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  1. Article ; Online: Undifferentiated Pleomorphic Sarcoma Invading the Internal Jugular Vein.

    Musha, Atsushi / Ohno, Tatsuya

    Practical radiation oncology

    2023  Volume 13, Issue 4, Page(s) 265–266

    Abstract: A 60-year-old woman received carbon ion radiotherapy (C-ion RT) (70.4 Gy [relative biological effectiveness]/16 fr) for undifferentiated pleomorphic sarcoma (UPS) (T4bN0M0) in the left pterygopalatine fossa. After 26 months, left parotid resection and ... ...

    Abstract A 60-year-old woman received carbon ion radiotherapy (C-ion RT) (70.4 Gy [relative biological effectiveness]/16 fr) for undifferentiated pleomorphic sarcoma (UPS) (T4bN0M0) in the left pterygopalatine fossa. After 26 months, left parotid resection and left neck dissection were performed for lymph node metastasis in the left parotid gland (no irradiation field). Pathological findings revealed a lymph node with UPS metastasis in the left parotid gland. However, no other metastases in the left cervical lymph node or vascular invasion were observed. Four months after surgery, magnetic resonance imaging revealed an invasion of the left internal jugular vein. Pathological examination of the vascular lesion was not possible because the patient did not consent to surgery. Undifferentiated pleomorphic sarcoma most commonly metastasizes to the lung, and there is currently no known report of vascular invasion. In this case, vascular invasion possibly developed due to changes in the perivascular tissues after the left neck dissection, which may have facilitated tumor invasion into the vascular wall. Based on the images and the clinical course, a rare condition for vascular invasion from UPS recurrence was considered.
    MeSH term(s) Female ; Humans ; Middle Aged ; Jugular Veins ; Lymph Nodes ; Lymphatic Metastasis ; Parotid Gland ; Sarcoma/radiotherapy
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2655748-4
    ISSN 1879-8519 ; 1879-8500
    ISSN (online) 1879-8519
    ISSN 1879-8500
    DOI 10.1016/j.prro.2023.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dose Distribution Degradation of Carbon-ion Radiotherapy Caused by Tumor Cell-specific Relative Biological Effectiveness of Osteosarcoma: A Simulation Study Using

    Shiba, Shintaro / Kawashima, Motohiro / Okamoto, Masahiko / Ohno, Tatsuya

    Anticancer research

    2023  Volume 43, Issue 11, Page(s) 4873–4878

    Abstract: Background/aim: Dose distributions of carbon-ion radiotherapy (C-ion RT) have been created with the relative biological effectiveness (RBE) of human salivary gland cells (HSG). However, no dose distributions have been created using various tumor cell- ... ...

    Abstract Background/aim: Dose distributions of carbon-ion radiotherapy (C-ion RT) have been created with the relative biological effectiveness (RBE) of human salivary gland cells (HSG). However, no dose distributions have been created using various tumor cell-specific RBE values. Hence, we conducted in vitro experiments to determine the RBE of human osteosarcoma cells (U2OS) and used this RBE value (RBE
    Materials and methods: To obtain RBE values for various linear energy transfer (LET) levels, we exposed U2OS cells to different doses of X-rays and varying doses and LET levels of C-ion beams (13, 30, 50, and 70 keV/μm). Subsequently, we converted the RBE of HSG (RBE
    Results: The RBE
    Conclusion: We utilized RBE
    MeSH term(s) Humans ; Relative Biological Effectiveness ; Heavy Ion Radiotherapy ; Osteosarcoma/radiotherapy ; Bone Neoplasms/radiotherapy ; Carbon
    Chemical Substances Carbon (7440-44-0)
    Language English
    Publishing date 2023-11-01
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Current status and future prospects of particle therapy (proton beam and heavy ion therapy) in Japan-in the special issue of the Journal of Radiation Research.

    Sakurai, Hideyuki / Ohno, Tatsuya / Ogawa, Kazuhiko

    Journal of radiation research

    2023  Volume 64, Issue Suppl 1, Page(s) i1

    MeSH term(s) Protons ; Japan ; Heavy Ion Radiotherapy ; Proton Therapy
    Chemical Substances Protons
    Language English
    Publishing date 2023-05-19
    Publishing country England
    Document type Editorial
    ZDB-ID 603983-2
    ISSN 1349-9157 ; 0449-3060
    ISSN (online) 1349-9157
    ISSN 0449-3060
    DOI 10.1093/jrr/rrad034
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 388: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Dose distribution estimation toward CT-less adaptive carbon ion radiotherapy for liver tumors using the divided-volume matching technique.

    Chen, Jing-Ni / Ohno, Tatsuya / Tashiro, Mutsumi

    Physics in medicine and biology

    2023  Volume 68, Issue 20

    Abstract: ... ...

    Abstract Objective
    Language English
    Publishing date 2023-10-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/acfc93
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 199: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: ASO Author Reflections: Long-Term Perspective in Choosing Between Carbon-Ion Radiotherapy and Surgery for Malignant Pelvic Bone Tumors.

    Zhang, Liuzhe / Akiyama, Toru / Ohno, Tatsuya

    Annals of surgical oncology

    2023  Volume 30, Issue 7, Page(s) 4485–4486

    MeSH term(s) Humans ; Bone Neoplasms/radiotherapy ; Bone Neoplasms/surgery ; Pelvis ; Carbon
    Chemical Substances Carbon (7440-44-0)
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13293-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Subcutaneous Emphysema Caused by Third Molar Extraction.

    Musha, Atsushi / Ohno, Tatsuya

    OTO open

    2021  Volume 5, Issue 1, Page(s) 2473974X211004527

    Language English
    Publishing date 2021-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 2473-974X
    ISSN (online) 2473-974X
    DOI 10.1177/2473974X211004527
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  7. Article: Association between Tumor Mutational Burden, Stromal CD8

    Ruan, Hanguang / Oike, Takahiro / Sato, Hiro / Ando, Ken / Ohno, Tatsuya

    Cancers

    2023  Volume 15, Issue 4

    Abstract: Background: Tumor mutational burden (TMB) and stromal CD8-positive tumor-infiltrating lymphocytes (CD8: Methods: Patients with squamous cell carcinoma of the uterine cervix treated with definitive radiotherapy, and with available somatic mutation ... ...

    Abstract Background: Tumor mutational burden (TMB) and stromal CD8-positive tumor-infiltrating lymphocytes (CD8
    Methods: Patients with squamous cell carcinoma of the uterine cervix treated with definitive radiotherapy, and with available somatic mutation data and immunohistochemical staining data from identical tumor tissues, were enrolled retrospectively. The association between TMB and/or CD8
    Results: The study analyzed 44 patients (median follow-up period, 61 months). There was no significant correlation between TMB and CD8
    Conclusions: These data indicate independence of TMB and CD8
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15041210
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  8. Article: Particle radiotherapy for breast cancer.

    Ruan, Hanguang / Okamoto, Masahiko / Ohno, Tatsuya / Li, Yang / Zhou, Yuan

    Frontiers in oncology

    2023  Volume 13, Page(s) 1107703

    Abstract: Breast cancer is the most common malignant tumor in female patients. Along with surgery, radiotherapy is one of the most commonly prescribed treatments for breast cancer. Over the past few decades, breast cancer radiotherapy technology has significantly ... ...

    Abstract Breast cancer is the most common malignant tumor in female patients. Along with surgery, radiotherapy is one of the most commonly prescribed treatments for breast cancer. Over the past few decades, breast cancer radiotherapy technology has significantly improved. Nevertheless, related posttherapy complications should not be overlooked. Common complications include dose-related coronary toxicity, radiation pneumonia, and the risk of second primary cancer of the contralateral breast. Particle radiotherapy with protons or carbon ions is widely attracting interest as a potential competitor to conventional photon radiotherapy because of its superior physical and biological characteristics. This article summarizes the results of clinical research on proton and carbon-ion radiotherapy for treating breast cancer.
    Language English
    Publishing date 2023-08-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1107703
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  9. Article ; Online: Visualizing Bioabsorbable Spacer Effectiveness by Confirming the Distal-Tail of Carbon-Ion Beams: First-In-Human Report.

    Shiba, Shintaro / Okamoto, Masahiko / Sakai, Makoto / Ohno, Tatsuya

    Tomography (Ann Arbor, Mich.)

    2022  Volume 8, Issue 5, Page(s) 2339–2346

    Abstract: In particle therapy, bioabsorbable polyglycolic acid (PGA) spacer was developed to reduce the healthy organ irradiation dose, especially in the gastrointestinal tract. The PGA spacer is safe and effective; however, there are no reports that have ... ...

    Abstract In particle therapy, bioabsorbable polyglycolic acid (PGA) spacer was developed to reduce the healthy organ irradiation dose, especially in the gastrointestinal tract. The PGA spacer is safe and effective; however, there are no reports that have confirmed whether the PGA spacer which inserted in the body actually stops the carbon-ion (C-ion) beams. Here, we visualized and confirmed that the PGA spacer stops the C-ion beams in the body based on the dose distribution using auto-activation positron emission tomography (AAPET). A 59-year-old dedifferentiated retroperitoneal liposarcoma patient underwent C-ion radiotherapy (C-ion RT) on referral. A month before C-ion RT initiation, the patient underwent PGA spacer placement. Postoperatively, the patient received 4.4 Gy (RBE) per fraction of C-ion RT, followed by AAPET. AAPET revealed lower positron emitter concentrations at the distal tissue ventral to the PGA spacer than in the planning target volume. In observing the efficacy of the PGA spacer, the AAPET images and the average count per second of the positron emitter suggested that the PGA spacer stopped the C-ion beams in the body in accordance with the dose distribution. Therefore, AAPET was useful in confirming the PGA spacer's effectiveness in this study, and the PGA spacer stopped the C-ion beams.
    MeSH term(s) Humans ; Middle Aged ; Carbon/therapeutic use ; Absorbable Implants ; Prostaglandins A ; Tomography, X-Ray Computed ; Ions ; Polyglycolic Acid
    Chemical Substances Carbon (7440-44-0) ; Prostaglandins A ; Ions ; Polyglycolic Acid (26009-03-0)
    Language English
    Publishing date 2022-09-21
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2379-139X
    ISSN (online) 2379-139X
    DOI 10.3390/tomography8050195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Pembrolizumab After Carbon Ion Radiation Therapy for Alveolar Soft Part Sarcoma Shows a Remarkable Abscopal Effect: A Case Report.

    Okamoto, Masahiko / Sato, Hiro / Gao, Xianshu / Ohno, Tatsuya

    Advances in radiation oncology

    2022  Volume 7, Issue 3, Page(s) 100893

    Language English
    Publishing date 2022-01-04
    Publishing country United States
    Document type Case Reports
    ISSN 2452-1094
    ISSN 2452-1094
    DOI 10.1016/j.adro.2021.100893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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