Article ; Online: Anthelmintic activity and non-cytotoxicity of phaeophorbide-a isolated from the leaf of Spondias mombin L.
2021 Volume 280, Page(s) 114392
Abstract: Ethnopharmacological relevance: Helminthosis (worm infection) is a disease of grazing livestock, with significant economic implications. Increasing resistance to existing synthetic anthelmintics used to control helminthosis and the unwanted presence of ... ...
| Abstract | Ethnopharmacological relevance: Helminthosis (worm infection) is a disease of grazing livestock, with significant economic implications. Increasing resistance to existing synthetic anthelmintics used to control helminthosis and the unwanted presence of residues of the anthelmintics reported in meat and dairy products present a serious global health challenge. These challenges have necessitated the development of novel anthelmintics that could combat drug resistance and exhibit better safety profiles. Spondias mombin L. (Anacardiaceae) is a plant that has been used traditionally as a worm expeller. Aim of study: The aim of the work reported herein was to isolate and characterise anthelmintic compound(s) from S. mombin leaf, establishing their bioactivity and safety profile. Materials and methods: Adult Haemonchus placei motility assay was used to assess anthelmintic bioactivity. Bioassay-guided chromatographic fractionation of acetone extract of S. mombin leaf was carried out on a silica gel stationary phase. The structure of the compound was elucidated using spectroscopy ( Results: The acetone extract yielded an active fraction 8 (Ethyl acetate: methanol 90:10; anthelmintic LC Conclusions: Phaeophorbide-a (1) isolated from S. mombin leaf extract and reported in the plant for the first time in this species demonstrated anthelmintic activity. No significant toxicity to mammalian cells was observed. It therefore represents a novel anthelmintic pharmacophore as a potential lead for the development of novel anthelmintics. |
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| MeSH term(s) | 3T3 Cells ; Anacardiaceae/chemistry ; Animals ; Anthelmintics/chemistry ; Anthelmintics/isolation & purification ; Anthelmintics/pharmacology ; Caco-2 Cells ; Cell Line ; Haemonchus/drug effects ; Humans ; Lethal Dose 50 ; Mice ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/toxicity ; Plant Leaves ; Tetrapyrroles/chemistry ; Tetrapyrroles/pharmacology ; Tetrapyrroles/toxicity |
| Chemical Substances | Anthelmintics ; Plant Extracts ; Tetrapyrroles ; phaeophorbide-a |
| Language | English |
| Publishing date | 2021-07-04 |
| Publishing country | Ireland |
| Document type | Journal Article |
| ZDB-ID | 134511-4 |
| ISSN | 1872-7573 ; 0378-8741 |
| ISSN (online) | 1872-7573 |
| ISSN | 0378-8741 |
| DOI | 10.1016/j.jep.2021.114392 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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