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  1. Article: Introduction of Extracorporeal Membrane Oxygenation on Ninth Day of Ventilator Management for Severe Acute Respiratory Distress Syndrome due to COVID-19: A Case Report.

    Takeda, Akiko / Higashitani, Michiaki / Kuroda, Yuko / Ohgi, Kentaro / Yanagita, Kunio

    Cureus

    2022  Volume 14, Issue 5, Page(s) e24869

    Abstract: The reported case is of a 68-year-old man who was admitted to the ICU at our tertiary care medical center with severe COVID-19. He was admitted to the ICU due to a worsening respiratory condition during his hospitalization at the same medical center, ... ...

    Abstract The reported case is of a 68-year-old man who was admitted to the ICU at our tertiary care medical center with severe COVID-19. He was admitted to the ICU due to a worsening respiratory condition during his hospitalization at the same medical center, which included the development of severe acute respiratory distress syndrome (ARDS). Ventilator management was started with alveolar protection in mind. On the ninth day of ventilator management, we judged that it was necessary to introduce extracorporeal membrane oxygenation (ECMO). Although the ninth day of ventilator management is considered relatively late for starting ECMO, there are no absolute contraindications for ECMO at this stage, and improvements in oxygenation can be expected. After introducing ECMO, the patient's oxygenation capacity improved, and ECMO was successfully withdrawn within 16 days. The patient required long-term rehabilitation but was discharged from the hospital to his home without lingering disease complications on the 150th day of illness and subsequently resumed his former work, daily activities, and quality of life. We conclude that, in regard to the introduction of ECMO for ARDS, it is necessary to reach a comprehensive judgment without being bound by any one index (such as the ventilation management period prior to ECMO introduction).
    Language English
    Publishing date 2022-05-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.24869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: NT-pro BNP level at dialysis initiation is a useful biomarker for predicting hospitalization for ischemic heart disease.

    Shimohata, Homare / Usui, Joichi / Tawara-Iida, Takashi / Ebihara, Itaru / Ishizu, Takashi / Maeda, Yoshitaka / Kobayashi, Hiroaki / Numajiri, Daichi / Kaneshige, Ayaka / Sega, Masatoshi / Yamashita, Marina / Ohgi, Kentaro / Maruyama, Hiroshi / Takayasu, Mamiko / Hirayama, Kouichi / Kobayashi, Masaki / Yamagata, Kunihiro

    Clinical and experimental nephrology

    2024  Volume 28, Issue 5, Page(s) 457–464

    Abstract: Background: Patients with end-stage kidney disease (ESKD) are at high risk of cardiovascular disease including stroke, heart failure, and ischemic heart disease (IHD). To prevent the occurrence and progression of CVD, a reliable prognostic cardiac ... ...

    Abstract Background: Patients with end-stage kidney disease (ESKD) are at high risk of cardiovascular disease including stroke, heart failure, and ischemic heart disease (IHD). To prevent the occurrence and progression of CVD, a reliable prognostic cardiac biomarker is essential. We investigated the prognostic value of NT-proBNP for each incident type of CVD.
    Methods: Male patients from the Ibaraki Dialysis Initiation Cohort (iDIC) study with preserved serum samples from dialysis initiation day (n = 212) were analyzed. Patients were classified into four groups according to quartiles of baseline NT-pro BNP levels. The relationship between NT-proBNP levels at the initiation of dialysis and the subsequent incidence of hospitalization events due to IHD, heart failure, and stroke was analyzed.
    Results: The incidence rate for hospitalization due to IHD was significantly higher in the highest NT-proBNP category (Log rank p = 0.008); those of stroke and heart failure showed no significant differences among quartiles. Cox proportional hazards regression analysis revealed that serum NT-proBNT was the only prognostic factor for hospitalization for IHD after adjustment by major known IHD risk factors. (HR, 1.008; 95% confidence interval, 1.002-1.014; p = 0.01) The ROC curve analysis for the incidence of hospitalization due to IHD showed that NT-proBNP had an area under the curve (AUC) of 0.759 (95% CI 0.622-0.897; p = 0.004) at a cut-off value of 956.6 pg/mL.
    Conclusion: NT-proBNP measurement at the initiation of dialysis therapy is useful to predict later hospitalization for IHD.
    Trial registration: UMIN000010806.
    MeSH term(s) Humans ; Male ; Natriuretic Peptide, Brain/blood ; Biomarkers/blood ; Peptide Fragments/blood ; Myocardial Ischemia/blood ; Myocardial Ischemia/epidemiology ; Myocardial Ischemia/diagnosis ; Renal Dialysis ; Middle Aged ; Aged ; Hospitalization ; Kidney Failure, Chronic/therapy ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/complications ; Heart Failure/blood ; Heart Failure/therapy ; Heart Failure/epidemiology ; Prognosis ; Incidence ; Stroke/blood ; Stroke/epidemiology ; Predictive Value of Tests ; ROC Curve ; Proportional Hazards Models ; Japan/epidemiology
    Chemical Substances Natriuretic Peptide, Brain (114471-18-0) ; pro-brain natriuretic peptide (1-76) ; Biomarkers ; Peptide Fragments
    Language English
    Publishing date 2024-01-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-023-02442-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clinical course and pathological findings of two late-onset Fabry hemizygous patients including mulberry cell counts after enzyme replacement therapy.

    Shimohata, Homare / Yamashita, Marina / Ohgi, Kentaro / Maruyama, Hiroshi / Takayasu, Mamiko / Hirayama, Kouichi / Kobayashi, Masaki

    CEN case reports

    2020  Volume 9, Issue 3, Page(s) 237–242

    Abstract: Fabry disease is an X-linked inherited lysosomal storage disorder caused by a deficiency of α-galactosidase A activity, resulting in the intracellular accumulation of globotriaosylceramide and related glycosphingolipids. The phenotypes of Fabry disease ... ...

    Abstract Fabry disease is an X-linked inherited lysosomal storage disorder caused by a deficiency of α-galactosidase A activity, resulting in the intracellular accumulation of globotriaosylceramide and related glycosphingolipids. The phenotypes of Fabry disease in both males and females are grouped into two categories: the classical type and the late-onset type. The classical type shows general symptoms including angiokeratoma(s), acroparesthesia, hypohidrosis, corneal opacity, and gastrointestinal symptoms from an early age. The late-onset type shows cardiac or renal (or both) symptoms from a late age. We present herein the clinical course and pathological findings of two late-onset hemizygous Fabry patients after the initiation of enzyme replacement therapy (ERT), along with their mulberry cell counts during treatment. One patient's case was a renal-variant type without general symptoms; he showed stable renal function and mild proteinuria but little histological improvement with no change in the mulberry cell count during ERT. The other patient had a cardiac-variant type with renal pathological abnormality. He achieved a mild improvement of renal pathological findings, and his mulberry cell count gradually decreased during the treatment. These findings indicate that monitoring the mulberry cell count might help assess the efficacy of ERT, as a renal pathology tool.
    MeSH term(s) Adult ; Asian People/ethnology ; Biopsy/methods ; Cardiomyopathies/diagnosis ; Cardiomyopathies/etiology ; Cell Count/methods ; Enzyme Replacement Therapy/methods ; Fabry Disease/diagnosis ; Fabry Disease/genetics ; Fabry Disease/pathology ; Fabry Disease/therapy ; Glycosphingolipids/analysis ; Humans ; Kidney/abnormalities ; Kidney/pathology ; Kidney Diseases/etiology ; Kidney Diseases/pathology ; Kidney Diseases/physiopathology ; Kidney Diseases/therapy ; Late Onset Disorders/diagnosis ; Late Onset Disorders/genetics ; Late Onset Disorders/pathology ; Male ; Microscopy, Electron/methods ; Middle Aged ; Morus ; Phenotype ; Podocytes/pathology ; Podocytes/ultrastructure ; Proteinuria/diagnosis ; Proteinuria/etiology ; Treatment Outcome
    Chemical Substances Glycosphingolipids
    Language English
    Publishing date 2020-03-18
    Publishing country Japan
    Document type Journal Article ; Case Reports
    ZDB-ID 2660492-9
    ISSN 2192-4449 ; 2192-4449
    ISSN (online) 2192-4449
    ISSN 2192-4449
    DOI 10.1007/s13730-020-00463-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The effect of sodium-glucose cotransporter 2 inhibitor (tofogliflozin) on renal tubular damage in diabetic patients without albuminuria.

    Shimohata, Homare / Iwaki, Yoshiki / Yamashita, Marina / Ohgi, Kentaro / Maruyama, Hiroshi / Takayasu, Mamiko / Hirayama, Kouichi / Kobayashi, Masaki

    International urology and nephrology

    2021  Volume 54, Issue 8, Page(s) 1907–1914

    Abstract: Purpose: The sodium-glucose cotransporter 2 (SGLT2) inhibitors comprise a new class of glucose-lowering drugs for individuals with diabetes. Large-scale clinical trials indicated that SGLT2 inhibitors have both a cardiovascular-protective and renal- ... ...

    Abstract Purpose: The sodium-glucose cotransporter 2 (SGLT2) inhibitors comprise a new class of glucose-lowering drugs for individuals with diabetes. Large-scale clinical trials indicated that SGLT2 inhibitors have both a cardiovascular-protective and renal-protective effects. A reduction in glomerular hyperfiltration and a decrease in albuminuria are suspected as the main causes of SGLT2 inhibitors' renoprotective effect. The effects of SGLT2 inhibitors on tubular damage in non-albuminuric diabetic patients are unclear.
    Methods: The SGLT2 inhibitor tofogliflozin (20 mg, 1 × /day) was orally administered to 14 non-albuminuric diabetic patients. Serum and urine samples were collected at baseline (before) and after the start of tofogliflozin treatment. Hemoglobin A1c, hemoglobin, estimated glomerular filtration rate (eGFR), body weight, and blood pressure (BP) were analyzed as clinical parameters at baseline and 1, 3, and 6 months later. Urinary neutrophil gelatinase-associated lipocalin (NGAL) and N-acetyl-β-D-glucosaminidase were measured as tubular damage markers and the urinary 8-hidroxydeoxyguanosine (8-OHdG) values were measured as an oxidative stress marker at baseline and at 1 and 3 months.
    Results: Compared to baseline, the patients' HbA1c values and body weights were significantly decreased post-tofogliflozin administration, and their eGFR values were decreased at 3 months but recovered at 6 months; the hemoglobin concentrations were significantly increased at 3 and 6 months and the urinary NGAL level tended to be decreased at 3 months. No significant changes in blood urea nitrogen, BP, NAG, urine sodium concentration, or urinary 8-OHdG values occurred. The effect of this SGLT2 inhibitor was not influenced by the use of an angiotensin receptor blocker or dipeptidyl-peptidase 4 inhibitor.
    Conclusion: For individuals with non-albuminuric diabetes, tofogliflozin has a good glucose-lowering effect and might have a tubular-protective effect.
    MeSH term(s) Albuminuria/drug therapy ; Albuminuria/etiology ; Benzhydryl Compounds ; Biomarkers ; Blood Glucose ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Glucosides ; Humans ; Lipocalin-2 ; Sodium ; Sodium-Glucose Transporter 2/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
    Chemical Substances Benzhydryl Compounds ; Biomarkers ; Blood Glucose ; Glucosides ; Lipocalin-2 ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors ; Sodium (9NEZ333N27) ; 6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol (P8DD8KX4O4)
    Language English
    Publishing date 2021-11-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-021-03064-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Microscopic polyangiitis associated with thymic tumor: a case report and review of the literature.

    Miyamoto, Yasunori / Hirayama, Kouichi / Maruyama, Hiroshi / Ohgi, Kentaro / Takayasu, Mamiko / Shimohata, Homare / Kobayashi, Masaki

    BMC nephrology

    2019  Volume 20, Issue 1, Page(s) 123

    Abstract: Background: Thymic hyperplasia and thymic epithelial tumor (thymoma) have been associated with a variety of autoimmune diseases. Renal involvement has been reported in patients with thymoma. Minimal change disease and membranous nephropathy are ... ...

    Abstract Background: Thymic hyperplasia and thymic epithelial tumor (thymoma) have been associated with a variety of autoimmune diseases. Renal involvement has been reported in patients with thymoma. Minimal change disease and membranous nephropathy are frequently observed in glomerular lesions of thymoma patients, but ANCA-associated renal vasculitis is rare. We present a case of thymoma-associated microscopic polyangiitis with positivity for three ANCAs: MPO-ANCA, PR3-ANCA and azurocidin-ANCA.
    Case presentation: An 89-year-old Japanese woman was admitted to our hospital following an episode of general fatigue, nausea, muscle weakness of the lower limbs, and ophthalmoplegia. On urinalysis, proteinuria, hematuria, and cellular casts were observed. Elevated levels of serum creatinine and C-reactive protein were also demonstrated, and MPO-, PR3- and azurocidin-ANCA were detected on serological examination. Renal biopsy showed pauci-immune crescentic glomerulonephritis. We therefore diagnosed rapidly progressive glomerulonephritis due to microscopic polyangiitis. Acetylcholine-receptor antibody was also detected. Chest computed tomography and MRI revealed a lobulated tumor in the anterior mediastinum. We thus also diagnosed myasthenia gravis with thymoma.
    Conclusion: Considering the patient's triple-ANCA positivity, thymic diseases may be associated with the pathogenesis of ANCA-associated vasculitis due to central T-cell tolerance. A further accumulation of cases is needed, because thymectomy does not always induce the remission of thymoma-associated autoimmune diseases.
    MeSH term(s) Aged, 80 and over ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/blood ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Antibodies, Antineutrophil Cytoplasmic/blood ; Antibodies, Antineutrophil Cytoplasmic/classification ; Biopsy/methods ; Diagnosis, Differential ; Disease Progression ; Female ; Humans ; Kidney Glomerulus/pathology ; Magnetic Resonance Imaging/methods ; Mediastinum/diagnostic imaging ; Microscopic Polyangiitis/complications ; Microscopic Polyangiitis/immunology ; Microscopic Polyangiitis/pathology ; Microscopic Polyangiitis/urine ; Patient Care Management ; Thymoma/complications ; Thymoma/diagnosis ; Thymoma/immunology ; Thymoma/pathology ; Thymus Neoplasms/complications ; Thymus Neoplasms/diagnosis ; Thymus Neoplasms/immunology ; Thymus Neoplasms/pathology ; Tomography, X-Ray Computed/methods ; Urinalysis/methods
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic
    Language English
    Publishing date 2019-04-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-019-1319-9
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  6. Article ; Online: Serum 20S proteasome levels are associated with disease activity in MPO-ANCA-associated microscopic polyangiitis.

    Maruyama, Hiroshi / Hirayama, Kouichi / Yamashita, Marina / Ohgi, Kentaro / Tsujimoto, Ryuji / Takayasu, Mamiko / Shimohata, Homare / Kobayashi, Masaki

    BMC rheumatology

    2020  Volume 4, Page(s) 36

    Abstract: Background: Proteasomes are found in both the cell nucleus and cytoplasm and play a major role in the ubiquitin-dependent and -independent non-lysosomal pathways of intracellular protein degradation. Proteasomes are also involved in the turnover of ... ...

    Abstract Background: Proteasomes are found in both the cell nucleus and cytoplasm and play a major role in the ubiquitin-dependent and -independent non-lysosomal pathways of intracellular protein degradation. Proteasomes are also involved in the turnover of various regulatory proteins, antigen processing, cell differentiation, and apoptosis. To determine the diagnostic value of serum proteasome in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), we investigated patients with AAV at various stages of the disease.
    Methods: Serum 20S-proteasome was measured by ELISA in 44 patients with MPO-ANCA-associated microscopic polyangiitis (MPA) and renal involvement. Thirty of the patients provided serum samples before the initial treatment, and 30 provided samples during remission; 16 provided samples at both time points.
    Results: The mean serum 20S-proteasome level was significantly higher in the active-vasculitis patients (3414.6 ± 2738.9 ng/mL;
    Conclusion: The serum level of 20S-proteasome may be a useful marker for disease activity in AAV.
    Language English
    Publishing date 2020-08-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2918121-5
    ISSN 2520-1026 ; 2520-1026
    ISSN (online) 2520-1026
    ISSN 2520-1026
    DOI 10.1186/s41927-020-00137-4
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  7. Article ; Online: An Adult Patient with Alagille Syndrome Showing Mainly Renal Failure and Vascular Abnormality without Liver Manifestation.

    Shimohata, Homare / Imagawa, Kazuo / Yamashita, Marina / Ohgi, Kentaro / Maruyama, Hiroshi / Takayasu, Mamiko / Hirayama, Kouichi / Kobayashi, Masaki

    Internal medicine (Tokyo, Japan)

    2020  Volume 59, Issue 22, Page(s) 2907–2910

    Abstract: Alagille syndrome is an inherited multisystemic disorder. We herein report an atypical case of a Japanese adult patient with Alagille syndrome. He had been diagnosed with Alagille syndrome as an infant based on a liver biopsy. At 27 years of age, he ... ...

    Abstract Alagille syndrome is an inherited multisystemic disorder. We herein report an atypical case of a Japanese adult patient with Alagille syndrome. He had been diagnosed with Alagille syndrome as an infant based on a liver biopsy. At 27 years of age, he needed to start hemodialysis therapy, but an arteriovenous fistula was not created because his peripheral blood vessels were too narrow. He also had a recurrent brain infarction due to cerebral vascular stenosis. Alagille syndrome is generally recognized as a pediatric hepatic disease, but general physicians should be aware of its potential existence with renal involvement and vascular abnormalities.
    MeSH term(s) Adult ; Alagille Syndrome/complications ; Alagille Syndrome/diagnosis ; Biopsy ; Child ; Humans ; Infant ; Liver Diseases ; Male ; Renal Insufficiency
    Language English
    Publishing date 2020-07-28
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.4780-20
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  8. Article: A Case of Proliferative Glomerulonephritis with Monoclonal IgG Deposits That Showed Predominantly Membranous Features.

    Shimohata, Homare / Ohgi, Kentaro / Maruyama, Hiroshi / Miyamoto, Yasunori / Takayashu, Mamiko / Hirayama, Kouichi / Kobayashi, Masaki

    Case reports in nephrology

    2017  Volume 2017, Page(s) 1027376

    Abstract: In 2004, the novel category of monoclonal IgG deposition disease has been proposed and termed "proliferative glomerulonephritis with monoclonal IgG deposits" (PGNMID). This disease is characterized by membranoproliferative glomerulonephritis and staining ...

    Abstract In 2004, the novel category of monoclonal IgG deposition disease has been proposed and termed "proliferative glomerulonephritis with monoclonal IgG deposits" (PGNMID). This disease is characterized by membranoproliferative glomerulonephritis and staining for a single light-chain isotype and gamma heavy-chain subclass. A 76-year-old male who had monoclonal gammopathy was referred to our hospital because of proteinuria. The renal biopsy showed diffuse thickening of the glomerular capillary walls with focal mesangial proliferation. On immunofluorescence study, only IgG1 among the four subclasses and lambda light chains were detected mainly in the glomerular capillary walls. From these results, we diagnosed our case as PGNMID showing predominantly membranous features. Almost all pathological findings on light microscopy of PGNMID are membranoproliferative GN or endocapillary proliferative GN, while membranous GN cases are rare. Here, we present the case of PGNMID that showed predominantly membranous features on light microscopy.
    Language English
    Publishing date 2017-10-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627652-5
    ISSN 2090-665X ; 2090-6641
    ISSN (online) 2090-665X
    ISSN 2090-6641
    DOI 10.1155/2017/1027376
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  9. Article ; Online: The relationship between serum magnesium levels and mortality in non-diabetic hemodialysis patients: A 10-year follow-up study.

    Shimohata, Homare / Yamashita, Marina / Ohgi, Kentaro / Tsujimoto, Ryuji / Maruyama, Hiroshi / Takayasu, Mamiko / Hirayama, Kouichi / Kobayashi, Masaki

    Hemodialysis international. International Symposium on Home Hemodialysis

    2019  Volume 23, Issue 3, Page(s) 369–374

    Abstract: Introduction Recently, although there are many reports showing that serum magnesium concentration is a predictor of mortality in dialysis patients, the observation periods of those reports were of short duration, typically around 12 months. Thus, we ... ...

    Abstract Introduction Recently, although there are many reports showing that serum magnesium concentration is a predictor of mortality in dialysis patients, the observation periods of those reports were of short duration, typically around 12 months. Thus, we investigated this relationship over a longer follow-up period. Methods This retrospective, observational study included a total of 83 non-diabetic hemodialysis patients. The follow-up period was 120 months. Patients were divided into two groups, those with serum magnesium ≥2.5 mg/dL (Mg ≥2.5 mg/dL group) and serum magnesium <2.5 mg/dL (Mg <2.5 mg/dL group), and Kaplan-Meier analysis and Cox proportional hazards analysis were conducted. In addition to the above analysis, single and multiple regression analysis were performed at baseline to reveal the relationship between serum magnesium and clinical parameters. Findings During the follow-up period, 31 out of 83 patients died. Kaplan-Meier analysis showed a significantly higher incidence of death in the Mg <2.5 mg/dL group (log-rank test 4.951, P = 0.026). Multivariate Cox proportional hazards analysis showed a 62% decreased risk of mortality in the Mg ≥2.5 mg/dL group compared to the Mg <2.5 mg/dL group after adjustment for several confounding factors. Simple correlation coefficient analysis showed positive correlations of serum magnesium levels with serum creatinine, phosphorus, high-density lipoprotein, ankle-brachial index and KT/V, and a negative correlation with age. Multiple linear regression analysis showed that the ankle-brachial index was the only parameter that had a positive and significant correlation with the serum magnesium level. Conclusion Our study demonstrated that higher serum magnesium levels were associated with improved survival in non-diabetic hemodialysis patients.
    MeSH term(s) Female ; Follow-Up Studies ; Humans ; Magnesium/adverse effects ; Magnesium/blood ; Male ; Middle Aged ; Renal Dialysis/mortality ; Retrospective Studies ; Survival Analysis ; Time Factors
    Chemical Substances Magnesium (I38ZP9992A)
    Language English
    Publishing date 2019-04-30
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2192458-2
    ISSN 1542-4758 ; 1492-7535
    ISSN (online) 1542-4758
    ISSN 1492-7535
    DOI 10.1111/hdi.12759
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