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Article ; Online: SH-SY5Y human neuronal cells with mutations of the

Ohno-Oishi, Michiko / Meiai, Zou / Sato, Kota / Kanno, Seiya / Kawano, Chihiro / Ishikawa, Makoto / Nakazawa, Toru

2024 Volume 38, Page(s) 101723

Abstract: Glaucoma is a common cause of blindness worldwide. Genetic effects are believed to contribute to the onset and progress of glaucoma, but the underlying pathological mechanisms are not fully understood. Here, we set out to introduce mutations into ... ...

Abstract	Glaucoma is a common cause of blindness worldwide. Genetic effects are believed to contribute to the onset and progress of glaucoma, but the underlying pathological mechanisms are not fully understood. Here, we set out to introduce mutations into the
Language	English
Publishing date	2024-05-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2831046-9
ISSN	2405-5808 ; 2405-5808
ISSN (online)	2405-5808
ISSN	2405-5808
DOI	10.1016/j.bbrep.2024.101723
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Article ; Online: New Dihydropyridine Derivative Attenuates NF-κB Activation via Suppression of Calcium Influx in a Mouse BV-2 Microglial Cell Line.

Sato, Kota / Sasaki, Yuto / Ohno-Oishi, Michiko / Kano, Kuniyuki / Aoki, Junken / Ohsawa, Kosuke / Doi, Takayuki / Yamakoshi, Hiroyuki / Iwabuchi, Yoshiharu / Kawano, Chihiro / Hirata, Yoshiyuki / Nakazawa, Toru

The Tohoku journal of experimental medicine

2024

Language	English
Publishing date	2024-04-04
Publishing country	Japan
Document type	Journal Article
ZDB-ID	123477-8
ISSN	1349-3329 ; 0040-8727
ISSN (online)	1349-3329
ISSN	0040-8727
DOI	10.1620/tjem.2024.J024
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Article: A Plant-Derived Antioxidant Supplement Prevents the Loss of Retinal Ganglion Cells in the Retinas of NMDA-Injured Mice.

Maekawa, Shigeto / Sato, Kota / Kokubun, Taiki / Himori, Noriko / Yabana, Takeshi / Ohno-Oishi, Michiko / Shi, Ge / Omodaka, Kazuko / Nakazawa, Toru

Clinical ophthalmology (Auckland, N.Z.)

2022 Volume 16, Page(s) 823–832

Abstract: Purpose: To investigate the effect of plant-derived antioxidant compounds, identified with primary culture screening, on retinal ganglion cell (RGC) survival in mice under excitotoxic conditions. Additionally, to determine the effect of these compounds ... ...

Abstract	Purpose: To investigate the effect of plant-derived antioxidant compounds, identified with primary culture screening, on retinal ganglion cell (RGC) survival in mice under excitotoxic conditions. Additionally, to determine the effect of these compounds on the involvement of calpain inactivation. Materials and methods: Plant-derived antioxidant compounds including hesperidin, crocetin, and Results: Plant-derived antioxidant compounds significantly ameliorated the increase in the level of MDA in the retinas after NMDA injury. Cleaved α-fodrin fragments were detected in the NMDA-injured retinas, and these fragments were significantly lower in mice that received the plant-derived antioxidant compounds. The plant-derived antioxidants also ameliorated increases in TUNEL-positive cells and RGC death after NMDA injection. Conclusion: These results indicate that oral administration of plant-derived antioxidant compounds such as hesperidin, crocetin, and
Language	English
Publishing date	2022-03-18
Publishing country	New Zealand
Document type	Journal Article
ISSN	1177-5467
ISSN	1177-5467
DOI	10.2147/OPTH.S354958
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Article ; Online: Author Correction: Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma.

Sato, Kota / Saigusa, Daisuke / Kokubun, Taiki / Fujioka, Amane / Feng, Qiwei / Saito, Ritsumi / Uruno, Akira / Matsukawa, Naomi / Ohno-Oishi, Michiko / Kunikata, Hiroshi / Yokoyama, Yu / Yasuda, Masayuki / Himori, Noriko / Omodaka, Kazuko / Tsuda, Satoru / Maekawa, Shigeto / Yamamoto, Masayuki / Nakazawa, Toru

npj aging

2024 Volume 10, Issue 1, Page(s) 8

Language	English
Publishing date	2024-01-20
Publishing country	England
Document type	Published Erratum
ISSN	2731-6068
ISSN (online)	2731-6068
DOI	10.1038/s41514-024-00137-5
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Article ; Online: Identification of a novel enhancer essential for

Nomura, Aneela / Kobayashi, Tetsuro / Seo, Wooseok / Ohno-Oishi, Michiko / Kakugawa, Kiyokazu / Muroi, Sawako / Yoshida, Hideyuki / Endo, Takaho A / Moro, Kazuyo / Taniuchi, Ichiro

Life science alliance

2023 Volume 6, Issue 8

Abstract: The genome organizer, special AT-rich binding protein-1 (SATB1), functions to globally regulate gene networks during primary T cell development and plays a pivotal role in lineage specification in ... ...

Abstract	The genome organizer, special AT-rich binding protein-1 (SATB1), functions to globally regulate gene networks during primary T cell development and plays a pivotal role in lineage specification in CD4
MeSH term(s)	Animals ; Mice ; Matrix Attachment Region Binding Proteins/genetics ; Matrix Attachment Region Binding Proteins/metabolism ; Immunity, Innate ; Lymphocytes ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Cell Differentiation
Chemical Substances	Matrix Attachment Region Binding Proteins ; Transcription Factors ; Satb1 protein, mouse
Language	English
Publishing date	2023-05-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2575-1077
ISSN (online)	2575-1077
DOI	10.26508/lsa.202301897
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Article ; Online: The GPR84 molecule is a mediator of a subpopulation of retinal microglia that promote TNF/IL-1α expression via the rho-ROCK pathway after optic nerve injury.

Sato, Kota / Ohno-Oishi, Michiko / Yoshida, Masaaki / Sato, Taimu / Aizawa, Takaharu / Sasaki, Yuto / Maekawa, Shigeto / Ishikawa, Makoto / Omodaka, Kazuko / Kawano, Chihiro / Ohue-Kitano, Ryuji / Kimura, Ikuo / Nakazawa, Toru

Glia

2023 Volume 71, Issue 11, Page(s) 2609–2622

Abstract: Resident microglia are important to maintain homeostasis in the central nervous system, which includes the retina. The retinal microglia become activated in numerous pathological conditions, but the molecular signatures of these changes are poorly ... ...

Abstract	Resident microglia are important to maintain homeostasis in the central nervous system, which includes the retina. The retinal microglia become activated in numerous pathological conditions, but the molecular signatures of these changes are poorly understood. Here, using an approach based on FACS and RNA-seq, we show that microglial gene expression patterns gradually change during RGC degeneration induced by optic nerve injury. Most importantly, we found that the microglial cells strongly expressed Tnf and Il1α, both of which are known to induce neurotoxic reactive astrocytes, and were characterized by Gpr84
MeSH term(s)	Mice ; Animals ; Optic Nerve Injuries ; Microglia/metabolism ; Retinal Ganglion Cells ; rho-Associated Kinases/metabolism ; Neuroglia/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism
Chemical Substances	rho-Associated Kinases (EC 2.7.11.1) ; Gpr84 protein, mouse ; Receptors, G-Protein-Coupled
Language	English
Publishing date	2023-07-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639414-0
ISSN	1098-1136 ; 0894-1491
ISSN (online)	1098-1136
ISSN	0894-1491
DOI	10.1002/glia.24442
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Zs.A 2345: Show issues

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Article ; Online: Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma.

npj aging

2023 Volume 9, Issue 1, Page(s) 28

Abstract: Glaucoma is a leading cause of blindness worldwide in older people. Profiling the aqueous humor, including the metabolites it contains, is useful to understand physiological and pathological conditions in the eye. In the current study, we used mass ... ...

Abstract	Glaucoma is a leading cause of blindness worldwide in older people. Profiling the aqueous humor, including the metabolites it contains, is useful to understand physiological and pathological conditions in the eye. In the current study, we used mass spectrometry (MS) to characterize the aqueous humor metabolomic profile and biological features of patients with glaucoma. Aqueous humor samples were collected during trabeculectomy surgery or cataract surgery and analyzed with global metabolomics. We included 40 patients with glaucoma (32 with POAG, 8 with NTG) and 37 control subjects in a discovery study. VIP analysis revealed five metabolites that were elevated and three metabolites that were reduced in the glaucoma patients. The identified metabolomic profile had an area under the receiver operating characteristic curve of 0.953. Among eight selected metabolites, the glutathione level was significantly decreased in association with visual field defects. Moreover, in a validation study to confirm the reproducibility of our findings, the glutathione level was reduced in NTG and POAG patients compared with a cataract control group. Our findings demonstrate that aqueous humor profiling can help to diagnose glaucoma and that various aqueous humor metabolites are correlated with clinical parameters in glaucoma patients. In addition, glutathione is clearly reduced in the aqueous humor of glaucoma patients with both IOP-dependent and IOP-independent disease subtypes. These findings indicate that antioxidant agents in the aqueous humor reflect glaucomatous optic nerve damage and that excessive oxidative stress may be involved in the pathogenesis of glaucoma.
Language	English
Publishing date	2023-11-21
Publishing country	England
Document type	Journal Article
ISSN	2731-6068
ISSN (online)	2731-6068
DOI	10.1038/s41514-023-00124-2
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Article ; Online: Constitutive CD8 expression drives innate CD8

Kojo, Satoshi / Ohno-Oishi, Michiko / Wada, Hisashi / Nieke, Sebastian / Seo, Wooseok / Muroi, Sawako / Taniuchi, Ichiro

Life science alliance

2020 Volume 3, Issue 2

Abstract: Temporal down-regulation of the CD8 co-receptor after receiving positive-selection signals has been proposed to serve as an important determinant to segregate helper versus cytotoxic lineages by generating differences in the duration of TCR signaling ... ...

Abstract	Temporal down-regulation of the CD8 co-receptor after receiving positive-selection signals has been proposed to serve as an important determinant to segregate helper versus cytotoxic lineages by generating differences in the duration of TCR signaling between MHC-I and MHC-II selected thymocytes. By contrast, little is known about whether CD8 also modulates TCR signaling engaged by the non-classical MHC-I-like molecule, CD1d, during development of invariant natural killer T (iNKT) cells. Here, we show that constitutive transgenic CD8 expression resulted in enhanced differentiation of innate memory-like CD8
MeSH term(s)	Animals ; CD8 Antigens/genetics ; CD8 Antigens/metabolism ; CD8-Positive T-Lymphocytes/immunology ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Cells, Cultured ; Immunity, Innate ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Natural Killer T-Cells/immunology ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction/genetics ; Thymocytes/immunology ; Transfection
Chemical Substances	CD8 Antigens ; CD8 antigen, alpha chain ; Cd8b1 protein, mouse ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2020-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2575-1077
ISSN (online)	2575-1077
DOI	10.26508/lsa.202000642
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Article ; Online: CHOP deletion and anti-neuroinflammation treatment with hesperidin synergistically attenuate NMDA retinal injury in mice.

Sato, Kota / Sato, Taimu / Ohno-Oishi, Michiko / Ozawa, Mikako / Maekawa, Shigeto / Shiga, Yukihiro / Yabana, Takeshi / Yasuda, Masayuki / Himori, Noriko / Omodaka, Kazuko / Fujita, Kosuke / Nishiguchi, Koji M / Ge, Shi / Nakazawa, Toru

Experimental eye research

2021 Volume 213, Page(s) 108826

Abstract: Glaucoma is a leading cause of blindness worldwide and is characterized by degeneration associated with the death of retinal ganglion cells (RGCs). It is believed that glaucoma is a group of heterogeneous diseases with multifactorial pathomechanisms. ... ...

Abstract	Glaucoma is a leading cause of blindness worldwide and is characterized by degeneration associated with the death of retinal ganglion cells (RGCs). It is believed that glaucoma is a group of heterogeneous diseases with multifactorial pathomechanisms. Here, we investigate whether anti-inflammation treatment with an ER stress blockade can selectively promote neuroprotection against NMDA injury in the RGCs. Retinal excitotoxicity was induced with an intravitreal NMDA injection. Microglial activation and neuroinflammation were evaluated with Iba1 immunostaining and cytokine gene expression. A stable HT22 cell line transfected with an NF-kB reporter was used to assess NF-kB activity after hesperidin treatment. CHOP-deficient mice were used as a model of ER stress blockade. Retinal cell death was evaluated with a TUNEL assay. As results, in the NMDA injury group, Iba1-positive microglia increased 6 h after NMDA injection. Also at 6 h, pro-inflammatory cytokines and chemokine increased, including TNFα, IL-1b, IL-6 and MCP-1. In addition, the MCP-1 promoter-driven EGFP signal, which we previously identified as a stress signal in injured RGCs, also increased; hesperidin treatment suppressed this inflammatory response and reduced stressed RGCs. In CHOP-deficient mice that received an NMDA injection, the gene expression of pro-inflammatory cytokines, chemokines, markers of active microglia, and inflammatory regulators was greater than in WT mice. In WT mice, hesperidin treatment partially prevented retinal cell death after NMDA injury; this neuroprotective effect was enhanced in CHOP-deficient mice. These findings demonstrate that ER stress blockade is not enough by itself to prevent RGC loss due to neuroinflammation in the retina, but it has a synergistic neuroprotective effect after NMDA injury when combined with an anti-inflammatory treatment based on hesperidin.
MeSH term(s)	Animals ; Blotting, Western ; Calcium-Binding Proteins/metabolism ; Cytokines/metabolism ; Disease Models, Animal ; Drug Synergism ; Gene Deletion ; Hesperidin/therapeutic use ; Immunohistochemistry ; In Situ Nick-End Labeling ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microfilament Proteins/metabolism ; Microglia/metabolism ; N-Methylaspartate/toxicity ; NF-kappa B/metabolism ; Neuroprotection ; Oxidative Stress/drug effects ; Real-Time Polymerase Chain Reaction ; Retinal Diseases/chemically induced ; Retinal Diseases/drug therapy ; Retinal Diseases/metabolism ; Retinal Ganglion Cells/drug effects ; Retinal Ganglion Cells/metabolism ; Transcription Factor CHOP/deficiency
Chemical Substances	Aif1 protein, mouse ; Calcium-Binding Proteins ; Cytokines ; Ddit3 protein, mouse ; Microfilament Proteins ; NF-kappa B ; Transcription Factor CHOP (147336-12-7) ; N-Methylaspartate (6384-92-5) ; Hesperidin (E750O06Y6O)
Language	English
Publishing date	2021-11-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80122-7
ISSN	1096-0007 ; 0014-4835
ISSN (online)	1096-0007
ISSN	0014-4835
DOI	10.1016/j.exer.2021.108826
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Zs.A 163: Show issues

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Article ; Online: Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues.

Hisamatsu, Daisuke / Ohno-Oishi, Michiko / Nakamura, Shiho / Mabuchi, Yo / Naka-Kaneda, Hayato

Aging

2016 Volume 8, Issue 6, Page(s) 1259–1275

Abstract: The senescence-associated secretory phenotype (SASP) has attracted attention as a mechanism that connects cellular senescence to tissue dysfunction, and specific SASP factors have been identified as systemic pro-aging factors. However, little is known ... ...

Abstract	The senescence-associated secretory phenotype (SASP) has attracted attention as a mechanism that connects cellular senescence to tissue dysfunction, and specific SASP factors have been identified as systemic pro-aging factors. However, little is known about the age-dependent changes in the secretory properties of stem cells. Young, but not old, mesenchymal stem/stromal cells (MSCs) are a well-known source of critical regenerative factors, but the identity of these factors remains elusive. In this study, we identified growth differentiation factor 6 (Gdf6; also known as Bmp13 and CDMP-2) as a regenerative factor secreted from young MSCs. The expression of specific secretory factors, including Gdf6, was regulated by the microRNA (miRNA) miR-17, whose expression declined with age. Upregulation of Gdf6 restored the osteogenic capacity of old MSCs in vitro and exerted positive effects in vivo on aging-associated pathologies such as reduced lymphopoiesis, insufficient muscle repair, reduced numbers of neural progenitors in the brain, and chronic inflammation. Our results suggest that manipulation of miRNA could enable control of the SASP, and that regenerative factors derived from certain types of young cells could be used to treat geriatric diseases.
MeSH term(s)	Animals ; Cell Differentiation/physiology ; Cell Proliferation/physiology ; Cells, Cultured ; Cellular Senescence/physiology ; Growth Differentiation Factor 6/metabolism ; Mesenchymal Stromal Cells/metabolism ; Mice ; MicroRNAs/metabolism ; Osteogenesis/physiology ; Up-Regulation
Chemical Substances	Growth Differentiation Factor 6 ; MicroRNAs
Language	English
Publishing date	2016-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.100982
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