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Article ; Online: Follow the time course of inflammation caused by intraperitoneal administration of multi-wall carbon nanotubes in mice.

Horie, Masanori / Sugino, Sakiko / Ohno, Tomoki

International journal of immunopathology and pharmacology

2023 Volume 37, Page(s) 3946320231176402

Abstract: Objective: Understand the progress of inflammation over time caused by multi-walled carbon nanotubes (MWCNT).: Methods: Two types of MWCNTs were administered to C57BL/6N mice via intraperitoneal administration at low and high doses (0.05 and 1.0 mg/ ... ...

Abstract	Objective: Understand the progress of inflammation over time caused by multi-walled carbon nanotubes (MWCNT). Methods: Two types of MWCNTs were administered to C57BL/6N mice via intraperitoneal administration at low and high doses (0.05 and 1.0 mg/mouse, respectively). Inflammation was evaluated until 6 months after administration based on cytokine levels and pathological observations. The abdominal cavity lavage fluid was collected and analyzed 1 week, 1, 3, and 6 month(s) after administration. IL-6 expression markedly increased 3 months after the administration of high-dose MWCNT-7. Results: Notable inflammation was observed in the groups administered with one of the MWCNT, MWCNT-7. On the other hand, inflammation in another MWCNT-treated group was milder than that in the MWCNT-7-treated group. MWCNT-7 induced pronounced inflammation but did not induce tumor formation during the experimental period. Inflammation reaction is one of the most important biological responses to MWCNT. Conclusion: Three months post-exposure becomes a turning point for the harmful effects of the intraperitoneally administered MWCNT-7.
MeSH term(s)	Mice ; Animals ; Lung ; Nanotubes, Carbon/toxicity ; Mice, Inbred C57BL ; Cytokines/metabolism ; Inflammation/metabolism ; Bronchoalveolar Lavage Fluid
Chemical Substances	Nanotubes, Carbon ; Cytokines
Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Journal Article
ZDB-ID	645171-8
ISSN	2058-7384 ; 0394-6320
ISSN (online)	2058-7384
ISSN	0394-6320
DOI	10.1177/03946320231176402
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Article ; Online: Variations in fungal and bacterial microbiome and chemical composition among fermenting Kishu-Narezushi batches.

Kubo, Miki / Niwa, Ryo / Ohno, Tomoki / Iwahashi, Hitoshi

Bioscience, biotechnology, and biochemistry

2022 Volume 86, Issue 12, Page(s) 1705–1717

Abstract: Kishu-Narezushi is a spontaneously fermented food comprising fish, rice, and salt. During spontaneous fermentation, the microbiome may differ among batches, even when manufactured in the same way. In addition, analyses of changes in the chemical ... ...

Abstract	Kishu-Narezushi is a spontaneously fermented food comprising fish, rice, and salt. During spontaneous fermentation, the microbiome may differ among batches, even when manufactured in the same way. In addition, analyses of changes in the chemical composition of the product are important for clarifying flavor characteristics. We collected basic information on the microbiome and chemical composition of Kishu-Narezushi using multiple batches of fermentation and evaluated whether the microbiome was homogeneous. The fungal microbiome of Kishu-Narezushi was dominated by Saccharomycetales and Trichosporonales. The bacterial microbiome was diverse, although seven specific genera of lactic acid bacteria were identified. Glutamic acid, histidine, and serine levels decreased after ∼10 days of fermentation. Succinic acid, characteristic of Kishu-Narezushi, accumulated upon the consumption of glutamic acid. Though the microbiome was diverse, the chemical composition was similar among the batches.
MeSH term(s)	Animals ; Glutamic Acid ; Bacteria ; Microbiota ; Fermentation ; Lactobacillales
Chemical Substances	Glutamic Acid (3KX376GY7L)
Language	English
Publishing date	2022-10-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1106450-x
ISSN	1347-6947 ; 0916-8451
ISSN (online)	1347-6947
ISSN	0916-8451
DOI	10.1093/bbb/zbac165
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Article ; Online: Diversity of Lactic Acid Bacteria Involved in the Fermentation of Awa-bancha.

Nishioka, Hiroki / Ohno, Tomoki / Iwahashi, Hitoshi / Horie, Masanori

Microbes and environments

2021 Volume 36, Issue 4

Abstract: The lactic acid bacteria involved in fermentation and components in the tea leaves of Awa-bancha, a post-fermented tea produced in Naka, Kamikatsu, and Miyoshi, Tokushima, were investigated in the present study. Lactic acid bacteria were isolated from ... ...

Abstract	The lactic acid bacteria involved in fermentation and components in the tea leaves of Awa-bancha, a post-fermented tea produced in Naka, Kamikatsu, and Miyoshi, Tokushima, were investigated in the present study. Lactic acid bacteria were isolated from tea leaves after anaerobic fermentation and identified by multiplex PCR targeting of the recA gene and 16S ribosomal RNA gene homology. Lactiplantibacillus pentosus was the most frequently isolated species in Naka and Kamikatsu and Lactiplantibacillus plantarum in Miyoshi. In the phylogenetic tree based on the dnaK gene, L. pentosus isolated from Awa-bancha was roughly grouped by the production area and producer. The bacterial flora after anaerobic fermentation was dominated by Lactiplantibacillus spp. for most producers, and the compositions of samples from each producer varied. Organic acids, free amino acids, and catechins were analyzed as components related to the flavor of Awa-bancha. These components were unique to each producer. The present results revealed diversity in the lactic acid bacteria and flavor of Awa-bancha that depended on the producer.
MeSH term(s)	Fermentation ; Japan ; Lactobacillales/cytology ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Tea/microbiology
Chemical Substances	RNA, Ribosomal, 16S ; Tea
Language	English
Publishing date	2021-11-25
Publishing country	Japan
Document type	Journal Article
ISSN	1347-4405
ISSN (online)	1347-4405
DOI	10.1264/jsme2.ME21029
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Article ; Online: Recycling salmon meat by decontamination under mild conditions using high-pressure carbon dioxide.

Yu, Tonghuan / Kuwahara, Shinichi / Ohno, Tomoki / Iwahashi, Hitoshi

Waste management (New York, N.Y.)

2021 Volume 124, Page(s) 102–109

Abstract: The 2011-2016 reports from the Food and Agriculture Organization of the United Nations has stated that annual food loss and waste occurs on a massive scale in fisheries and aquaculture. This study aimed to explore advanced technologies to recycle wasted ... ...

Abstract	The 2011-2016 reports from the Food and Agriculture Organization of the United Nations has stated that annual food loss and waste occurs on a massive scale in fisheries and aquaculture. This study aimed to explore advanced technologies to recycle wasted salmon as an industrial resource with high commercial value by applying enzymatic hydrolysis under HPCD. Our results showed that HPCD treatment at 50 °C and 1 MPa for 16 h effectively prevents salmon from microbial contamination. Real-time PCR analysis demonstrated that HPCD was also able to inhibit an increase in bacteria at moderate temperatures. Based on NGS analysis, there was a very low abundance of Bacillus and some histamine producers, such as Pseudomonas, Acinetobacter, Enterobacter, and Klebsiella, detected in samples treated using HPCD at 50 °C and 1 MPa for 16 h. Hydrolysate analysis showed that HPCD treatment at 1 MPa did not affect the hydrolysates from salmon. It is anticipated that the results from this study will support the application of HPCD in industrial enzymatic hydrolysis and increase the sustainability of bio-based materials.
MeSH term(s)	Animals ; Carbon Dioxide ; Decontamination ; Food Microbiology ; Meat ; Salmon
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2021-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2001471-5
ISSN	1879-2456 ; 0956-053X
ISSN (online)	1879-2456
ISSN	0956-053X
DOI	10.1016/j.wasman.2021.01.041
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Article ; Online: Molecular networking-based lipid profiling and multi-omics approaches reveal new contributions of functional vanilloids to gut microbiota and lipometabolism changes.

Hattori, Hiroyuki / Moriyama, Akihiro / Ohno, Tomoki / Shibata, Takahiro / Iwahashi, Hitoshi / Mitsunaga, Tohru

Food chemistry. Molecular sciences

2022 Volume 5, Page(s) 100123

Abstract: Obesity is now recognized as an epidemic, requiring rapid intervention. We previously demonstrated that vanilloids from the African spice known as Grains of Paradise (GOP) exhibit strong anti-obesity effects. Here, the molecular mechanism behind the ... ...

Abstract	Obesity is now recognized as an epidemic, requiring rapid intervention. We previously demonstrated that vanilloids from the African spice known as Grains of Paradise (GOP) exhibit strong anti-obesity effects. Here, the molecular mechanism behind the obesity prevention property of the GOP extract was investigated by employing molecular networking-based lipid profiling and 16S rRNA sequencing. Administration of either GOP extract or two of its components, 6-paradol and 6-gingerol, reversed the unbalanced gut microbiota composition induced by a high-fat diet (HFD) with a decrease in Firmicutes / Bacteroidetes ratio and increase in genera
Language	English
Publishing date	2022-07-18
Publishing country	England
Document type	Journal Article
ISSN	2666-5662
ISSN (online)	2666-5662
DOI	10.1016/j.fochms.2022.100123
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Article ; Online: Controlling the microbial composition during the fermentation of Ishizuchi-kurocha.

Li, Zuoqian / Jiang, Lei / Wei, Lingdong / Ohno, Tomoki / Syaputri, Yolani / Horie, Masanori / Iwahashi, Hitoshi

Bioscience, biotechnology, and biochemistry

2021 Volume 86, Issue 1, Page(s) 117–124

Abstract: Ishizuchi-kurocha is a popular postfermented tea in Japan. It is performed by domestic and natural fermentation relied on microorganisms derived from tea leaves or the environment of the manufacturing. Ishizuchi-kurocha undergoes aerobic fermentation of ... ...

Abstract	Ishizuchi-kurocha is a popular postfermented tea in Japan. It is performed by domestic and natural fermentation relied on microorganisms derived from tea leaves or the environment of the manufacturing. Ishizuchi-kurocha undergoes aerobic fermentation of fungi first, then second fermented by anaerobic fermentation of lactic acid bacteria during natural fermentation processing. Aspergillus niger that produces mycotoxin is included in natural fermentation. This research aimed to build a novel fermentation method of Ishizuchi-kurocha by adding industrial koji fungi products and laboratory-cultivated Lactobacillus plantarum (Lactiplantibacillus plantarum) artificially. Thus, safety and quality of tea products could be controlled simply. We found artificial fermentation of Ishizuchi-kurocha could get high lactic acid production within 8 days. Final products only consisted of genus Aspergillus and genus Lactobacillus, while harmful Aspergillus niger was not found. However, artificial fermentation methods also decreased the content of polyphenols when compared with commercial tea.
MeSH term(s)	Aspergillus
Language	English
Publishing date	2021-11-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1106450-x
ISSN	1347-6947 ; 0916-8451
ISSN (online)	1347-6947
ISSN	0916-8451
DOI	10.1093/bbb/zbab184
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Zs.A 4647: Show issues

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Article: Clinical Outcomes and Prevalence of Sarcopenia in Patients with Moderate to Severe COVID-19.

Yamamoto, Shuhei / Sakai, Yasunari / Matsumori, Keiji / Osawa, Ryuji / Ito, Shun / Tsukakoshi, Daichi / Ohno, Tomoki / Ohta, Hiroaki / Ichiyama, Takashi / Komatsu, Masamichi / Wada, Yosuke / Hanaoka, Masayuki / Ikegami, Shota / Horiuchi, Hiroshi

Journal of clinical medicine

2022 Volume 11, Issue 21

Abstract: Background: The purpose of this study was to investigate the effectiveness and clinical outcomes of inpatient rehabilitation for patients with severe COVID-19 in Japan. Methods: Patients with severe COVID-19 who underwent rehabilitation during ... ...

Abstract	Background: The purpose of this study was to investigate the effectiveness and clinical outcomes of inpatient rehabilitation for patients with severe COVID-19 in Japan. Methods: Patients with severe COVID-19 who underwent rehabilitation during hospitalization were included. The Medical Research Council (MRC) score and short physical performance battery (SPPB), such as physical function assessment and the intensive care unit (ICU) mobility scale, the functional status score for the ICU, and Barthel index as activities of daily living (ADLs) were evaluated at admission and discharge or transfer from the hospital. The correlation between SPPB at discharge and each factor at admission were also analyzed. Furthermore, the prevalence of sarcopenia was evaluated by defining SPPB of <9 points at discharge as sarcopenia. Results: The median age of the total of 23 patients was 59 years (interquartile range (IQR): 47−67), 73.9% were male, and the median PaO2/FiO2 at admission was 172.0 (IQR: 123.0−209.0). All physical function and ADL parameters were significantly improved from the time of admission to discharge (p = 0.014 for the MRC score and p < 0.001 for all others). Moreover, SPPB at discharge significantly correlated with WBC (Spearman’s rho = −0.473, p = 0.041), C-reactive protein (Spearman’s rho = −0.468, p = 0.044), and exhibited a significant trend with PaO2/FiO2 (Spearman’s rho = 0.429, p = 0.067) and age (Spearman’s rho = 0.409, p = 0.083). Although the median Barthel index at discharge was 90 points, 47% of patients had sarcopenia as defined by an SPPB of <9 points. Conclusions: Early rehabilitation for patients with severe COVID-19 improved physical function and ADLs during hospitalization. However, 47% of patients had the same level of sarcopenia at discharge.
Language	English
Publishing date	2022-11-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11216578
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Article ; Online: Study of surface plasmon chirality induced by Archimedes' spiral grooves.

Ohno, Tomoki / Miyanishi, Shintaro

Optics express

2009 Volume 14, Issue 13, Page(s) 6285–6290

Abstract: A chirality of surface plasmons excited on a silver film with Archimedes' spiral grooves during incidence of a circularly polarized light is analytically and numerically studied by using the finite-difference time-domain (FDTD) modeling method. We found ... ...

Abstract	A chirality of surface plasmons excited on a silver film with Archimedes' spiral grooves during incidence of a circularly polarized light is analytically and numerically studied by using the finite-difference time-domain (FDTD) modeling method. We found that the surface of a plasmon has selective chirality, which is given by the sum of the chiralities of the incident light and the spiral structure. The surface plasmons with the chirality lead to zero-order, first-order, and high-order evanescent Bessel beams with electric charge distributions on the film. This selectivity could be widely applied for chiral detection of the incident light and chiral excitation of several optical modes in nanophotonics.
Language	English
Publishing date	2009-08-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/oe.14.006285
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Book ; Online: Radiative–convective equilibrium model intercomparison project

Wing, Allison A. / Reed, Kevin A. / Satoh, Masaki / Stevens, Bjorn / Bony, Sandrine / Ohno, Tomoki

eISSN: 1991-9603

2018

Abstract: RCEMIP, an intercomparison of multiple types of models configured in radiative–convective equilibrium (RCE), is proposed. RCE is an idealization of the climate system in which there is a balance between radiative cooling of the atmosphere and heating by ... ...

Abstract	RCEMIP, an intercomparison of multiple types of models configured in radiative–convective equilibrium (RCE), is proposed. RCE is an idealization of the climate system in which there is a balance between radiative cooling of the atmosphere and heating by convection. The scientific objectives of RCEMIP are three-fold. First, clouds and climate sensitivity will be investigated in the RCE setting. This includes determining how cloud fraction changes with warming and the role of self-aggregation of convection in climate sensitivity. Second, RCEMIP will quantify the dependence of the degree of convective aggregation and tropical circulation regimes on temperature. Finally, by providing a common baseline, RCEMIP will allow the robustness of the RCE state across the spectrum of models to be assessed, which is essential for interpreting the results found regarding clouds, climate sensitivity, and aggregation, and more generally, determining which features of tropical climate a RCE framework is useful for. A novel aspect and major advantage of RCEMIP is the accessibility of the RCE framework to a variety of models, including cloud-resolving models, general circulation models, global cloud-resolving models, single-column models, and large-eddy simulation models.
Subject code	551
Language	English
Publishing date	2018-09-27
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Radiative-Convective Equilibrium Model Intercomparison Project

Wing, Allison A. / Reed, Kevin A. / Satoh, Masaki / Stevens, Bjorn / Bony, Sandrine / Ohno, Tomoki

eISSN: 1991-9603

2017

Abstract: RCEMIP , an intercomparison of multiple types of models configured in radiative-convective equilibrium ( RCE ), is proposed. RCE is an idealization of the climate system in which there is a balance between radiative cooling of the atmosphere and heating ... ...

Abstract	RCEMIP , an intercomparison of multiple types of models configured in radiative-convective equilibrium ( RCE ), is proposed. RCE is an idealization of the climate system in which there is a balance between radiative cooling of the atmosphere and heating by convection. The scientific objectives of RCEMIP are three-fold. First, clouds and climate sensitivity will be investigated in the RCE setting. This includes determining how cloud fraction changes with warming and the role of self-aggregation of convection. Second, RCEMIP will quantify the dependence of the degree of convective aggregation and tropical circulation regimes on temperature. Finally, by providing a common baseline, RCEMIP will allow the robustness of the RCE state, cloud feedbacks, and convective aggregation across the spectrum of models to be assessed. A novel aspect and major advantage of RCEMIP is the accessibility of the RCE framework to a variety of models, including cloud-resolving models, general circulation models, global cloud-resolving models, and single column models.
Subject code	551
Language	English
Publishing date	2017-09-19
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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