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  1. Article ; Online: Supplementation with cassis polyphenol has no effect on menopausal symptoms in healthy middle-aged women: A randomized, double-blind, parallel-group, placebo-controlled trial.

    Ohtsuka, Mayumi / Yamaguchi, Tohru / Oishi, Sachiko / Misawa, Koichi / Suzuki, Atsushi / Hibi, Masanobu / Terauchi, Masakazu

    Nutrition research (New York, N.Y.)

    2024  Volume 126, Page(s) 14–22

    Abstract: Hormonal changes during the menopause transition may lead to vasomotor symptoms, including hot flashes (HFs) and neuropsychiatric symptoms such as anxiety and irritability. We hypothesized that the effects of cassis polyphenol (CaP) to improve ... ...

    Abstract Hormonal changes during the menopause transition may lead to vasomotor symptoms, including hot flashes (HFs) and neuropsychiatric symptoms such as anxiety and irritability. We hypothesized that the effects of cassis polyphenol (CaP) to improve microcirculation and vasorelaxation may alleviate menopausal symptoms. We performed a randomized, double-blind, parallel-group, placebo-controlled trial involving 59 healthy women (mean [standard deviation] age, 51.3 [4.3] years; body mass index, 20.8 [2.6] kg/m
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 582432-1
    ISSN 1879-0739 ; 0271-5317
    ISSN (online) 1879-0739
    ISSN 0271-5317
    DOI 10.1016/j.nutres.2024.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Ingestion of coffee polyphenols suppresses deterioration of skin barrier function after barrier disruption, concomitant with the modulation of autonomic nervous system activity in healthy subjects

    Kagawa, Daiji / Fujii, Akihiko / Ohtsuka, Mayumi / Murase, Takatoshi

    Bioscience, biotechnology, and biochemistry. 2018 May 4, v. 82, no. 5

    2018  

    Abstract: The aim of this study was to evaluate the effect of consumption of coffee polyphenols (CPPs) on the autonomic nervous system activity and decreased skin barrier function caused by sodium dodecyl sulfate (SDS) treatment. In this single-blind, placebo- ... ...

    Abstract The aim of this study was to evaluate the effect of consumption of coffee polyphenols (CPPs) on the autonomic nervous system activity and decreased skin barrier function caused by sodium dodecyl sulfate (SDS) treatment. In this single-blind, placebo-controlled study, ten healthy male subjects consumed either a beverage containing CPPs or a placebo beverage for four weeks. CPPs significantly suppressed the deterioration in skin barrier function and skin moisture content induced by SDS treatment after the third week. Furthermore, in the heart rate variability analysis, CPPs significantly produced an increase in parasympathetic nervous activity, and a decrease in sympathetic nervous activity after the four weeks of beverage consumption. These results suggest that CPPs might influence the regulation of the autonomic nervous system and contribute to the suppressive effect on deterioration of skin barrier function.
    Keywords autonomic nervous system ; beverages ; biotechnology ; heart rate ; ingestion ; males ; placebos ; polyphenols ; sodium dodecyl sulfate ; water content
    Language English
    Dates of publication 2018-0504
    Size p. 879-884.
    Publishing place Taylor & Francis
    Document type Article
    Note NAL-light
    ZDB-ID 1106450-x
    ISSN 1347-6947 ; 0916-8451
    ISSN (online) 1347-6947
    ISSN 0916-8451
    DOI 10.1080/09168451.2018.1445520
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Ingestion of coffee polyphenols suppresses deterioration of skin barrier function after barrier disruption, concomitant with the modulation of autonomic nervous system activity in healthy subjects.

    Kagawa, Daiji / Fujii, Akihiko / Ohtsuka, Mayumi / Murase, Takatoshi

    Bioscience, biotechnology, and biochemistry

    2018  Volume 82, Issue 5, Page(s) 879–884

    Abstract: The aim of this study was to evaluate the effect of consumption of coffee polyphenols (CPPs) on the autonomic nervous system activity and decreased skin barrier function caused by sodium dodecyl sulfate (SDS) treatment. In this single-blind, placebo- ... ...

    Abstract The aim of this study was to evaluate the effect of consumption of coffee polyphenols (CPPs) on the autonomic nervous system activity and decreased skin barrier function caused by sodium dodecyl sulfate (SDS) treatment. In this single-blind, placebo-controlled study, ten healthy male subjects consumed either a beverage containing CPPs or a placebo beverage for four weeks. CPPs significantly suppressed the deterioration in skin barrier function and skin moisture content induced by SDS treatment after the third week. Furthermore, in the heart rate variability analysis, CPPs significantly produced an increase in parasympathetic nervous activity, and a decrease in sympathetic nervous activity after the four weeks of beverage consumption. These results suggest that CPPs might influence the regulation of the autonomic nervous system and contribute to the suppressive effect on deterioration of skin barrier function.
    Language English
    Publishing date 2018-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1106450-x
    ISSN 1347-6947 ; 0916-8451
    ISSN (online) 1347-6947
    ISSN 0916-8451
    DOI 10.1080/09168451.2018.1445520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A new method for the visualization and quantification of internal skin elasticity by ultrasound imaging.

    Osanai, Osamu / Ohtsuka, Mayumi / Hotta, Mitsuyuki / Kitaharai, Takashi / Takema, Yoshinori

    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

    2011  Volume 17, Issue 3, Page(s) 270–277

    Abstract: Background/purpose: Skin elasticity has been assessed previously only in the surface layer. We developed a new method that uses tissue strain imaging (TSI) technology, and the aim of this study was to test this new method to assess internal skin ... ...

    Abstract Background/purpose: Skin elasticity has been assessed previously only in the surface layer. We developed a new method that uses tissue strain imaging (TSI) technology, and the aim of this study was to test this new method to assess internal skin elasticity.
    Methods: Using a pressure device with a 12 MHz ultrasound transducer, constant and linear compressions were applied to the cheek skin of 35 volunteers (aged: 20-60 years). The elasticity of each layer (dermis, subcutaneous and muscle) was measured and analyzed using the TSI application software incorporated into the Toshiba Aplio(™) XV ultrasound system. A skin tissue-equivalent phantom, which is a block of material with the acoustic velocity (1530 m/s) of human skin, was collaboratively developed by OST Inc. This phantom was placed between the skin and the transducer as a reference material.
    Results: Skin elasticity was clearly visualized and quantified in each layer of the skin. Age-dependent decreases in elasticity were determined in all layers of the skin. Among the three internal skin layers, the highest elasticity was determined in the subcutaneous layer followed by the muscle layer.
    Conclusion: These findings support the validity and sensitivity of the TSI method to assess the elasticity of various layers of skin.
    MeSH term(s) Adult ; Elastic Modulus/physiology ; Elasticity Imaging Techniques/instrumentation ; Elasticity Imaging Techniques/methods ; Female ; Hardness Tests/methods ; Humans ; Male ; Middle Aged ; Palpation/methods ; Phantoms, Imaging ; Physical Stimulation/methods ; Pressure ; Reproducibility of Results ; Sensitivity and Specificity ; Skin/diagnostic imaging ; Skin Physiological Phenomena ; Suction ; Vibration
    Language English
    Publishing date 2011-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1229160-2
    ISSN 1600-0846 ; 0909-752X ; 1397-1344
    ISSN (online) 1600-0846
    ISSN 0909-752X ; 1397-1344
    DOI 10.1111/j.1600-0846.2010.00492.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Assessment of Multidimensional Health Care Parameters Among Adults in Japan for Developing a Virtual Human Generative Model: Protocol for a Cross-sectional Study.

    Hibi, Masanobu / Katada, Shun / Kawakami, Aya / Bito, Kotatsu / Ohtsuka, Mayumi / Sugitani, Kei / Muliandi, Adeline / Yamanaka, Nami / Hasumura, Takahiro / Ando, Yasutoshi / Fushimi, Takashi / Fujimatsu, Teruhisa / Akatsu, Tomoki / Kawano, Sawako / Kimura, Ren / Tsuchiya, Shigeki / Yamamoto, Yuuki / Haneoka, Mai / Kushida, Ken /
    Hideshima, Tomoki / Shimizu, Eri / Suzuki, Jumpei / Kirino, Aya / Tsujimura, Hisashi / Nakamura, Shun / Sakamoto, Takashi / Tazoe, Yuki / Yabuki, Masayuki / Nagase, Shinobu / Hirano, Tamaki / Fukuda, Reiko / Yamashiro, Yukari / Nagashima, Yoshinao / Ojima, Nobutoshi / Sudo, Motoki / Oya, Naoki / Minegishi, Yoshihiko / Misawa, Koichi / Charoenphakdee, Nontawat / Gao, Zhengyan / Hayashi, Kohei / Oono, Kenta / Sugawara, Yohei / Yamaguchi, Shoichiro / Ono, Takahiro / Maruyama, Hiroshi

    JMIR research protocols

    2023  Volume 12, Page(s) e47024

    Abstract: Background: Human health status can be measured on the basis of many different parameters. Statistical relationships among these different health parameters will enable several possible health care applications and an approximation of the current health ...

    Abstract Background: Human health status can be measured on the basis of many different parameters. Statistical relationships among these different health parameters will enable several possible health care applications and an approximation of the current health status of individuals, which will allow for more personalized and preventive health care by informing the potential risks and developing personalized interventions. Furthermore, a better understanding of the modifiable risk factors related to lifestyle, diet, and physical activity will facilitate the design of optimal treatment approaches for individuals.
    Objective: This study aims to provide a high-dimensional, cross-sectional data set of comprehensive health care information to construct a combined statistical model as a single joint probability distribution and enable further studies on individual relationships among the multidimensional data obtained.
    Methods: In this cross-sectional observational study, data were collected from a population of 1000 adult men and women (aged ≥20 years) matching the age ratio of the typical adult Japanese population. Data include biochemical and metabolic profiles from blood, urine, saliva, and oral glucose tolerance tests; bacterial profiles from feces, facial skin, scalp skin, and saliva; messenger RNA, proteome, and metabolite analyses of facial and scalp skin surface lipids; lifestyle surveys and questionnaires; physical, motor, cognitive, and vascular function analyses; alopecia analysis; and comprehensive analyses of body odor components. Statistical analyses will be performed in 2 modes: one to train a joint probability distribution by combining a commercially available health care data set containing large amounts of relatively low-dimensional data with the cross-sectional data set described in this paper and another to individually investigate the relationships among the variables obtained in this study.
    Results: Recruitment for this study started in October 2021 and ended in February 2022, with a total of 997 participants enrolled. The collected data will be used to build a joint probability distribution called a Virtual Human Generative Model. Both the model and the collected data are expected to provide information on the relationships between various health statuses.
    Conclusions: As different degrees of health status correlations are expected to differentially affect individual health status, this study will contribute to the development of empirically justified interventions based on the population.
    International registered report identifier (irrid): DERR1-10.2196/47024.
    Language English
    Publishing date 2023-06-09
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2719222-2
    ISSN 1929-0748
    ISSN 1929-0748
    DOI 10.2196/47024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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