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Article ; Online: Hemolytic anemia associated with intravenous immunoglobulin in Kawasaki disease.

Cheon, Eun Jung / Oh, Jun Suk

2024 Volume 24, Issue 1, Page(s) 69

Abstract: Background: The administration of high-dose intravenous immunoglobulin (IVIG) is a standard treatment for the management of Kawasaki disease (KD). IVIG is known to be a highly effective and safe treatment.: Case presentation: We report the ... ...

Abstract	Background: The administration of high-dose intravenous immunoglobulin (IVIG) is a standard treatment for the management of Kawasaki disease (KD). IVIG is known to be a highly effective and safe treatment. Case presentation: We report the development of hemolytic anemia in seven children receiving repeated doses of IVIG. The children were aged 3-44 months and included 4 girls and 3 boys. All children received 10% IVIG and a second course of immunoglobulin because they did not respond to the first course of immunoglobulin. Two received high-dose aspirin (50 mg/kg), and five received low-dose aspirin (5 mg/kg). Two patients required additional methylprednisolone pulse therapy (30 mg/kg) after the second dose of immunoglobulin, and three patients received oral prednisolone therapy for defervescence. Three patients showed coronary artery dilation during hospitalization and normalized within two months. Pretreatment hemoglobin averaged 11.3-14.2 g/dL, and post-hemolytic anemia hemoglobin ranged from 7.4 to 9.6 g/dL, with a difference of 1.7-6.8 g/dL. Reticulocytes were increased to 3.3-13.2%. Peripheral blood smears showed normochromic normocytic anemia, and anisopoikilocytosis. All children were positive for warm-type antibodies with IgG+, C3d- in direct antiglobulin test, and the blood group was A + in five and B + in two. None of the patients received immunomodulatory therapy or red blood cell transfusions. They were followed for a year and all recovered. Conclusion: Especially, in non-O blood group KD patients who are refractory to initial IVIG and require a second dose of IVIG or 10% formulation the possibility of immune hemolytic anemia should be carefully considered, and close follow-up should be maintained after therapy.
MeSH term(s)	Child ; Female ; Humans ; Male ; Anemia, Hemolytic/chemically induced ; Anemia, Hemolytic/therapy ; Aspirin/therapeutic use ; Hemoglobins/therapeutic use ; Immunoglobulins, Intravenous/adverse effects ; Mucocutaneous Lymph Node Syndrome/drug therapy ; ABO Blood-Group System
Chemical Substances	Aspirin (R16CO5Y76E) ; Hemoglobins ; Immunoglobulins, Intravenous ; ABO Blood-Group System
Language	English
Publishing date	2024-01-20
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-024-04546-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Brachial Artery Pseudoaneurysm Treated with a Bifurcated Y-Shaped Artificial Vessel Graft.

Oh, Joon Seok / Eun, Seokchan

Archives of plastic surgery

2022 Volume 49, Issue 6, Page(s) 755–759

Abstract: Brachial artery aneurysms are rare diseases that may be caused by infection or trauma. We report a case of a 71-year-old man who presented with a mass in his right antecubital fossa that increased in size slowly over time. Three years ago, the patient ... ...

Abstract	Brachial artery aneurysms are rare diseases that may be caused by infection or trauma. We report a case of a 71-year-old man who presented with a mass in his right antecubital fossa that increased in size slowly over time. Three years ago, the patient underwent ascending and total-arch replacement with artificial vessel graft to treat aortic root and ascending aorta aneurysm. Preoperative physical examination of right upper extremity showed a nonpulsatile mass with normal pulse of axillary, brachial, and radial arteries. The mass was removed and brachial artery reconstruction was done initially using saphenous vein graft. Two months later, the patient revisited with recurrent pseudoaneurysm, involving the bifurcation point of brachial artery. Aneurysm was totally resected and the brachial artery was reconstructed by interposition graft using a bifurcated GORE-TEX artificial vessel graft. The patient healed without complication and no recurrence was observed. Artificial vessel graft is an available option for reconstruction, and revascularization of vessel defect after excision of brachial artery aneurysm may involve bifurcation point.
Language	English
Publishing date	2022-12-13
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2694943-X
ISSN	2234-6171 ; 2234-6163
ISSN (online)	2234-6171
ISSN	2234-6163
DOI	10.1055/s-0042-1751025
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Article ; Online: MDC1 is essential for G2/M transition and spindle assembly in mouse oocytes.

Leem, Jiyeon / Oh, Jeong Su

Cellular and molecular life sciences : CMLS

2022 Volume 79, Issue 4, Page(s) 200

Abstract: Mammalian oocytes are particularly susceptible to accumulating DNA damage. However, unlike mitotic cells in which DNA damage induces G2 arrest by activating the ATM-Chk1/2-Cdc25 pathway, oocytes readily enter M-phase immediately following DNA damage. ... ...

Abstract	Mammalian oocytes are particularly susceptible to accumulating DNA damage. However, unlike mitotic cells in which DNA damage induces G2 arrest by activating the ATM-Chk1/2-Cdc25 pathway, oocytes readily enter M-phase immediately following DNA damage. This implies a lack of a robust canonical G2/M DNA damage checkpoint in oocytes. Here we show that MDC1 plays a non-canonical role in controlling G2/M transition by regulating APC/C-Cdh1-mediated cyclin B1 degradation in response to DNA damage in mouse oocytes. Depletion of MDC1 impaired M-phase entry by decreasing cyclin B1 levels via the APC/C-Cdh1 pathway. Notably, the APC/C-Cdh1 regulation mediated by MDC1 was achieved by a direct interaction between MDC1 and APC/C-Cdh1. This interaction was transiently disrupted after DNA damage with a concomitant increase in Cdh1 levels, which, in turn, decreased cyclin B1 levels and delayed M-phase entry. Moreover, MDC1 depletion impaired spindle assembly by decreasing the integrity of microtubule organizing centers (MTOCs). Therefore, our results demonstrate that MDC1 is an essential molecule in regulating G2/M transition in response to DNA damage and in regulating spindle assembly in mouse oocytes. These results provide new insights into the regulation of the G2/M DNA damage checkpoint and cell cycle control in oocytes.
MeSH term(s)	Animals ; Cell Cycle ; Cell Cycle Proteins/metabolism ; Cell Division ; DNA Damage ; Mammals/metabolism ; Mice ; Oocytes/metabolism
Chemical Substances	Cell Cycle Proteins
Language	English
Publishing date	2022-03-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-022-04241-1
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Article ; Online: In Reply to the Letter to the Editor Regarding "Efficacy and Safety of Emergency Extracranial-Intracranial Bypass for Revascularization Within 24 Hours on Large Artery Occlusion with Intracranial Stenosis".

Noh, Yun Ho / Oh, Jae Sang

World neurosurgery

2022 Volume 158, Page(s) 333

MeSH term(s)	Arterial Occlusive Diseases/diagnostic imaging ; Arterial Occlusive Diseases/surgery ; Arteries/surgery ; Cerebral Revascularization ; Constriction, Pathologic/surgery ; Humans ; Vascular Surgical Procedures
Language	English
Publishing date	2022-08-04
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2021.07.140
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Article: Bell's palsy after concomitant chemoradiotherapy: a case report and literature review.

Choi, Sul Gi / Oh, Ji Seok / Myoung, Hoon / Seo, Mi Hyun

Journal of dental anesthesia and pain medicine

2024 Volume 24, Issue 2, Page(s) 129–135

Abstract: Concomitant chemoradiotherapy (CCRT) treated patients experience various complications. We present a rare case of post-CCRT Bell's palsy and describe its various possible causes, so as to increase awareness among clinicians about Bell's palsy being a ... ...

Abstract	Concomitant chemoradiotherapy (CCRT) treated patients experience various complications. We present a rare case of post-CCRT Bell's palsy and describe its various possible causes, so as to increase awareness among clinicians about Bell's palsy being a CCRT-associated adverse effect. The patient was a 48-year-old man diagnosed with squamous cell carcinoma who presented with post-CCRT Bell's palsy. After radiotherapy for 6 weeks (overall 67.5 Gy) and four rounds of cisplatin chemotherapy, he complained of paralysis of the entire left face. A test was performed 33 days after the last CCRT session to differentiate Bell's palsy from other causative factors. Based on magnetic resonance imaging findings, facial nerve invasion due to tumor size increase was determined to not cause Bell's palsy. Inflammation of the left Eustachian tube was observed. Hence, steroids and famciclovir were administered, which markedly improved the facial paralysis symptoms within 56 days after facial paralysis development. In conclusion, patients can develop Bell's palsy owing to complex effects of various CCRT mechanisms. Although the exact cause of Bell's palsy has not been identified and the effectiveness of drug treatment was questionable in this case, unlikely causative factors should be excluded through various tests and appropriate and timely measures must be adopted.
Language	English
Publishing date	2024-03-28
Publishing country	Korea (South)
Document type	Case Reports
ZDB-ID	3024253-8
ISSN	2383-9317 ; 2383-9309
ISSN (online)	2383-9317
ISSN	2383-9309
DOI	10.17245/jdapm.2024.24.2.129
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Article: Complete and Incomplete Alcohol Sclerotherapy for Treatment of Symptomatic Hepatic Cysts: Comparison of Volume Reduction and Clinical Outcomes.

Kim, Ran / Oh, Jung-Suk / Kim, Su-Ho / Chun, Ho-Jong

Journal of clinical medicine

2024 Volume 13, Issue 5

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13051472
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Article ; Online: Distinct characteristics of the DNA damage response in mammalian oocytes.

Leem, Jiyeon / Lee, Crystal / Choi, Da Yi / Oh, Jeong Su

Experimental & molecular medicine

2024 Volume 56, Issue 2, Page(s) 319–328

Abstract: DNA damage is a critical threat that poses significant challenges to all cells. To address this issue, cells have evolved a sophisticated molecular and cellular process known as the DNA damage response (DDR). Among the various cell types, mammalian ... ...

Abstract	DNA damage is a critical threat that poses significant challenges to all cells. To address this issue, cells have evolved a sophisticated molecular and cellular process known as the DNA damage response (DDR). Among the various cell types, mammalian oocytes, which remain dormant in the ovary for extended periods, are particularly susceptible to DNA damage. The occurrence of DNA damage in oocytes can result in genetic abnormalities, potentially leading to infertility, birth defects, and even abortion. Therefore, understanding how oocytes detect and repair DNA damage is of paramount importance in maintaining oocyte quality and preserving fertility. Although the fundamental concept of the DDR is conserved across various cell types, an emerging body of evidence reveals striking distinctions in the DDR between mammalian oocytes and somatic cells. In this review, we highlight the distinctive characteristics of the DDR in oocytes and discuss the clinical implications of DNA damage in oocytes.
MeSH term(s)	Animals ; Female ; Pregnancy ; Oocytes/metabolism ; DNA Repair ; Ovary ; DNA Damage ; Mammals
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1328915-9
ISSN	2092-6413 ; 1226-3613 ; 0378-8512
ISSN (online)	2092-6413
ISSN	1226-3613 ; 0378-8512
DOI	10.1038/s12276-024-01178-2
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Zs.A 4775: Show issues

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Article: Use of carefully titrated ultra-low doses of alteplase in infected haemothorax caused by initial alteplase use to drain loculated malignant pleural effusion.

Oh, Jeong Suk / Yoo, Chris / Wong, Donny

Respirology case reports

2023 Volume 11, Issue 9, Page(s) e01202

Abstract: Alteplase as a fibrinolytic can be used to break up fibrin to encourage clot breakdown for clinical use. In the pleural space, it is used for symptomatic loculated malignant pleural effusions and pleural infections and can potentially avoid the need for ... ...

Abstract	Alteplase as a fibrinolytic can be used to break up fibrin to encourage clot breakdown for clinical use. In the pleural space, it is used for symptomatic loculated malignant pleural effusions and pleural infections and can potentially avoid the need for surgical intervention. The optimal dose and dosing regimen of intrapleural fibrinolytics is still unknown. Although generally considered safe, bleeding is a serious potential complication and studies are ongoing to try and determine the lowest effective dose of alteplase to successfully treat pleural infections. This case highlighted the safe use of very low doses of alteplase ranging from 0.25 to 0.5 mg following pleural bleeding after the use of alteplase to treat a patient with symptomatic malignant loculated effusion. It demonstrates once pleural bleeding has stopped, there is a role for carefully titrated intrapleural alteplase use to avoid surgery.
Language	English
Publishing date	2023-08-09
Publishing country	United States
Document type	Case Reports
ZDB-ID	2750180-2
ISSN	2051-3380
ISSN	2051-3380
DOI	10.1002/rcr2.1202
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Article ; Online: Effect of Selective Serotonin Reuptake Inhibitors on Motor Recovery After Stroke: A Systematic Meta-analysis.

Oh, Ju Sun / Choo, Yoo Jin / Chang, Min Cheol

American journal of physical medicine & rehabilitation

2023 Volume 102, Issue 12, Page(s) 1097–1101

Abstract: Objective: We conducted a meta-analysis to determine the effectiveness of selective serotonin reuptake inhibitors in improving motor outcomes after stroke. For accuracy, we only included studies in which selective serotonin reuptake inhibitors were ... ...

Abstract	Objective: We conducted a meta-analysis to determine the effectiveness of selective serotonin reuptake inhibitors in improving motor outcomes after stroke. For accuracy, we only included studies in which selective serotonin reuptake inhibitors were administered to patients in the recovery phase after stroke (<6 mos after stroke). Design: Meta-analyses were conducted according to the tools used to measure motor function. We searched the SCOPUS, PubMed, Embase, and Cochrane Library databases for studies, which compared motor recovery in patients who receive selective serotonin reuptake inhibitor medication in the recovery phase after stroke with a control group that did not receive any selective serotonin reuptake inhibitor. Results: A total of 3715 publications were assessed, and nine studies met the study criteria. The group, which received selective serotonin reuptake inhibitors, showed improved Fugl-Meyer Motor Scale and Barthel index scores compared with the control group. However, there was no significant difference in the modified Rankin Scale scores between the selective serotonin reuptake inhibitor and control groups. The incidence of adverse effects after the administration of selective serotonin reuptake inhibitors did not differ from that in the control group. Conclusions: Our study showed that the use of selective serotonin reuptake inhibitor in the recovery phase of stroke improved motor function without significant increase in adverse effects.
MeSH term(s)	Humans ; Selective Serotonin Reuptake Inhibitors/therapeutic use ; Stroke/drug therapy ; Stroke Rehabilitation ; Incidence
Chemical Substances	Selective Serotonin Reuptake Inhibitors
Language	English
Publishing date	2023-05-16
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ZDB-ID	219390-5
ISSN	1537-7385 ; 0002-9491 ; 0894-9115
ISSN (online)	1537-7385
ISSN	0002-9491 ; 0894-9115
DOI	10.1097/PHM.0000000000002289
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Article ; Online: The effects of biofeedback training for efficient activation of infraspinatus on proprioception and EMG activity during shoulder external rotation.

Yu, Il-Young / Ko, Min-Joo / Oh, Jae-Seop

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology

2023 Volume 71, Page(s) 102798

Abstract: The purpose of this study investigated which biofeedback (BF) training enables efficient activation of the infraspinatus muscle that affect joint position sense (JPS) and force sense (FS) of the shoulder joint. Twenty healthy males participated and ... ...

Abstract	The purpose of this study investigated which biofeedback (BF) training enables efficient activation of the infraspinatus muscle that affect joint position sense (JPS) and force sense (FS) of the shoulder joint. Twenty healthy males participated and performed three external rotation (ER) exercises under three randomly assigned training conditions: 1) non-biofeedback (NBF), 2) BF and 3) force biofeedback (FBF). Each exercise was performed at intervals of one week between training conditions. After performed the ER exercise under each training condition, the relative error (RE) was calculated at shoulder ER 45° and 80°, and then shoulder ER force were measured to determine the JPS error and FS error, respectively. Muscle activity of infraspinatus and posterior deltoid were measured and compared between training conditions. The RE of shoulder ER 45° and 80° were significantly lower under the FBF conditions than other training conditions (P < 0.05). The RE of shoulder ER force were also significantly lower under the FBF conditions compared to those under the other training conditions (P < 0.05). The activity of the infraspinatus muscle was significantly higher under the FBF conditions during all three ER exercises than other training conditions (p < 0.05). We suggest that BF trainings can be useful to improve the proprioception of shoulder joint as well as activation of infraspinatus muscle while performing the ER exercises.
MeSH term(s)	Male ; Humans ; Shoulder/physiology ; Rotator Cuff/physiology ; Muscle, Skeletal/physiology ; Electromyography ; Shoulder Joint/physiology ; Proprioception/physiology
Language	English
Publishing date	2023-06-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1073161-1
ISSN	1873-5711 ; 1050-6411
ISSN (online)	1873-5711
ISSN	1050-6411
DOI	10.1016/j.jelekin.2023.102798
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