for palliation; 9 for ... ...

    Abstract Purpose: Assess safety and local tumor progression-free survival (LTPFS) of percutaneous cryoablation for pleural-based thoracic malignancies.
    Materials and methods: Retrospective study of 46 patients (17 treated for palliation; 9 for oligoprogression; 20 for curative intent), with 62 pleural-based thoracic lesions, treated in 59 cryoablation sessions. Patients were treated from 9/2005-11/2021 with CryoCare CS (Varian, Irvine, CA) or IceFORCE (Boston Scientific, Marlborough, MA) systems. For tumors treated with curative intent and/or oligoprogression, LTPFS of the treated tumor(s) and overall survival (OS) were estimated using Kaplan-Meier method. Post-operative complications were reported for all sessions, including those with palliative intent; univariate analyses were used to calculate factors associated with increased complication risk.
    Results: Median number of tumors treated in a single treatment session was 1 (range 1-4). Largest dimension of the treated tumor was 2.1 cm [IQR:0.9-5 cm]. Of the 59 treatments, 98.3 % were technically successful. Median LTPFS was 14.4 (95 % CI: 9.4-25.6) months. Tumor size was a significant predictor of LTPFS (HR: 1.21, 95 % CI: 1.03-1.44, p = 0.023). Median OS was 52.4 (28.1-NR) months. Complications occurred in 28/59 sessions (47.5 %); 2/59 (3.4 %) were ≥ grade D by Society of Interventional Radiology adverse event criteria (death; hypoxia requiring supplemental oxygen upon discharge). Pain and pneumothorax were the most common complications. The length of lung parenchyma traversed was a significant predictor of pneumothorax: HR 0.48 (95 %CI: 0.14-0.83), p = 0.0024.
    Conclusion: Percutaneous cryoablation for pleural lesions is associated with a long duration of local control and most complications were minor and self-limited.
    MeSH term(s) Humans ; Cryosurgery/methods ; Cryosurgery/adverse effects ; Male ; Female ; Middle Aged ; Retrospective Studies ; Aged ; Treatment Outcome ; Pleural Neoplasms/surgery ; Adult ; Aged, 80 and over ; Postoperative Complications ; Survival Rate
    Language English
    Publishing date 2024-04-10
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 138815-0
    ISSN 1872-7727 ; 0720-048X
    ISSN (online) 1872-7727
    ISSN 0720-048X
    DOI 10.1016/j.ejrad.2024.111465
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    Zs.A 1630: Show issues Location:
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  3. Article ; Online: Evolving Landscape of Initial Treatments for Patients with Malignant Pleural Mesotheliomas: Clinical Trials to Clinical Practice.

    Offin, Michael / Rusch, Valerie W / Rimner, Andreas / Adusumilli, Prasad S / Zauderer, Marjorie G

    The oncologist

    2022  Volume 27, Issue 8, Page(s) 610–614

    MeSH term(s) Clinical Trials as Topic ; Humans ; Mesothelioma, Malignant/therapy
    Language English
    Publishing date 2022-06-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1093/oncolo/oyac113
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    Zs.A 4845: Show issues Location:
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    Zs.MO 494: Show issues

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  4. Article ; Online: Diffuse Pleural Mesothelioma: Advances in Molecular Pathogenesis, Diagnosis, and Treatment.

    Febres-Aldana, Christopher A / Fanaroff, Rachel / Offin, Michael / Zauderer, Marjorie G / Sauter, Jennifer L / Yang, Soo-Ryum / Ladanyi, Marc

    Annual review of pathology

    2023  Volume 19, Page(s) 11–42

    Abstract: Diffuse pleural mesothelioma (DPM) is a highly aggressive malignant neoplasm arising from the mesothelial cells lining the pleural surfaces. While DPM is a well-recognized disease linked to asbestos exposure, recent advances have expanded our ... ...

    Abstract Diffuse pleural mesothelioma (DPM) is a highly aggressive malignant neoplasm arising from the mesothelial cells lining the pleural surfaces. While DPM is a well-recognized disease linked to asbestos exposure, recent advances have expanded our understanding of molecular pathogenesis and transformed our clinical practice. This comprehensive review explores the current concepts and emerging trends in DPM, including risk factors, pathobiology, histologic subtyping, and therapeutic management, with an emphasis on a multidisciplinary approach to this complex disease.
    MeSH term(s) Humans ; Mesothelioma ; Risk Factors
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2227429-7
    ISSN 1553-4014 ; 1553-4006
    ISSN (online) 1553-4014
    ISSN 1553-4006
    DOI 10.1146/annurev-pathol-042420-092719
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  5. Article ; Online: Diffuse pleural mesotheliomas with genomic near-haploidization: a newly recognized subset with distinct clinical, histologic, and molecular features.

    Yang, Soo-Ryum / Jayakumaran, Gowtham / Benhamida, Jamal / Febres Aldana, Christopher A / Fanaroff, Rachel / Chang, Jason / Gedvilaite, Erika / Villafania, Liliana B / Sauter, Jennifer L / Offin, Michael / Zauderer, Marjorie G / Ladanyi, Marc

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2024  

    Abstract: Purpose: Diffuse pleural mesotheliomas (DPMs) with genomic near-haploidization (GNH) represent a novel subtype first recognized by the TCGA project; however, its clinicopathologic and molecular features remain poorly defined.: Experimental design: We ...

    Abstract Purpose: Diffuse pleural mesotheliomas (DPMs) with genomic near-haploidization (GNH) represent a novel subtype first recognized by the TCGA project; however, its clinicopathologic and molecular features remain poorly defined.
    Experimental design: We analyzed clinical genomic profiling data from 290 patients with DPM using the MSK-IMPACT assay. Allele-specific copy number analysis was performed using the FACETS algorithm.
    Results: 210 patients were evaluable for LOH analysis using FACETS. In this cohort, GNH was detected in 10 cases (4.8%). Compared to non-GNH tumors, GNH DPMs were associated with younger age and less frequent self-reported history of occupational asbestos exposure. Histologically, GNH DPMs were enriched in biphasic subtype (80% vs. 14.5%) and showed abundant tumor infiltrating lymphocytes (TILs). Genomic analysis revealed a higher frequency of TP53 alterations, while SETDB1 mutations were present in nearly all and only in this subset. The clinicopathologic and molecular findings were further validated in a separate cohort. Despite the younger age, patients with GNH DPMs had a shorter overall survival (10.9 vs. 25.4 months, p=0.004); the poor prognostic impact of GNH remained significant after controlling for biphasic histology. Out of three patients with GNH DPMs who received immune checkpoint blockade (ICB), two achieved a clinician assessed partial response.
    Conclusions: GNH defines an aggressive subtype of mainly biphasic DPMs in younger patients with recurrent alterations in SETDB1 and TP53. The enrichment in biphasic histology and TILs, together with our preliminary ICB response data and anecdotal clinical trial data, suggests that further evaluation of immunotherapy may be warranted in this subset.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-24-0085
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    Zs.A 4223: Show issues Location:
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  6. Article ; Online: Entrectinib

    Liu D / Offin M / Harnicar S / Li BT / Drilon A

    Therapeutics and Clinical Risk Management, Vol Volume 14, Pp 1247-

    an orally available, selective tyrosine kinase inhibitor for the treatment of NTRK, ROS1, and ALK fusion-positive solid tumors

    2018  Volume 1252

    Abstract: Dazhi Liu,1 Michael Offin,2 Stephen Harnicar,1 Bob T Li,2 Alexander Drilon2 1Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, NY, USA; 2Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial ...

    Abstract Dazhi Liu,1 Michael Offin,2 Stephen Harnicar,1 Bob T Li,2 Alexander Drilon2 1Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, NY, USA; 2Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA Abstract: Entrectinib is a potent small-molecule tyrosine kinase inhibitor that targets oncogenic rearrangements in NTRK, ROS1, and ALK. The consolidated results of 2 Phase I trials demonstrated activity in tyrosine kinase inhibitor-naïve patients along with substantial intracranial activity. In ROS1-rearranged lung cancers, entrectinib results in durable disease control and prolonged progression-free survival. The drug is well tolerated and has a safety profile that includes adverse events mediated by on-target tropomyosin-related kinase A/B/C inhibition. Keywords: entrectinib, lung cancer, NSCLC, TRK, ALK, ROS1
    Keywords entrectinib ; lung cancer ; TRK ; ALK ; ROS1 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2018-07-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Tumor-Agnostic Drug Development.

    Offin, Michael / Liu, Dazhi / Drilon, Alexander

    American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

    2018  Volume 38, Page(s) 184–187

    Abstract: Therapies designed to target cancers that harbor specific molecular signatures have reshaped the landscape of oncologic drug development, and advances in next generation sequencing have led to an increase in the identification of these alterations across ...

    Abstract Therapies designed to target cancers that harbor specific molecular signatures have reshaped the landscape of oncologic drug development, and advances in next generation sequencing have led to an increase in the identification of these alterations across tumor types. Tumor-agnostic trial designs, such as the "basket trial," have been developed as an approach to study the efficacy of these treatments and increase patient access, especially for patients whose tumors carry these alterations infrequently. We review key aspects of these genomically enriched trial strategies and their impact on drug development and approval.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor ; Clinical Trials as Topic ; Drug Discovery/methods ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Mutation ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Signal Transduction/drug effects
    Chemical Substances Antineoplastic Agents ; Biomarkers, Tumor
    Language English
    Publishing date 2018-09-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2431126-1
    ISSN 1548-8756 ; 1548-8748
    ISSN (online) 1548-8756
    ISSN 1548-8748
    DOI 10.1200/EDBK_200831
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  8. Book ; Online: Leveraging Time Irreversibility with Order-Contrastive Pre-training

    Agrawal, Monica / Lang, Hunter / Offin, Michael / Gazit, Lior / Sontag, David

    2021  

    Abstract: Label-scarce, high-dimensional domains such as healthcare present a challenge for modern machine learning techniques. To overcome the difficulties posed by a lack of labeled data, we explore an "order-contrastive" method for self-supervised pre-training ... ...

    Abstract Label-scarce, high-dimensional domains such as healthcare present a challenge for modern machine learning techniques. To overcome the difficulties posed by a lack of labeled data, we explore an "order-contrastive" method for self-supervised pre-training on longitudinal data. We sample pairs of time segments, switch the order for half of them, and train a model to predict whether a given pair is in the correct order. Intuitively, the ordering task allows the model to attend to the least time-reversible features (for example, features that indicate progression of a chronic disease). The same features are often useful for downstream tasks of interest. To quantify this, we study a simple theoretical setting where we prove a finite-sample guarantee for the downstream error of a representation learned with order-contrastive pre-training. Empirically, in synthetic and longitudinal healthcare settings, we demonstrate the effectiveness of order-contrastive pre-training in the small-data regime over supervised learning and other self-supervised pre-training baselines. Our results indicate that pre-training methods designed for particular classes of distributions and downstream tasks can improve the performance of self-supervised learning.
    Keywords Computer Science - Machine Learning
    Subject code 006
    Publishing date 2021-11-03
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Liquid biopsy guided precision therapy for lung cancers.

    Xu, Chongrui / Offin, Michael / Paik, Paul K / Li, Bob T

    Journal of thoracic disease

    2019  Volume 10, Issue Suppl 33, Page(s) S4173–S4175

    Language English
    Publishing date 2019-06-03
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.11.02
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  10. Article ; Online: Response letter to "Stereotactic body radiation therapy for pleural mesothelioma: Which goal, which patients".

    Shin, Jacob Y / Offin, Michael / Simone, Charles B / Shepherd, Annemarie F / Wu, Abraham J / Shaverdian, Narek / Gelblum, Daphna Y / Gomez, Daniel R / Sauter, Jennifer L / Ginsberg, Michelle S / Adusumilli, Prasad S / Rusch, Valerie W / Zauderer, Marjorie G / Rimner, Andreas

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2024  Volume 193, Page(s) 110138

    MeSH term(s) Humans ; Goals ; Mesothelioma, Malignant ; Mesothelioma/radiotherapy ; Pleural Neoplasms/radiotherapy ; Combined Modality Therapy ; Lung Neoplasms/radiotherapy
    Language English
    Publishing date 2024-02-10
    Publishing country Ireland
    Document type Letter
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2024.110138
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