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Article ; Online: How to approach and follow adrenal incidentaloma?

Oh, Jee-Young

2013 Volume 28, Issue 5, Page(s) 541–543

MeSH term(s)	Adrenal Gland Neoplasms ; Cushing Syndrome ; Female ; Humans ; Hyperaldosteronism ; Male ; Pheochromocytoma
Language	English
Publishing date	2013-08-14
Publishing country	Korea (South)
Document type	Editorial ; Comment
ZDB-ID	639023-7
ISSN	2005-6648 ; 1226-3303
ISSN (online)	2005-6648
ISSN	1226-3303
DOI	10.3904/kjim.2013.28.5.541
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Article: Regional adiposity, adipokines, and insulin resistance in type 2 diabetes.

Oh, Jee-Young

Diabetes & metabolism journal

2012 Volume 36, Issue 6, Page(s) 412–414

Language	English
Publishing date	2012-12-12
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2602402-0
ISSN	2233-6087 ; 2233-6079
ISSN (online)	2233-6087
ISSN	2233-6079
DOI	10.4093/dmj.2012.36.6.412
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Article ; Online: Letter: predictive clinical parameters for the therapeutic efficacy of sitagliptin in korean type 2 diabetes mellitus (diabetes metab j 2011;35:159-65).

Oh, Jee-Young

Diabetes & metabolism journal

2011 Volume 35, Issue 3, Page(s) 298–299

Language	English
Publishing date	2011-06-30
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2602402-0
ISSN	2233-6087 ; 2233-6087
ISSN (online)	2233-6087
ISSN	2233-6087
DOI	10.4093/dmj.2011.35.3.298
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Article ; Online: Serum cystatin C as a biomarker for predicting coronary artery disease in diabetes.

Oh, Jee-Young

Korean diabetes journal

2010 Volume 34, Issue 2, Page(s) 84–85

Language	English
Publishing date	2010-04-30
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2574451-3
ISSN	2093-2650 ; 2093-2650
ISSN (online)	2093-2650
ISSN	2093-2650
DOI	10.4093/kdj.2010.34.2.84
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Article ; Online: Different impacts of hypertension and diabetes mellitus on all-cause and cardiovascular mortality in community-dwelling older adults: the Rancho Bernardo Study.

Oh, Jee-Young / Allison, Matthew A / Barrett-Connor, Elizabeth

Journal of hypertension

2017 Volume 35, Issue 1, Page(s) 55–62

Abstract: Objectives: Although the prevalence rates of hypertension (HTN) and diabetes mellitus are slowing in some high-income countries, HTN and diabetes mellitus remain as the two major risk factors for atherosclerotic cardiovascular disease (CVD), the leading ...

Abstract	Objectives: Although the prevalence rates of hypertension (HTN) and diabetes mellitus are slowing in some high-income countries, HTN and diabetes mellitus remain as the two major risk factors for atherosclerotic cardiovascular disease (CVD), the leading cause of death in the United States and worldwide. We aimed to observe the association of HTN and diabetes mellitus with all-cause and CVD mortality in older white adults. Methods: All community-dwelling Rancho Bernardo Study participants who were at least 55 years old and had carefully measured blood pressure and plasma glucose from 75-g oral glucose tolerance test at the baseline visit (1984-1987, n = 2186) were followed up until death or the last clinic visit in 2013 (median 14.3 years, interquartile range 8.4-21.3). Results: In unadjusted analyses, diabetes mellitus was associated with all-cause mortality [hazard ratio 1.40, 95% confidence interval (CI) 1.23-1.60] and CVD mortality (hazard ratio 1.67, 95% CI 1.39-2.00); HTN with all-cause mortality [hazard ratio 1.93 (1.73-2.15)] and CVD mortality [hazard ratio 2.45 (2.10-2.93)]. After adjustment for cardiovascular risk factors, including age, BMI, triglycerides, HDL-cholesterol, smoking, exercise, and alcohol consumption, diabetes mellitus was associated with CVD mortality only (hazard ratio 1.25, P = 0.0213). Conversely, HTN was associated with both all-cause (hazard ratio 1.34, P < 0.0001) and CVD mortality (hazard ratio 1.40, P = 0.0003). Having both diabetes mellitus and HTN was associated with all-cause (hazard ratio 1.38, P = 0.0002) and CVD mortality (hazard ratio 1.70, P < 0.0001). Conclusion: We report the novel finding that HTN is more strongly associated with all-cause and CVD mortality than diabetes mellitus. Having both confers a modest increase in the hazards for these types of mortality.
MeSH term(s)	Aged ; Aged, 80 and over ; California/epidemiology ; Cardiovascular Diseases/mortality ; Diabetes Mellitus/epidemiology ; Female ; Humans ; Hypertension/epidemiology ; Male ; Middle Aged ; Residence Characteristics
Language	English
Publishing date	2017-01
Publishing country	England
Document type	Journal Article
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000001145
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Article ; Online: Differentiation between polycystic ovary syndrome and polycystic ovarian morphology by means of an anti-Müllerian hormone cutoff value.

Song, Do Kyeong / Oh, Jee-Young / Lee, Hyejin / Sung, Yeon-Ah

The Korean journal of internal medicine

2017 Volume 32, Issue 4, Page(s) 690–698

Abstract: Background/aims: Although increased serum anti-Müllerian hormone (AMH) level has been suggested to be a surrogate marker of polycystic ovarian morphology (PCOM), its association with polycystic ovary syndrome (PCOS) is controversial, and its diagnostic ... ...

Abstract	Background/aims: Although increased serum anti-Müllerian hormone (AMH) level has been suggested to be a surrogate marker of polycystic ovarian morphology (PCOM), its association with polycystic ovary syndrome (PCOS) is controversial, and its diagnostic value has not been determined. We aimed to observe the relationship between the AMH level and PCOS phenotypes and to determine the optimal cutoff value of AMH for the diagnosis of PCOS in young Korean women. Methods: We recruited 207 women with PCOS (120 with PCOM and 87 without PCOM) and 220 regular cycling women with normoandrogenemia (100 with PCOM and 120 without PCOM). Subjects underwent testing at a single outpatient visit. Serum AMH level was measured. Results: Women with PCOS had higher serum AMH levels than did regular cycling women with normoandrogenemia ( Conclusion: The serum AMH level can be useful for the diagnosis of PCOS at any age less than 40 years, and the optimal cutoff value for the diagnosis of PCOS identified in this study of young Korean women was 10.0 ng/mL.
Language	English
Publishing date	2017-07
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	639023-7
ISSN	2005-6648 ; 1226-3303
ISSN (online)	2005-6648
ISSN	1226-3303
DOI	10.3904/kjim.2016.038
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Article ; Online: Triglycerides to High-Density Lipoprotein Cholesterol Ratio Can Predict Impaired Glucose Tolerance in Young Women with Polycystic Ovary Syndrome.

Song, Do Kyeong / Lee, Hyejin / Sung, Yeon Ah / Oh, Jee Young

Yonsei medical journal

2016 Volume 57, Issue 6, Page(s) 1404–1411

Abstract: Purpose: The triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio could be related to insulin resistance (IR). We previously reported that Korean women with polycystic ovary syndrome (PCOS) had a high prevalence of impaired glucose ... ...

Abstract	Purpose: The triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio could be related to insulin resistance (IR). We previously reported that Korean women with polycystic ovary syndrome (PCOS) had a high prevalence of impaired glucose tolerance (IGT). We aimed to determine the cutoff value of the TG/HDL-C ratio for predicting IR and to examine whether the TG/HDL-C ratio is useful for identifying individuals at risk of IGT in young Korean women with PCOS. Materials and methods: We recruited 450 women with PCOS (24±5 yrs) and performed a 75-g oral glucose tolerance test (OGTT). IR was assessed by a homeostasis model assessment index over that of the 95th percentile of regular-cycling women who served as the controls (n=450, 24±4 yrs). Results: The cutoff value of the TG/HDL-C ratio for predicting IR was 2.5 in women with PCOS. Among the women with PCOS who had normal fasting glucose (NFG), the prevalence of IGT was significantly higher in the women with PCOS who had a high TG/HDL-C ratio compared with those with a low TG/HDL-C ratio (15.6% vs. 5.6%, p<0.05). Conclusion: The cutoff value of the TG/HDL-C ratio for predicting IR was 2.5 in young Korean women with PCOS, and women with NFG and a high TG/HDL-C ratio had a higher prevalence of IGT. Therefore, Korean women with PCOS with a TG/HDL-C ratio >2.5 are recommended to be administered an OGTT to detect IGT even if they have NFG.
MeSH term(s)	Adult ; Blood Glucose/analysis ; Blood Glucose/metabolism ; Body Mass Index ; Cardiovascular Diseases/epidemiology ; Cholesterol, HDL/blood ; Dyslipidemias/epidemiology ; Fasting ; Female ; Glucose Intolerance/epidemiology ; Glucose Intolerance/etiology ; Glucose Tolerance Test ; Humans ; Insulin Resistance ; Lipoproteins, HDL ; Polycystic Ovary Syndrome/blood ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/epidemiology ; Prevalence ; Triglycerides/blood ; Young Adult
Chemical Substances	Blood Glucose ; Cholesterol, HDL ; Lipoproteins, HDL ; Triglycerides
Language	English
Publishing date	2016-11
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	303740-x
ISSN	1976-2437 ; 0513-5796
ISSN (online)	1976-2437
ISSN	0513-5796
DOI	10.3349/ymj.2016.57.6.1404
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Article ; Online: A genetic risk score is associated with polycystic ovary syndrome-related traits.

Lee, Hyejin / Oh, Jee-Young / Sung, Yeon-Ah / Chung, Hye Won

Human reproduction (Oxford, England)

2016 Volume 31, Issue 1, Page(s) 209–215

Abstract: Study question: Is a genetic risk score (GRS) associated with polycystic ovary syndrome (PCOS) and its related clinical features?: Summary answer: The GRS calculated by genome-wide association studies (GWASs) was significantly associated with PCOS ... ...

Abstract	Study question: Is a genetic risk score (GRS) associated with polycystic ovary syndrome (PCOS) and its related clinical features? Summary answer: The GRS calculated by genome-wide association studies (GWASs) was significantly associated with PCOS status and its related clinical features. What is known already: PCOS is a heterogeneous disorder and is characterized by oligomenorrhea, hyperandrogenism and polycystic ovary morphology. Although recent GWASs have identified multiple genes associated with PCOS, a comprehensive genetic risk study of these loci with PCOS and related traits (e.g. free testosterone, menstruation number/year and ovarian morphology) has not been performed. Study design, size, duration: This study was designed as a cross-sectional case-control study. We recruited 862 women with PCOS and 860 controls. Women with PCOS were divided into four subgroups: (1) oligomenorrhea + hyperandrogenism + polycystic ovary, (2) oligomenorrhea + hyperandrogenism, (3) oligomenorrhea + polycystic ovary and (4) hyperandrogenism + polycystic ovary. Participants/materials, settings, methods: Genomic DNA was genotyped for the PCOS susceptibility loci using the HumanOmni1-Quad v1 array. Venous blood was drawn in the early follicular phase to measure baseline metabolic and hormonal parameters. A GRS was calculated by summing the number of risk alleles from 11 single-nucleotide polymorphisms (SNPs) that were identified in previous GWASs on PCOS. A weighted GRS (wGRS) was calculated by multiplying the number of risk alleles for each SNP by its estimated effect (beta) obtained from the association analysis. Main results and the role of chance: The GRS was higher in women with PCOS than in controls (8.8 versus 8.2, P < 0.01) and was significantly associated with PCOS after adjusting for age and BMI. An analysis of GRS quartiles (Q1 = 3-5, Q2 = 6-8, Q3 = 9-11, Q4 = 12-15) revealed that the subjects in the highest quartile showed a remarkable increased risk of PCOS compared with those in the lowest quartile (odds ratio = 6.28, P < 0.001). Free testosterone level, menstruation number per year, ovarian volume and ovarian follicle numbers were significantly associated with the GRS (in all cases, P < 0.01). The wGRS yielded similar results. Limitations, reasons for caution: We used 11 loci for the calculation of GRS, but a higher number of PCOS risk alleles was reported in previous studies. Therefore, further studies should assess the value of GRS including the additional SNPs related to PCOS. Although a GRS of ≥12 was significantly associated with PCOS, the GRS showed a poor predictive value; therefore, the use of genetic information based on current GWAS data only may present problems. Wider implications of the findings: The GRS could be used to identify asymptomatic individuals among people at risk and stratify them into accurate risk categories for the purpose of individualizing treatment approaches, which could potentially improve health outcomes. Study funding/competing interests: None of the authors have any conflicts of interest to declare. No funding was obtained for the study.
MeSH term(s)	Adult ; Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Hyperandrogenism/genetics ; Hyperandrogenism/pathology ; Hyperandrogenism/physiopathology ; Oligomenorrhea/genetics ; Oligomenorrhea/pathology ; Oligomenorrhea/physiopathology ; Polycystic Ovary Syndrome/genetics ; Polycystic Ovary Syndrome/pathology ; Polycystic Ovary Syndrome/physiopathology ; Risk Assessment ; Young Adult
Language	English
Publishing date	2016-01
Publishing country	England
Document type	Journal Article
ZDB-ID	632776-x
ISSN	1460-2350 ; 0268-1161 ; 1477-741X
ISSN (online)	1460-2350
ISSN	0268-1161 ; 1477-741X
DOI	10.1093/humrep/dev282
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Article ; Online: Comparison of the body adiposity index to body mass index in Korean women.

Sung, Yeon-Ah / Oh, Jee-Young / Lee, Hyejin

Yonsei medical journal

2014 Volume 55, Issue 4, Page(s) 1028–1035

Abstract: Purpose: Obesity is a major public health issue and is associated with many metabolic abnormalities. Consequently, the assessment of obesity is very important. A new measurement, the body adiposity index (BAI), has recently been proposed to provide ... ...

Abstract	Purpose: Obesity is a major public health issue and is associated with many metabolic abnormalities. Consequently, the assessment of obesity is very important. A new measurement, the body adiposity index (BAI), has recently been proposed to provide valid estimates of body fat percentages. The objective of this study was to compare the BAI and body mass index (BMI) as measurements of body adiposity and metabolic risk. Materials and methods: This was a cross-sectional analysis performed on Korean women. The weight, height, and hip circumferences of 2950 women (mean age 25±5 years old, 18-39 years) were measured, and their BMI and BAI [hip circumference (cm)/height (m)1.5-18] values were calculated. Bioelectric impedance analysis was used to evaluate body fat content. Glucose tolerance status was assessed with a 75-g oral glucose tolerance test, and insulin sensitivity was estimated with the insulin sensitivity index. Results: BMI was more significantly correlated with fat mass and fat percentage. Additionally, BMI was also more significantly associated with metabolic parameters, including fasting glucose, post-load 2-h glucose, fasting insulin, post-load 2-h insulin, triglycerides, and high density lipoprotein cholesterol than BAI. Receiver operating characteristic curve analysis revealed that BMI was a better tool for predicting body fat percentage than BAI. Insulin sensitivity and metabolic syndrome were more significantly associated with BMI than with BAI. Conclusion: In Korean women, the current BMI-based classifications for obesity might be superior to BAI-based measurements for determining obesity and predicting metabolic risk.
MeSH term(s)	Adiposity/physiology ; Adolescent ; Adult ; Body Composition/physiology ; Body Mass Index ; Body Weight/physiology ; Cholesterol, HDL/blood ; Cross-Sectional Studies ; Female ; Humans ; Obesity/blood ; Obesity/physiopathology ; Triglycerides/blood ; Waist Circumference/physiology ; Young Adult
Chemical Substances	Cholesterol, HDL ; Triglycerides
Language	English
Publishing date	2014-07-14
Publishing country	Korea (South)
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	303740-x
ISSN	1976-2437 ; 0513-5796
ISSN (online)	1976-2437
ISSN	0513-5796
DOI	10.3349/ymj.2014.55.4.1028
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Article ; Online: Clinical implications of menstrual cycle length in oligomenorrhoeic young women.

Oh, Jee-Young / Sung, Yeon-Ah / Lee, Hye Jin

Clinical endocrinology

2014 Volume 80, Issue 1, Page(s) 115–121

Abstract: Objective: Although menstrual irregularity is associated with insulin resistance and hyperandrogenism, the relationship between the severity of menstrual infrequency and clinical phenotypes in young women with oligomenorrhoea (OM) is unclear. We ... ...

Abstract	Objective: Although menstrual irregularity is associated with insulin resistance and hyperandrogenism, the relationship between the severity of menstrual infrequency and clinical phenotypes in young women with oligomenorrhoea (OM) is unclear. We evaluated whether a longer menstrual cycle length is associated with less favourable metabolic features. Design/patients/measurements: A total of 1174 young women (aged 19-39 years) with a menstrual cycle length over 40 days and 1430 women with regular menstrual cycles participated voluntarily. Metabolic parameters, insulin sensitivity index (ISI) and testosterone were measured. Oligomenorrhoeic women were divided into three groups: (i) polycystic ovary syndrome (PCOS) by National Institute of Health criteria, (ii) severe OM (menstrual cycle length >60 days), and (iii) mild OM (menstrual cycle length 40-60 days). Results: In normal-weight women (BMI < 23 kg/m(2)), the degrees of insulin resistance and hyperandrogenaemia are the highest in PCOS and higher in severe OM compared with mild OM. In overweight or obese women, PCOS was more insulin resistant and hyperandrogenaemic, but there was no difference between severe and mild OM. After excluding PCOS, women with severe OM showed a twofold increased risk of metabolic syndrome compared with regular cycling women (odds ratio 2·4, 95% confidence interval 1·1-5·6). By linear regression analysis, a longer menstrual cycle length was associated with ISI after adjustment for age, BMI, metabolic risk factors and testosterone. Conclusions: Women with a menstrual cycle length over 60 days should be more closely monitored for the metabolic syndrome than women with a menstrual cycle length of 40-60 days, even if they have no PCOS.
MeSH term(s)	Adult ; Blood Glucose/metabolism ; Body Weight/physiology ; Female ; Humans ; Insulin Resistance/physiology ; Menstrual Cycle/physiology ; Oligomenorrhea/physiopathology ; Polycystic Ovary Syndrome/physiopathology ; Young Adult
Chemical Substances	Blood Glucose
Language	English
Publishing date	2014-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121745-8
ISSN	1365-2265 ; 0300-0664
ISSN (online)	1365-2265
ISSN	0300-0664
DOI	10.1111/cen.12243
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