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  1. Article ; Online: Myocardial microthrombi after COVID-19 mRNA vaccination.

    Aikawa, Tadao / Ogino, Jiro / Kita, Yuichi / Funayama, Naohiro

    European heart journal

    2023  Volume 42, Issue 43, Page(s) 4501

    MeSH term(s) Humans ; COVID-19/prevention & control ; Thrombosis ; Myocardium ; Vaccination ; RNA, Messenger
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2023-03-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab727
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    Zs.A 1563: Show issues Location:
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  2. Article ; Online: Myocardial microthrombi after COVID-19 mRNA vaccination.

    Aikawa, Tadao / Ogino, Jiro / Kita, Yuichi / Funayama, Naohiro

    European heart journal

    2021  Volume 42, Issue 43, Page(s) 4501

    MeSH term(s) COVID-19 ; Humans ; Myocardium ; RNA, Messenger ; SARS-CoV-2 ; Vaccination
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2021-10-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab727
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  3. Article ; Online: Late-onset endocarditis after coronavirus disease 2019 infection.

    Aikawa, Tadao / Ogino, Jiro / Kudo, Tamaki / Kashiwagi, Yusuke

    European heart journal

    2021  Volume 42, Issue 32, Page(s) 3108

    MeSH term(s) COVID-19 ; Endocarditis/etiology ; Endocarditis, Bacterial ; Heart Valve Prosthesis ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-02-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab065
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  4. Article: [A Case of Breast Carcinoma That Changed Subtype to Squamous Cell Carcinoma after Chemotherapy].

    Konishi, Kazuya / Araya, Jun / Nagabuchi, Makoto / Sakamoto, Takashi / Ogino, Jiro / Hirano, Satoshi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2023  Volume 50, Issue 7, Page(s) 825–827

    Abstract: Metaplastic carcinoma is a rare histological malignancy, often triple-negative, and has a poor prognosis. Here, we report a case of breast cancer in which the primary lesion degenerated into squamous cell carcinoma(triple negative)after drug treatment ... ...

    Abstract Metaplastic carcinoma is a rare histological malignancy, often triple-negative, and has a poor prognosis. Here, we report a case of breast cancer in which the primary lesion degenerated into squamous cell carcinoma(triple negative)after drug treatment for invasive ductal carcinoma(Luminal type). The patient was a 41-year-old woman who was diagnosed with Stage Ⅳ left breast cancer T2N2bM1(HEP)(ER 90%, PR 70%, HER2 2+, FISH-)at another hospital and participated in the PATHWAY study(tamoxifen plus goserelin plus palbociclib/placebo). Since the primary lesion and liver metastasis increased in size, the study was discontinued after 8 weeks. She was treated at our hospital thereafter, with capecitabine plus cyclophosphamide, palbociclib plus fulvestrant plus leuprorelin, paclitaxel plus bevacizumab, eribulin, EC therapy, and docetaxel. However, both the primary lesion and liver metastasis increased. In particular, the increase in primary lesion size was remarkable, and the QOL significantly reduced due to bleeding and exudation. Biopsy performed during docetaxel treatment revealed metaplastic/squamous cell carcinoma(ER-, PR-, HER2 0, Ki-67 90-100%)histopathological findings. BRCA and microsatellite instability tests were negative, and PDL1 expression was less than 1%. Although Mohs ointment was used, tumor bleeding, exudate, and stink were poorly controlled, and the patient experienced painful symptoms due to the weight of the tumor. Therefore, left mastectomy plus pectoralis major muscle resection was performed. The patient died one month after the operation.
    MeSH term(s) Female ; Humans ; Breast Neoplasms/drug therapy ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Docetaxel/therapeutic use ; Mastectomy ; Quality of Life ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/surgery ; Carcinoma, Squamous Cell/pathology ; Capecitabine/therapeutic use ; Cyclophosphamide/therapeutic use ; Liver Neoplasms/drug therapy ; Liver Neoplasms/surgery ; Liver Neoplasms/secondary
    Chemical Substances Docetaxel (15H5577CQD) ; Capecitabine (6804DJ8Z9U) ; Cyclophosphamide (8N3DW7272P)
    Language Japanese
    Publishing date 2023-07-27
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
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  5. Article ; Online: Vasospastic Angina: A Cause of Post-acute COVID-19 Syndrome.

    Aikawa, Tadao / Ogino, Jiro / Oyama-Manabe, Noriko / Funayama, Naohiro

    Internal medicine (Tokyo, Japan)

    2022  Volume 61, Issue 17, Page(s) 2693–2695

    MeSH term(s) Angina Pectoris/complications ; Angina Pectoris, Variant/complications ; COVID-19/complications ; Coronary Vasospasm/etiology ; Humans
    Language English
    Publishing date 2022-06-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.0137-22
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  6. Article ; Online: Pericarditis with Increased Vascular Permeability after COVID-19 Vaccination.

    Aikawa, Tadao / Ogino, Jiro / Aikawa, Nozomi / Oyama-Manabe, Noriko

    Internal medicine (Tokyo, Japan)

    2022  Volume 61, Issue 10, Page(s) 1623–1624

    MeSH term(s) COVID-19 ; COVID-19 Vaccines/adverse effects ; Capillary Permeability ; Humans ; Pericarditis/diagnostic imaging ; Pericarditis/etiology ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-03-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.9407-22
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  7. Article ; Online: Microvascular thrombi in recurrent myocardial injury after coronavirus disease 2019 infection.

    Aikawa, Tadao / Ogino, Jiro / Hirofuji, Aina / Oyama-Manabe, Noriko

    European heart journal

    2021  Volume 42, Issue 36, Page(s) 3804

    MeSH term(s) COVID-19 ; Heart Injuries ; Humans ; SARS-CoV-2 ; Thrombosis
    Language English
    Publishing date 2021-08-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab539
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  8. Article ; Online: Non-infectious endocarditis and myocarditis after COVID-19 mRNA vaccination.

    Aikawa, Tadao / Ogino, Jiro / Kita, Yuichi / Funayama, Naohiro / Oyama-Manabe, Noriko

    European heart journal. Case reports

    2022  Volume 6, Issue 1, Page(s) ytab533

    Language English
    Publishing date 2022-01-03
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytab533
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  9. Article ; Online: Cardiac resynchronization therapy through a subcutaneous tunnel assessed by phase analysis of gated myocardial perfusion SPECT imaging.

    Aikawa, Tadao / Kamada, Rui / Ogino, Jiro / Saitou, Toshinori / Funayama, Naohiro / Hotta, Daisuke

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2022  Volume 30, Issue 3, Page(s) 1277–1282

    MeSH term(s) Humans ; Cardiac Resynchronization Therapy ; Tomography, Emission-Computed, Single-Photon/methods ; Perfusion ; Myocardial Perfusion Imaging/methods ; Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography/methods ; Ventricular Dysfunction, Left
    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-022-02916-7
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    Zs.A 4121: Show issues Location:
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  10. Article ; Online: Elucidation of Melanogenesis Cascade for Identifying Pathophysiology and Therapeutic Approach of Pigmentary Disorders and Melanoma.

    Hida, Tokimasa / Kamiya, Takafumi / Kawakami, Akinori / Ogino, Jiro / Sohma, Hitoshi / Uhara, Hisashi / Jimbow, Kowichi

    International journal of molecular sciences

    2020  Volume 21, Issue 17

    Abstract: Melanogenesis is the biological and biochemical process of melanin and melanosome biosynthesis. Melanin is formed by enzymic reactions of tyrosinase family proteins that convert tyrosine to form brown-black eumelanin and yellow-red pheomelanin within ... ...

    Abstract Melanogenesis is the biological and biochemical process of melanin and melanosome biosynthesis. Melanin is formed by enzymic reactions of tyrosinase family proteins that convert tyrosine to form brown-black eumelanin and yellow-red pheomelanin within melanosomal compartments in melanocytes, following the cascades of events interacting with a series of autocrine and paracrine signals. Fully melanized melanosomes are delivered to keratinocytes of the skin and hair. The symbiotic relation of a melanocyte and an associated pool of keratinocytes is called epidermal melanin unit (EMU). Microphthalmia-associated transcription factor (MITF) plays a vital role in melanocyte development and differentiation. MITF regulates expression of numerous pigmentation genes for promoting melanocyte differentiation, as well as fundamental genes for maintaining cell homeostasis. Diseases involving alterations of EMU show various forms of pigmentation phenotypes. This review introduces four major topics of melanogenesis cascade that include (1) melanocyte development and differentiation, (2) melanogenesis and intracellular trafficking for melanosome biosynthesis, (3) melanin pigmentation and pigment-type switching, and (4) development of a novel therapeutic approach for malignant melanoma by elucidation of melanogenesis cascade.
    MeSH term(s) Cell Differentiation ; Humans ; Melanins/metabolism ; Melanocytes/cytology ; Melanocytes/metabolism ; Melanoma/drug therapy ; Melanoma/metabolism ; Microphthalmia-Associated Transcription Factor/metabolism ; Pigmentation Disorders/drug therapy ; Pigmentation Disorders/metabolism
    Chemical Substances MITF protein, human ; Melanins ; Microphthalmia-Associated Transcription Factor
    Language English
    Publishing date 2020-08-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21176129
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