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Article: [PNES in General Practice].

Ogyu, Kamiyu

Brain and nerve = Shinkei kenkyu no shinpo

2023 Volume 75, Issue 4, Page(s) 329–333

Abstract: Psychogenic non-epileptic seizures (PNES) are a disease concept that is defined by the nuance of "not" epilepsy. In cases where it is unclear from the electroencephalogram alone whether the patient has epilepsy or PNES, even though the seizure pattern ... ...

Abstract	Psychogenic non-epileptic seizures (PNES) are a disease concept that is defined by the nuance of "not" epilepsy. In cases where it is unclear from the electroencephalogram alone whether the patient has epilepsy or PNES, even though the seizure pattern and course may be considered as "non-epileptic," those who are not familiar with the treatment of epilepsy may become concerned about the slight "epileptic-like" nature of the seizures. This may easily sway the direction of the treatment. It is important to consider that in treatment this tendency to waver can be a product of the interaction of the psychodynamics between the physician and the patient.
MeSH term(s)	Humans ; Diagnosis, Differential ; Seizures/diagnosis ; Epilepsy/therapy ; Epilepsy/diagnosis ; Electroencephalography ; General Practice
Language	Japanese
Publishing date	2023-04-10
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	390389-8
ISSN	1344-8129 ; 1881-6096 ; 0006-8969
ISSN (online)	1344-8129
ISSN	1881-6096 ; 0006-8969
DOI	10.11477/mf.1416202334
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Article: [Morphine and Apomorphine, in Sad Cypress].

Ogyu, Kamiyu

Brain and nerve = Shinkei kenkyu no shinpo

2023 Volume 75, Issue 12, Page(s) 1315–1318

Abstract: Christie's Sad Cypress features an impressive trick with morphine and apomorphine. I read the book as if I were this killer, and also thought about the effects of morphine and apomorphine. ...

Abstract	Christie's Sad Cypress features an impressive trick with morphine and apomorphine. I read the book as if I were this killer, and also thought about the effects of morphine and apomorphine.
MeSH term(s)	Humans ; Morphine/pharmacology ; Apomorphine/pharmacology ; Apomorphine/therapeutic use ; Cupressus
Chemical Substances	Morphine (76I7G6D29C) ; Apomorphine (N21FAR7B4S)
Language	Japanese
Publishing date	2023-12-12
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	390389-8
ISSN	1344-8129 ; 1881-6096 ; 0006-8969
ISSN (online)	1344-8129
ISSN	1881-6096 ; 0006-8969
DOI	10.11477/mf.1416202530
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Article: Case Report: Culture-Dependent Postures in Japanese Patients With Schizophrenia.

Koreki, Akihiro / Koizumi, Teruki / Ogyu, Kamiyu / Onaya, Mitsumoto

Frontiers in psychiatry

2021 Volume 12, Page(s) 686817

Abstract: Cross-cultural understanding of psychiatric symptoms is important in the current globalised society. Lack of knowledge regarding culture-dependent manifestations of psychiatric illnesses may lead to misjudgement by clinicians, resulting in inappropriate ... ...

Abstract	Cross-cultural understanding of psychiatric symptoms is important in the current globalised society. Lack of knowledge regarding culture-dependent manifestations of psychiatric illnesses may lead to misjudgement by clinicians, resulting in inappropriate treatment. We present the cases of two patients with schizophrenia who showed Japanese-culture-dependent postures (
Language	English
Publishing date	2021-08-05
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2021.686817
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Article ; Online: Mask-induced ear injury in schizophrenia: A novel complication in the COVID-19 era.

Koreki, Akihiro / Koizumi, Teruki / Ogyu, Kamiyu / Mashima, Yuki / Taguchi, Kaoru / Onaya, Mitsumoto

Psychiatry and clinical neurosciences

2022 Volume 76, Issue 8, Page(s) 403–404

MeSH term(s)	COVID-19 ; Humans ; SARS-CoV-2 ; Schizophrenia/complications
Language	English
Publishing date	2022-06-09
Publishing country	Australia
Document type	Letter
ZDB-ID	1292906-2
ISSN	1440-1819 ; 1323-1316
ISSN (online)	1440-1819
ISSN	1323-1316
DOI	10.1111/pcn.13374
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Article ; Online: Intravenous pulse methylprednisolone and corticosteroid-induced psychiatric disorders: A retrospective study.

Ogyu, Kamiyu / Mashima, Yuki / Nishi, Akira / Kusudo, Keisuke / Kato, Hideo / Kurose, Shin / Uchida, Hiroyuki / Fujisawa, Daisuke / Mimura, Masaru / Takeuchi, Hiroyoshi

Journal of psychosomatic research

2023 Volume 167, Page(s) 111179

Abstract: Objective: Corticosteroids can cause psychiatric symptoms known as corticosteroid-induced psychiatric disorders (CIPDs). Little is known regarding the relationship between intravenous pulse methylprednisolone (IVMP) and CIPDs. Therefore, we aimed to ... ...

Abstract	Objective: Corticosteroids can cause psychiatric symptoms known as corticosteroid-induced psychiatric disorders (CIPDs). Little is known regarding the relationship between intravenous pulse methylprednisolone (IVMP) and CIPDs. Therefore, we aimed to examine the relationship between corticosteroid use and CIPDs in this retrospective study. Methods: Patients who were prescribed corticosteroids during their hospitalization at a university hospital and referred to our consultation-liaison service were selected. Patients diagnosed with CIPDs according to the ICD-10 codes were included. The incidence rates were compared between patients receiving IVMP and those receiving any other corticosteroid treatment. The association between IVMP and CIPDs was examined by classifying patients with CIPD into three groups according to the use of IVMP and timing of CIPD onset. Results: Of the 14,585 patients who received corticosteroids, 85 were diagnosed with CIPDs, with an incidence rate of 0.6%. Among the 523 patients who received IVMP, the incidence rate of CIPDs was 6.1% (n = 32), which was significantly higher than that in patients receiving any other corticosteroid treatment. Among the patients with CIPDs, 12 (14.1%) developed CIPDs during IVMP, 19 (22.4%) developed CIPDs after IVMP, and 49 (57.6%) developed CIPDs without IVMP. There was no significant difference in the doses at the time of CIPD improvement among the three groups when we excluded one patient whose CIPD improved during IVMP. Conclusion: Patients receiving IVMP were more likely to develop CIPDs than those who did not receive IVMP. Furthermore, corticosteroid doses at the time of improvement of CIPDs were constant, regardless of IVMP use.
MeSH term(s)	Humans ; Methylprednisolone/adverse effects ; Retrospective Studies ; Adrenal Cortex Hormones/adverse effects ; Mental Disorders
Chemical Substances	Methylprednisolone (X4W7ZR7023) ; Adrenal Cortex Hormones
Language	English
Publishing date	2023-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	80166-5
ISSN	1879-1360 ; 0022-3999
ISSN (online)	1879-1360
ISSN	0022-3999
DOI	10.1016/j.jpsychores.2023.111179
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Article ; Online: Aberrant heartbeat-evoked potential in schizophrenia.

Koreki, Akihiro / Ogyu, Kamiyu / Miyazaki, Takahiro / Takenouchi, Kazumasa / Matsushita, Karin / Honda, Shiori / Koizumi, Teruki / Onaya, Mitsumoto / Uchida, Hiroyuki / Mimura, Masaru / Nakajima, Shinichiro / Noda, Yoshihiro

Progress in neuro-psychopharmacology & biological psychiatry

2024 Volume 132, Page(s) 110969

Abstract: Self-disturbance is considered a core feature underlying the psychopathology of schizophrenia. Interoception has an important role in the development of a sense of self, leading to increased interest in the potential contribution of abnormal ... ...

Abstract	Self-disturbance is considered a core feature underlying the psychopathology of schizophrenia. Interoception has an important role in the development of a sense of self, leading to increased interest in the potential contribution of abnormal interoception to self-disturbances in schizophrenia. Several neuropsychological studies have demonstrated aberrant interoception in schizophrenia. However, cortical interoceptive processing has not yet been thoroughly investigated. Thus, we sought to examine resting-state heartbeat-evoked potential (HEP) in this population. We hypothesized that patients with schizophrenia would exhibit significant alterations in HEP compared to healthy controls (HCs). In this cross-sectional electroencephalogram (EEG) study, we compared the HEPs between age- and sex-matched groups of patients with schizophrenia and HCs. A 10-min resting-state EEG with eyes closed and an electrocardiogram (ECG) were recorded and analyzed for the time window of 450 ms to 500 ms after an ECG R peak. A positive HEP shift was observed in the frontal-central regions (F [1, 82] = 7.402, p = 0.008, partial η
MeSH term(s)	Humans ; Heart Rate/physiology ; Schizophrenia ; Cross-Sectional Studies ; Evoked Potentials/physiology ; Electroencephalography
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	781181-0
ISSN	1878-4216 ; 0278-5846
ISSN (online)	1878-4216
ISSN	0278-5846
DOI	10.1016/j.pnpbp.2024.110969
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Article ; Online: Clinical features of catatonic non-convulsive status epilepticus: A systematic review of cases.

Ogyu, Kamiyu / Kurose, Shin / Uchida, Hiroyuki / Kanemoto, Kousuke / Mimura, Masaru / Takeuchi, Hiroyoshi

Journal of psychosomatic research

2021 Volume 151, Page(s) 110660

Abstract: Objective: Non-convulsive status epilepticus (NCSE) can manifest as catatonia, although it is unclear how frequently such cases have been reported. The common clinical features of these two conditions are also unclear.: Methods: Using the MEDLINE and ...

Abstract	Objective: Non-convulsive status epilepticus (NCSE) can manifest as catatonia, although it is unclear how frequently such cases have been reported. The common clinical features of these two conditions are also unclear. Methods: Using the MEDLINE and Embase databases, we performed a systematic literature search to identify cases diagnosed with both catatonia, according to the Bush-Francis Catatonia Rating Scale, and NCSE, according to the Salzburg Consensus Criteria (last search: March 29, 2021). We extracted data on demographics, clinical features of catatonia, EEG findings, and treatments. Results: A total of 66 patients with catatonic NSCE (men, 49%; mean age, 42.0 years) were identified from our search. Of the 66 cases described: 30 (46%) showed motor symptoms; 35 (38%) occurred in patients with preceding episodes of epileptic seizures; 19 (29%) showed subtle ictal clinical phenomena, such as minor twitching of the mouth, periorbital region, and extremities; 22 (33%) presented with psychiatric symptoms prior to the onset of catatonia; 17 (26%) had a history of psychiatric diseases; and in 10 cases (15%), NSCE was confirmed by intentional or non-intentional long-term EEG monitoring. Benzodiazepines were used as the initial treatment for NCSE in 30 cases (49%), of which 20 cases (73%) improved with monotherapy. Discussion: A substantial number of cases included in the present review involved catatonia without any symptoms indicative of epilepsy, suggesting that NCSE may be misdiagnosed as a psychiatric disease, and highlighting the importance of the accurate diagnosis and treatment of NCSE in patients presenting with catatonia.
MeSH term(s)	Adult ; Catatonia/diagnosis ; Electroencephalography ; Epilepsy ; Humans ; Male ; Seizures ; Status Epilepticus/diagnosis
Language	English
Publishing date	2021-10-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
ZDB-ID	80166-5
ISSN	1879-1360 ; 0022-3999
ISSN (online)	1879-1360
ISSN	0022-3999
DOI	10.1016/j.jpsychores.2021.110660
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Article ; Online: Associations Between Structural Covariance Network and Antipsychotic Treatment Response in Schizophrenia.

Tsugawa, Sakiko / Honda, Shiori / Noda, Yoshihiro / Wannan, Cassandra / Zalesky, Andrew / Tarumi, Ryosuke / Iwata, Yusuke / Ogyu, Kamiyu / Plitman, Eric / Ueno, Fumihiko / Mimura, Masaru / Uchida, Hiroyuki / Chakravarty, Mallar / Graff-Guerrero, Ariel / Nakajima, Shinichiro

Schizophrenia bulletin

2023 Volume 50, Issue 2, Page(s) 382–392

Abstract: Background and hypothesis: Schizophrenia is associated with widespread cortical thinning and abnormality in the structural covariance network, which may reflect connectome alterations due to treatment effect or disease progression. Notably, patients ... ...

Abstract	Background and hypothesis: Schizophrenia is associated with widespread cortical thinning and abnormality in the structural covariance network, which may reflect connectome alterations due to treatment effect or disease progression. Notably, patients with treatment-resistant schizophrenia (TRS) have stronger and more widespread cortical thinning, but it remains unclear whether structural covariance is associated with treatment response in schizophrenia. Study design: We organized a multicenter magnetic resonance imaging study to assess structural covariance in a large population of TRS and non-TRS, who had been resistant and responsive to non-clozapine antipsychotics, respectively. Whole-brain structural covariance for cortical thickness was assessed in 102 patients with TRS, 77 patients with non-TRS, and 79 healthy controls (HC). Network-based statistics were used to examine the difference in structural covariance networks among the 3 groups. Moreover, the relationship between altered individual differentiated structural covariance and clinico-demographics was also explored. Study results: Patients with non-TRS exhibited greater structural covariance compared with HC, mainly in the fronto-temporal and fronto-occipital regions, while there were no significant differences in structural covariance between TRS and non-TRS or HC. Higher individual differentiated structural covariance was associated with lower general scores of the Positive and Negative Syndrome Scale in the non-TRS group, but not in the TRS group. Conclusions: These findings suggest that reconfiguration of brain networks via coordinated cortical thinning is related to treatment response in schizophrenia. Further longitudinal studies are warranted to confirm if greater structural covariance could serve as a marker for treatment response in this disease.
MeSH term(s)	Humans ; Schizophrenia/diagnostic imaging ; Schizophrenia/drug therapy ; Schizophrenia/pathology ; Antipsychotic Agents/pharmacology ; Antipsychotic Agents/therapeutic use ; Cerebral Cortical Thinning ; Brain/pathology ; Magnetic Resonance Imaging/methods
Chemical Substances	Antipsychotic Agents
Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	439173-1
ISSN	1745-1701 ; 0586-7614
ISSN (online)	1745-1701
ISSN	0586-7614
DOI	10.1093/schbul/sbad160
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Article ; Online: Improved 123I-Ioflupane Binding After Immunotherapy in Anti-NAE Antibody-Positive Hashimoto Encephalopathy That Clinically Mimicked Multiple System Atrophy.

Otsuka, Juuri / Hida, Ayumi / Ogyu, Kamiyu / Minamimoto, Ryogo / Takeuchi, Sousuke

Clinical nuclear medicine

2017 Volume 42, Issue 8, Page(s) e390–e391

Abstract: We describe an 84-year-old man with anti-NH2-terminal of α-enolase antibody-positive Hashimoto encephalopathy that clinically mimicked multiple system atrophy who underwent investigation by dopamine transporter SPECT before and after immunotherapy. ... ...

Abstract	We describe an 84-year-old man with anti-NH2-terminal of α-enolase antibody-positive Hashimoto encephalopathy that clinically mimicked multiple system atrophy who underwent investigation by dopamine transporter SPECT before and after immunotherapy. Before treatment, dopamine transporter SPECT showed reduced striatal I-ioflupane binding, with a mean specific binding ratio of 2.42, even though he had no apparent parkinsonism. After immunotherapy, mean specific binding ratio was improved to 3.22. Dopamine transporter SPECT was useful in this case to detect subclinical striatal dysfunction, and evaluation both before and after immunotherapy helped to distinguish between neurodegenerative disease and neuroimmunological disorder.
Language	English
Publishing date	2017-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000001728
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Article ; Online: Decrease in gamma-band auditory steady-state response in patients with treatment-resistant schizophrenia.

Schizophrenia research

2023 Volume 252, Page(s) 129–137

Abstract: Background: Thirty percent of patients with schizophrenia do not respond to non-clozapine antipsychotics and are termed treatment-resistant schizophrenia (TRS). The 40-Hz auditory steady-state response (ASSR) is a well-known to be reduced in patients ... ...

Abstract	Background: Thirty percent of patients with schizophrenia do not respond to non-clozapine antipsychotics and are termed treatment-resistant schizophrenia (TRS). The 40-Hz auditory steady-state response (ASSR) is a well-known to be reduced in patients with schizophrenia compared to healthy controls (HCs), suggesting impaired gamma oscillation in schizophrenia. Given no ASSR study on TRS, we aimed to examine the neurophysiological basis of TRS employing 40-Hz ASSR paradigm. Method: We compared ASSR measures among HCs, patients with non-TRS, and patients with TRS. TRS criteria were defined by a score of 4 or higher on two items of the Positive and Negative Syndrome Scale (PANSS) positive symptoms despite standard antipsychotic treatment. Participants were examined for ASSR with 40-Hz click-train stimulus, and then time-frequency analysis was performed to calculate evoked power and phase-locking factor (PLF) of 40-Hz ASSR. Results: A total of 79 participants were included: 27 patients with TRS (PANSS = 92.6 ± 15.8); 27 patients with non-TRS (PANSS = 63.3 ± 14.7); and 25 HCs. Evoked power in 40-Hz ASSR was lower in the TRS group than in the HC group (F Conclusion: These results suggest that glutamatergic and GABAergic neurophysiological dysfunctions are involved in the pathophysiology of TRS. Our findings warrant more comprehensive and longitudinal studies for deep phenotyping of TRS.
MeSH term(s)	Humans ; Schizophrenia ; Evoked Potentials, Auditory/physiology ; Acoustic Stimulation/methods ; Schizophrenia, Treatment-Resistant ; Electroencephalography/methods ; Auditory Cortex
Language	English
Publishing date	2023-01-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639422-x
ISSN	1573-2509 ; 0920-9964
ISSN (online)	1573-2509
ISSN	0920-9964
DOI	10.1016/j.schres.2023.01.011
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