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Article ; Online: Clinical significance of sarcopenic dysphagia for patients with esophageal cancer undergoing esophagectomy: A review.

Oguma, Junya / Ozawa, Soji / Ishiyama, Koshiro / Daiko, Hiroyuki

Annals of gastroenterological surgery

2022 Volume 6, Issue 6, Page(s) 738–745

Abstract: The relationships among esophagectomy for esophageal cancer, dysphagia, and sarcopenia are still unclear. We considered appropriate interventions for patients with resectable esophageal cancer for the purpose of reducing postoperative dysphagia and ... ...

Abstract	The relationships among esophagectomy for esophageal cancer, dysphagia, and sarcopenia are still unclear. We considered appropriate interventions for patients with resectable esophageal cancer for the purpose of reducing postoperative dysphagia and aspiration pneumonia. Dysphagia in patients with esophageal cancer is caused by patient characteristics, such as pathophysiology and age, or complications after esophagectomy. Recently, sarcopenic dysphagia, defined as dysphagia associated with whole-body sarcopenia, has attracted attention in various fields, and a large proportion of patients with esophageal cancer are expected to have sarcopenic dysphagia. Our systematic review and meta-analysis suggested that preoperative sarcopenia in patients with esophageal cancer is related to pulmonary complications after esophagectomy, and some reports also suggested that sarcopenia in swallowing-related muscles, such as the geniohyoid muscle and tongue, might be associated with postoperative pneumonia or dysphagia after esophagectomy. However, clinical studies on sarcopenic dysphagia in patients with esophageal cancer have been limited. To prevent sarcopenic dysphagia after esophagectomy, perioperative interventions involving not only swallowing rehabilitation, but also physical exercise and nutritional support are important. Moreover, several reports have suggested that the chin-down maneuver might be effective for preventing aspiration after an esophagectomy. To inhibit the progression of sarcopenic dysphagia after esophagectomy, evaluations and interventions by multidisciplinary staff are likely to be necessary.
Language	English
Publishing date	2022-07-28
Publishing country	Japan
Document type	Journal Article ; Review
ISSN	2475-0328
ISSN (online)	2475-0328
DOI	10.1002/ags3.12603
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Article ; Online: Perioperative Decrease in Tongue Pressure is an Intervenable Predictor of Aspiration After Esophagectomy.

Kojima, Kazuhiro / Fukushima, Takuya / Kurita, Daisuke / Matsuoka, Aiko / Ishiyama, Koshiro / Oguma, Junya / Daiko, Hiroyuki

Dysphagia

2022 Volume 38, Issue 4, Page(s) 1147–1155

Abstract: Despite the increasing use of minimally invasive esophagectomies, aspiration pneumonia remains the most serious complication. This study clarified the association between perioperative tongue pressure and postoperative aspiration after thoracoscopic- ... ...

Abstract	Despite the increasing use of minimally invasive esophagectomies, aspiration pneumonia remains the most serious complication. This study clarified the association between perioperative tongue pressure and postoperative aspiration after thoracoscopic-laparoscopic esophagectomy in patients with esophageal cancer. This retrospective, single-center, observational study evaluated data of 216 patients scheduled for thoracoscopic-laparoscopic esophagectomy. Tongue pressure was measured before the procedure and on postoperative day 6; perioperative changes were assessed. Patients were divided into non-aspiration and aspiration groups according to penetration-aspiration scale scores. Hierarchical and stratified logistic regression analyses were performed to identify factors associated with aspiration. Receiver operating characteristic curves were used to assess the cut-off value of perioperative changes in tongue pressure for aspiration. Perioperative changes in tongue pressure (odds ratio 0.92; 95% confidence interval 0.88-0.96, P < 0.001), age (odds ratio 1.07; 95% confidence interval 1.01-1.13, P = 0.013), and postoperative recurrent laryngeal nerve palsy (odds ratio 3.04; 95% confidence interval 1.15-8.03, P = 0.025) were significantly associated with aspiration. The cut-off value of perioperative changes in tongue pressure for postoperative aspiration was - 6.58%. In addition, decreases in tongue pressure were associated with aspiration regardless of recurrent laryngeal nerve palsy and age. The perioperative decrease in tongue pressure, higher age, and postoperative recurrent laryngeal nerve palsy were significant factors strongly associated with aspiration in the acute phase post-esophagectomy. Decreased tongue pressure is the only intervenable predictor of aspiration. Rehabilitation for preventing decreases in tongue pressure may reduce the risk of aspiration.
MeSH term(s)	Humans ; Retrospective Studies ; Esophagectomy/adverse effects ; Esophagectomy/methods ; Vocal Cord Paralysis/complications ; Pressure ; Tongue ; Esophageal Neoplasms/surgery ; Esophageal Neoplasms/complications ; Postoperative Complications/etiology
Language	English
Publishing date	2022-12-01
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	632764-3
ISSN	1432-0460 ; 0179-051X
ISSN (online)	1432-0460
ISSN	0179-051X
DOI	10.1007/s00455-022-10541-2
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Zs.A 2130: Show issues

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Article ; Online: Does Preoperative Corticosteroid Administration Improve the Short-Term Outcome of Minimally Invasive Esophagectomy for Esophageal Cancer? A Propensity Score-Matched Analysis.

Ishiyama, Koshiro / Oguma, Junya / Kubo, Kentaro / Kanematsu, Kyohei / Fujii, Yusuke / Kurita, Daisuke / Daiko, Hiroyuki

Annals of surgical oncology

2022 Volume 29, Issue 11, Page(s) 6886–6893

Abstract: Background: In open esophagectomy for esophageal cancer, steroid administration is associated with attenuated postoperative inflammation and reduced complications. However, the efficacy of steroids in minimally invasive esophagectomy (MIE) is uncertain. ...

Abstract	Background: In open esophagectomy for esophageal cancer, steroid administration is associated with attenuated postoperative inflammation and reduced complications. However, the efficacy of steroids in minimally invasive esophagectomy (MIE) is uncertain. This study aimed to investigate the impact of steroid administration on short-term postoperative outcomes in MIE. Methods: The study compared 458 patients who underwent MIE between April 2017 and December 2021. The patients were divided into steroid (n = 206) and non-steroid (n = 252) groups, and 160 paired cases were compared by 1:1 propensity score-matching. Results: In the steroid group versus the non-steroid group, the intensive care unit stay was significantly shorter (2.6 vs 3.3 days; P = 0.001), and the incidence of surgical-site infection (SSI) was significantly lower (1.2 % vs 13.1 %; P < 0.001). The incidence of pneumonia tended to be lower in the steroid group, but not significantly lower (19.3 % vs 29.3 %; P = 0.065). Multivariate analysis showed that steroid administration independently affected SSI (odds ratio, 11.6; 95 % confidence interval, 3.3-73.6; P < 0.001). Compared with the non-steroid group, the steroid group had more favorable arterial partial pressure of oxygen/fraction of inspired oxygen ratio (503 ± 178 vs 380 ± 104; P < 0.001) and body temperature (37.2 ± 0.54 °C vs 38.3 ± 0.66 °C; P < 0.001) on postoperative day (POD) 0, heart rate (beats per minute) (74.6 ± 8.9 vs 84 ± 11.4; P < 0.001) on POD 1, and C-reactive protein concentration (7.07 ± 3.4 vs 13.7 ± 6.4 mg/dL; P < 0.001) on POD 3. Conclusions: In MIE, steroid administration was associated with reduced SSI, suggesting an attenuated inflammatory response to surgical stress.
MeSH term(s)	Adrenal Cortex Hormones ; C-Reactive Protein ; Esophageal Neoplasms/surgery ; Esophagectomy/adverse effects ; Humans ; Oxygen ; Propensity Score ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Adrenal Cortex Hormones ; C-Reactive Protein (9007-41-4) ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-06-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-022-11821-9
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Article ; Online: Prognostic significance of sarcopenia in patients undergoing esophagectomy for superficial esophageal squamous cell carcinoma.

Oguma, J / Ozawa, S / Kazuno, A / Yamamoto, M / Ninomiya, Y / Yatabe, K

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

2019 Volume 32, Issue 7

Abstract: Nononcological prognostic factors in superficial esophageal squamous cell carcinoma (SESCC) patients remain unclear. The aim of this study is to evaluate the relationship between sarcopenia and surgical outcome in patients with SESCC who had undergone ... ...

Abstract	Nononcological prognostic factors in superficial esophageal squamous cell carcinoma (SESCC) patients remain unclear. The aim of this study is to evaluate the relationship between sarcopenia and surgical outcome in patients with SESCC who had undergone definitive surgery. A total of 194 SESCC patients who had undergone thoracic esophagectomy with three-field lymphadenectomy without neoadjuvant therapy at Tokai University Hospital between January 2006 and December 2015 were analyzed retrospectively. Manual tracing using CT imaging was used to measure the cross-sectional areas of the skeletal muscle mass. The cutoff values for the skeletal muscle index used to define sarcopenia were based on the results of a previous study. Twenty-eight patients (14.4%) had sarcopenia, while the remaining 166 patients (85.6%) did not. A multivariate analysis suggested that sarcopenia was an independent risk factor for postoperative pulmonary complications (OR = 3.232, P = 0.026). The overall survival rate and the disease-free survival rate were both significantly worse in the sarcopenia group than in the nonsarcopenia group (P < 0.001). In a multivariate analysis, sarcopenia was an independent prognostic factor affecting overall survival (HR = 7.121, P < 0.001) and disease-free survival (HR = 6.000, P < 0.001). Patients with sarcopenia and lymph node metastasis (n = 18) had a worse outcome than the other patients (P < 0.001). This study suggests that the alleviation of sarcopenia through nutritional support and rehabilitation in SESCC patients scheduled to undergo surgery might help to prevent postoperative pulmonary complications and to improve the long-term outcome.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Disease-Free Survival ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Esophageal Squamous Cell Carcinoma/secondary ; Esophageal Squamous Cell Carcinoma/surgery ; Esophagectomy/adverse effects ; Female ; Humans ; Lung Diseases/etiology ; Lymph Node Excision ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Staging ; Postoperative Complications/etiology ; Retrospective Studies ; Risk Factors ; Sarcopenia/complications ; Sarcopenia/diagnostic imaging ; Survival Rate ; Tomography, X-Ray Computed ; Treatment Outcome
Language	English
Publishing date	2019-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	639470-x
ISSN	1442-2050 ; 1120-8694
ISSN (online)	1442-2050
ISSN	1120-8694
DOI	10.1093/dote/doy104
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Zs.A 2378: Show issues

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Article ; Online: Effectiveness of computed tomography scoring for the early diagnosis of anastomotic leakage after esophagectomy.

Yatabe, Kentaro / Koyanagi, Kazuo / Higuchi, Tadashi / Shoji, Yoshiaki / Yamamoto, Miho / Ninomiya, Yamato / Kazuno, Akihito / Oguma, Junya / Mori, Masaki / Ozawa, Soji

Langenbeck's archives of surgery

2023 Volume 408, Issue 1, Page(s) 259

Abstract: Purpose: Anastomotic leakage after esophagectomy is associated with increased mortality; therefore, early diagnosis is highly important. This study aimed to identify the characteristic computed tomography (CT) findings of cervical anastomotic leakage ... ...

Abstract	Purpose: Anastomotic leakage after esophagectomy is associated with increased mortality; therefore, early diagnosis is highly important. This study aimed to identify the characteristic computed tomography (CT) findings of cervical anastomotic leakage after esophagectomy for esophageal cancer and evaluate the effectiveness of CT scoring in screening the anastomotic leakage. Methods: Overall, 91 patients who underwent thoracoscopic esophagectomy with cervical esophago-gastric anastomosis were included. We investigated the correlation between anastomotic leakage and the presence of the microbubble sign, evident air retention, and fluid collection in the cervical and mediastinal regions. CT findings were scored, and the cutoff value was set to 2 points on the receiver operating characteristic curve. The patients were divided into two groups based on the CT score (≥ 2 points and ≤ 1 point). Results: CT findings of the microbubble sign (p = 0.01; odds ratio [OR], 8.545; 95% confidence interval [CI], 1.596-45.73), cervical air retention (p < 0.01; OR, 12.43; 95% CI, 2.084-74.17), and cervical fluid collection (p < 0.01; OR, 9.359; 95% CI, 1.753-49.96) significantly correlated with anastomotic leakage. The ≥ 2-point CT score group showed a significantly higher incidence of anastomotic leakage than the ≤ 1-point group (p < 0.01; OR, 16.28; 95% CI [4.704-56.38]). A ≥ 2-point CT score had higher sensitivity (84.2%) than upper gastrointestinal series (36.8%). Conclusion: The presence of microbubble sign, air retention, and fluid collection in the cervical area correlated with anastomotic leakage after cervical anastomosis in thoracoscopic esophagectomy. CT scores are useful early anastomotic leakage detectors.
MeSH term(s)	Humans ; Anastomotic Leak/diagnostic imaging ; Anastomotic Leak/etiology ; Esophagectomy/adverse effects ; Early Detection of Cancer ; Anastomosis, Surgical/adverse effects ; Tomography, X-Ray Computed
Language	English
Publishing date	2023-07-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-023-03007-y
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Uk I Zs.10: Show issues

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Article ; Online: Non-curative resection for surgical T4b esophageal cancer: esophagectomy or non-esophagectomy?

Fujii, Yusuke / Daiko, Hiroyuki / Kubo, Kentaro / Kanematsu, Kyohei / Utsunomiya, Daichi / Kurita, Daisuke / Ishiyama, Koshiro / Oguma, Junya

Langenbeck's archives of surgery

2023 Volume 408, Issue 1, Page(s) 201

Abstract: Background: Recently, with the development of multidisciplinary treatment, the treatment outcomes of esophageal cancer (EC) have improved. However, despite advances in diagnostic imaging modalities, preoperative diagnosis of T4 EC is still difficult, ... ...

Abstract	Background: Recently, with the development of multidisciplinary treatment, the treatment outcomes of esophageal cancer (EC) have improved. However, despite advances in diagnostic imaging modalities, preoperative diagnosis of T4 EC is still difficult, and the prognosis of T4 EC remains very poor. In addition, the prognosis of surgical T4b EC (sT4b EC) after surgery remains unclear. In this study, we retrospectively reviewed sT4b EC. Methods: We evaluated the clinical course of sT4b EC and compared palliative esophagectomy with R2 resection (PE group) with other procedures without esophagectomy (NE group) (e.g., only esophagostomy) for sT4b EC. Results: Forty-seven patients with thoracic EC underwent R2 resection at our institution between January 2009 and December 2020. Thirty-four patients were in the PE group, and 13 patients were in the NE group. The 2-year overall survival rate was 0% in the PE group and 20.2% in the NE group (p = 0.882). There was one case of long-term survival in the NE group that underwent surgery followed by definitive chemoradiation. Postoperative complications (Clavien-Dindo grade ≥ 3) were observed in 25 patients (73.5%) in the PE group and in three patients (23.1%) in the NE group (p = 0.031). The median time to the initiation of postoperative treatment was 68.1 days in the PE group and 18.6 days in the NE group (p = 0191). Conclusions: If EC is diagnosed as sT4b, palliative esophagectomy should be avoided because of the high complication rate and the lack of long-term survival.
MeSH term(s)	Humans ; Retrospective Studies ; Esophageal Neoplasms/surgery ; Treatment Outcome ; Prognosis ; Carcinoma, Squamous Cell/surgery
Language	English
Publishing date	2023-05-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-023-02940-2
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Article ; Online: Usefulness of three-dimensional thoracoscope for prone position thoracoscopic esophagectomy improves mediastinal lymph node dissection and prognosis for esophageal cancer.

Kanamori, Kohei / Koyanagi, Kazuo / Ozawa, Soji / Oguma, Junya / Kazuno, Akihito / Ninomiya, Yamato / Yamamoto, Miho / Shoji, Yoshiaki / Yatabe, Kentaro / Mori, Masaki

Cancer reports (Hoboken, N.J.)

2023 Volume 6, Issue 8, Page(s) e1850

Abstract: Objectives: This study aimed to assess the superiority of 3D flexible thoracoscope against 2D thoracoscope for lymph node dissection (LND) and prognosis for prone-position thoracoscopic esophagectomy (TE) in esophageal cancer.: Methods: Three hundred ...

Abstract	Objectives: This study aimed to assess the superiority of 3D flexible thoracoscope against 2D thoracoscope for lymph node dissection (LND) and prognosis for prone-position thoracoscopic esophagectomy (TE) in esophageal cancer. Methods: Three hundred and sixty-seven esophageal cancer patients who underwent prone-position TE with 3-field LND between 2009 and 2018 were evaluated. 2D and 3D thoracoscope was used in 182 (2D group) and 185 cases (3D group), respectively. Short-term surgical outcomes, numbers of retrieved mediastinal lymph node (LN), and rates of LN recurrence were compared. Risk factors for mediastinal LN recurrence and long-time prognosis were also evaluated. Results: No differences in postoperative complications were observed between the groups. The numbers of retrieved mediastinal LN were significantly higher, and the rates of LN recurrence were significantly lower in the 3D group compared to 2D group. Use of 2D thoracoscope was a significant independent factor of middle mediastinal LN recurrence by multivariable analysis. Survival was compared by cox regression analysis, and the 3D group had a significantly better prognosis than the 2D group. Conclusions: Prone position TE using 3D thoracoscope may improve the accuracy of mediastinal LND and prognosis without increasing postoperative complications for esophageal cancer.
MeSH term(s)	Humans ; Prone Position ; Thoracoscopes ; Esophagectomy/adverse effects ; Retrospective Studies ; Lymph Node Excision/methods ; Esophageal Neoplasms/surgery ; Esophageal Neoplasms/pathology ; Prognosis ; Postoperative Complications/surgery
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article
ISSN	2573-8348
ISSN (online)	2573-8348
DOI	10.1002/cnr2.1850
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Article ; Online: ASO Author Reflections: Preservation of the Thoracic Duct is Feasible for Esophageal Squamous Cell Carcinoma Patients Treated with Esophagectomy After Neoadjuvant Chemoradiotherapy.

Oshikiri, Taro / Numasaki, Hodaka / Oguma, Junya / Toh, Yasushi / Watanabe, Masayuki / Muto, Manabu / Kakeji, Yoshihiro / Doki, Yuichiro

Annals of surgical oncology

2023 Volume 30, Issue 5, Page(s) 2699–2700

MeSH term(s)	Humans ; Esophageal Squamous Cell Carcinoma/pathology ; Esophageal Neoplasms/pathology ; Neoadjuvant Therapy ; Esophagectomy ; Thoracic Duct/pathology ; Chemoradiotherapy
Language	English
Publishing date	2023-01-11
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-022-12892-4
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Article ; Online: Prognosis of Patients with Esophageal Carcinoma After Routine Thoracic Duct Resection: A Propensity-matched Analysis of 12,237 Patients Based on the Comprehensive Registry of Esophageal Cancer in Japan.

Oshikiri, Taro / Numasaki, Hodaka / Oguma, Junya / Toh, Yasushi / Watanabe, Masayuki / Muto, Manabu / Kakeji, Yoshihiro / Doki, Yuichiro

Annals of surgery

2023 Volume 277, Issue 5, Page(s) e1018–e1025

Abstract: Objective: To clarify whether routine thoracic duct (TD) resection improves the prognosis of patients with esophageal cancer after radical esophagectomy.: Summary of background data: Although TD resection can cause nutritional disadvantage and immune ...

Abstract	Objective: To clarify whether routine thoracic duct (TD) resection improves the prognosis of patients with esophageal cancer after radical esophagectomy. Summary of background data: Although TD resection can cause nutritional disadvantage and immune suppression, it has been performed for the resection of surrounding lymph nodes. Methods: We analyzed 12,237 patients from the Comprehensive Registry of Esophageal Cancer in Japan who underwent esophagectomy between 2007 and 2012. TD resection and preservation groups were compared in terms of prognosis, perioperative outcomes, and initial recurrent patterns using strict propensity score matching. Particularly, the year of esophagectomy and history of primary cancer of other organs were added as covariates. Results: After propensity score matching, 1638 c-Stage I-IV patients participated in each group. The 5 year overall survival and cause-specific survival rates were 57.5% and 65.6% in the TD-resected group and 55.2% and 63.4% in the TD-preserved group, respectively, without significant differences. The TD-resected group had significantly more retrieved mediastinal nodes (30 vs 21, P < 0.0001) and significantly fewer lymph node recurrence (376 vs 450, P = 0.0029) compared with the TD-preserved group. However, the total number of distant metastatic organs was significantly greater in TD-resected group than in the TD-preserved group (499 vs 421, P = 0.0024). Conclusions: TD resection did not improve survival in patients with esoph-ageal cancer. Despite having retrieved more lymph nodes, TD resection caused distant metastases in more organs compared to TD preservation. Hence, prophylactic TD resection should not be recommended in patients with esophageal cancer.
MeSH term(s)	Humans ; Thoracic Duct/surgery ; Thoracic Duct/pathology ; Lymph Node Excision ; Japan/epidemiology ; Retrospective Studies ; Follow-Up Studies ; Esophageal Neoplasms ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Prognosis ; Esophagectomy ; Neoplasm Staging
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000005340
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Article ; Online: Preoperative physical activity is associated with prognosis in patients with esophageal cancer undergoing thoracoscopic-laparoscopic esophagectomy after neoadjuvant chemotherapy.

Fukushima, Takuya / Watanabe, Noriko / Okita, Yusuke / Yokota, Shota / Kurita, Daisuke / Ishiyama, Koshiro / Oguma, Junya / Kawai, Akira / Daiko, Hiroyuki

General thoracic and cardiovascular surgery

2023 Volume 72, Issue 2, Page(s) 134–143

Abstract: Objective: This study examined the association between a single preoperative physiotherapy session during neoadjuvant chemotherapy and physical function and that between preoperative physical activity and prognosis.: Methods: In this retrospective, ... ...

Abstract	Objective: This study examined the association between a single preoperative physiotherapy session during neoadjuvant chemotherapy and physical function and that between preoperative physical activity and prognosis. Methods: In this retrospective, single-center, observational study, we evaluated data from 234 patients scheduled for neoadjuvant chemotherapy and thoracoscopic-laparoscopic esophagectomy who underwent a single preoperative physiotherapy session. The five-repetition sit-to-stand test was performed before and after neoadjuvant chemotherapy. After neoadjuvant chemotherapy, patients were classified into high- and low-physical activity groups based on preoperative physical activity. To examine the association between preoperative physiotherapy and changes in physical function, a multivariate regression analysis was performed. The Cox proportional hazards model was used to investigate the association between preoperative physical activity and overall survival. Results: The median percentage change in the five-repetition sit-to-stand test score was - 3.36%. In the multivariate regression analysis, the regression coefficient of the constant term was - 23.93 (95% confidence interval - 45.31 to - 2.56; P = 0.028). Low physical activity was significantly associated with overall survival after adjustment for confounding factors (P = 0.040). Conclusions: This study demonstrated that a single preoperative physiotherapy session during neoadjuvant chemotherapy improves physical function, and preoperative physical activity is significantly associated with prognosis.
MeSH term(s)	Humans ; Esophagectomy/adverse effects ; Retrospective Studies ; Neoadjuvant Therapy ; Esophageal Neoplasms/surgery ; Esophageal Neoplasms/drug therapy ; Prognosis
Language	English
Publishing date	2023-09-27
Publishing country	Japan
Document type	Observational Study ; Journal Article
ZDB-ID	2376888-5
ISSN	1863-6713 ; 1863-6705
ISSN (online)	1863-6713
ISSN	1863-6705
DOI	10.1007/s11748-023-01977-w
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