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  1. Article ; Online: Curcumin and Its Derivatives Induce Apoptosis in Human Cancer Cells by Mobilizing and Redox Cycling Genomic Copper Ions.

    Alhasawi, Mohammed Ahmed Ismail / Aatif, Mohammad / Muteeb, Ghazala / Alam, Mir Waqas / Oirdi, Mohamed El / Farhan, Mohd

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 21

    Abstract: Turmeric spice contains curcuminoids, which are polyphenolic compounds found in the Curcuma longa plant's rhizome. This class of molecules includes curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Using prostate cancer cell lines PC3, LNCaP, DU145, ...

    Abstract Turmeric spice contains curcuminoids, which are polyphenolic compounds found in the Curcuma longa plant's rhizome. This class of molecules includes curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Using prostate cancer cell lines PC3, LNCaP, DU145, and C42B, we show that curcuminoids inhibit cell proliferation (measured by MTT assay) and induce apoptosis-like cell death (measured by DNA/histone ELISA). A copper chelator (neocuproine) and reactive oxygen species scavengers (thiourea for hydroxyl radical, superoxide dismutase for superoxide anion, and catalase for hydrogen peroxide) significantly inhibit this reaction, thus demonstrating that intracellular copper reacts with curcuminoids in cancer cells to cause DNA damage via ROS generation. We further show that copper-supplemented media sensitize normal breast epithelial cells (MCF-10A) to curcumin-mediated growth inhibition, as determined by decreased cell proliferation. Copper supplementation results in increased expression of copper transporters CTR1 and ATP7A in MCF-10A cells, which is attenuated by the addition of curcumin in the medium. We propose that the copper-mediated, ROS-induced mechanism of selective cell death of cancer cells may in part explain the anticancer effects of curcuminoids.
    MeSH term(s) Male ; Humans ; Curcumin ; Copper/pharmacology ; Reactive Oxygen Species/metabolism ; Curcuma/metabolism ; Diarylheptanoids/pharmacology ; Apoptosis ; Oxidation-Reduction ; Hydrogen Peroxide/pharmacology ; Genomics ; Neoplasms/drug therapy
    Chemical Substances Curcumin (IT942ZTH98) ; Copper (789U1901C5) ; Reactive Oxygen Species ; Diarylheptanoids ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2022-11-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27217410
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  2. Article: Necrotrophic Pathogens Use the Salicylic Acid Signaling Pathway to Promote Disease Development in Tomato

    Rahman, Taha Abd El / Bouarab Kamal / Gonzalez-Lamothe Rocio / Oirdi Mohamed El

    Molecular plant-microbe interactions. 2012 Dec., v. 25, no. 12

    2012  

    Abstract: Plants use different immune pathways to combat pathogens. The activation of the jasmonic acid (JA)-signaling pathway is required for resistance against necrotrophic pathogens; however, to combat biotrophic pathogens, the plants activate mainly the ... ...

    Abstract Plants use different immune pathways to combat pathogens. The activation of the jasmonic acid (JA)-signaling pathway is required for resistance against necrotrophic pathogens; however, to combat biotrophic pathogens, the plants activate mainly the salicylic acid (SA)-signaling pathway. SA can antagonize JA signaling and vice versa. NPR1 (noninducible pathogenesis-related 1) is considered a master regulator of SA signaling. NPR1 interacts with TGA transcription factors, ultimately leading to the activation of SA-dependent responses. SA has been shown to promote disease development caused by the necrotrophic pathogen Botrytis cinerea through NPR1, by suppressing the expression of two JA-dependent defense genes, proteinase inhibitors I and II. We show here that the transcription factor TGA1.a contributes to disease development caused by B. cinerea in tomato by suppressing the expression of proteinase inhibitors I and II. Finally, we present evidence that the SA-signaling pathway contributes to disease development caused by another necrotrophic pathogen, Alternaria solani, in tomato. Disease development promoted by SA through NPR1 requires the TGA1.a transcription factor. These data highlight how necrotrophs manipulate the SA-signaling pathway to promote their disease in tomato.
    Keywords Alternaria solani ; Botrytis cinerea ; genes ; jasmonic acid ; pathogens ; proteinase inhibitors ; salicylic acid ; signal transduction ; tomatoes ; transcription factors
    Language English
    Dates of publication 2012-12
    Size p. 1584-1593.
    Publishing place The American Phytopathological Society
    Document type Article
    ZDB-ID 743331-1
    ISSN 1943-7706 ; 0894-0282
    ISSN (online) 1943-7706
    ISSN 0894-0282
    DOI 10.1094%2FMPMI-07-12-0187-R
    Database NAL-Catalogue (AGRICOLA)

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    Z 4734: Show issues

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  3. Article: Necrotrophic pathogens use the salicylic acid signaling pathway to promote disease development in tomato.

    Rahman, Taha Abd El / Oirdi, Mohamed El / Gonzalez-Lamothe, Rocio / Bouarab, Kamal

    Molecular plant-microbe interactions : MPMI

    2012  Volume 25, Issue 12, Page(s) 1584–1593

    Abstract: Plants use different immune pathways to combat pathogens. The activation of the jasmonic acid (JA)-signaling pathway is required for resistance against necrotrophic pathogens; however, to combat biotrophic pathogens, the plants activate mainly the ... ...

    Abstract Plants use different immune pathways to combat pathogens. The activation of the jasmonic acid (JA)-signaling pathway is required for resistance against necrotrophic pathogens; however, to combat biotrophic pathogens, the plants activate mainly the salicylic acid (SA)-signaling pathway. SA can antagonize JA signaling and vice versa. NPR1 (noninducible pathogenesis-related 1) is considered a master regulator of SA signaling. NPR1 interacts with TGA transcription factors, ultimately leading to the activation of SA-dependent responses. SA has been shown to promote disease development caused by the necrotrophic pathogen Botrytis cinerea through NPR1, by suppressing the expression of two JA-dependent defense genes, proteinase inhibitors I and II. We show here that the transcription factor TGA1.a contributes to disease development caused by B. cinerea in tomato by suppressing the expression of proteinase inhibitors I and II. Finally, we present evidence that the SA-signaling pathway contributes to disease development caused by another necrotrophic pathogen, Alternaria solani, in tomato. Disease development promoted by SA through NPR1 requires the TGA1.a transcription factor. These data highlight how necrotrophs manipulate the SAsignaling pathway to promote their disease in tomato.
    MeSH term(s) Alternaria/pathogenicity ; Botrytis/pathogenicity ; Cyclopentanes/antagonists & inhibitors ; Cyclopentanes/metabolism ; Gene Expression Regulation, Plant/drug effects ; Host-Pathogen Interactions ; Lycopersicon esculentum/genetics ; Lycopersicon esculentum/microbiology ; Lycopersicon esculentum/physiology ; Models, Biological ; Oxylipins/antagonists & inhibitors ; Oxylipins/metabolism ; Plant Diseases/microbiology ; Plant Growth Regulators/metabolism ; Plant Immunity ; Plant Leaves/genetics ; Plant Leaves/microbiology ; Plant Leaves/physiology ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Protease Inhibitors ; Salicylic Acid/metabolism ; Salicylic Acid/pharmacology ; Signal Transduction ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemical Substances Cyclopentanes ; Oxylipins ; Plant Growth Regulators ; Plant Proteins ; Protease Inhibitors ; Transcription Factors ; jasmonic acid (6RI5N05OWW) ; Salicylic Acid (O414PZ4LPZ)
    Language English
    Publishing date 2012-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 743331-1
    ISSN 1943-7706 ; 0894-0282
    ISSN (online) 1943-7706
    ISSN 0894-0282
    DOI 10.1094/MPMI-07-12-0187-R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3530: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Bacterial cyclic beta-(1,2)-glucan acts in systemic suppression of plant immune responses.

    Rigano, Luciano Ariel / Payette, Caroline / Brouillard, Geneviève / Marano, Maria Rosa / Abramowicz, Laura / Torres, Pablo Sebastián / Yun, Maximina / Castagnaro, Atilio Pedro / Oirdi, Mohamed El / Dufour, Vanessa / Malamud, Florencia / Dow, John Maxwell / Bouarab, Kamal / Vojnov, Adrian Alberto

    The Plant cell

    2007  Volume 19, Issue 6, Page(s) 2077–2089

    Abstract: Although cyclic glucans have been shown to be important for a number of symbiotic and pathogenic bacterium-plant interactions, their precise roles are unclear. Here, we examined the role of cyclic beta-(1,2)-glucan in the virulence of the black rot ... ...

    Abstract Although cyclic glucans have been shown to be important for a number of symbiotic and pathogenic bacterium-plant interactions, their precise roles are unclear. Here, we examined the role of cyclic beta-(1,2)-glucan in the virulence of the black rot pathogen Xanthomonas campestris pv campestris (Xcc). Disruption of the Xcc nodule development B (ndvB) gene, which encodes a glycosyltransferase required for cyclic glucan synthesis, generated a mutant that failed to synthesize extracellular cyclic beta-(1,2)-glucan and was compromised in virulence in the model plants Arabidopsis thaliana and Nicotiana benthamiana. Infection of the mutant bacterium in N. benthamiana was associated with enhanced callose deposition and earlier expression of the PATHOGENESIS-RELATED1 (PR-1) gene. Application of purified cyclic beta-(1,2)-glucan prior to inoculation of the ndvB mutant suppressed the accumulation of callose deposition and the expression of PR-1 in N. benthamiana and restored virulence in both N. benthamiana and Arabidopsis plants. These effects were seen when cyclic glucan and bacteria were applied either to the same or to different leaves. Cyclic beta-(1,2)-glucan-induced systemic suppression was associated with the transport of the molecule throughout the plant. Systemic suppression is a novel counterdefensive strategy that may facilitate pathogen spread in plants and may have important implications for the understanding of plant-pathogen coevolution and for the development of phytoprotection measures.
    MeSH term(s) Arabidopsis/immunology ; Arabidopsis/metabolism ; Arabidopsis/microbiology ; Dose-Response Relationship, Drug ; Immunity, Innate ; Plant Diseases/immunology ; Plant Leaves/microbiology ; Signal Transduction ; Time Factors ; Nicotiana/immunology ; Nicotiana/metabolism ; Nicotiana/microbiology ; Virulence Factors ; Xanthomonas campestris/pathogenicity ; beta-Glucans/metabolism
    Chemical Substances Virulence Factors ; beta-Glucans
    Language English
    Publishing date 2007-06-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 623171-8
    ISSN 1532-298X ; 1040-4651
    ISSN (online) 1532-298X
    ISSN 1040-4651
    DOI 10.1105/tpc.106.047944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4952: Show issues

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  5. Article: Bacterial Cyclic β-(1,2)-Glucan Acts in Systemic Suppression of Plant Immune Responses

    Rigano, Luciano Ariel / Payette, Caroline / Brouillard, Geneviève / Marano, Maria Rosa / Abramowicz, Laura / Torres, Pablo Sebastián / Yun, Maximina / Castagnaro, Atilio Pedro / Oirdi, Mohamed El / Dufour, Vanessa / Malamud, Florencia / Dow, John Maxwell / Bouarab, Kamal / Vojnov, Adrian Alberto

    Plant cell. 2007 June, v. 19, no. 6

    2007  

    Abstract: Although cyclic glucans have been shown to be important for a number of symbiotic and pathogenic bacterium-plant interactions, their precise roles are unclear. Here, we examined the role of cyclic β-(1,2)-glucan in the virulence of the black rot pathogen ...

    Abstract Although cyclic glucans have been shown to be important for a number of symbiotic and pathogenic bacterium-plant interactions, their precise roles are unclear. Here, we examined the role of cyclic β-(1,2)-glucan in the virulence of the black rot pathogen Xanthomonas campestris pv campestris (Xcc). Disruption of the Xcc nodule development B (ndvB) gene, which encodes a glycosyltransferase required for cyclic glucan synthesis, generated a mutant that failed to synthesize extracellular cyclic β-(1,2)-glucan and was compromised in virulence in the model plants Arabidopsis thaliana and Nicotiana benthamiana. Infection of the mutant bacterium in N. benthamiana was associated with enhanced callose deposition and earlier expression of the PATHOGENESIS-RELATED1 (PR-1) gene. Application of purified cyclic β-(1,2)-glucan prior to inoculation of the ndvB mutant suppressed the accumulation of callose deposition and the expression of PR-1 in N. benthamiana and restored virulence in both N. benthamiana and Arabidopsis plants. These effects were seen when cyclic glucan and bacteria were applied either to the same or to different leaves. Cyclic β-(1,2)-glucan-induced systemic suppression was associated with the transport of the molecule throughout the plant. Systemic suppression is a novel counterdefensive strategy that may facilitate pathogen spread in plants and may have important implications for the understanding of plant-pathogen coevolution and for the development of phytoprotection measures.
    Keywords Arabidopsis thaliana ; Nicotiana benthamiana ; Xanthomonas campestris pv. campestris ; bacteria ; callose ; coevolution ; genes ; glucans ; immune response ; leaves ; mutants ; pathogens ; virulence
    Language English
    Dates of publication 2007-06
    Size p. 2077-2089.
    Publishing place American Society of Plant Biologists
    Document type Article
    ZDB-ID 623171-8
    ISSN 1532-298X ; 1040-4651
    ISSN (online) 1532-298X
    ISSN 1040-4651
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4952: Show issues
    IZMB/IMBIO: Kirschallee: Show issues

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  6. Article: Xanthan Induces Plant Susceptibility by Suppressing Callose Deposition

    Yun, Maximina H / Torres, Pablo S / Oirdi, Mohamed El / Rigano, Luciano A / Gonzalez-Lamothe, Rocio / Marano, María Rosa / Castagnaro, Atilio P / Dankert, Marcelo A / Bouarab, Kamal / Vojnov, Adrián A

    Plant physiology. 2006 May, v. 141, no. 1

    2006  

    Abstract: Xanthan is the major exopolysaccharide secreted by Xanthomonas spp. Despite its diverse roles in bacterial pathogenesis of plants, little is known about the real implication of this molecule in Xanthomonas pathogenesis. In this study we show that in ... ...

    Abstract Xanthan is the major exopolysaccharide secreted by Xanthomonas spp. Despite its diverse roles in bacterial pathogenesis of plants, little is known about the real implication of this molecule in Xanthomonas pathogenesis. In this study we show that in contrast to Xanthomonas campestris pv campestris strain 8004 (wild type), the xanthan minus mutant (strain 8397) and the mutant strain 8396, which is producing truncated xanthan, fail to cause disease in both Nicotiana benthamiana and Arabidopsis (Arabidopsis thaliana) plants. In contrast to wild type, 8397 and 8396 strains induce callose deposition in N. benthamiana and Arabidopsis plants. Interestingly, treatment with xanthan but not truncated xanthan, suppresses the accumulation of callose and enhances the susceptibility of both N. benthamiana and Arabidopsis plants to 8397 and 8396 mutant strains. Finally, in concordance, we also show that treatment with an inhibitor of callose deposition previous to infection induces susceptibility to 8397 and 8396 strains. Thus, xanthan suppression effect on callose deposition seems to be important for Xanthomonas infectivity.
    Keywords Arabidopsis thaliana ; Nicotiana benthamiana ; Xanthomonas campestris pv. campestris ; callose ; mutants ; xanthan gum
    Language English
    Dates of publication 2006-05
    Size p. 178-187.
    Publishing place American Society of Plant Biologists
    Document type Article
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    Database NAL-Catalogue (AGRICOLA)

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    Z 1193: Show issues
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