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  1. Article: [Drugs for Amyotrophic Lateral Sclerosis].

    Ogino, Mieko

    Brain and nerve = Shinkei kenkyu no shinpo

    2023  Volume 75, Issue 5, Page(s) 503–506

    Abstract: Riluzole and edaravone for the treatment of amyotrophic lateral sclerosis (ALS) are currently covered by insurance in Japan. Both have been shown to prolong survival and/or inhibit progression, but neither is a cure-all treatment, and the effects are ... ...

    Abstract Riluzole and edaravone for the treatment of amyotrophic lateral sclerosis (ALS) are currently covered by insurance in Japan. Both have been shown to prolong survival and/or inhibit progression, but neither is a cure-all treatment, and the effects are difficult to realize. The data presented in clinical trials are not applicable to all patients with ALS; the risks and benefits should be explained carefully before use. So far, edaravone has been administered intravenously, but an oral form became available in Japan on April 17, 2023. For symptomatic treatment, morphine hydrochloride and morphine sulfate are insurance-covered alternatives.
    MeSH term(s) Humans ; Amyotrophic Lateral Sclerosis/drug therapy ; Edaravone/therapeutic use ; Neuroprotective Agents/therapeutic use ; Riluzole/therapeutic use ; Japan
    Chemical Substances Edaravone (S798V6YJRP) ; Neuroprotective Agents ; Riluzole (7LJ087RS6F)
    Language Japanese
    Publishing date 2023-03-07
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416202367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 398: Show issues Location:
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  2. Article: [Video Works on Amyotrophic Lateral Sclerosis].

    Ogino, Mieko

    Brain and nerve = Shinkei kenkyu no shinpo

    2022  Volume 74, Issue 12, Page(s) 1384–1387

    Abstract: Amyotrophic lateral sclerosis (ALS) is known to many as a disease that is infrequent but causes progressive disability and death within three to five years if a tracheostomy ventilator are not used. The patient must choose whether to live with a crippled ...

    Abstract Amyotrophic lateral sclerosis (ALS) is known to many as a disease that is infrequent but causes progressive disability and death within three to five years if a tracheostomy ventilator are not used. The patient must choose whether to live with a crippled body or die, and is faced with the question of what kind of condition is considered "living". By watching a video that addresses this theme, we can grasp this question even more deeply.
    Language Japanese
    Publishing date 2022-12-08
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416202254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Home Care for Cancer Patients and Outreach from the Hospital].

    Ogino, Mieko

    Gan to kagaku ryoho. Cancer & chemotherapy

    2020  Volume 47, Issue 3, Page(s) 413–416

    Abstract: Japan is entering a multi-dying era. In this situation palliative care is increasingly important. More than half of Japanese state that they want to stay at home even when facing the end of life, especially in cancer area. But in reality, more than 80% ... ...

    Abstract Japan is entering a multi-dying era. In this situation palliative care is increasingly important. More than half of Japanese state that they want to stay at home even when facing the end of life, especially in cancer area. But in reality, more than 80% of people die in hospitals. People are not confident about caring and palliative care at home. Therefore, if palliative specialist can visit their homes to care for their patients and family and work with home visiting physician, they can back to home. This type of outreach also helps the doctors working in hospitals understand home care.
    MeSH term(s) Home Care Services ; Hospitals ; Humans ; Japan ; Neoplasms/therapy ; Palliative Care
    Language Japanese
    Publishing date 2020-05-08
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Basics of Clinical Ethics].

    Ogino, Mieko

    Brain and nerve = Shinkei kenkyu no shinpo

    2020  Volume 72, Issue 7, Page(s) 677–687

    Abstract: Neurologists encounter patients who develop diseases that suddenly change their life one day, such as stroke, and diseases that are difficult to cure and progressive, such as intractable neurological diseases. There are many types of ethical issues, ... ...

    Abstract Neurologists encounter patients who develop diseases that suddenly change their life one day, such as stroke, and diseases that are difficult to cure and progressive, such as intractable neurological diseases. There are many types of ethical issues, including the choice of medical intervention, caregiver conflict, genetic disease issues, end-of-life issues, etc. In this article, I will describe the matters advocated in general clinical ethics and discuss the interpretation and application in the field of neurology based on my own experience. The issue is why clinical ethics is necessary, methodologies and systems for dealing with ethical issues, four principles of clinical ethics, Jonsen's four contingency table, ethical consultation, application in neurological diseases, and issues to be noted.
    MeSH term(s) Caregivers ; Ethics, Clinical ; Ethics, Medical ; Humans ; Nervous System Diseases/therapy ; Neurology
    Language Japanese
    Publishing date 2020-05-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416201585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Future issues of the multiple sclerosis treatment from a medical economic viewpoint].

    Ogino, Mieko

    Nihon rinsho. Japanese journal of clinical medicine

    2015  Volume 73 Suppl 7, Page(s) 862–868

    MeSH term(s) Arthritis, Rheumatoid/economics ; Drug Discovery ; Economics, Medical ; Humans ; Insurance, Health ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/economics
    Language Japanese
    Publishing date 2015-09
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 429: Show issues Location:
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  6. Article: [Technical evaluation of medical practice--conversion from things to skill and art. Topics; V. Toward establishment of technical evaluation on medical practice; 4. Informed consent under unusual conditions, 1) Medical fee for the decision-making support of end of life].

    Ogino, Mieko

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2015  Volume 103, Issue 12, Page(s) 2957–2961

    MeSH term(s) Aging ; Decision Making ; Fees, Medical ; Humans ; Informed Consent ; Japan ; Reimbursement Mechanisms/economics ; Reimbursement Mechanisms/legislation & jurisprudence ; Surveys and Questionnaires/economics
    Language Japanese
    Publishing date 2015-03-20
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    DOI 10.2169/naika.103.2957
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 594: Show issues Location:
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  7. Article ; Online: Effects of Rehabilitative Intervention for Augmenting Cough Function in Patients with Multiple System Atrophy.

    Asakawa, Takashi / Ogino, Mieko / Tominaga, Naomi / Ozaki, Naoto / Kubo, Jin / Kakuda, Wataru

    Progress in rehabilitation medicine

    2023  Volume 8, Page(s) 20230035

    Abstract: Objectives: One of the causes of death in patients with multiple system atrophy (MSA) is aspiration pneumonia caused by cough dysfunction. This study aimed to identify an effective approach to improve coughing and to explore the establishment of ... ...

    Abstract Objectives: One of the causes of death in patients with multiple system atrophy (MSA) is aspiration pneumonia caused by cough dysfunction. This study aimed to identify an effective approach to improve coughing and to explore the establishment of criteria for the use of gastrostomy based on cough and respiratory dysfunctions.
    Methods: Eighteen probable MSA patients participated in the study. They were categorized into air stacking and non-air stacking groups. First, we investigated how the inspiration volume changes by applying maximum insufflation capacity (MIC). Second, peak cough flow (PCF) was measured by different cough augmentation methods: 1) spontaneous coughing (SpC); 2) SpC with MIC (SpC + MIC); 3) SpC with manually assisted cough (MAC) (SpC + MAC); and 4) SpC with MIC and MAC (SpC + MIC + MAC). Among these four conditions, PCF values were compared to determine the most effective approach for cough augmentation. Receiver operating characteristic analysis was performed on percent forced vital capacity (%FVC) to determine an index for discriminating PCF below160 L/min, which indicates a high risk of suffocation, involving SpC and SpC + MIC.
    Results: Inspiration volume increased significantly with MIC in both groups (P < 0.05), and PCF increased significantly with MIC in the air stacking group (P < 0.01). PCF could not be maintained at 160 L/min when %FVC fell below 59%, even when MIC was applied.
    Conclusions: PCF increases with MIC in patients with MSA. It may be meaningful to consider the timing of gastrostomy introduction based on the severity of cough and respiratory dysfunction.
    Language English
    Publishing date 2023-10-03
    Publishing country Japan
    Document type Journal Article
    ISSN 2432-1354
    ISSN (online) 2432-1354
    DOI 10.2490/prm.20230035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Deterioration of Cough, Respiratory, and Vocal Cord Functions in Patients with Multiple System Atrophy.

    Asakawa, Takashi / Ogino, Mieko / Tominaga, Naomi / Ozaki, Naoto / Kubo, Jin / Kakuda, Wataru

    Neurology international

    2023  Volume 15, Issue 4, Page(s) 1227–1237

    Abstract: The purpose of this study was to clarify changes in cough function in patients with multiple system atrophy (MSA). Seventeen probable patients with MSA were studied. Peak cough flow (PCF), respiratory function (percentage of vital capacity, percentage of ...

    Abstract The purpose of this study was to clarify changes in cough function in patients with multiple system atrophy (MSA). Seventeen probable patients with MSA were studied. Peak cough flow (PCF), respiratory function (percentage of vital capacity, percentage of forced vital capacity, and percentage of predicted forced expiratory volume in one second), respiratory muscle strength (percentage of maximal inspiratory mouth pressure and percentage of maximal expiratory mouth pressure), and maximum phonation time (MPT) were assessed. Walking ability, disease duration, possibility of air stacking, Unified MSA Rating Scale (UMSARS), and Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III were also assessed. Data were separately analyzed for ambulatory and non-ambulatory groups categorized by Functional Ambulation Categories. PCF, respiratory function, respiratory muscle strength, and MPT were significantly lower in the non-ambulatory group than in the ambulatory group. On the other hand, no correlation between PCF and disease duration was observed. A significant number of patients in the non-ambulatory group were unable to hold their breath. The UMSARS and MDS-UPDRS Part III in the non-ambulatory group were significantly higher than in the ambulatory group. It was concluded that ambulatory dysfunction is associated with the decline of cough function and respiratory-related function in patients with MSA.
    Language English
    Publishing date 2023-10-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2514727-4
    ISSN 2035-8377 ; 2035-8385
    ISSN (online) 2035-8377
    ISSN 2035-8385
    DOI 10.3390/neurolint15040077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: [Future medical care for intractable diseases, general view].

    Ogino, Mieko

    Rinsho shinkeigaku = Clinical neurology

    2013  Volume 23, Issue 11, Page(s) 1281

    MeSH term(s) Chronic Disease/therapy ; Humans ; Japan ; Medical Assistance
    Language Japanese
    Publishing date 2013-09-05
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604200-4
    ISSN 1882-0654 ; 0009-918X
    ISSN (online) 1882-0654
    ISSN 0009-918X
    DOI 10.5692/clinicalneurol.53.1281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: [Series of clinical ethics necessary for neurological medicine -"bad news telling" with a focus on notification of intractable diseases].

    Ogino, Mieko

    Rinsho shinkeigaku = Clinical neurology

    2012  Volume 52, Issue 11, Page(s) 877

    MeSH term(s) Humans ; Neurodegenerative Diseases ; Truth Disclosure/ethics
    Language Japanese
    Publishing date 2012-11-08
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604200-4
    ISSN 1882-0654 ; 0009-918X
    ISSN (online) 1882-0654
    ISSN 0009-918X
    DOI 10.5692/clinicalneurol.52.877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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