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Article ; Online: Ruptured Saccular Aneurysm Caused by Necrotizing Arteritis of the Polyarteritis Nodosa Type in Primary Angiitis of Central Nervous System.

Matsumoto, Toshiharu / Ogura, Kanako / Tokugawa, Joji / Mitsuhashi, Takashi / Hishii, Makoto

International journal of surgical pathology

2024 , Page(s) 10668969241228292

Abstract: Primary angiitis of central nervous system (PACNS) is a rare idiopathic vasculitis that typically involves small arteries. An 18-year-old woman was operated on for resection of a ruptured aneurysm in a cerebral artery. Multiple aneurysms of cerebral ... ...

Abstract	Primary angiitis of central nervous system (PACNS) is a rare idiopathic vasculitis that typically involves small arteries. An 18-year-old woman was operated on for resection of a ruptured aneurysm in a cerebral artery. Multiple aneurysms of cerebral arteries had been detected by neuroimaging examinations since the age of 12, and she had been administered drugs following a diagnosis of PACNS since the age of 15. The resected aneurysm was a ruptured saccular aneurysm occurring in a medium-sized artery. Histologically, necrotizing arteritis of the polyarteritis nodosa (PAN) type was noted in the aneurysmal wall. It consisted of an admixture of acute and healing stages. In the acute stage, fibrinoid necrosis in the intima and media and intense inflammatory cell infiltrate in the entire wall were present. The inflammatory cells mainly consisted of lymphocytes, including plasma cells, neutrophils, and macrophages. In the healing stage, disappearance of fibrinoid necrosis, fibrosis in the intima and media, and scarce inflammatory cells were noted. The acute stage was mainly present near the ruptured site. From these findings, the aneurysm was considered to have been caused by necrotizing arteritis of the PAN type. Although saccular aneurysmal formation in a medium-sized artery is rare in PACNS, an understanding of aneurysms produced by necrotizing arteritis of the PAN type offers useful information for the diagnosis and treatment of PACNS.
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1336393-1
ISSN	1940-2465 ; 1066-8969
ISSN (online)	1940-2465
ISSN	1066-8969
DOI	10.1177/10668969241228292
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Article: A Case of a Grade 3 Gallbladder Neuroendocrine Tumor With Rapid Recurrence After Curative Resection.

Iwanaga, Naoki / Sugo, Hiroyuki / Noro, Takuji / Watanobe, Ikuo / Ogura, Kanako

Cureus

2023 Volume 15, Issue 10, Page(s) e47193

Abstract: Primary gallbladder neuroendocrine tumor (GB-NET) is extremely rare. Therefore, tumor behavior and adequate treatment in GB-NETs are still unclear. A 74-year-old man without any specific complaints was referred to our hospital cause of gallbladder tumor. ...

Abstract	Primary gallbladder neuroendocrine tumor (GB-NET) is extremely rare. Therefore, tumor behavior and adequate treatment in GB-NETs are still unclear. A 74-year-old man without any specific complaints was referred to our hospital cause of gallbladder tumor. Abdominal ultrasonography examination revealed a 22-mm non-pedunculated tumor in the gallbladder body. Contrast-enhanced computed tomography showed a polyp that was enhanced in the arterial phase. The patient underwent gallbladder bed resection and radical lymphadenectomy with a diagnosis of gallbladder carcinoma. Macroscopically, the resected specimen showed a nodular expanding tumor measuring 32×15 mm in the gallbladder body. From the pathological findings, a grade 3 GB-NET was diagnosed. Only cystic lymph node metastasis was observed. The patient was discharged uneventfully, but bone and lymph node metastasis were detected eight months after surgery. We conclude that grade 3 GB-NET shows occasionally malignant biological behavior although NET G3 is distinguished from neuroendocrine carcinoma in the current WHO 2019 classification of NET.
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.47193
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Article ; Online: Traction-assisted endoscopic submucosal dissection for esophageal neoplasms using a novel traction device.

Ogura, Kanako / Ichijima, Ryoji / Ikehara, Hisatomo

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

2022 Volume 34, Issue 5, Page(s) 103–104

MeSH term(s)	Dissection ; Endoscopic Mucosal Resection ; Esophageal Neoplasms/surgery ; Humans ; Traction ; Treatment Outcome
Language	English
Publishing date	2022-05-10
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1171589-3
ISSN	1443-1661 ; 0915-5635
ISSN (online)	1443-1661
ISSN	0915-5635
DOI	10.1111/den.14316
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Article: A case of phyllodes tumor with rapid growth during pregnancy and lactation period: a case report.

Tohyama, Shiori / Horimoto, Yoshiya / Ushiyama, Yumiko / Semba, Ryoko / Hotchi, Shiori / Sugano, Naomi / Ogura, Kanako / Murakami, Fumi

Surgical case reports

2024 Volume 10, Issue 1, Page(s) 98

Abstract: Background: The age of onset of the phyllodes tumor is generally in the late 40 s, and diagnosis and treatment during pregnancy and lactation are rare. We herein present a case of a phyllodes tumor that rapidly increased in size during the pregnancy and ...

Abstract	Background: The age of onset of the phyllodes tumor is generally in the late 40 s, and diagnosis and treatment during pregnancy and lactation are rare. We herein present a case of a phyllodes tumor that rapidly increased in size during the pregnancy and lactation period. Case presentation: A 39-year-old woman was referred to our hospital with a mass in the right breast that increased in size during the pregnancy and lactation period. On ultrasound (5 week postpartum), a well-defined lobulated mass with internal septations and fluid retention was observed. Magnetic resonance imaging of the breast at 8 week postpartum revealed a 70-mm-sized smooth-margin mass with multilocular cystic components. Marked proliferation of stromal cells with high cell density was observed in a biopsy specimen taken at the previous hospital. We diagnosed the mass as a phyllodes tumor of borderline malignancy and excised it at 13 week postpartum. The excised tumor was 85 mm in diameter and its interior was filled with a milk-like substance. Histologically, there was only a mild increase in stromal cell density but fibrosis with associated degeneration was prominent. The final diagnosis was benign phyllodes tumor with degeneration. Conclusions: We report a case of a phyllodes tumor that rapidly increased in size during pregnancy and the lactation period. The accumulation of a milk-like substance was thought to be responsible for the rapid growth of the tumor.
Language	English
Publishing date	2024-04-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2809613-7
ISSN	2198-7793
ISSN	2198-7793
DOI	10.1186/s40792-024-01895-w
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Article: A Predictive Rule for COVID-19 Pneumonia Among COVID-19 Patients: A Classification and Regression Tree (CART) Analysis Model.

Fukui, Sayato / Inui, Akihiro / Komatsu, Takayuki / Ogura, Kanako / Ozaki, Yutaka / Sugita, Manabu / Saita, Mizue / Kobayashi, Daiki / Naito, Toshio

Cureus

2023 Volume 15, Issue 9, Page(s) e45199

Abstract: Background: In this study, we aimed to identify predictive factors for coronavirus disease 2019 (COVID-19) patients with complicated pneumonia and determine which COVID-19 patients should undergo computed tomography (CT) using classification and ... ...

Abstract	Background: In this study, we aimed to identify predictive factors for coronavirus disease 2019 (COVID-19) patients with complicated pneumonia and determine which COVID-19 patients should undergo computed tomography (CT) using classification and regression tree (CART) analysis. Methods: This retrospective cross-sectional survey was conducted at a university hospital. We recruited patients diagnosed with COVID-19 between January 1 and December 31, 2020. We extracted clinical information (e.g., vital signs, symptoms, laboratory results, and CT findings) from patient records. Factors potentially predicting COVID-19 pneumonia were analyzed using Student's Results: Among 221 patients (119 men (53.8%); mean age, 54.59±18.61 years), 160 (72.4%) had pneumonia. The CART analysis revealed that patients were at high risk of pneumonia if they had C-reactive protein (CRP) levels of >1.60 mg/dL (incidence of pneumonia: 95.7%); CRP levels of ≤1.60 mg/dL + age >35.5 years + lactate dehydrogenase (LDH)>225.5 IU/L (incidence of pneumonia: 95.5%); and CRP levels of ≤1.60 mg/dL + age >35.5 years + LDH≤225.5 IU/L + hemoglobin ≤14.65 g/dL (incidence of pneumonia: 69.6%). The area of the curve of the receiver operating characteristic of the model was 0.860 (95% CI: 0.804-0.915), indicating sufficient explanatory power. Conclusions: The present results are useful for deciding whether to perform CT in COVID-19 patients. High-risk patients such as those mentioned above should undergo CT.
Language	English
Publishing date	2023-09-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.45199
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Article ; Online: A single-center prospective study on pain alleviation during peroral upper endoscopy with an ultrathin endoscope.

Aya, Iwao / Ichijima, Ryoji / Sugita, Tomomi / Nakayama, Masako / Takasu, Ayaka / Ogura, Kanako / Gotoda, Takuji / Kogure, Hirofumi

BMC gastroenterology

2023 Volume 23, Issue 1, Page(s) 325

Abstract: Background: The efficacy of transnasal endoscopy using an ultrathin endoscope has been reported in several studies. However, few studies regarding peroral endoscopy with ultrathin endoscopes with high resolution have been reported. This study ... ...

Abstract	Background: The efficacy of transnasal endoscopy using an ultrathin endoscope has been reported in several studies. However, few studies regarding peroral endoscopy with ultrathin endoscopes with high resolution have been reported. This study investigates the pain alleviation of peroral endoscopy with an ultrathin endoscope. Methods: Patients with a history of peroral endoscopy using a conventional, normal-diameter scope with no sedation who underwent peroral esophagogastroduodenoscopy (EGD) using a thin scope between April-July 2022 were included in this study. After the procedure, the patients completed a questionnaire evaluating pain during the examination and willingness to repeat the procedure. The physicians were surveyed regarding their level of satisfaction. The primary endpoint was patient satisfaction, which corresponded to the rate of patients who rated the thin endoscope as more comfortable or somewhat more comfortable than the previously-used, conventional endoscope. Results: One hundred and forty-five patients were included in the analyses. Patient satisfaction was achieved in 86.2% (125/145) of patients. The median visual analog scale pain score was 3 (0-7) points in this study, which is significantly lower than the pain score after the previous endoscopy (5 (0-10) points; p < 0.001). In addition, 96% (24/25) of patients who underwent EGD by an expert and 95.8% (115/120) who underwent EGD by a non-expert were willing to repeat endoscopy using the thin scope (p = 0.69). Conclusion: Peroral endoscopy using a thin scope reduces patient pain regardless of the endoscopist's experience.
MeSH term(s)	Humans ; Prospective Studies ; Endoscopy, Gastrointestinal ; Endoscopes ; Pain/etiology ; Pain/prevention & control ; Patient Satisfaction
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-023-02965-3
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Article ; Online: Randomized controlled trial of remimazolam compared with placebo in Japanese patients undergoing upper gastrointestinal endoscopy: Phase III investigator-initiated clinical trial.

Ichijima, Ryoji / Ikehara, Hisatomo / Yamaguchi, Daisuke / Nagata, Yasuhiko / Ogura, Kanako / Esaki, Mitsuru / Minoda, Yosuke / Ono, Hiroyuki / Maeda, Yuki / Kiriyama, Shinsuke / Sumiyoshi, Tetsuya / Kanmura, Yuichi / Gotoda, Takuji

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

2024

Abstract: Objectives: To assess the effectiveness of remimazolam against normal saline (placebo) as a sedative agent for endoscopy in a multicenter, randomized, double-blind, investigator-initiated phase III controlled trial.: Methods: We included 48 Japanese ... ...

Abstract	Objectives: To assess the effectiveness of remimazolam against normal saline (placebo) as a sedative agent for endoscopy in a multicenter, randomized, double-blind, investigator-initiated phase III controlled trial. Methods: We included 48 Japanese patients undergoing upper gastrointestinal endoscopy. For the procedure, an initial remimazolam dose of 3 mg and additional doses of 1 mg were administered, as determined in the phase II clinical study. The primary study end-point was the successful sedation rate during gastrointestinal endoscopy, determined as a Modified Observer's Assessment of Alertness/Sedation score ≤4 before the start of endoscopy, the completion of gastrointestinal endoscopy, and two or fewer additional doses per 6 min. Results: The successful endoscopy sedation rates were 91.9% and 9.1% in the remimazolam and placebo groups, respectively (P < 0.01). The time from the end of endoscopy to arousal was 0.0 (0.0-0.0) min for both groups. The number of additional doses required to achieve sedation was lower in the remimazolam group than that in the placebo group (P < 0.01). Conclusions: Remimazolam demonstrated a significantly higher sedation effect during upper gastrointestinal endoscopy in Japanese patients with safe and fast recovery compared with placebo.
Language	English
Publishing date	2024-02-25
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1171589-3
ISSN	1443-1661 ; 0915-5635
ISSN (online)	1443-1661
ISSN	0915-5635
DOI	10.1111/den.14758
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Article ; Online: Aquagenic urticaria: Severe extra-cutaneous symptoms following cold water exposure.

Fukumoto, Takeshi / Ogura, Kanako / Fukunaga, Atsushi / Nishigori, Chikako

Allergology international : official journal of the Japanese Society of Allergology

2018 Volume 67, Issue 2, Page(s) 295–297

MeSH term(s)	Child ; Cold Temperature/adverse effects ; Dyspnea/drug therapy ; Dyspnea/etiology ; Female ; Histamine H1 Antagonists, Non-Sedating/therapeutic use ; Humans ; Loratadine/therapeutic use ; Syncope/drug therapy ; Syncope/etiology ; Urticaria/drug therapy ; Urticaria/etiology ; Water/adverse effects
Chemical Substances	Histamine H1 Antagonists, Non-Sedating ; Water (059QF0KO0R) ; Loratadine (7AJO3BO7QN)
Language	English
Publishing date	2018-01-09
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1336498-4
ISSN	1440-1592 ; 1323-8930
ISSN (online)	1440-1592
ISSN	1323-8930
DOI	10.1016/j.alit.2017.10.007
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Article ; Online: Mixed neuroendocrine carcinoma and hepatocellular carcinoma in the liver.

Tanaka, Haruka / Sugo, Hiroyuki / Iwanaga, Naoki / Machida, Michio / Watanobe, Ikuo / Okubo, Hironao / Hotchi, Shiori / Ogura, Kanako

Cancer reports (Hoboken, N.J.)

2022 Volume 6, Issue 1, Page(s) e1772

Abstract: Background: Mixed neuroendocrine carcinoma (NEC) and hepatocellular carcinoma (HCC) is extremely rare, thus radiological features have not been fully clarified.: Case: A male patient (age: 70 years) visited our hospital due to a tumor in the liver. ... ...

Abstract	Background: Mixed neuroendocrine carcinoma (NEC) and hepatocellular carcinoma (HCC) is extremely rare, thus radiological features have not been fully clarified. Case: A male patient (age: 70 years) visited our hospital due to a tumor in the liver. Examination using contrast-enhanced computed tomography (CT) revealed a tumor (diameter: 5.0 cm) in hepatic segment 5, with early enhancement of the peripheral area and slight internal heterogeneous enhancement in the arterial and delayed phases, respectively. F-18 fluorodeoxyglucose (FDG)-positron emission tomography (PET)/CT revealed intratumoral heterogeneity, characterized by increased uptake (standardized uptake value, 12.10) in the corresponding low-density area detected using enhanced CT relative to the surrounding areas of the tumor. On magnetic resonance imaging, diffusion-weighted imaging also showed high intensity in the corresponding low-density area detected using CT. Preoperatively, the patient was diagnosed with HCC and underwent anterior sectionectomy. Pathological findings revealed both HCC and NEC components, and the patient was diagnosed with mixed NEC and HCC. Comparison of component distribution with FDG-PET/CT revealed an increased uptake area was congruent with the NEC component in the tumor. Conclusion: In this case, the difference in tumor components affected the uptake in FDG-PET/CT. Such heterogeneous uptake with an enhanced spot may be useful for suspecting the presence of mixed NEC and HCC in patients with atypical HCC.
MeSH term(s)	Humans ; Male ; Aged ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/surgery ; Positron Emission Tomography Computed Tomography/methods ; Fluorodeoxyglucose F18 ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/surgery ; Radiopharmaceuticals ; Carcinoma, Neuroendocrine/diagnostic imaging ; Carcinoma, Neuroendocrine/surgery
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
Language	English
Publishing date	2022-12-22
Publishing country	United States
Document type	Case Reports
ISSN	2573-8348
ISSN (online)	2573-8348
DOI	10.1002/cnr2.1772
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Article: Intraosseous Lipoma of the Calvaria in the Early Stage Resembling Normal Fatty Marrow.

Nagase, Shunsuke / Ogura, Kanako / Ashizawa, Karin / Sakaguchi, Asumi / Hotchi, Shiori / Hishii, Makoto / Fukunaga, Masaharu / Matsumoto, Toshiharu

Journal of neurological surgery reports

2022 Volume 83, Issue 2, Page(s) e29–e32

Abstract: Intraosseous lipoma (IOL) is a benign bone tumor that usually arises from the lower limb and rarely arises from the skull. Radiological diagnosis of a typical case is not problematic due to its characteristic calcification and marginal sclerosis. Here, ... ...

Abstract	Intraosseous lipoma (IOL) is a benign bone tumor that usually arises from the lower limb and rarely arises from the skull. Radiological diagnosis of a typical case is not problematic due to its characteristic calcification and marginal sclerosis. Here, we report a case of calvarial IOL in the early stage lacking conventional radiopathological features. The patient is a 7-year-old girl who presented with a slow-growing protuberance on the vertex of the head. Computed tomography displayed a low-density mass without calcification that was continuous with the surrounding diploe. The mass was resected piece by piece for diagnostic and cosmetic reasons. Histologically, the specimen consisted of bony trabeculae and intertrabecular adipose tissue, which resembled normal fatty marrow. However, adipose tissue was considered neoplastic since it lacked hematopoietic elements. The final diagnosis of IOL was made by radiopathological correlation. This case suggests that IOL should be included in the differential diagnosis of diploic expansion, even if calcification is absent. The histology of an early-stage IOL resembles normal fatty marrow, but recognizing the absence of hematopoietic elements aids the diagnosis. Also, our literature review indicates that such cases are likely to be encountered in the calvaria than cranial base.
Language	English
Publishing date	2022-05-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2653397-2
ISSN	2193-6366 ; 2193-6358
ISSN (online)	2193-6366
ISSN	2193-6358
DOI	10.1055/s-0042-1747972
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