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Article ; Online: Aqueous Sugar-Based Amphiphile Systems: Recent Advances in Phase Behavior and Nanoarchitectonics.

Ogawa, Shigesaburo

2023 Volume 72, Issue 5, Page(s) 489–499

Abstract: Currently, numerous fascinating molecular assemblies are used in food, cosmetics, and pharmaceuticals. Sugar-based amphiphiles are representative constituents of these molecular assemblies. Despite numerous studies on these generic compounds, many ... ...

Abstract	Currently, numerous fascinating molecular assemblies are used in food, cosmetics, and pharmaceuticals. Sugar-based amphiphiles are representative constituents of these molecular assemblies. Despite numerous studies on these generic compounds, many aspects remain unexplored even in aqueous systems. In this review, molecular assembly studies of sugar-based amphiphiles in aqueous systems are summarized. First, recent advances in molecular assembly studies, including the glassy state of lyotropic and thermotropic liquid crystalline (LC) phases, modulated crystal phases, and coagels consisting of nanofibers of alkyl β-D-glycosides, are presented. Second, research on thermotropic LC phases under desiccated conditions of trehalose fatty acid monoesters to clarify the fundamental behaviors of the glassy state and their use as stabilizers of glass-forming surfactants for pharmaceutical applications are discussed. Several effective X-ray analytical approaches are included to identify or clarify these phenomena, unknown or unsolved for a long time. Third, a comprehensive analysis of vitamin E (tocopherol)-cyclodextrin in aqueous systems is presented. Along with these topics, the importance of investigating stabilizer-free functional components, considered minor components, is highlighted. These unveiled phenomena or concepts will contribute to the development of nanoarchitectonics covering the self-assembly and selforganization of soft molecules.
MeSH term(s)	Sugars ; Carbohydrates ; Water/chemistry ; Glycosides ; Fatty Acids
Chemical Substances	Sugars ; Carbohydrates ; Water (059QF0KO0R) ; Glycosides ; Fatty Acids
Language	English
Publishing date	2023-04-15
Publishing country	Japan
Document type	Review ; Journal Article
ZDB-ID	2218264-0
ISSN	1347-3352 ; 1345-8957
ISSN (online)	1347-3352
ISSN	1345-8957
DOI	10.5650/jos.ess22391
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Article ; Online: Improvement of analysis throughput for LC/MS assay.

Ogawa, Shoujiro

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

2022 Volume 38, Issue 4, Page(s) 633–634

MeSH term(s)	Chromatography, Liquid ; Tandem Mass Spectrometry
Language	English
Publishing date	2022-04-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1483376-1
ISSN	1348-2246 ; 1348-2246
ISSN (online)	1348-2246
ISSN	1348-2246
DOI	10.1007/s44211-022-00089-4
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Article ; Online: Targeting lineage plasticity overcomes chemoresistance.

Ogawa, Seishi

Cancer cell

2022 Volume 40, Issue 9, Page(s) 905–907

Abstract: In this issue of Cancer Cell, Wang et al. reveal that chemoresistant muscle-invasive bladder cancer is associated with partial squamous differentiation. Targeting of Cathepsin H overcomes this chemotherapy-induced semi-squamatization and promotes ... ...

Abstract	In this issue of Cancer Cell, Wang et al. reveal that chemoresistant muscle-invasive bladder cancer is associated with partial squamous differentiation. Targeting of Cathepsin H overcomes this chemotherapy-induced semi-squamatization and promotes terminal squamous differentiation and tumor suppression.
MeSH term(s)	Carcinoma, Squamous Cell ; Drug Resistance, Neoplasm ; Humans ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/pathology
Language	English
Publishing date	2022-08-25
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2078448-X
ISSN	1878-3686 ; 1535-6108
ISSN (online)	1878-3686
ISSN	1535-6108
DOI	10.1016/j.ccell.2022.08.020
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Article ; Online: A growing genetic tree in the soil of prostate.

Ogawa, Seishi

Cell stem cell

2021 Volume 28, Issue 7, Page(s) 1185–1187

Abstract: In this issue of Cell Stem Cell, Grossmann et al. (2021) reconstructed the developmental history of the prostate gland in a 59-year-old male by 3D tracking of somatic mutations across 319 micro-dissected specimens. It provides a genetic picture of how ... ...

Abstract	In this issue of Cell Stem Cell, Grossmann et al. (2021) reconstructed the developmental history of the prostate gland in a 59-year-old male by 3D tracking of somatic mutations across 319 micro-dissected specimens. It provides a genetic picture of how the human prostate gland is shaped during embryogenesis, puberty, and adult life.
MeSH term(s)	Adult ; Embryonic Development ; Humans ; Male ; Middle Aged ; Prostate ; Soil ; Trees
Chemical Substances	Soil
Language	English
Publishing date	2021-07-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2375354-7
ISSN	1875-9777 ; 1934-5909
ISSN (online)	1875-9777
ISSN	1934-5909
DOI	10.1016/j.stem.2021.06.002
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Article ; Online: α-Tocopherol: New Perspectives and Challenges for Achieving the Sustainable Development Goals (SDG) Target.

Ogawa, Shigesaburo / Iuchi, Katsuya

Journal of oleo science

2024 Volume 73, Issue 4, Page(s) 519–538

Abstract: Vitamin E (VE) is a lipophilic vitamin, and Evans and Bishop demonstrated the existence of a hitherto unrecognized dietary factor essential for normal reproduction in rat. During 100 years after the discovery, α-tocopherol (α-Toc) has been the ... ...

Abstract	Vitamin E (VE) is a lipophilic vitamin, and Evans and Bishop demonstrated the existence of a hitherto unrecognized dietary factor essential for normal reproduction in rat. During 100 years after the discovery, α-tocopherol (α-Toc) has been the representative species in VE homologues, and both naturally occurring and synthetically prepared α-Toc have been widely used and studied. Although it is indicated by a single-word VE, research on VE involves various chemical species. It is important to understand the fine structure and accurate characteristics of individual VE species when using VE. Each VE sample has compositional and/or isomer issues, and furthermore, the usability greatly varies depending on the modified species of esterification. The VE industry involves many interdisciplinary fields. Improvements in formulation technology and confirmation of the novel biological activity of VE greatly owns its utility and opens up new applications. As the interim period between the start and end of the agenda for Sustainable Development Goals (SDGs), in this minireview, the recent trends and future guidelines of VE, especially α- Toc, in relation to the SDGs have been demonstrated.
MeSH term(s)	Rats ; Animals ; alpha-Tocopherol ; Sustainable Development ; Vitamin E ; Vitamins ; Isomerism
Chemical Substances	alpha-Tocopherol (H4N855PNZ1) ; Vitamin E (1406-18-4) ; Vitamins
Language	English
Publishing date	2024-04-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2218264-0
ISSN	1347-3352 ; 1345-8957
ISSN (online)	1347-3352
ISSN	1345-8957
DOI	10.5650/jos.ess23199
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Article ; Online: Indirect revascularization for pediatric moyamoya disease.

Ogawa, Shotaro / Ogiwara, Hideki

Journal of neurosurgery. Pediatrics

2024 , Page(s) 1–7

Abstract: Objective: Indirect revascularization is a common and effective treatment for pediatric moyamoya disease. However, in several cases postoperative angiogenesis is not sufficient. It is not fully understood which factors are involved in the development of ...

Abstract	Objective: Indirect revascularization is a common and effective treatment for pediatric moyamoya disease. However, in several cases postoperative angiogenesis is not sufficient. It is not fully understood which factors are involved in the development of postoperative collateral circulation. In this study, the authors aimed to elucidate the factors related to postoperative angiogenesis in indirect revascularization. Methods: Among the patients who underwent indirect revascularization for moyamoya disease from January 2015 to December 2022, those whose angiogenesis was evaluated using angiography were included. Age, onset symptoms, comorbidities, preoperative imaging findings, surgical details, perioperative complications, postoperative imaging findings, and modified Rankin Scale (mRS) score at the last outpatient visit were retrospectively examined. Results: Ninety cases (53 patients; 37 bilateral, 16 unilateral) were included. Sixty-eight cases (75.6%) were symptomatic. The mean age at surgery was 7.9 years, and the mean postoperative follow-up duration was 48.5 months. Frontotemporal encephalo-duro-arterio-synangiosis (EDAS) was performed in all cases, and simultaneous frontal encephalo-galeo-synangiosis (EGS) was performed in 34 cases. Postoperative angiography revealed insufficient angiogenesis in 14 of 90 cases (15.6%) after frontotemporal EDAS and in 8 of 34 cases (23.5%) after frontal EGS. A high degree of ivy sign depicted on preoperative MRI was found to be significantly correlated with good angiogenesis after both surgical procedures (p = 0.00030 for EDAS and p = 0.0039 for frontal EGS). In addition, an advanced preoperative Suzuki stage was significantly correlated with good postoperative angiogenesis after EDAS (p = 0.00040). Good angiogenesis was significantly correlated with postoperative improvement of the ivy sign in both procedures (p = 0.0005 in EDAS and p = 0.030 in frontal EGS) as well as correlated with a better mRS score at long-term follow-up after EDAS (p = 0.018). Conclusions: Preoperative ivy sign and Suzuki classification are related to the degree of angiogenesis achieved after indirect revascularization for pediatric moyamoya disease.
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2403985-8
ISSN	1933-0715 ; 1933-0707
ISSN (online)	1933-0715
ISSN	1933-0707
DOI	10.3171/2024.2.PEDS23414
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Article ; Online: Deciphering the Clonal Origin of Relapsed Acute Lymphoblastic Leukemia in Children.

Ogawa, Seishi

Blood cancer discovery

2020 Volume 1, Issue 1, Page(s) 21–22

Abstract: In this issue ... ...

Abstract	In this issue of
MeSH term(s)	Child ; Clonal Evolution/genetics ; Clone Cells/pathology ; Genomics ; Humans ; Mutation ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis
Language	English
Publishing date	2020-06-22
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	3028898-8
ISSN	2643-3249 ; 2643-3230
ISSN (online)	2643-3249
ISSN	2643-3230
DOI	10.1158/2643-3249.BCD-20-0056
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Article ; Online: Genetic basis of myelodysplastic syndromes.

Ogawa, Seishi

Proceedings of the Japan Academy. Series B, Physical and biological sciences

2020 Volume 96, Issue 3, Page(s) 107–121

Abstract: During the past decade, substantial progress has been made in the field of the genetics of myelodysplastic syndromes (MDS). These comprise a group of chronic myeloid neoplasms with abnormal cell morphology and progression to acute myeloid leukemia (AML), ...

Abstract	During the past decade, substantial progress has been made in the field of the genetics of myelodysplastic syndromes (MDS). These comprise a group of chronic myeloid neoplasms with abnormal cell morphology and progression to acute myeloid leukemia (AML), where revolutionary sequencing technologies have played a major role. Through extensive sequencing of a large number of MDS genomes, a comprehensive registry of driver mutations involved in the pathogenesis of MDS has been revealed, along with their impacts on clinical phenotype and prognosis. The most frequently affected molecules are involved in DNA methylations, chromatin modification, RNA splicing, transcription, signal transduction, cohesin regulation, and DNA repair. These mutations show strong positive and negative correlations with each other, suggesting the presence of functional interactions between mutations, which dictate disease progression. Because these mutations are associated with disease phenotype, drug response, and clinical outcomes, it is essential to be familiar with MDS genetics not only for better understanding of MDS pathogenesis but also for management of patients.
MeSH term(s)	Cell Cycle Proteins/genetics ; Chromosomal Proteins, Non-Histone/genetics ; DNA Methylation ; DNA Repair ; DNA, Neoplasm/genetics ; DNA, Neoplasm/metabolism ; Disease Progression ; Gene Expression Regulation, Leukemic ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Chronic-Phase/genetics ; Mutation ; Myelodysplastic Syndromes/classification ; Myelodysplastic Syndromes/genetics ; Phenotype ; Prognosis ; RNA Splicing ; Sequence Analysis, DNA ; Signal Transduction ; Cohesins
Chemical Substances	Cell Cycle Proteins ; Chromosomal Proteins, Non-Histone ; DNA, Neoplasm
Language	English
Publishing date	2020-03-05
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	161781-3
ISSN	1349-2896 ; 0386-2208
ISSN (online)	1349-2896
ISSN	0386-2208
DOI	10.2183/pjab.96.009
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Article: Cranial distraction osteogenesis for craniosynostosis associated with osteopetrosis: A case report.

Ogawa, Shotaro / Ogiwara, Hideki

Surgical neurology international

2023 Volume 14, Page(s) 368

Abstract: Background: Osteopetrosis is a rare disease characterized by systemic osteosclerosis and hematopoietic disturbances. Childhood-onset cases are often accompanied by hydrocephalus and craniosynostosis; however, there have been no established treatments. ... ...

Abstract	Background: Osteopetrosis is a rare disease characterized by systemic osteosclerosis and hematopoietic disturbances. Childhood-onset cases are often accompanied by hydrocephalus and craniosynostosis; however, there have been no established treatments. We performed cranial distraction in a child with osteopetrosis who presented with craniosynostosis and intracranial hypertension. Case description: The patient was a 4-year-1-month-old boy. His pregnancy and birth were normal, but at 4 months of age, he was diagnosed with osteopetrosis based on generalized osteosclerosis and family history. A computed tomography scan of the head revealed early sagittal suture fusion and ventricular enlargement. A ventriculoperitoneal shunt was placed for intracranial hypertension; however, slit ventricle syndrome ensued and pansynostosis developed. To improve uncontrolled high intracranial pressure, cranial distraction was performed for intracranial volume expansion. No perioperative hemorrhagic or infectious complications were observed. After the start of distraction, the intracranial pressure gradually decreased, and clinical findings such as disturbance of consciousness and bradycardia disappeared. Bone regeneration in the defect site was good, and the extension device was removed 6 months after the operation. Conclusion: For osteopetrosis with poorly controlled intracranial hypertension, cranial distraction was considered to be an effective treatment.
Language	English
Publishing date	2023-10-13
Publishing country	United States
Document type	Case Reports
ISSN	2229-5097
ISSN	2229-5097
DOI	10.25259/SNI_623_2023
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Article ; Online: Prevention of retethering in untethering surgery of a tight filum terminale.

Ogawa, Shotaro / Ogiwara, Hideki

Journal of neurosurgery. Pediatrics

2023 Volume 32, Issue 2, Page(s) 158–162

Abstract: Objective: Untethering surgery for a tight filum terminale is a common treatment with considerable efficacy and safety. On the other hand, retethering has been reported to occur. One of the major mechanisms of retethering is adherence of the cut end of ... ...

Abstract	Objective: Untethering surgery for a tight filum terminale is a common treatment with considerable efficacy and safety. On the other hand, retethering has been reported to occur. One of the major mechanisms of retethering is adherence of the cut end of the sectioned filum to the midline dorsal dural surface. To prevent retethering, the authors sectioned a filum terminale at the rostral level to the dural incision to keep the distance between the cut end of the sectioned filum and the dural incision and investigated whether this procedure decreased the occurrence of retethering. Methods: Among the patients who underwent untethering surgery for a tight filum terminale between 2012 and 2016, patients followed up more than 5 years were included in the study. Symptoms, comorbid malformations, preoperative imaging, surgical details, perioperative complications, and long-term outcomes were reviewed retrospectively. Results: Retrospective data for a total of 342 cases were included. The median age at surgery was 11 months (range 3-156 months). Preoperative MRI revealed 254 patients (74.3%) had a low-set conus. There were 142 patients (41.5%) with filar lipoma and 42 patients (12.3%) with terminal cyst. Syringomyelia was found in 29 patients (8.5%). In total, 246 patients (71.9%) were symptomatic and 96 patients (28.1%) were asymptomatic. There were no perioperative complications that required surgical intervention or prolonged hospitalization. The mean postoperative follow-up was 88 months (range 60-127 months). There were 4 patients (1.2%) with retethering who presented with bladder and bowel dysfunction. The mean time from initial untethering to retethering was 54 months (range 36-80 months). All 4 patients underwent untethering surgery, and preoperative symptoms resolved in 3 patients. Conclusions: The retethering rate after untethering surgery for a tight filum terminale in our series was lower than those in previously reported studies. Sectioning the filum terminale at the rostral level to the dural incision was considered an effective way to prevent retethering.
MeSH term(s)	Humans ; Cauda Equina/diagnostic imaging ; Cauda Equina/surgery ; Retrospective Studies ; Neurosurgical Procedures/methods ; Neural Tube Defects/diagnostic imaging ; Neural Tube Defects/surgery ; Surgical Wound/surgery
Language	English
Publishing date	2023-05-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2403985-8
ISSN	1933-0715 ; 1933-0707
ISSN (online)	1933-0715
ISSN	1933-0707
DOI	10.3171/2023.3.PEDS22542
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