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  1. Article ; Online: An Update on the Pathophysiology and Diagnosis of Inappropriate Secretion of Thyroid-Stimulating Hormone.

    Ohba, Kenji

    International journal of molecular sciences

    2021  Volume 22, Issue 12

    Abstract: Inappropriate secretion of thyroid-stimulating hormone (IST), also known as central hyperthyroidism, is a clinical condition characterized by elevated free thyroxine and triiodothyronine concentrations concurrent with detectable thyroid-stimulating ... ...

    Abstract Inappropriate secretion of thyroid-stimulating hormone (IST), also known as central hyperthyroidism, is a clinical condition characterized by elevated free thyroxine and triiodothyronine concentrations concurrent with detectable thyroid-stimulating hormone (TSH) concentrations. Similarly, the term syndrome of IST (SITSH) is widely used in Japan to refer to a closely related condition; however, unlike that for IST, an elevated serum free triiodothyronine concentration is not a requisite criterion for SITSH diagnosis. IST or SITSH is an important indicator of resistance to thyroid hormone β (RTHβ) caused by germline mutations in genes encoding thyroid hormone receptor β (TRβ) and TSH-secreting pituitary adenoma. Recent evidence has accumulated for several conditions associated with IST, including RTH without mutations in the TRβ gene (non-TR-RTH), the phenomenon of hysteresis involving the hypothalamus-pituitary-thyroid axis (HPT-axis), methodological interference, and Cushing's syndrome after surgical resection. However, little information is available on the systematic pathophysiological aspects of IST in previous review articles. This report presents an overview of the recent advances in our understanding of the etiological aspects of IST that are relevant for diagnosis and treatment. Moreover, the report focuses on the potential mechanism of IST caused by hysteresis in the HPT-axis (lagging TSH recovery) in terms of epigenetic regulation.
    MeSH term(s) Diagnosis, Differential ; Humans ; Hyperpituitarism/diagnosis ; Hyperpituitarism/epidemiology ; Hyperpituitarism/etiology ; Hyperpituitarism/therapy
    Language English
    Publishing date 2021-06-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22126611
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  2. Article ; Online: Editorial Comment to Spontaneous regression of multiple pulmonary metastases accompanied by normalization of serum immune markers following cytoreductive nephrectomy in a patient with clear-cell renal cell carcinoma.

    Ohba, Kojiro

    IJU case reports

    2021  Volume 4, Issue 2, Page(s) 100

    Language English
    Publishing date 2021-01-20
    Publishing country Australia
    Document type Editorial
    ISSN 2577-171X
    ISSN (online) 2577-171X
    DOI 10.1002/iju5.12256
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  3. Article: The final report of KEYNOTE-426 showed the efficacy and safety as a treatment for advanced renal cell carcinoma.

    Ohba, Kojiro / Imamura, Ryoichi

    Translational andrology and urology

    2024  Volume 13, Issue 2, Page(s) 353–355

    Language English
    Publishing date 2024-02-01
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2851630-8
    ISSN 2223-4691 ; 2223-4691 ; 2223-4683
    ISSN (online) 2223-4691
    ISSN 2223-4691 ; 2223-4683
    DOI 10.21037/tau-23-588
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  4. Article ; Online: Protocol for producing an adeno-associated virus vector by controlling capsid expression timing.

    Ohba, Kenji / Mizukami, Hiroaki

    STAR protocols

    2023  Volume 4, Issue 4, Page(s) 102542

    Abstract: Conventional adeno-associated virus (AAV) production systems generate vast numbers of empty capsids, which should be eliminated before clinical use. Here, we present a protocol for efficient AAV vector production. We describe steps for separating ... ...

    Abstract Conventional adeno-associated virus (AAV) production systems generate vast numbers of empty capsids, which should be eliminated before clinical use. Here, we present a protocol for efficient AAV vector production. We describe steps for separating replicase and capsid genes from the plasmid and controlling capsid expression until sufficient AAV vector genome replication is achieved. This protocol can produce AAV vectors in various serotypes. For complete details on the use and execution of this protocol, please refer to Ohba et al.
    MeSH term(s) Capsid/metabolism ; Dependovirus/genetics ; Dependovirus/metabolism ; Capsid Proteins/genetics
    Chemical Substances Capsid Proteins
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102542
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  5. Article ; Online: Minocycline and black thyroid.

    Goto, Y / Ohba, K / Sasaki, S / Nishino, N

    QJM : monthly journal of the Association of Physicians

    2022  Volume 115, Issue 6, Page(s) 403–404

    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Humans ; Minocycline/adverse effects ; Thyroid Gland/diagnostic imaging
    Chemical Substances Anti-Bacterial Agents ; Minocycline (FYY3R43WGO)
    Language English
    Publishing date 2022-04-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcac113
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    Ua VI Zs.131: Show issues Location:
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  6. Article ; Online: Role of thyroid hormone in an experimental model of atherosclerosis: the potential mediating role of immune response and autophagy.

    Ohba, Kenji / Iwaki, Takayuki

    Endocrine journal

    2022  Volume 69, Issue 9, Page(s) 1043–1052

    Abstract: Accumulating evidence has revealed that several conditions related to abnormal thyroid hormone status, such as dyslipidemia, hypertension, or hypercoagulable state, can exacerbate atherosclerotic vascular disease. Thyroid hormone effects on vascular ... ...

    Abstract Accumulating evidence has revealed that several conditions related to abnormal thyroid hormone status, such as dyslipidemia, hypertension, or hypercoagulable state, can exacerbate atherosclerotic vascular disease. Thyroid hormone effects on vascular smooth muscle cells and endothelial cells have also been studied extensively. However, only limited information is available on thyroid hormone-mediated immune response in current review articles on the pathophysiology of atherosclerosis. This report thus presents an overview of the recent advances in the understanding of the dynamic interactions taking place between thyroid hormone status and immune response in the pathogenesis of atherosclerosis. In particular, we focus on macrophages and T-lymphocytes, which have been recognized as important determinants for the initiation and development of atherosclerosis. Numerous studies have revealed the role of autophagy in immune cells produced in atherosclerosis. In addition, thyroid hormones induce autophagy in several cells and tissues, such as liver, skeletal muscles, lungs, and brown adipose tissue. Our research group, among others, have reported different targets of thyroid hormone-mediated autophagy, including lipid droplets (lipophagy), mitochondria (mitophagy), and aggregated proteins (aggrephagy). Based on these findings, thyroid hormone-mediated autophagy could serve as a novel therapeutic approach for atherosclerosis. We also consider the limitations of the current murine models for studies on atherosclerosis, especially in relation to low-density lipoprotein-cholesterol driven atherosclerotic plaque.
    MeSH term(s) Animals ; Atherosclerosis ; Autophagy ; Cholesterol ; Endothelial Cells/metabolism ; Immunity ; Lipoproteins, LDL ; Mice ; Models, Theoretical ; Plaque, Atherosclerotic ; Thyroid Hormones/metabolism
    Chemical Substances Lipoproteins, LDL ; Thyroid Hormones ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2022-07-23
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1151918-6
    ISSN 1348-4540 ; 0918-8959
    ISSN (online) 1348-4540
    ISSN 0918-8959
    DOI 10.1507/endocrj.EJ22-0177
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.207: Show issues Location:
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  7. Article ; Online: Intratumoral metastasis of sigmoid colon cancer to chromophobe renal cell carcinoma: a case report.

    Sakai, Suzuna / Ohba, Kojiro / Migita, Kazunari / Sekine, Ichiro / Yamazaki, Yasuto

    International cancer conference journal

    2024  Volume 13, Issue 2, Page(s) 134–138

    Abstract: We herein report an extremely rare case of intratumoral metastasis of colon cancer to chromophobe renal cell carcinoma. A 71-year-old woman was diagnosed with lung metastasis of sigmoid colon cancer and underwent sigmoid colon resection with D3 lymph ... ...

    Abstract We herein report an extremely rare case of intratumoral metastasis of colon cancer to chromophobe renal cell carcinoma. A 71-year-old woman was diagnosed with lung metastasis of sigmoid colon cancer and underwent sigmoid colon resection with D3 lymph node dissection. Preoperative contrast-enhanced computed tomography (CT) revealed a left renal tumor; however, colon resection was prioritized, and the renal tumor was placed under observation. Two years later, CT revealed enlargement of the left renal tumor, and laparoscopic partial left nephrectomy was performed 1 month later. Histopathologic examination showed that the resected renal tumor was a chromophobe renal cell carcinoma with intratumoral metastasis of colon cancer to the renal tumor center, and adjuvant chemotherapy with bevacizumab plus SOX (L-OHP + S-1) was initiated. Because of severe chemotherapy-induced fatigue and nausea, the patient was switched to bevacizumab + S-1. However, the patient's nausea did not improve after this change, and postoperative adjuvant chemotherapy was discontinued at the patient's request 4 months after the partial nephrectomy. Two months after discontinuation of chemotherapy, CT showed no renal recurrence; however, increased lung metastases and a new bone metastasis in the left sciatic bone were observed. Palliative treatment was then initiated because of severe adverse events that made it difficult to continue treatment. In patients who have multiple cancers and an increase in renal tumor size, the possibility of intratumoral metastasis to the renal tumor should be considered.
    Language English
    Publishing date 2024-02-03
    Publishing country Singapore
    Document type Journal Article
    ISSN 2192-3183
    ISSN (online) 2192-3183
    DOI 10.1007/s13691-023-00651-5
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  8. Article ; Online: Involvement of metal transporters in the intestinal uptake of cadmium.

    Ohta, Hisayoshi / Ohba, Kenichi

    The Journal of toxicological sciences

    2020  Volume 45, Issue 9, Page(s) 539–548

    Abstract: We investigated the mechanism underlying intestinal cadmium (Cd) uptake based on the mediators (metal transporters) of essential elements, such as Fe, Zn, Cu, and Ca, under normal conditions in female rats. These elements interact with Cd uptake from the ...

    Abstract We investigated the mechanism underlying intestinal cadmium (Cd) uptake based on the mediators (metal transporters) of essential elements, such as Fe, Zn, Cu, and Ca, under normal conditions in female rats. These elements interact with Cd uptake from the intestinal tract. Cd concentration at each site of the small intestine (duodenum, jejunum, and ileum) increased as Cd exposure increased. However, Cd concentration was the highest in the duodenum. The gene expression of ZIP14, DMT1, and ATP7A increased with increase in Cd concentration. Further, Cu concentration decreased as Cd concentration increased. In contrast, Fe concentration displayed a decreasing tendency with the increase in Cd concentration. The gene expression levels of ZIP14, DMT1, and ATP7A were positively correlated with Cd concentration. Immunohistochemical staining revealed the positive sites of ZIP14 and DMT1 scattered in the area adjacent to the goblet cells, resorbable epithelial cells, and lamina propria in the duodenum tissue, according to the increase in Cd concentration. Cd is induced to synthesize and bind to metallothionein (MT-I and -II) and accumulate in the intestinal tissues, mainly in the duodenum. Such findings suggest that Cd, a contaminant element, is taken up from the intestinal tract by multiple metal transporters such as Cu, Fe, and Zn, thereby involving in the intestinal Cd absorption.
    MeSH term(s) Animals ; Cadmium/metabolism ; Cation Transport Proteins/genetics ; Cation Transport Proteins/metabolism ; Copper ; Copper-Transporting ATPases/genetics ; Copper-Transporting ATPases/metabolism ; Duodenum/metabolism ; Female ; Gene Expression ; Intestinal Absorption/genetics ; Intestinal Mucosa/metabolism ; Intestine, Small/metabolism ; Iron ; Metallothionein/metabolism ; Rats ; Zinc
    Chemical Substances Cation Transport Proteins ; Slc39a14 protein, rat ; solute carrier family 11- (proton-coupled divalent metal ion transporters), member 2 ; Cadmium (00BH33GNGH) ; Copper (789U1901C5) ; Metallothionein (9038-94-2) ; Iron (E1UOL152H7) ; Atp7a protein, rat (EC 7.2.2.8) ; Copper-Transporting ATPases (EC 7.2.2.8) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2020-09-02
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 770623-6
    ISSN 1880-3989 ; 0388-1350
    ISSN (online) 1880-3989
    ISSN 0388-1350
    DOI 10.2131/jts.45.539
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1682: Show issues Location:
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  9. Article ; Online: Adeno-associated virus vector system controlling capsid expression improves viral quantity and quality.

    Ohba, Kenji / Sehara, Yoshihide / Enoki, Tatsuji / Mineno, Junichi / Ozawa, Keiya / Mizukami, Hiroaki

    iScience

    2023  Volume 26, Issue 4, Page(s) 106487

    Abstract: Adeno-associated virus (AAV) vectors are promising tools for gene therapy. The current AAV vector system produces an abundance of empty capsids that are eliminated before clinical use, leading to increased costs for gene therapy. In the present study, we ...

    Abstract Adeno-associated virus (AAV) vectors are promising tools for gene therapy. The current AAV vector system produces an abundance of empty capsids that are eliminated before clinical use, leading to increased costs for gene therapy. In the present study, we established an AAV production system that regulates the timing of capsid expression using a tetracycline-dependent promoter. Tetracycline-regulating capsid expression increased viral yield and reduced empty capsids in various serotypes without altering AAV vector infectivity
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.106487
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  10. Article: The Incidence and Management of Cancer-Related Anorexia During Treatment with Vascular Endothelial Growth Factor Receptor-Tyrosine Kinase Inhibitors.

    Takahashi, Shunji / Matsumoto, Koji / Ohba, Kojiro / Nakano, Yasuhiro / Miyazawa, Yasushi / Kawaguchi, Takumi

    Cancer management and research

    2023  Volume 15, Page(s) 1033–1046

    Abstract: Cancer-related anorexia is a common complication and frequently occurs in cancer patients treated with vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFR-TKIs). Anorexia contributes to malnutrition, body weight loss, and ... ...

    Abstract Cancer-related anorexia is a common complication and frequently occurs in cancer patients treated with vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFR-TKIs). Anorexia contributes to malnutrition, body weight loss, and cachexia in affected patients. Furthermore, patients who experience anorexia have worse outcomes than those who maintain their appetite, highlighting the importance of managing anorexia and related symptoms. However, as the causes of anorexia are both diverse and interconnected, there have been challenges in evaluating and implementing effective interventions. In this review, we described the contributing factors to cancer-related anorexia and reviewed recent literature for the frequency of anorexia symptoms in patients treated with VEGFR-TKIs. Additionally, we evaluated the evidence for current interventions and the potential benefits of multimodal and multidisciplinary approaches to care. The frequency of anorexia symptoms in patients who received VEGFR-TKIs ranged from 14%-58% for all-grade anorexia and 0%-6% for grade 3 or 4 anorexia. While many of the interventions for cancer-related anorexia have minimal benefit or adverse events, recent advances in our understanding of cancer-related anorexia suggest that multimodal therapy with multidisciplinary care is a promising avenue of investigation. Several studies currently underway are anticipated to further assess the effectiveness of multimodal approaches.
    Language English
    Publishing date 2023-09-22
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2508013-1
    ISSN 1179-1322
    ISSN 1179-1322
    DOI 10.2147/CMAR.S417238
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