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  1. Article: [113th Scientific Meeting of the Japanese Society of Internal Medicine: Presidential Lecture: Panel Discussion: Molecular Mechanism of Metabolic Syndrome].

    Ogawa, Yoshihiro

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2018  Volume 105, Issue 9, Page(s) 1632–1636

    MeSH term(s) Chronic Disease ; Fibrosis ; Humans ; Inflammation/metabolism ; Internal Medicine ; Intracellular Space/metabolism ; Japan ; Metabolic Syndrome/metabolism ; Metabolic Syndrome/pathology ; Societies, Medical
    Language Japanese
    Publishing date 2018-10-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
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    Zs.B 594: Show issues Location:
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  2. Article: Molecular Mechanism of Lifestyle-related Diseases : See Both the Wood and Trees!

    Ogawa, Yoshihiro

    Fukuoka igaku zasshi = Hukuoka acta medica

    2016  Volume 107, Issue 11, Page(s) 191–198

    MeSH term(s) Adipocytes ; Animals ; Fatty Liver ; Humans ; Inflammation ; Life Style ; Macrophages ; Obesity/metabolism
    Language Japanese
    Publishing date 2016
    Publishing country Japan
    Document type Journal Article ; Review ; English Abstract
    ZDB-ID 41251-x
    ISSN 0016-254X
    ISSN 0016-254X
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  3. Article: Three-point traction method for endoscopic submucosal dissection using clip-with-thread and clip-with-silicon bands for large early gastric neoplasms.

    Maruoka, Ryohei / Esaki, Mitsuru / Minoda, Yosuke / Tokunaga, Noriko / Haraguchi, Kazuhiro / Ihara, Eikichi / Ogawa, Yoshihiro

    Endoscopy international open

    2024  Volume 12, Issue 1, Page(s) E57–E58

    Language English
    Publishing date 2024-01-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722
    ISSN (online) 2196-9736
    ISSN 2364-3722
    DOI 10.1055/a-2219-8130
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  4. Article ; Online: HNF1A Mutations and Beta Cell Dysfunction in Diabetes.

    Miyachi, Yasutaka / Miyazawa, Takashi / Ogawa, Yoshihiro

    International journal of molecular sciences

    2022  Volume 23, Issue 6

    Abstract: Understanding the genetic factors of diabetes is essential for addressing the global increase in type 2 diabetes. HNF1A mutations cause a monogenic form of diabetes called maturity-onset diabetes of the young (MODY), and HNF1A single-nucleotide ... ...

    Abstract Understanding the genetic factors of diabetes is essential for addressing the global increase in type 2 diabetes. HNF1A mutations cause a monogenic form of diabetes called maturity-onset diabetes of the young (MODY), and HNF1A single-nucleotide polymorphisms are associated with the development of type 2 diabetes. Numerous studies have been conducted, mainly using genetically modified mice, to explore the molecular basis for the development of diabetes caused by HNF1A mutations, and to reveal the roles of HNF1A in multiple organs, including insulin secretion from pancreatic beta cells, lipid metabolism and protein synthesis in the liver, and urinary glucose reabsorption in the kidneys. Recent studies using human stem cells that mimic MODY have provided new insights into beta cell dysfunction. In this article, we discuss the involvement of HNF1A in beta cell dysfunction by reviewing previous studies using genetically modified mice and recent findings in human stem cell-derived beta cells.
    MeSH term(s) Animals ; Diabetes Mellitus, Type 2/genetics ; Insulin Secretion ; Insulin-Secreting Cells ; Mice ; Mutation
    Language English
    Publishing date 2022-03-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23063222
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  5. Article ; Online: What is the best modality for diagnosing pancreatic cancer?

    Fujimori, Nao / Minoda, Yosuke / Ogawa, Yoshihiro

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

    2022  Volume 34, Issue 4, Page(s) 744–746

    MeSH term(s) Humans ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms
    Language English
    Publishing date 2022-03-22
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 1171589-3
    ISSN 1443-1661 ; 0915-5635
    ISSN (online) 1443-1661
    ISSN 0915-5635
    DOI 10.1111/den.14283
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  6. Article ; Online: Two cases of pancreatic neuroendocrine tumors with ectopic ACTH syndrome during their disease course.

    Murakami, Masatoshi / Hirahata, Keisuke / Fujimori, Nao / Yamamoto, Takeo / Oda, Yoshinao / Kozono, Shingo / Ueda, Keijiro / Ito, Testuhide / Nakamura, Masafumi / Ogawa, Yoshihiro

    Clinical journal of gastroenterology

    2024  Volume 17, Issue 2, Page(s) 363–370

    Abstract: Pancreatic neuroendocrine tumors (PanNETs) are rare malignant tumors that occur in the pancreas. They are divided into functioning and non-functioning tumors based on the presence or absence of their specific hormonal hyper-expression symptoms. ... ...

    Abstract Pancreatic neuroendocrine tumors (PanNETs) are rare malignant tumors that occur in the pancreas. They are divided into functioning and non-functioning tumors based on the presence or absence of their specific hormonal hyper-expression symptoms. Adrenocorticotropic hormone (ACTH)-producing PanNETs are rare, functional tumors, and their clinical characteristics and outcomes have not been well reported.Here, we report the cases of two patients with PanNETs who presented with ectopic ACTH syndrome (EAS) during the course of their disease. Case 1 involved a non-functioning PanNET at the time of surgery. During treatment for recurrent liver metastases, the patient presented with EAS and tumor-associated hypercalcemia, probably due to ACTH and parathyroid hormone-related peptide (PTHrP) production from the liver tumor. Case 2 was a gastrinoma, and similar to Case 1, this patient presented with EAS during the treatment of recurrent liver metastases.It is not uncommon for patients with PanNETs to have multiple hormones and develop secondary hormone secretion during their disease course, although tumor phenotypes differ between primary and metastatic sites. In patients with functioning PanNETs, symptom control with anti-hormonal therapy is essential, in addition to anti-tumor therapy, especially for EAS, which is an endocrine emergency disease that requires prompt diagnosis and treatment.
    MeSH term(s) Humans ; ACTH Syndrome, Ectopic/diagnosis ; ACTH Syndrome, Ectopic/etiology ; Neuroendocrine Tumors/complications ; Neuroendocrine Tumors/pathology ; Cushing Syndrome/diagnosis ; Cushing Syndrome/pathology ; Adrenocorticotropic Hormone/therapeutic use ; Liver Neoplasms/complications ; Pancreatic Neoplasms/diagnosis
    Chemical Substances Adrenocorticotropic Hormone (9002-60-2)
    Language English
    Publishing date 2024-01-20
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2429411-1
    ISSN 1865-7265 ; 1865-7257
    ISSN (online) 1865-7265
    ISSN 1865-7257
    DOI 10.1007/s12328-023-01908-5
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  7. Article ; Online: Clinicopathological significance of microsatellite instability and immune escape mechanism in patients with gastric solid-type poorly differentiated adenocarcinoma.

    Umekita, Shinya / Kiyozawa, Daisuke / Kohashi, Kenichi / Kawatoko, Shinichiro / Sasaki, Taisuke / Ihara, Eikichi / Oki, Eiji / Nakamura, Masafumi / Ogawa, Yoshihiro / Oda, Yoshinao

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

    2024  Volume 27, Issue 3, Page(s) 484–494

    Abstract: Background: In gastric solid-type poorly differentiated adenocarcinoma (PDA), the role of microsatellite instability and immune escape mechanism remains unclear. The current study aimed to elucidate the clinical significance of mismatch repair (MMR) ... ...

    Abstract Background: In gastric solid-type poorly differentiated adenocarcinoma (PDA), the role of microsatellite instability and immune escape mechanism remains unclear. The current study aimed to elucidate the clinical significance of mismatch repair (MMR) status, genome profile, C-X-C motif chemokine receptor 2 (CXCR2) expression, and myeloid-derived suppressor cell (MDSC) infiltration in solid-type PDA.
    Methods: In total, 102 primary solid-type PDA cases were retrieved, and classified into 46 deficient-MMR (dMMR) and 56 proficient-MMR (pMMR) cases based on immunohistochemistry (IHC) and polymerase chain reaction-based molecular testing results. The mRNA expression profiles (NanoString nCounter Assay) of stage-matched dMMR (n = 6) and pMMR (n = 6) cases were examined. The CXCR2 expression and MDSC infiltration (CD11b- and CD33-positive cells) were investigated via IHC in all solid-type PDA cases.
    Results: mRNA analysis revealed several differentially expressed genes and differences in biological behavior between the dMMR (n = 46) and pMMR (n = 56) groups. In the multivariate analysis, the dMMR status was significantly associated with a longer disease-free survival (hazard ratio = 5.152, p = 0.002) and overall survival (OS) (hazard ratio = 5.050, p = 0.005). CXCR2-high expression was significantly correlated with a shorter OS in the dMMR group (p = 0.018). A high infiltration of CD11b- and CD33-positive cells was significantly correlated with a shorter OS in the pMMR group (p = 0.022, 0.016, respectively).
    Conclusions: dMMR status can be a useful prognostic predictor, and CXCR2 and MDSCs can be novel therapeutic targets in patients with solid-type PDA.
    MeSH term(s) Humans ; Stomach Neoplasms/genetics ; Microsatellite Instability ; Colorectal Neoplasms ; Adenocarcinoma/pathology ; DNA Mismatch Repair/genetics ; RNA, Messenger/genetics ; Brain Neoplasms ; Neoplastic Syndromes, Hereditary
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2024-03-05
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1463526-4
    ISSN 1436-3305 ; 1436-3291
    ISSN (online) 1436-3305
    ISSN 1436-3291
    DOI 10.1007/s10120-024-01474-w
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    Zs.A 5290: Show issues Location:
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  8. Article ; Online: Safety and efficacy of tirzepatide as an add-on to single oral antihyperglycaemic medication in patients with type 2 diabetes in Japan (SURPASS J-combo): a multicentre, randomised, open-label, parallel-group, phase 3 trial.

    Kadowaki, Takashi / Chin, Rina / Ozeki, Akichika / Imaoka, Takeshi / Ogawa, Yoshihiro

    The lancet. Diabetes & endocrinology

    2022  Volume 10, Issue 9, Page(s) 634–644

    Abstract: Background: Due to potential ethnic differences in the pathophysiology of type 2 diabetes, new therapeutics need to be evaluated in Japanese patients. We aimed to assess the safety and glycaemic efficacy of tirzepatide as an add-on treatment in Japanese ...

    Abstract Background: Due to potential ethnic differences in the pathophysiology of type 2 diabetes, new therapeutics need to be evaluated in Japanese patients. We aimed to assess the safety and glycaemic efficacy of tirzepatide as an add-on treatment in Japanese patients with type 2 diabetes who had inadequate glycaemic control with stable doses of various oral antihyperglycaemic monotherapies.
    Methods: This multicentre, open-label, parallel-group, randomised, phase 3 trial was conducted at 34 medical research centres and hospitals in Japan. Eligible participants were aged 20 years or older with inadequately controlled (HbA
    Findings: Between March 30, 2019, and Feb 16, 2021, with recruitment and enrolment continuing until Feb 4, 2020, 484 participants were assessed for eligibility and 443 were randomly assigned to receive at least one dose of tirzepatide (148 [33%] in the 5 mg group, 147 [33%] in the 10 mg group, and 148 [33%] in the 15 mg group). 398 (90%) participants completed the study and treatment. Most participants (343 [77%] of 443) had at least one treatment-emergent adverse event. Treatment-emergent adverse events were more frequent in the tirzepatide 15 mg group (125 [84%] of 148) than the 5 mg (109 [74%] of 148) and 10 mg groups (109 [74%] of 147). The most frequent treatment-emergent adverse events with tirzepatide were mild or moderate nasopharyngitis (75 [17%]), nausea (74 [17%]), constipation (54 [12%]), diarrhoea (51 [12%]), and decreased appetite (44 [10%]). At week 52, mean changes from baseline in bodyweight were -3·8 kg (SE 0·5; -5·1% reduction) in the 5 mg group, -7·5 kg (0·5; -10·1% reduction) in the 10 mg group, and -10·2 kg (0·5; -13·2% reduction) in the 15 mg group. Least squares mean HbA
    Interpretation: Tirzepatide was well tolerated as an add-on to oral antihyperglycaemic monotherapy in Japanese participants with type 2 diabetes and showed improvement in glycaemic control and bodyweight, irrespective of background oral antihyperglycaemic medication. Tirzepatide is a potential new treatment option for Japanese patients with type 2 diabetes that is inadequately controlled with single oral antihyperglycaemic medication.
    Funding: Eli Lilly and Company.
    Translation: For the Japanese translation of the abstract see Supplementary Materials section.
    MeSH term(s) Body Weight ; Diabetes Mellitus, Type 2 ; Double-Blind Method ; Gastric Inhibitory Polypeptide ; Glucagon-Like Peptides ; Humans ; Hypoglycemic Agents ; Japan ; Treatment Outcome
    Chemical Substances Hypoglycemic Agents ; Gastric Inhibitory Polypeptide (59392-49-3) ; Glucagon-Like Peptides (62340-29-8) ; tirzepatide (OYN3CCI6QE)
    Language English
    Publishing date 2022-07-30
    Publishing country England
    Document type Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(22)00187-5
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  9. Article ; Online: Role of chronic inflammation in the pathogenesis of nonalcoholic steatohepatitis: lessons from a unique mouse model using melanocortin receptor-deficient mice.

    Itoh, Michiko / Suganami, Takayoshi / Ogawa, Yoshihiro

    Endocrine journal

    2021  Volume 68, Issue 7, Page(s) 743–749

    Abstract: Nonalcoholic fatty liver disease (NAFLD) is a clinical spectrum that encompasses simple steatosis to nonalcoholic steatohepatitis (NASH), the latter of which is characterized by chronic inflammation and fibrosis. NASH is now becoming the leading cause of ...

    Abstract Nonalcoholic fatty liver disease (NAFLD) is a clinical spectrum that encompasses simple steatosis to nonalcoholic steatohepatitis (NASH), the latter of which is characterized by chronic inflammation and fibrosis. NASH is now becoming the leading cause of cirrhosis and hepatocellular carcinoma worldwide. The pathophysiology of NASH is multifactorial and, therefore, not yet completely understood, although it is pointed out that hepatocyte death and subsequent inflammation play a central roles in disease pathogenesis. Since stromal cells dramatically change their cellular components and activation status as liver fibrosis develops, it is important to reveal the subset responsible for the disease development in each etiology. Macrophages foam crown-like structures (CLS), in which CD11c-positive macrophages surround dead hepatocytes induced by lipotoxic injury in mouse and human NASH. Hepatic CLS-constituting macrophages exhibit gene expression profiles distinct from other scattered macrophages in the liver, suggesting NASH-specific macrophages represent a subset that drives metabolic stress-induced liver fibrosis. Moreover, cancer-associated pathways are upregulated in activated fibroblasts from the liver of a mouse NASH model, suggesting that fibroblasts provide the microenvironment that promotes tumor progression. A better understanding of the upstream signals and regulatory mechanisms that drive the generation of NASH-specific macrophage and fibroblast subsets is crucial for the development of novel diagnostic and therapeutic strategies.
    MeSH term(s) Adipose Tissue/metabolism ; Animals ; Cell Death/physiology ; Disease Models, Animal ; Inflammation/genetics ; Inflammation/metabolism ; Liver/metabolism ; Liver Cirrhosis/metabolism ; Mice ; Mice, Knockout ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/metabolism ; Receptor, Melanocortin, Type 1/genetics ; Receptor, Melanocortin, Type 1/metabolism
    Chemical Substances Receptor, Melanocortin, Type 1
    Language English
    Publishing date 2021-05-07
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1151918-6
    ISSN 1348-4540 ; 0918-8959
    ISSN (online) 1348-4540
    ISSN 0918-8959
    DOI 10.1507/endocrj.EJ21-0002
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  10. Article ; Online: Two-point fixed pulley-traction method in endoscopic submucosal dissection for early gastric neoplasm.

    Takeuchi, Tsubasa / Esaki, Mitsuru / Minoda, Yosuke / Hata, Yoshitaka / Ogino, Haruei / Ihara, Eikichi / Ogawa, Yoshihiro

    Endoscopy

    2023  Volume 55, Issue S 01, Page(s) E1087–E1088

    Language English
    Publishing date 2023-09-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2173-8010
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