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  1. Article: HIV Associated Neurocognitive Disorders Subsidence Through Citalopram Addition in Anti-retroviral Therapy (HANDS-CARE): A Concept Note.

    Ojagbemi, Akin

    Frontiers in neurology

    2021  Volume 12, Page(s) 658705

    Abstract: There is a pressing need to effectively manage HIV Associated Neurocognitive Disorders (HAND) in sub-Saharan Africa (SSA) where the burden is among the highest in the world. Contemporary approaches based on the use of Highly Active Antiretroviral Therapy ...

    Abstract There is a pressing need to effectively manage HIV Associated Neurocognitive Disorders (HAND) in sub-Saharan Africa (SSA) where the burden is among the highest in the world. Contemporary approaches based on the use of Highly Active Antiretroviral Therapy (HAART) alone are inadequate interventions for HAND, especially in SSA where there is limited availability of the required combinations of HAART for effective central nervous system penetration and where many currently prescribed agents, including efavirenz, have neurotoxicity as a major drawback. This article reviews data supporting the rationale for additive citalopram in antiretroviral therapy as a latent approach to abate HAND. It proposes the conduct of a HIV Associated Neurocognitive Disorders Subsidence through Citalopram addition in
    Language English
    Publishing date 2021-07-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.658705
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  2. Article ; Online: Applicability and future status of schizophrenia as a construct in Africa.

    Gureje, Oye / Ojagbemi, Akin

    Schizophrenia research

    2022  Volume 242, Page(s) 52–55

    MeSH term(s) Africa/epidemiology ; Humans ; Patient Acceptance of Health Care ; Psychotic Disorders ; Schizophrenia/therapy
    Language English
    Publishing date 2022-02-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2022.01.023
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  3. Article ; Online: Sociocultural contexts of mental illness experience among Africans.

    Ojagbemi, Akin / Gureje, Oye

    Transcultural psychiatry

    2021  Volume 58, Issue 4, Page(s) 455–459

    MeSH term(s) Humans ; Mental Disorders
    Language English
    Publishing date 2021-08-24
    Publishing country England
    Document type Editorial
    ZDB-ID 1378978-8
    ISSN 1461-7471 ; 1363-4615
    ISSN (online) 1461-7471
    ISSN 1363-4615
    DOI 10.1177/13634615211029055
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  4. Article ; Online: The Potential Role of Traditional Medicine in the Management of Schizophrenia.

    Ojagbemi, Akin / Gureje, Oye

    Current psychiatry reports

    2020  Volume 22, Issue 12, Page(s) 71

    Abstract: Purpose of review: This article presents an overview of recent literature examining the place of traditional methods of mental healthcare in the management of schizophrenia.: Recent findings: Patients with schizophrenia make up a large proportion of ... ...

    Abstract Purpose of review: This article presents an overview of recent literature examining the place of traditional methods of mental healthcare in the management of schizophrenia.
    Recent findings: Patients with schizophrenia make up a large proportion of people seeking traditional methods of mental healthcare, and a majority of such users perceive traditional medicine treatment as helpful. Adherence rates to traditional treatment methods among users may be well over 80%. Nevertheless, evidence is currently too weak to inform recommendation of traditional methods as standalone treatments for schizophrenia. Collaboration between traditional medicine practitioners and biomedical mental healthcare providers is feasible and may lead to safer treatments and better outcomes for patients with schizophrenia. Many patients with schizophrenia preferentially use traditional methods of mental healthcare. A collaborative working relationship that includes training and clinical support for traditional medicine providers by biomedical providers is feasible and may help narrow the global treatment gap for schizophrenia.
    MeSH term(s) Humans ; Medicine, Traditional ; Schizophrenia/drug therapy
    Language English
    Publishing date 2020-10-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055376-6
    ISSN 1535-1645 ; 1523-3812
    ISSN (online) 1535-1645
    ISSN 1523-3812
    DOI 10.1007/s11920-020-01196-7
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  5. Article ; Online: The importance of faith-based mental healthcare in African urbanized sites.

    Ojagbemi, Akin / Gureje, Oye

    Current opinion in psychiatry

    2020  Volume 33, Issue 3, Page(s) 271–277

    Abstract: Purpose of review: This review highlights what current research says about how local beliefs and norms can facilitate expansion of mental healthcare to meet the large unmet need for services in Africa.: Recent findings: In contemporary Africa, ... ...

    Abstract Purpose of review: This review highlights what current research says about how local beliefs and norms can facilitate expansion of mental healthcare to meet the large unmet need for services in Africa.
    Recent findings: In contemporary Africa, religious beliefs exert important influences on mental health as well as the way people with mental illnesses are viewed and cared for. Mental healthcare practices based on traditional and other religious beliefs, and offered by complementary and alternative health providers (CAPs), reflect the people's culture and are often preferentially sought by a majority of the population. Despite important differences in the worldviews of CAPs and biomedical mental healthcare practitioners in regard to causal explanations, there are nevertheless overlaps in the approaches of both sectors to the management of mental health conditions. These overlaps may provide a platform for collaboration and facilitate the scaling-up of evidence-based mental health services to underserved African populations, especially those residing in ever-expanding urban centres.
    Summary: Faith-based mental healthcare is an important but informal component of the mental health system in much of Africa. Collaboration between its practitioners and biomedical practice may help to bridge the large treatment gap for mental health conditions on the continent.
    MeSH term(s) Africa ; Humans ; Mental Disorders/psychology ; Mental Disorders/therapy ; Mental Health Services/organization & administration ; Religion ; Urban Population
    Language English
    Publishing date 2020-02-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645162-7
    ISSN 1473-6578 ; 0951-7367
    ISSN (online) 1473-6578
    ISSN 0951-7367
    DOI 10.1097/YCO.0000000000000590
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    Zs.A 2532: Show issues Location:
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  6. Article ; Online: The high rate of major depression after stroke in Nigeria may be the result of high cumulative morbidity burden: a call for greater efficiency in the management of stroke in developing countries.

    Ojagbemi, Akin

    International journal of stroke : official journal of the International Stroke Society

    2014  Volume 9, Issue 1, Page(s) E1

    MeSH term(s) Comorbidity ; Depressive Disorder, Major/epidemiology ; Depressive Disorder, Major/etiology ; Developing Countries/statistics & numerical data ; Female ; Humans ; Male ; Nigeria/epidemiology ; Stroke/complications ; Stroke/psychology
    Language English
    Publishing date 2014-01
    Publishing country United States
    Document type Letter
    ZDB-ID 2303728-3
    ISSN 1747-4949 ; 1747-4930
    ISSN (online) 1747-4949
    ISSN 1747-4930
    DOI 10.1111/ijs.12219
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    Zs.A 6582: Show issues Location:
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  7. Article ; Online: Participatory development of a home-based depression care model with lived experience older Nigerians and their caregivers: A theory of change.

    Ojagbemi, Akin / Daley, Stephanie / Feeney, Yvonne / Elugbadebo, Olufisayo / Kola, Lola / Gureje, Oye

    International journal of geriatric psychiatry

    2023  Volume 38, Issue 11, Page(s) e6019

    Abstract: Objectives: There is a huge treatment gap for late-life depression in sub-Saharan Africa. Building on prior work to scale-up mental healthcare with the aid of the WHO Mental Health Gap Action Programme Intervention Guide electronic version (emhGAP-IG), ... ...

    Abstract Objectives: There is a huge treatment gap for late-life depression in sub-Saharan Africa. Building on prior work to scale-up mental healthcare with the aid of the WHO Mental Health Gap Action Programme Intervention Guide electronic version (emhGAP-IG), this study aims to involve older people in the iterative development of innovations to overcome challenges in the detection and clinical management of late-life depression by frontline non-specialist primary healthcare workers (PHCW) in Nigeria.
    Methods: There were 43 participants in the study. We conducted formative qualitative research using 15 in-depth key informant interviews with persons who were 60 years or older and had a recent experience of depression. We also conducted two focus group discussions comprising 13 of their caregivers. Through a full day stakeholders workshop comprising 15 participants, we drew on the results of our qualitative explorations to identify the pathway to impact of an intervention package (emhGAP-Age) appropriate for the specific needs of persons with late-life depression in Nigeria.
    Results: A Theory of Change (ToC) map was produced. It highlights the expected long-term outcomes of emhGAP-Age to include the potential for improvement of the mental health and wellbeing of older people living in Nigeria and the generation of interest among governmental agencies concerned with policy and planning for mental healthcare. Key resources that serve as preconditions were identified to consist of the availability of PHCW who are skilled in the identification and treatment of depression and have interest in and commitment to providing care to older people. Required community resources include support from immediate family, neighbours, and informal groups. Interventions that are appropriate for depression in old age need to incorporate these community resources and address not only the symptoms of the condition but also comorbid physical health problems.
    Conclusions: A participatory ToC process led to the identification of the key components of an age-appropriate version of the emhGAP-IG for delivering care to older persons with depression by PHCW in Nigeria.
    MeSH term(s) Humans ; Aged ; Aged, 80 and over ; Caregivers/psychology ; Depression/therapy ; Depression/diagnosis ; Mental Health ; Health Personnel ; Home Care Services
    Language English
    Publishing date 2023-10-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 806736-3
    ISSN 1099-1166 ; 0885-6230
    ISSN (online) 1099-1166
    ISSN 0885-6230
    DOI 10.1002/gps.6019
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    Zs.A 2208: Show issues Location:
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  8. Article: Typology of Social Network Structures and Late-Life Depression in Low- and Middle-Income Countries.

    Ojagbemi, Akin / Gureje, Oye

    Clinical practice and epidemiology in mental health : CP & EMH

    2019  Volume 15, Page(s) 134–142

    Abstract: Background: Rapid social changes and youth migration ensures a continuous drain on the social networks of the elderly in Low- and Middle-Income Countries (LMICs).: Objective: We reviewed available literature on the relationship between social network ...

    Abstract Background: Rapid social changes and youth migration ensures a continuous drain on the social networks of the elderly in Low- and Middle-Income Countries (LMICs).
    Objective: We reviewed available literature on the relationship between social network structures and depression among community dwelling older persons in LMICs with a view to identifying patterns that might provide information for designing preventive psychosocial interventions.
    Methods: We searched the MEDLINE database through Pubmed, extracted information on the typologies of social network structures in LMICs and identified dimensions with the strongest systematic association with late-life depression, by weight, using the inverse of variance method. All analyses were conducted using the Cochrane review manager version 5.3.
    Results: Fourteen community-based surveys drawn from 16 LMIC contexts met criteria for syntheses. They included a total of 37,917 mostly female (58.8%) participants with an average age of 73.2 years. Social network size, contact with network, diversity of network, co-residency with own child, having more friends than family in the network, and prestigious standing of persons in the social network were protective structures against late-life depression. Conversely, low network diversity contributed 44.2% of the weight of all social network structures that are predictive of late-life depression.
    Conclusion: Recommendations are made for the design of new measures of social network structures in LMICs that captures the key dimensions identified. Epidemiological studies using such tools will provide more precise information for planning and prioritization of scarce resources for the prevention of late-life depression in LMICs.
    Language English
    Publishing date 2019-11-15
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2559748-6
    ISSN 1745-0179
    ISSN 1745-0179
    DOI 10.2174/1745017901915010134
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  9. Article: Dominant and Modifiable Risk Factors for Dementia in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.

    Ojagbemi, Akin / Okekunle, Akinkunmi Paul / Babatunde, Opeyemi

    Frontiers in neurology

    2021  Volume 12, Page(s) 627761

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-03-25
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.627761
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  10. Article ; Online: Cognitive decline before and after a first-ever stroke in Africans.

    Ojagbemi, Akin / Bello, Toyin / Owolabi, Mayowa / Baiyewu, Olusegun

    Acta neurologica Scandinavica

    2021  Volume 144, Issue 3, Page(s) 266–274

    Abstract: Objectives: There is a knowledge gap on the impact of pre-existing cognitive decline on poststroke decline in indigenous Africans. We describe the trajectories of domain-specific cognitive and activities of daily life (ADL) functioning across the first ... ...

    Abstract Objectives: There is a knowledge gap on the impact of pre-existing cognitive decline on poststroke decline in indigenous Africans. We describe the trajectories of domain-specific cognitive and activities of daily life (ADL) functioning across the first year of stroke in Nigerians with pre-existing cognitive decline.
    Materials and methods: Prospective observational study. Prestroke cognitive decline was ascertained retrospectively using the 16-item Informant Questionnaire for Cognitive Decline in the Elderly (IQCODE). Assessments for global cognition, learning, memory, executive and ADL functioning were conducted at 3 time points using the Mini-Mental state examination (MMSE), 10-words list learning and delayed recall test (10 WDRT), Animal naming test and Barthel index, respectively.
    Results: Among 150 stroke survivors, prestroke cognitive decline was found in 25 (16.7%, 95% C.I = 11.5%-23.6%). In linear regression analyses adjusting for the effect of age, education, stroke severity and comorbid diabetes mellitus, prestroke cognitive decline predicted poor memory scores at one year [Adjusted standardized mean difference (SMD) = -0.6, 95% C.I = -1.1, -0.1, p = 0.016)]. The association of prestroke cognitive decline with poststroke poor memory was substantially mediated by age (SMD = -0.9, 95% C.I = -1.4, -0.4, p < 0.001).
    Conclusion: Pre-existing cognitive decline in this sample was associated with an age-mediated poor memory function at one-year poststroke. Early institution of targeted cognitive rehabilitation in stroke survivors with pre-existing cognitive decline may reduce the neurocognitive burden of stroke in Black Africans.
    MeSH term(s) Africa ; Aged ; Cognition ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/etiology ; Humans ; Mental Status and Dementia Tests ; Retrospective Studies ; Risk Factors ; Stroke/complications ; Stroke/epidemiology
    Language English
    Publishing date 2021-04-29
    Publishing country Denmark
    Document type Journal Article ; Observational Study
    ZDB-ID 90-5
    ISSN 1600-0404 ; 0001-6314
    ISSN (online) 1600-0404
    ISSN 0001-6314
    DOI 10.1111/ane.13442
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