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Article ; Online: Development of systemwide pedestrian safety performance function using stratified random sampling and a proxy measure of pedestrian exposure.

Kwayu, Keneth Morgan / Kwigizile, Valerian / Oh, Jun-Seok

International journal of injury control and safety promotion

2020 Volume 27, Issue 4, Page(s) 420–431

Abstract: The lack of pedestrian counts at a systemwide level prompts the need to find other innovative ways of assessing pedestrian traffic crash risks using proxy measures of exposure. This study aims to formulate the methodology for developing pedestrian safety ...

Abstract	The lack of pedestrian counts at a systemwide level prompts the need to find other innovative ways of assessing pedestrian traffic crash risks using proxy measures of exposure. This study aims to formulate the methodology for developing pedestrian safety performance functions (SPF) using the proxy measure of pedestrian exposure and stratified random sampling. The case study was all urban intersections in Michigan State that comprise of collector and arterial roads. The stratified random sampling strategy was deployed to select the sample which is representative of all urban intersections in the state of Michigan. Factor analysis was used to develop a proxy measure of pedestrian exposure at urban intersections using a walkability measure (walk score), among other factors. The performances of various count models were compared using the goodness of fit measures based on the Akaike's Information Criterion (AIC), Bayesian Information Criterion (BIC), and Vuong test. The final pedestrian SPFs was formulated using the Zero-Inflated Poisson (ZIP) model with AADT at a major approach, AADT at the minor approach, and a proxy measure of pedestrian exposure. The proposed methodology in this study can benefit transportation agencies that have embarked on systemwide planning of pedestrian facilities to improve the safety of pedestrians but lack systemwide analytical tools and pedestrian counts to make data-driven decisions.
MeSH term(s)	Accidents, Traffic ; Factor Analysis, Statistical ; Humans ; Michigan ; Models, Statistical ; Pedestrians ; Safety
Language	English
Publishing date	2020-07-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2171097-1
ISSN	1745-7319 ; 1745-7300
ISSN (online)	1745-7319
ISSN	1745-7300
DOI	10.1080/17457300.2020.1791905
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Article ; Online: Assessing the safety impacts of raising the speed limit on Michigan freeways using the multilevel mixed-effects negative binomial model.

Kwayu, Keneth Morgan / Kwigizile, Valerian / Oh, Jun-Seok

Traffic injury prevention

2020 Volume 21, Issue 6, Page(s) 401–406

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Acceleration/adverse effects ; Accidents, Traffic/statistics & numerical data ; Automobile Driving/legislation & jurisprudence ; Built Environment/statistics & numerical data ; Humans ; Michigan ; Models, Statistical ; Multilevel Analysis ; Safety
Language	English
Publishing date	2020-06-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2089818-6
ISSN	1538-957X ; 1538-9588
ISSN (online)	1538-957X
ISSN	1538-9588
DOI	10.1080/15389588.2020.1773450
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Article ; Online: Preferential dissolution behaviour of the austenite phase in Fe-27Cr-

Lee, Jun-Seob / Lee, Jun-Hyeong / Rho, Seo-Young / Lee, Yoon-Hwa / Lee, Ye-Jin / Oh, Jun-Seok / Lee, Je-Hyun

RSC advances

2023 Volume 13, Issue 28, Page(s) 19220–19226

Abstract: Preferential dissolution behaviour of the austenite (γ) phase in Fe-27Cr- ...

Abstract	Preferential dissolution behaviour of the austenite (γ) phase in Fe-27Cr-
Language	English
Publishing date	2023-06-26
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra01015e
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Article ; Online: Fracture healing on non-union fracture model promoted by non-thermal atmospheric-pressure plasma.

Saito, Kosuke / Toyoda, Hiromitsu / Okada, Mitsuhiro / Oh, Jun-Seok / Nakazawa, Katsumasa / Ban, Yoshitaka / Orita, Kumi / Shimatani, Akiyoshi / Yao, Hana / Shirafuji, Tatsuru / Nakamura, Hiroaki

PloS one

2024 Volume 19, Issue 4, Page(s) e0298086

Abstract: Non-thermal atmospheric-pressure plasma (NTAPP) is attracting widespread interest for use in medical applications. The tissue repair capacity of NTAPP has been reported in various fields; however, little is known about its effect on fracture healing. Non- ...

Abstract	Non-thermal atmospheric-pressure plasma (NTAPP) is attracting widespread interest for use in medical applications. The tissue repair capacity of NTAPP has been reported in various fields; however, little is known about its effect on fracture healing. Non-union or delayed union after a fracture is a clinical challenge. In this study, we aimed to investigate how NTAPP irradiation promotes fracture healing in a non-union fracture model and its underlying mechanism, in vitro and in vivo. For the in vivo study, we created normal and non-union fracture models in LEW/SsNSlc rats to investigate the effects of NTAPP. To create a fracture, a transverse osteotomy was performed in the middle of the femoral shaft. To induce the non-union fracture model, the periosteum surrounding the fracture site was cauterized after a normal fracture model was created. The normal fracture model showed no significant difference in bone healing between the control and NTAPP-treated groups. The non-union fracture model demonstrated that the NTAPP-treated group showed consistent improvement in fracture healing. Histological and biomechanical assessments confirmed the fracture healing. The in vitro study using pre-osteoblastic MC3T3-E1 cells demonstrated that NTAPP irradiation under specific conditions did not reduce cell proliferation but did enhance osteoblastic differentiation. Overall, these results suggest that NTAPP is a novel approach to the treatment of bone fractures.
MeSH term(s)	Rats ; Animals ; Fracture Healing ; Plasma Gases/pharmacology ; Plasma Gases/therapeutic use ; Fractures, Bone ; Cell Differentiation ; Cell Proliferation ; Femoral Fractures/surgery
Chemical Substances	Plasma Gases
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0298086
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Article ; Online: In vivo study on the repair of rat Achilles tendon injury treated with non-thermal atmospheric-pressure helium microplasma jet.

Nakazawa, Katusmasa / Toyoda, Hiromitsu / Manaka, Tomoya / Orita, Kumi / Hirakawa, Yoshihiro / Saito, Kosuke / Iio, Ryosuke / Shimatani, Akiyoshi / Ban, Yoshitaka / Yao, Hana / Otsuki, Ryosuke / Torii, Yamato / Oh, Jun-Seok / Shirafuji, Tatsuru / Nakamura, Hiroaki

PloS one

2024 Volume 19, Issue 5, Page(s) e0301216

Abstract: Non-thermal atmospheric-pressure plasma (NTAPP) has been widely studied for clinical applications, e.g., disinfection, wound healing, cancer therapy, hemostasis, and bone regeneration. It is being revealed that the physical and chemical actions of plasma ...

Abstract	Non-thermal atmospheric-pressure plasma (NTAPP) has been widely studied for clinical applications, e.g., disinfection, wound healing, cancer therapy, hemostasis, and bone regeneration. It is being revealed that the physical and chemical actions of plasma have enabled these clinical applications. Based on our previous report regarding plasma-stimulated bone regeneration, this study focused on Achilles tendon repair by NTAPP. This is the first study to reveal that exposure to NTAPP can accelerate Achilles tendon repair using a well-established Achilles tendon injury rat model. Histological evaluation using the Stoll's and histological scores showed a significant improvement at 2 and 4 weeks, with type I collagen content being substantial at the early time point of 2 weeks post-surgery. Notably, the replacement of type III collagen with type I collagen occurred more frequently in the plasma-treated groups at the early stage of repair. Tensile strength test results showed that the maximum breaking strength in the plasma-treated group at two weeks was significantly higher than that in the untreated group. Overall, our results indicate that a single event of NTAPP treatment during the surgery can contribute to an early recovery of an injured tendon.
MeSH term(s)	Animals ; Achilles Tendon/injuries ; Rats ; Plasma Gases/pharmacology ; Plasma Gases/therapeutic use ; Wound Healing/drug effects ; Tendon Injuries/therapy ; Male ; Helium/pharmacology ; Rats, Sprague-Dawley ; Collagen Type I/metabolism ; Tensile Strength ; Atmospheric Pressure ; Collagen Type III/metabolism
Language	English
Publishing date	2024-05-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0301216
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Article ; Online: How does an increased freeway speed limit influence the frequency of crashes on adjacent roads?

Alhomaidat, Fadi / Kwigizile, Valerian / Oh, Jun-Seok / Houten, Ron Van

Accident; analysis and prevention

2020 Volume 136, Page(s) 105433

Abstract: Urban arterial roads carry the most traffic on urban road networks and experience the highest percentage of crashes in urban areas. Safety on urban arterials that are adjacent to a higher speed freeway may be impacted by speed spillover or adaptation. ... ...

Abstract	Urban arterial roads carry the most traffic on urban road networks and experience the highest percentage of crashes in urban areas. Safety on urban arterials that are adjacent to a higher speed freeway may be impacted by speed spillover or adaptation. The objective of this study was to determine the effects of raising freeway speed limits on the frequency of crashes on urban arterial roads adjacent to freeways (spillover effects). Crash data within Michigan were collected on 1393 urban arterial road segments before and after freeway speed limits were altered. Before-and-after data was collected simultaneously on 1470 comparison segments of urban arterial where speed limits did not change to control for the regression-to-the-mean bias. The mixed effects negative binomial (MENB) regression model was developed to analyze crash frequency on urban arterials. The results indicate that raising speed limits of freeways by as little as five miles per hour had a likelihood of increasing crash frequency on adjacent arterial roads by as much as 13.9 percent. To investigate if the safety impact of speed spillover changes with the distance from the freeway, influence areas (0-1 mile, 1-2 mile, and 2-3 mile) were used. The findings of this study provide insights into the effects of speed spillover on crash occurrences, and it demonstrates that increasing freeway speed limit has a negative influence on driver compliance with the speed limit on adjacent arterial roads. Correspondingly, the influence of freeway speed on drivers' speeding behavior on adjacent urban arterials fades away with the distance from the freeway.
MeSH term(s)	Accidents, Traffic/prevention & control ; Accidents, Traffic/statistics & numerical data ; Automobile Driving/legislation & jurisprudence ; Automobile Driving/psychology ; Built Environment ; Humans ; Michigan ; Models, Statistical ; Urban Population
Language	English
Publishing date	2020-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	210223-7
ISSN	1879-2057 ; 0001-4575
ISSN (online)	1879-2057
ISSN	0001-4575
DOI	10.1016/j.aap.2020.105433
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Article ; Online: Discovering latent themes in traffic fatal crash narratives using text mining analytics and network topology.

Kwayu, Keneth Morgan / Kwigizile, Valerian / Lee, Kevin / Oh, Jun-Seok

Accident; analysis and prevention

2020 Volume 150, Page(s) 105899

Abstract: The proliferation of digital textual archives in the transportation safety domain makes it imperative for the inventions of efficient ways of extracting information from the textual data sources. The present study aims at utilizing crash narratives ... ...

Abstract	The proliferation of digital textual archives in the transportation safety domain makes it imperative for the inventions of efficient ways of extracting information from the textual data sources. The present study aims at utilizing crash narratives complemented by crash metadata to discern the prevalence and co-occurrence of themes that contribute to crash incidents. Ten years (2009-2018) of Michigan traffic fatal crash narratives were used as a case study. The structural topic modeling (STM) and network topology analysis were used to generate and examine the prevalence and interaction of themes from the crash narratives that were mainly categorized into pre-crash events, crash locations and involved parties in the traffic crashes. The main advantage of the STM over the other topic modeling approaches is that it allows the researchers to discover themes from documents and estimate how the topic relates to the document metadata. Topics with the highest prevalence for the angle, head-on, rear-end, sideswipe and single motor vehicle crashes were crash at stop-sign, crossing the centerline, unable to stop, lane change maneuver and run-off-road crash, respectively. Eigenvector centrality measure in network topology showed that event-related topics were consistently central in articulating the crash occurrence. The centrality and association between topics varied across crash types. The efficacy of generated topics in classifying crashes by type was tested using a machine learning algorithm, Random Forest. The classification accuracy in the held-out sample ranged between 89.3 % for sideswipe crashes to 99.2 % for single motor vehicle crashes. High classification accuracy suggests that automation of crash typing and consistency checks can be accomplished effectively by using extracted latent themes from the crash narratives.
MeSH term(s)	Accidents, Traffic ; Automobile Driving ; Data Mining ; Humans ; Michigan ; Transportation
Language	English
Publishing date	2020-12-04
Publishing country	England
Document type	Journal Article
ZDB-ID	210223-7
ISSN	1879-2057 ; 0001-4575
ISSN (online)	1879-2057
ISSN	0001-4575
DOI	10.1016/j.aap.2020.105899
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Article: Vagally mediated atrioventricular block with ventricular asystole immediately after assuming prone position under spinal anestheisa: a case report.

Kim, Kyoung Ok / Oh, Jun Seok

Korean journal of anesthesiology

2016 Volume 69, Issue 1, Page(s) 63–65

Abstract: Vagally mediated atrioventricular (AV) block is a condition which a paroxysmal AV block occurs with the slowing of the sinus rate. Owing to its unpredictability and benign nature, it often goes unrecognized in clinical practice. We present the case of a ... ...

Abstract	Vagally mediated atrioventricular (AV) block is a condition which a paroxysmal AV block occurs with the slowing of the sinus rate. Owing to its unpredictability and benign nature, it often goes unrecognized in clinical practice. We present the case of a 49-year-old man who suddenly lost consciousness when he assumed a prone position for hemorrohoidectomy under spinal anesthesia; continuous electrocardiographic recording revealed AV block with ventricular asystole. He was completely recovered after returning to a supine position. This case calls our attention to fatal manifestation of vagally mediated AV block leading to syncope.
Language	English
Publishing date	2016-02
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2557340-8
ISSN	2005-7563 ; 2005-6419
ISSN (online)	2005-7563
ISSN	2005-6419
DOI	10.4097/kjae.2016.69.1.63
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Article ; Online: A comparison of safety benefits of pedestrian countdown signals with and without pushbuttons in Michigan.

Atta Boateng, Richard / Kwigizile, Valerian / Oh, Jun-Seok

Traffic injury prevention

2018 Volume 19, Issue 6, Page(s) 588–593

Abstract: Objective: This study evaluated the safety impacts of pedestrian countdown signals (PCSs) with and without pushbuttons based on pedestrian crashes and pedestrian injuries in Michigan.: Methodology: This study used 10 years of intersection data-5 ... ...

Abstract	Objective: This study evaluated the safety impacts of pedestrian countdown signals (PCSs) with and without pushbuttons based on pedestrian crashes and pedestrian injuries in Michigan. Methodology: This study used 10 years of intersection data-5 years before PCSs were installed and 5 years after they were installed-along with a comparison group, to evaluate the crash impacts of PCSs; at 107 intersections the PCS had a pushbutton and at 96 it did not. At these intersections, and at their comparison sites (where no PCS was installed), crash data (from 2004 to 2016) were examined, along with traffic and geometric characteristics, population, education, and poverty level data. Results: Intersections where PCSs with pushbuttons have been installed showed a 29% reduction in total pedestrian crashes and a 30% reduction in fatal/injury pedestrian crashes. Further, when considering only pedestrians age 65 and below, these respective reductions are 33 and 35%. Intersections with PCSs but without pushbuttons did not show any significant change in any type of pedestrian crash. Conclusions: Although the Manual on Uniform Traffic Control Devices (Federal Highway Administration [FHWA] 2009 ) requires the use of PCSs at new traffic signal installations, this study suggests a safety benefit of installing PCSs with pushbutton at signals where a PCS without a pushbutton is present.
MeSH term(s)	Accidents, Traffic ; Adult ; Algorithms ; Databases, Factual ; Equipment Design ; Female ; Humans ; Male ; Michigan ; Middle Aged ; Pedestrians ; Protective Devices ; Safety/statistics & numerical data ; Trauma Severity Indices ; Young Adult
Language	English
Publishing date	2018-05-24
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2089818-6
ISSN	1538-957X ; 1538-9588
ISSN (online)	1538-957X
ISSN	1538-9588
DOI	10.1080/15389588.2018.1462493
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Article ; Online: Expression of Inhibitory Receptors on T and NK Cells Defines Immunological Phenotypes of HCV Patients with Advanced Liver Fibrosis.

Okwor, Chisom Ifeoma Adaeze / Oh, Jun Seok / Crawley, Angela Marie / Cooper, Curtis Lindsey / Lee, Seung-Hwan

iScience

2020 Volume 23, Issue 9, Page(s) 101513

Abstract: Chronic HCV can result in advanced liver disease, including cirrhosis. Patients with advanced fibrosis experience poor clinical outcomes and increased risk for hepatocellular carcinoma (HCC). These outcomes are, in part, a consequence of immune ... ...

Abstract	Chronic HCV can result in advanced liver disease, including cirrhosis. Patients with advanced fibrosis experience poor clinical outcomes and increased risk for hepatocellular carcinoma (HCC). These outcomes are, in part, a consequence of immune dysfunction. Increased inhibitory receptor and Galectin-9 (GAL-9) expression is a possible mechanism promoting lymphocyte dysfunction. In this study, we measured the expression of inhibitory receptors and GAL-9 on T/NK cells of patients with chronic HCV with no to moderate fibrosis (F0-F2) and advanced fibrosis (F3-F4). To analyze their co-expression, we employed t-SNE analysis. Notably, we found that F3-F4 patients had higher frequencies of >3 inhibitory receptor co-expression on NK cells. Moreover, F3-F4 patients manifest a higher frequency of NK cells co-expressing TIGIT and TIM-3, and CD4/NK cells co-expressing LAG-3 and GAL-9. In conclusion, we identified phenotypes of immune dysregulation that could explain the increased susceptibility to infection and HCC in patients with chronic HCV with advanced fibrosis.
Language	English
Publishing date	2020-08-29
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2020.101513
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